Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X198_LEIDO

TriTrypDb:

LdBPK_280320.1 , LdCL_280009300 , LDHU3_28.0550

Length:

774

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X198

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X198

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	151	155	PF00656	0.691
CLV_C14_Caspase3-7	284	288	PF00656	0.658
CLV_NRD_NRD_1	177	179	PF00675	0.573
CLV_NRD_NRD_1	275	277	PF00675	0.691
CLV_NRD_NRD_1	348	350	PF00675	0.616
CLV_NRD_NRD_1	372	374	PF00675	0.511
CLV_NRD_NRD_1	493	495	PF00675	0.692
CLV_NRD_NRD_1	630	632	PF00675	0.570
CLV_PCSK_KEX2_1	177	179	PF00082	0.667
CLV_PCSK_KEX2_1	275	277	PF00082	0.691
CLV_PCSK_KEX2_1	307	309	PF00082	0.630
CLV_PCSK_KEX2_1	371	373	PF00082	0.516
CLV_PCSK_KEX2_1	570	572	PF00082	0.668
CLV_PCSK_KEX2_1	629	631	PF00082	0.546
CLV_PCSK_PC1ET2_1	307	309	PF00082	0.630
CLV_PCSK_PC1ET2_1	570	572	PF00082	0.668
CLV_PCSK_SKI1_1	158	162	PF00082	0.604
CLV_PCSK_SKI1_1	455	459	PF00082	0.538
DEG_APCC_DBOX_1	157	165	PF00400	0.398
DEG_APCC_DBOX_1	348	356	PF00400	0.509
DEG_SPOP_SBC_1	149	153	PF00917	0.556
DOC_CKS1_1	503	508	PF01111	0.648
DOC_CKS1_1	654	659	PF01111	0.689
DOC_CYCLIN_yCln2_LP_2	443	449	PF00134	0.663
DOC_CYCLIN_yCln2_LP_2	503	509	PF00134	0.659
DOC_MAPK_gen_1	275	282	PF00069	0.650
DOC_MAPK_gen_1	583	592	PF00069	0.616
DOC_MAPK_gen_1	6	15	PF00069	0.748
DOC_MAPK_MEF2A_6	439	447	PF00069	0.654
DOC_MAPK_MEF2A_6	583	592	PF00069	0.536
DOC_MAPK_MEF2A_6	6	15	PF00069	0.748
DOC_MAPK_MEF2A_6	681	688	PF00069	0.582
DOC_PP1_RVXF_1	10	16	PF00149	0.754
DOC_PP2B_LxvP_1	443	446	PF13499	0.664
DOC_PP2B_LxvP_1	518	521	PF13499	0.511
DOC_PP2B_LxvP_1	605	608	PF13499	0.566
DOC_PP4_FxxP_1	212	215	PF00568	0.681
DOC_USP7_MATH_1	102	106	PF00917	0.754
DOC_USP7_MATH_1	144	148	PF00917	0.746
DOC_USP7_MATH_1	183	187	PF00917	0.683
DOC_USP7_MATH_1	2	6	PF00917	0.600
DOC_USP7_MATH_1	249	253	PF00917	0.793
DOC_USP7_MATH_1	29	33	PF00917	0.745
DOC_USP7_MATH_1	546	550	PF00917	0.707
DOC_USP7_MATH_1	576	580	PF00917	0.755
DOC_USP7_MATH_1	706	710	PF00917	0.715
DOC_USP7_MATH_1	716	720	PF00917	0.531
DOC_USP7_MATH_1	736	740	PF00917	0.447
DOC_USP7_MATH_1	765	769	PF00917	0.568
DOC_USP7_UBL2_3	8	12	PF12436	0.724
DOC_WW_Pin1_4	106	111	PF00397	0.713
DOC_WW_Pin1_4	126	131	PF00397	0.455
DOC_WW_Pin1_4	153	158	PF00397	0.646
DOC_WW_Pin1_4	25	30	PF00397	0.801
DOC_WW_Pin1_4	253	258	PF00397	0.557
DOC_WW_Pin1_4	339	344	PF00397	0.606
DOC_WW_Pin1_4	411	416	PF00397	0.676
DOC_WW_Pin1_4	489	494	PF00397	0.804
DOC_WW_Pin1_4	502	507	PF00397	0.532
DOC_WW_Pin1_4	616	621	PF00397	0.583
DOC_WW_Pin1_4	653	658	PF00397	0.622
DOC_WW_Pin1_4	749	754	PF00397	0.565
DOC_WW_Pin1_4	87	92	PF00397	0.615
LIG_14-3-3_CanoR_1	197	203	PF00244	0.574
LIG_14-3-3_CanoR_1	313	319	PF00244	0.456
LIG_14-3-3_CanoR_1	373	383	PF00244	0.605
LIG_14-3-3_CanoR_1	455	461	PF00244	0.495
LIG_14-3-3_CanoR_1	574	584	PF00244	0.662
LIG_14-3-3_CanoR_1	646	654	PF00244	0.619
LIG_14-3-3_CanoR_1	710	718	PF00244	0.714
LIG_14-3-3_CanoR_1	735	744	PF00244	0.628
LIG_14-3-3_CanoR_1	79	85	PF00244	0.594
LIG_Actin_WH2_2	298	315	PF00022	0.516
LIG_Actin_WH2_2	359	377	PF00022	0.618
LIG_BIR_II_1	1	5	PF00653	0.680
LIG_BIR_III_2	154	158	PF00653	0.635
LIG_BIR_III_3	1	5	PF00653	0.680
LIG_BRCT_BRCA1_1	146	150	PF00533	0.585
LIG_BRCT_BRCA1_1	195	199	PF00533	0.584
LIG_Clathr_ClatBox_1	602	606	PF01394	0.561
LIG_Clathr_ClatBox_1	623	627	PF01394	0.678
LIG_CSL_BTD_1	518	521	PF09270	0.511
LIG_EVH1_2	620	624	PF00568	0.607
LIG_FHA_1	333	339	PF00498	0.714
LIG_FHA_1	392	398	PF00498	0.576
LIG_FHA_1	435	441	PF00498	0.593
LIG_FHA_1	465	471	PF00498	0.656
LIG_FHA_1	498	504	PF00498	0.659
LIG_FHA_1	649	655	PF00498	0.674
LIG_FHA_1	75	81	PF00498	0.787
LIG_FHA_2	220	226	PF00498	0.706
LIG_FHA_2	343	349	PF00498	0.605
LIG_FHA_2	503	509	PF00498	0.570
LIG_FHA_2	552	558	PF00498	0.615
LIG_FHA_2	728	734	PF00498	0.597
LIG_GBD_Chelix_1	164	172	PF00786	0.465
LIG_Integrin_RGD_1	681	683	PF01839	0.591
LIG_LIR_Apic_2	210	215	PF02991	0.706
LIG_LIR_Apic_2	223	229	PF02991	0.682
LIG_LIR_Gen_1	166	176	PF02991	0.492
LIG_LIR_Gen_1	196	207	PF02991	0.582
LIG_LIR_Gen_1	221	229	PF02991	0.683
LIG_LIR_Gen_1	353	363	PF02991	0.474
LIG_LIR_Gen_1	687	696	PF02991	0.606
LIG_LIR_Nem_3	166	172	PF02991	0.480
LIG_LIR_Nem_3	196	202	PF02991	0.582
LIG_LIR_Nem_3	221	227	PF02991	0.801
LIG_LIR_Nem_3	353	359	PF02991	0.469
LIG_LIR_Nem_3	687	691	PF02991	0.563
LIG_NRBOX	167	173	PF00104	0.572
LIG_NRP_CendR_1	771	774	PF00754	0.625
LIG_PTB_Apo_2	206	213	PF02174	0.659
LIG_SH2_CRK	169	173	PF00017	0.502
LIG_SH2_CRK	277	281	PF00017	0.746
LIG_SH2_CRK	531	535	PF00017	0.609
LIG_SH2_NCK_1	41	45	PF00017	0.689
LIG_SH2_STAP1	116	120	PF00017	0.617
LIG_SH2_STAP1	383	387	PF00017	0.584
LIG_SH2_STAP1	41	45	PF00017	0.786
LIG_SH2_STAP1	614	618	PF00017	0.484
LIG_SH2_STAT5	175	178	PF00017	0.612
LIG_SH2_STAT5	649	652	PF00017	0.527
LIG_SH3_1	268	274	PF00018	0.743
LIG_SH3_2	270	275	PF14604	0.799
LIG_SH3_3	23	29	PF00018	0.737
LIG_SH3_3	251	257	PF00018	0.679
LIG_SH3_3	267	273	PF00018	0.636
LIG_SH3_3	524	530	PF00018	0.577
LIG_SH3_3	589	595	PF00018	0.678
LIG_SH3_3	651	657	PF00018	0.662
LIG_SH3_3	712	718	PF00018	0.584
LIG_SH3_CIN85_PxpxPR_1	270	275	PF14604	0.784
LIG_SUMO_SIM_anti_2	278	284	PF11976	0.718
LIG_SUMO_SIM_anti_2	384	390	PF11976	0.374
LIG_SUMO_SIM_par_1	393	402	PF11976	0.520
LIG_TYR_ITIM	167	172	PF00017	0.491
LIG_WW_3	272	276	PF00397	0.676
LIG_WW_3	593	597	PF00397	0.587
MOD_CDK_SPK_2	153	158	PF00069	0.646
MOD_CDK_SPK_2	489	494	PF00069	0.701
MOD_CDK_SPxK_1	489	495	PF00069	0.703
MOD_CDK_SPxK_1	653	659	PF00069	0.716
MOD_CDK_SPxxK_3	339	346	PF00069	0.601
MOD_CK1_1	148	154	PF00069	0.613
MOD_CK1_1	17	23	PF00069	0.717
MOD_CK1_1	256	262	PF00069	0.659
MOD_CK1_1	281	287	PF00069	0.594
MOD_CK1_1	342	348	PF00069	0.578
MOD_CK1_1	408	414	PF00069	0.710
MOD_CK1_1	456	462	PF00069	0.543
MOD_CK1_1	647	653	PF00069	0.609
MOD_CK1_1	662	668	PF00069	0.510
MOD_CK1_1	699	705	PF00069	0.702
MOD_CK1_1	97	103	PF00069	0.709
MOD_CK2_1	183	189	PF00069	0.713
MOD_CK2_1	237	243	PF00069	0.608
MOD_CK2_1	401	407	PF00069	0.638
MOD_CK2_1	727	733	PF00069	0.595
MOD_CK2_1	87	93	PF00069	0.767
MOD_GlcNHglycan	147	150	PF01048	0.637
MOD_GlcNHglycan	2	5	PF01048	0.741
MOD_GlcNHglycan	204	207	PF01048	0.654
MOD_GlcNHglycan	239	242	PF01048	0.761
MOD_GlcNHglycan	251	254	PF01048	0.585
MOD_GlcNHglycan	31	34	PF01048	0.656
MOD_GlcNHglycan	389	392	PF01048	0.560
MOD_GlcNHglycan	403	406	PF01048	0.579
MOD_GlcNHglycan	407	410	PF01048	0.558
MOD_GlcNHglycan	455	458	PF01048	0.646
MOD_GlcNHglycan	660	664	PF01048	0.672
MOD_GlcNHglycan	740	743	PF01048	0.602
MOD_GlcNHglycan	99	102	PF01048	0.754
MOD_GSK3_1	102	109	PF00069	0.728
MOD_GSK3_1	144	151	PF00069	0.627
MOD_GSK3_1	198	205	PF00069	0.524
MOD_GSK3_1	249	256	PF00069	0.660
MOD_GSK3_1	25	32	PF00069	0.758
MOD_GSK3_1	328	335	PF00069	0.651
MOD_GSK3_1	387	394	PF00069	0.514
MOD_GSK3_1	401	408	PF00069	0.569
MOD_GSK3_1	497	504	PF00069	0.682
MOD_GSK3_1	547	554	PF00069	0.692
MOD_GSK3_1	644	651	PF00069	0.540
MOD_GSK3_1	696	703	PF00069	0.686
MOD_GSK3_1	706	713	PF00069	0.663
MOD_GSK3_1	74	81	PF00069	0.678
MOD_GSK3_1	87	94	PF00069	0.720
MOD_LATS_1	82	88	PF00433	0.710
MOD_N-GLC_1	210	215	PF02516	0.682
MOD_N-GLC_1	357	362	PF02516	0.486
MOD_N-GLC_1	644	649	PF02516	0.665
MOD_N-GLC_1	65	70	PF02516	0.722
MOD_N-GLC_2	292	294	PF02516	0.538
MOD_NEK2_1	202	207	PF00069	0.559
MOD_NEK2_1	426	431	PF00069	0.489
MOD_NEK2_1	644	649	PF00069	0.665
MOD_NEK2_2	49	54	PF00069	0.716
MOD_PIKK_1	456	462	PF00454	0.588
MOD_PKA_2	243	249	PF00069	0.588
MOD_PKA_2	374	380	PF00069	0.612
MOD_PKA_2	563	569	PF00069	0.567
MOD_PKA_2	665	671	PF00069	0.592
MOD_PKA_2	736	742	PF00069	0.630
MOD_PKA_2	78	84	PF00069	0.628
MOD_PKA_2	94	100	PF00069	0.685
MOD_PKB_1	373	381	PF00069	0.607
MOD_Plk_1	220	226	PF00069	0.676
MOD_Plk_1	357	363	PF00069	0.493
MOD_Plk_1	399	405	PF00069	0.650
MOD_Plk_1	426	432	PF00069	0.498
MOD_Plk_1	434	440	PF00069	0.531
MOD_Plk_1	644	650	PF00069	0.673
MOD_Plk_4	163	169	PF00069	0.415
MOD_Plk_4	198	204	PF00069	0.520
MOD_Plk_4	278	284	PF00069	0.616
MOD_Plk_4	34	40	PF00069	0.724
MOD_Plk_4	351	357	PF00069	0.529
MOD_Plk_4	391	397	PF00069	0.573
MOD_Plk_4	49	55	PF00069	0.747
MOD_Plk_4	551	557	PF00069	0.553
MOD_Plk_4	598	604	PF00069	0.597
MOD_Plk_4	717	723	PF00069	0.716
MOD_ProDKin_1	106	112	PF00069	0.710
MOD_ProDKin_1	126	132	PF00069	0.457
MOD_ProDKin_1	153	159	PF00069	0.636
MOD_ProDKin_1	25	31	PF00069	0.795
MOD_ProDKin_1	253	259	PF00069	0.555
MOD_ProDKin_1	339	345	PF00069	0.604
MOD_ProDKin_1	411	417	PF00069	0.658
MOD_ProDKin_1	489	495	PF00069	0.806
MOD_ProDKin_1	502	508	PF00069	0.525
MOD_ProDKin_1	616	622	PF00069	0.594
MOD_ProDKin_1	653	659	PF00069	0.625
MOD_ProDKin_1	749	755	PF00069	0.555
MOD_ProDKin_1	87	93	PF00069	0.614
MOD_SUMO_rev_2	213	222	PF00179	0.687
MOD_SUMO_rev_2	342	352	PF00179	0.671
TRG_DiLeu_BaEn_1	639	644	PF01217	0.629
TRG_DiLeu_BaLyEn_6	618	623	PF01217	0.590
TRG_DiLeu_BaLyEn_6	707	712	PF01217	0.750
TRG_ENDOCYTIC_2	169	172	PF00928	0.494
TRG_ENDOCYTIC_2	277	280	PF00928	0.657
TRG_ENDOCYTIC_2	614	617	PF00928	0.482
TRG_ER_diArg_1	176	178	PF00400	0.653
TRG_ER_diArg_1	263	266	PF00400	0.752
TRG_ER_diArg_1	274	276	PF00400	0.634
TRG_ER_diArg_1	370	373	PF00400	0.508
TRG_ER_diArg_1	629	631	PF00400	0.606
TRG_ER_diArg_1	734	737	PF00400	0.543
TRG_NES_CRM1_1	364	379	PF08389	0.546
TRG_NES_CRM1_1	386	401	PF08389	0.492
TRG_Pf-PMV_PEXEL_1	710	714	PF00026	0.689

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCI4	Leptomonas seymouri	43%	99%
A4HG83	Leishmania braziliensis	69%	99%
A4I3A4	Leishmania infantum	98%	100%
E9AZK4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q8M7	Leishmania major	91%	100%