Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X196_LEIDO

TriTrypDb:

LdBPK_280700.1 , LdCL_280011600 , LDHU3_28.0870

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005635	nuclear envelope	4	1
GO:0005737	cytoplasm	2	1
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A0A3S7X196

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X196

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.508
CLV_NRD_NRD_1	19	21	PF00675	0.359
CLV_NRD_NRD_1	322	324	PF00675	0.358
CLV_NRD_NRD_1	337	339	PF00675	0.404
CLV_NRD_NRD_1	4	6	PF00675	0.451
CLV_PCSK_FUR_1	17	21	PF00082	0.484
CLV_PCSK_KEX2_1	17	19	PF00082	0.378
CLV_PCSK_KEX2_1	321	323	PF00082	0.361
CLV_PCSK_KEX2_1	4	6	PF00082	0.449
CLV_PCSK_PC1ET2_1	321	323	PF00082	0.455
CLV_PCSK_SKI1_1	152	156	PF00082	0.287
CLV_PCSK_SKI1_1	210	214	PF00082	0.356
CLV_PCSK_SKI1_1	28	32	PF00082	0.349
CLV_PCSK_SKI1_1	332	336	PF00082	0.452
CLV_PCSK_SKI1_1	7	11	PF00082	0.533
DEG_APCC_DBOX_1	77	85	PF00400	0.600
DEG_Nend_UBRbox_2	1	3	PF02207	0.658
DOC_MAPK_FxFP_2	58	61	PF00069	0.550
DOC_MAPK_gen_1	17	26	PF00069	0.605
DOC_MAPK_gen_1	188	196	PF00069	0.554
DOC_MAPK_gen_1	210	219	PF00069	0.589
DOC_MAPK_gen_1	227	237	PF00069	0.495
DOC_MAPK_gen_1	321	330	PF00069	0.597
DOC_PP4_FxxP_1	10	13	PF00568	0.617
DOC_PP4_FxxP_1	58	61	PF00568	0.537
DOC_USP7_MATH_1	211	215	PF00917	0.608
DOC_USP7_MATH_1	297	301	PF00917	0.412
DOC_USP7_UBL2_3	42	46	PF12436	0.560
LIG_14-3-3_CanoR_1	210	219	PF00244	0.597
LIG_14-3-3_CanoR_1	274	282	PF00244	0.354
LIG_Actin_WH2_2	195	212	PF00022	0.554
LIG_BRCT_BRCA1_1	240	244	PF00533	0.349
LIG_deltaCOP1_diTrp_1	221	228	PF00928	0.517
LIG_EH_1	11	15	PF12763	0.584
LIG_eIF4E_1	261	267	PF01652	0.418
LIG_FHA_1	178	184	PF00498	0.615
LIG_FHA_1	31	37	PF00498	0.602
LIG_FHA_1	331	337	PF00498	0.691
LIG_FHA_1	63	69	PF00498	0.503
LIG_FHA_2	199	205	PF00498	0.495
LIG_LIR_Apic_2	56	61	PF02991	0.538
LIG_LIR_Apic_2	70	75	PF02991	0.550
LIG_LIR_Gen_1	105	115	PF02991	0.524
LIG_LIR_Gen_1	241	252	PF02991	0.289
LIG_LIR_Gen_1	276	287	PF02991	0.277
LIG_LIR_Gen_1	308	318	PF02991	0.686
LIG_LIR_Gen_1	47	58	PF02991	0.577
LIG_LIR_Nem_3	105	110	PF02991	0.535
LIG_LIR_Nem_3	126	130	PF02991	0.498
LIG_LIR_Nem_3	22	26	PF02991	0.644
LIG_LIR_Nem_3	241	247	PF02991	0.274
LIG_LIR_Nem_3	276	282	PF02991	0.277
LIG_LIR_Nem_3	325	330	PF02991	0.652
LIG_LIR_Nem_3	47	53	PF02991	0.572
LIG_Pex14_1	6	10	PF04695	0.650
LIG_Pex14_2	10	14	PF04695	0.586
LIG_Pex14_2	240	244	PF04695	0.297
LIG_Pex14_2	248	252	PF04695	0.272
LIG_PTB_Apo_2	66	73	PF02174	0.545
LIG_PTB_Phospho_1	66	72	PF10480	0.542
LIG_REV1ctd_RIR_1	28	34	PF16727	0.542
LIG_SH2_CRK	264	268	PF00017	0.384
LIG_SH2_CRK	50	54	PF00017	0.631
LIG_SH2_NCK_1	50	54	PF00017	0.588
LIG_SH2_PTP2	127	130	PF00017	0.503
LIG_SH2_PTP2	23	26	PF00017	0.599
LIG_SH2_STAP1	249	253	PF00017	0.292
LIG_SH2_STAP1	279	283	PF00017	0.404
LIG_SH2_STAT5	127	130	PF00017	0.464
LIG_SH2_STAT5	218	221	PF00017	0.498
LIG_SH2_STAT5	23	26	PF00017	0.674
LIG_SH2_STAT5	279	282	PF00017	0.291
LIG_SH2_STAT5	316	319	PF00017	0.569
LIG_SH2_STAT5	72	75	PF00017	0.596
LIG_SH3_3	133	139	PF00018	0.558
LIG_SH3_3	253	259	PF00018	0.404
LIG_SH3_3	58	64	PF00018	0.572
LIG_SUMO_SIM_par_1	288	293	PF11976	0.253
LIG_TYR_ITIM	125	130	PF00017	0.306
LIG_TYR_ITIM	48	53	PF00017	0.532
LIG_UBA3_1	202	208	PF00899	0.378
LIG_WW_3	185	189	PF00397	0.473
MOD_CK1_1	76	82	PF00069	0.465
MOD_CK2_1	198	204	PF00069	0.351
MOD_GlcNHglycan	102	105	PF01048	0.472
MOD_GlcNHglycan	292	295	PF01048	0.422
MOD_GlcNHglycan	307	310	PF01048	0.322
MOD_GSK3_1	273	280	PF00069	0.423
MOD_GSK3_1	297	304	PF00069	0.472
MOD_NEK2_1	288	293	PF00069	0.329
MOD_NEK2_1	30	35	PF00069	0.575
MOD_PKA_2	226	232	PF00069	0.552
MOD_PKA_2	273	279	PF00069	0.446
MOD_PKA_2	305	311	PF00069	0.453
MOD_Plk_1	152	158	PF00069	0.429
MOD_Plk_1	192	198	PF00069	0.398
MOD_Plk_1	223	229	PF00069	0.411
MOD_Plk_2-3	179	185	PF00069	0.407
MOD_Plk_4	198	204	PF00069	0.345
MOD_Plk_4	277	283	PF00069	0.340
MOD_Plk_4	53	59	PF00069	0.426
MOD_Plk_4	92	98	PF00069	0.366
TRG_DiLeu_BaLyEn_6	110	115	PF01217	0.495
TRG_ENDOCYTIC_2	11	14	PF00928	0.553
TRG_ENDOCYTIC_2	127	130	PF00928	0.327
TRG_ENDOCYTIC_2	23	26	PF00928	0.447
TRG_ENDOCYTIC_2	249	252	PF00928	0.276
TRG_ENDOCYTIC_2	264	267	PF00928	0.365
TRG_ENDOCYTIC_2	27	30	PF00928	0.367
TRG_ENDOCYTIC_2	279	282	PF00928	0.150
TRG_ENDOCYTIC_2	316	319	PF00928	0.470
TRG_ENDOCYTIC_2	50	53	PF00928	0.487
TRG_ER_diArg_1	17	20	PF00400	0.457
TRG_ER_diArg_1	3	5	PF00400	0.570
TRG_ER_diArg_1	322	324	PF00400	0.440
TRG_ER_diArg_1	77	80	PF00400	0.541

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM72	Leptomonas seymouri	83%	100%
A0A0S4JAZ2	Bodo saltans	48%	100%
A0A1X0NZ41	Trypanosomatidae	63%	100%
A4HGA6	Leishmania braziliensis	85%	100%
A4I3E0	Leishmania infantum	100%	100%
D0A807	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9AZM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4Q8K4	Leishmania major	97%	100%
V5BG88	Trypanosoma cruzi	63%	100%