Sugar efflux transporter for intercellular exchange, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Sugar efflux transporter for intercellular exchange, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X189_LEIDO

TriTrypDb:

LdBPK_280490.1 , LdCL_280008400 , LDHU3_28.0450

Length:

242

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	17
GO:0110165	cellular anatomical entity	1	17

Expansion

Sequence features

A0A3S7X189

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X189

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	17
GO:0008643	carbohydrate transport	5	17
GO:0051179	localization	1	17
GO:0051234	establishment of localization	2	17
GO:0071702	organic substance transport	4	17

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	2
GO:0015144	carbohydrate transmembrane transporter activity	3	2
GO:0022857	transmembrane transporter activity	2	2
GO:0051119	sugar transmembrane transporter activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	224	226	PF00675	0.279
CLV_NRD_NRD_1	31	33	PF00675	0.215
CLV_NRD_NRD_1	92	94	PF00675	0.301
CLV_PCSK_KEX2_1	224	226	PF00082	0.253
CLV_PCSK_KEX2_1	31	33	PF00082	0.270
CLV_PCSK_KEX2_1	92	94	PF00082	0.326
CLV_PCSK_SKI1_1	108	112	PF00082	0.233
CLV_PCSK_SKI1_1	140	144	PF00082	0.507
DEG_Kelch_actinfilin_1	175	179	PF01344	0.222
DOC_CDC14_PxL_1	154	162	PF14671	0.229
DOC_CYCLIN_yClb1_LxF_4	204	210	PF00134	0.229
DOC_CYCLIN_yCln2_LP_2	155	161	PF00134	0.319
DOC_MAPK_DCC_7	169	179	PF00069	0.424
DOC_MAPK_RevD_3	18	32	PF00069	0.279
DOC_PP2B_LxvP_1	155	158	PF13499	0.297
DOC_PP2B_PxIxI_1	25	31	PF00149	0.383
DOC_WW_Pin1_4	22	27	PF00397	0.316
DOC_WW_Pin1_4	236	241	PF00397	0.709
LIG_BRCT_BRCA1_1	83	87	PF00533	0.255
LIG_FHA_2	141	147	PF00498	0.373
LIG_LIR_Gen_1	112	121	PF02991	0.300
LIG_LIR_Gen_1	198	207	PF02991	0.256
LIG_LIR_Gen_1	2	11	PF02991	0.365
LIG_LIR_Gen_1	80	90	PF02991	0.277
LIG_LIR_Nem_3	112	118	PF02991	0.300
LIG_LIR_Nem_3	186	191	PF02991	0.314
LIG_LIR_Nem_3	198	203	PF02991	0.226
LIG_LIR_Nem_3	2	7	PF02991	0.350
LIG_LIR_Nem_3	56	60	PF02991	0.255
LIG_LIR_Nem_3	64	70	PF02991	0.217
LIG_LIR_Nem_3	80	85	PF02991	0.223
LIG_LYPXL_yS_3	67	70	PF13949	0.307
LIG_Pex14_2	184	188	PF04695	0.321
LIG_PTB_Apo_2	182	189	PF02174	0.373
LIG_PTB_Apo_2	194	201	PF02174	0.307
LIG_SH2_CRK	52	56	PF00017	0.269
LIG_SH2_CRK	8	12	PF00017	0.307
LIG_SH2_CRK	82	86	PF00017	0.284
LIG_SH2_NCK_1	52	56	PF00017	0.373
LIG_SH2_STAP1	106	110	PF00017	0.506
LIG_SH2_STAP1	113	117	PF00017	0.358
LIG_SH2_STAT3	47	50	PF00017	0.298
LIG_SH2_STAT5	13	16	PF00017	0.255
LIG_SH2_STAT5	82	85	PF00017	0.284
LIG_SH3_3	170	176	PF00018	0.506
LIG_SH3_3	223	229	PF00018	0.521
LIG_SUMO_SIM_par_1	151	156	PF11976	0.326
LIG_TYR_ITIM	6	11	PF00017	0.335
MOD_CK1_1	109	115	PF00069	0.336
MOD_CK1_1	42	48	PF00069	0.392
MOD_CK1_1	97	103	PF00069	0.563
MOD_CK2_1	140	146	PF00069	0.291
MOD_Cter_Amidation	222	225	PF01082	0.247
MOD_GlcNHglycan	119	122	PF01048	0.354
MOD_GlcNHglycan	132	135	PF01048	0.509
MOD_GlcNHglycan	155	158	PF01048	0.306
MOD_GlcNHglycan	34	38	PF01048	0.298
MOD_GlcNHglycan	63	66	PF01048	0.457
MOD_GlcNHglycan	94	99	PF01048	0.342
MOD_GSK3_1	124	131	PF00069	0.445
MOD_GSK3_1	35	42	PF00069	0.490
MOD_GSK3_1	77	84	PF00069	0.474
MOD_GSK3_1	97	104	PF00069	0.541
MOD_N-GLC_1	22	27	PF02516	0.373
MOD_NEK2_1	101	106	PF00069	0.519
MOD_NEK2_1	11	16	PF00069	0.338
MOD_NEK2_1	117	122	PF00069	0.297
MOD_NEK2_1	124	129	PF00069	0.310
MOD_NEK2_1	130	135	PF00069	0.337
MOD_NEK2_1	183	188	PF00069	0.357
MOD_NEK2_1	199	204	PF00069	0.299
MOD_NEK2_1	33	38	PF00069	0.546
MOD_NEK2_1	63	68	PF00069	0.237
MOD_Plk_4	106	112	PF00069	0.498
MOD_Plk_4	124	130	PF00069	0.347
MOD_Plk_4	183	189	PF00069	0.301
MOD_Plk_4	42	48	PF00069	0.262
MOD_Plk_4	81	87	PF00069	0.325
MOD_ProDKin_1	22	28	PF00069	0.316
MOD_ProDKin_1	236	242	PF00069	0.711
TRG_DiLeu_BaEn_4	94	100	PF01217	0.419
TRG_DiLeu_BaLyEn_6	155	160	PF01217	0.229
TRG_DiLeu_BaLyEn_6	65	70	PF01217	0.307
TRG_ENDOCYTIC_2	113	116	PF00928	0.378
TRG_ENDOCYTIC_2	52	55	PF00928	0.264
TRG_ENDOCYTIC_2	60	63	PF00928	0.235
TRG_ENDOCYTIC_2	67	70	PF00928	0.204
TRG_ENDOCYTIC_2	8	11	PF00928	0.307
TRG_ENDOCYTIC_2	82	85	PF00928	0.259
TRG_ER_diArg_1	224	226	PF00400	0.486
TRG_ER_diArg_1	30	32	PF00400	0.470
TRG_Pf-PMV_PEXEL_1	31	35	PF00026	0.307

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVB3	Leptomonas seymouri	37%	100%
A0A0N1HZ27	Leptomonas seymouri	73%	100%
A0A0S4JK63	Bodo saltans	34%	100%
A0A0S4JP06	Bodo saltans	34%	84%
A0A1X0NHK1	Trypanosomatidae	43%	100%
A0A3Q8IJU9	Leishmania donovani	43%	100%
A0A3R7RTY4	Trypanosoma rangeli	43%	100%
A2YZ24	Oryza sativa subsp. indica	23%	91%
A3BWJ9	Oryza sativa subsp. japonica	23%	95%
A4HG76	Leishmania braziliensis	76%	100%
A4HQ04	Leishmania braziliensis	40%	100%
A4I3B9	Leishmania infantum	99%	100%
A4IDR5	Leishmania infantum	42%	100%
B9G2E6	Oryza sativa subsp. japonica	25%	88%
E9ATS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9AZJ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q0DJY3	Oryza sativa subsp. japonica	21%	98%
Q0J349	Oryza sativa subsp. japonica	23%	91%
Q19VE6	Oryza sativa subsp. indica	25%	79%
Q290X1	Drosophila pseudoobscura pseudoobscura	25%	100%
Q4Q0S5	Leishmania major	41%	100%
Q4Q8N5	Leishmania major	95%	100%
Q54JW5	Dictyostelium discoideum	24%	100%
Q5NAZ9	Oryza sativa subsp. japonica	26%	96%
Q6NQN5	Arabidopsis thaliana	22%	92%
Q6YZF3	Oryza sativa subsp. japonica	25%	79%
Q7JVE7	Drosophila melanogaster	23%	100%
Q9FY94	Arabidopsis thaliana	23%	83%
Q9LUE3	Arabidopsis thaliana	26%	84%