LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7X175_LEIDO
TriTrypDb:
LdBPK_280460.1 , LdCL_280008100 , LDHU3_28.0410
Length:
342

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X175
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X175

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 325 329 PF00656 0.402
CLV_MEL_PAP_1 330 336 PF00089 0.295
CLV_NRD_NRD_1 30 32 PF00675 0.567
CLV_PCSK_KEX2_1 30 32 PF00082 0.503
CLV_PCSK_KEX2_1 79 81 PF00082 0.488
CLV_PCSK_PC1ET2_1 79 81 PF00082 0.446
CLV_PCSK_PC7_1 26 32 PF00082 0.422
CLV_PCSK_PC7_1 75 81 PF00082 0.413
CLV_PCSK_SKI1_1 102 106 PF00082 0.412
CLV_PCSK_SKI1_1 175 179 PF00082 0.430
CLV_PCSK_SKI1_1 228 232 PF00082 0.429
DEG_MDM2_SWIB_1 292 299 PF02201 0.500
DOC_CYCLIN_yCln2_LP_2 128 134 PF00134 0.423
DOC_MAPK_MEF2A_6 228 235 PF00069 0.482
DOC_PP1_RVXF_1 165 171 PF00149 0.484
DOC_PP2B_LxvP_1 128 131 PF13499 0.374
DOC_PP2B_LxvP_1 242 245 PF13499 0.434
DOC_USP7_MATH_1 24 28 PF00917 0.513
DOC_USP7_MATH_1 245 249 PF00917 0.447
DOC_USP7_MATH_1 270 274 PF00917 0.389
DOC_USP7_MATH_1 316 320 PF00917 0.586
DOC_WW_Pin1_4 216 221 PF00397 0.365
DOC_WW_Pin1_4 271 276 PF00397 0.481
DOC_WW_Pin1_4 278 283 PF00397 0.517
DOC_WW_Pin1_4 35 40 PF00397 0.550
LIG_14-3-3_CanoR_1 102 107 PF00244 0.368
LIG_14-3-3_CanoR_1 114 121 PF00244 0.477
LIG_Actin_WH2_2 11 28 PF00022 0.484
LIG_BIR_II_1 1 5 PF00653 0.596
LIG_FHA_1 125 131 PF00498 0.462
LIG_FHA_1 194 200 PF00498 0.400
LIG_FHA_1 249 255 PF00498 0.457
LIG_FHA_1 266 272 PF00498 0.191
LIG_FHA_1 278 284 PF00498 0.379
LIG_FHA_1 286 292 PF00498 0.244
LIG_FHA_1 329 335 PF00498 0.402
LIG_FHA_1 36 42 PF00498 0.460
LIG_FHA_2 106 112 PF00498 0.431
LIG_LIR_Apic_2 35 40 PF02991 0.405
LIG_LIR_Apic_2 87 92 PF02991 0.398
LIG_LIR_Gen_1 148 159 PF02991 0.527
LIG_LIR_Gen_1 293 304 PF02991 0.497
LIG_LIR_Nem_3 148 154 PF02991 0.532
LIG_LIR_Nem_3 293 299 PF02991 0.474
LIG_PDZ_Class_1 337 342 PF00595 0.460
LIG_Pex14_2 292 296 PF04695 0.439
LIG_SH2_CRK 125 129 PF00017 0.305
LIG_SH2_SRC 151 154 PF00017 0.404
LIG_SH2_SRC 70 73 PF00017 0.376
LIG_SH2_STAP1 151 155 PF00017 0.373
LIG_SH2_STAP1 195 199 PF00017 0.460
LIG_SH2_STAT3 195 198 PF00017 0.465
LIG_SH2_STAT5 195 198 PF00017 0.427
LIG_SH2_STAT5 70 73 PF00017 0.453
LIG_SH3_3 127 133 PF00018 0.301
LIG_SH3_3 230 236 PF00018 0.414
LIG_SH3_3 272 278 PF00018 0.386
LIG_SH3_3 280 286 PF00018 0.383
LIG_SH3_3 58 64 PF00018 0.417
LIG_SUMO_SIM_par_1 102 108 PF11976 0.333
LIG_TRAF2_1 315 318 PF00917 0.451
LIG_TYR_ITSM 147 154 PF00017 0.371
LIG_WRC_WIRS_1 147 152 PF05994 0.483
MOD_CDK_SPK_2 216 221 PF00069 0.365
MOD_CK1_1 176 182 PF00069 0.310
MOD_CK1_1 248 254 PF00069 0.567
MOD_CK1_1 265 271 PF00069 0.331
MOD_CK1_1 285 291 PF00069 0.375
MOD_CK1_1 73 79 PF00069 0.468
MOD_CK2_1 54 60 PF00069 0.549
MOD_CMANNOS 170 173 PF00535 0.335
MOD_CMANNOS 91 94 PF00535 0.474
MOD_GlcNHglycan 175 178 PF01048 0.501
MOD_GlcNHglycan 236 239 PF01048 0.534
MOD_GlcNHglycan 246 250 PF01048 0.450
MOD_GlcNHglycan 26 29 PF01048 0.328
MOD_GlcNHglycan 298 302 PF01048 0.557
MOD_GlcNHglycan 56 59 PF01048 0.547
MOD_GlcNHglycan 8 11 PF01048 0.629
MOD_GlcNHglycan 82 85 PF01048 0.644
MOD_GSK3_1 222 229 PF00069 0.373
MOD_GSK3_1 261 268 PF00069 0.341
MOD_GSK3_1 278 285 PF00069 0.450
MOD_GSK3_1 80 87 PF00069 0.646
MOD_NEK2_1 1 6 PF00069 0.683
MOD_NEK2_1 200 205 PF00069 0.598
MOD_NEK2_1 291 296 PF00069 0.465
MOD_NEK2_1 53 58 PF00069 0.541
MOD_NEK2_1 8 13 PF00069 0.529
MOD_NEK2_2 70 75 PF00069 0.349
MOD_PIKK_1 194 200 PF00454 0.468
MOD_PIKK_1 84 90 PF00454 0.581
MOD_PKA_2 200 206 PF00069 0.526
MOD_PKA_2 33 39 PF00069 0.491
MOD_Plk_1 316 322 PF00069 0.525
MOD_Plk_4 1 7 PF00069 0.699
MOD_Plk_4 102 108 PF00069 0.461
MOD_Plk_4 146 152 PF00069 0.410
MOD_Plk_4 205 211 PF00069 0.393
MOD_Plk_4 63 69 PF00069 0.411
MOD_ProDKin_1 216 222 PF00069 0.363
MOD_ProDKin_1 271 277 PF00069 0.479
MOD_ProDKin_1 278 284 PF00069 0.512
MOD_ProDKin_1 35 41 PF00069 0.540
MOD_SUMO_rev_2 72 81 PF00179 0.400
TRG_DiLeu_BaLyEn_6 250 255 PF01217 0.486
TRG_ENDOCYTIC_2 125 128 PF00928 0.309
TRG_ENDOCYTIC_2 151 154 PF00928 0.404
TRG_ER_diArg_1 167 170 PF00400 0.473
TRG_ER_diArg_1 29 31 PF00400 0.495

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PEC4 Leptomonas seymouri 60% 91%
A0A1X0NW08 Trypanosomatidae 37% 100%
A0A422N6W1 Trypanosoma rangeli 34% 100%
A4HG73 Leishmania braziliensis 85% 100%
A4I3B6 Leishmania infantum 100% 100%
D0A7T5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 90%
E9AZJ3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4Q8N8 Leishmania major 96% 100%
V5BEI5 Trypanosoma cruzi 35% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS