Saccharopine_dehydrogenase_putative/Pfam:PF03435

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

saccharopine dehydrogenase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X166_LEIDO

TriTrypDb:

LdBPK_280520.1 , LdCL_280008700 , LDHU3_28.0480

Length:

392

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Show entries

Cellular components
Term	Name	Level	Count
GO:0005811	lipid droplet	5	1
GO:0016020	membrane	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2

Previous1Next

Expansion

Sequence features

A0A3S7X166

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X166

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	1
GO:0006643	membrane lipid metabolic process	4	1
GO:0006664	glycolipid metabolic process	5	1
GO:0008152	metabolic process	1	1
GO:0008610	lipid biosynthetic process	4	1
GO:0009058	biosynthetic process	2	1
GO:0009247	glycolipid biosynthetic process	5	1
GO:0009987	cellular process	1	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1

Previous1 2Next

Show entries

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016491	oxidoreductase activity	2	10

Previous1Next

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	114	116	PF00675	0.407
CLV_NRD_NRD_1	235	237	PF00675	0.333
CLV_NRD_NRD_1	25	27	PF00675	0.386
CLV_NRD_NRD_1	278	280	PF00675	0.432
CLV_NRD_NRD_1	346	348	PF00675	0.507
CLV_PCSK_KEX2_1	114	116	PF00082	0.438
CLV_PCSK_KEX2_1	235	237	PF00082	0.333
CLV_PCSK_KEX2_1	278	280	PF00082	0.432
CLV_PCSK_KEX2_1	315	317	PF00082	0.402
CLV_PCSK_PC1ET2_1	315	317	PF00082	0.461

Previous1 2 3 4 5…13Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYN7	Leptomonas seymouri	62%	100%
A0A0S4IJU8	Bodo saltans	41%	99%
A0A1X0NQA2	Trypanosomatidae	43%	99%
A0A3R7KXD1	Trypanosoma rangeli	46%	100%
A0A422NEM4	Trypanosoma rangeli	41%	100%
A0PQ21	Mycobacterium ulcerans (strain Agy99)	30%	94%
A1KMU7	Mycobacterium bovis (strain BCG / Pasteur 1173P2)	30%	94%
A4HG79	Leishmania braziliensis	83%	100%
A4I3C3	Leishmania infantum	99%	100%
A5U6W1	Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)	30%	94%

Previous1 2 3Next