Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X164_LEIDO

TriTrypDb:

LdBPK_280330.1 , LdCL_280009200 , LDHU3_28.0540

Length:

426

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X164

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X164

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	88	92	PF00656	0.558
CLV_PCSK_KEX2_1	115	117	PF00082	0.580
CLV_PCSK_KEX2_1	70	72	PF00082	0.493
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.580
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.493
CLV_PCSK_SKI1_1	122	126	PF00082	0.439
CLV_PCSK_SKI1_1	281	285	PF00082	0.451
CLV_PCSK_SKI1_1	327	331	PF00082	0.421
CLV_PCSK_SKI1_1	372	376	PF00082	0.467
CLV_PCSK_SKI1_1	389	393	PF00082	0.361
CLV_PCSK_SKI1_1	39	43	PF00082	0.472
CLV_PCSK_SKI1_1	8	12	PF00082	0.491
DEG_SCF_FBW7_1	252	259	PF00400	0.752
DOC_CKS1_1	185	190	PF01111	0.565
DOC_MAPK_DCC_7	378	388	PF00069	0.446
DOC_MAPK_gen_1	233	241	PF00069	0.652
DOC_MAPK_gen_1	276	285	PF00069	0.572
DOC_MAPK_gen_1	380	388	PF00069	0.573
DOC_MAPK_gen_1	412	420	PF00069	0.409
DOC_MAPK_gen_1	8	18	PF00069	0.534
DOC_MAPK_MEF2A_6	313	320	PF00069	0.527
DOC_MAPK_MEF2A_6	380	388	PF00069	0.451
DOC_MAPK_MEF2A_6	54	63	PF00069	0.466
DOC_PP1_RVXF_1	105	111	PF00149	0.459
DOC_USP7_MATH_1	261	265	PF00917	0.686
DOC_USP7_MATH_1	355	359	PF00917	0.469
DOC_USP7_UBL2_3	236	240	PF12436	0.765
DOC_USP7_UBL2_3	406	410	PF12436	0.506
DOC_USP7_UBL2_3	50	54	PF12436	0.499
DOC_USP7_UBL2_3	66	70	PF12436	0.492
DOC_WW_Pin1_4	184	189	PF00397	0.562
DOC_WW_Pin1_4	252	257	PF00397	0.777
DOC_WW_Pin1_4	297	302	PF00397	0.594
LIG_14-3-3_CanoR_1	231	239	PF00244	0.700
LIG_14-3-3_CanoR_1	281	286	PF00244	0.540
LIG_14-3-3_CanoR_1	350	354	PF00244	0.514
LIG_14-3-3_CanoR_1	82	87	PF00244	0.568
LIG_APCC_ABBA_1	22	27	PF00400	0.374
LIG_BIR_II_1	1	5	PF00653	0.588
LIG_BRCT_BRCA1_1	19	23	PF00533	0.435
LIG_BRCT_BRCA1_1	384	388	PF00533	0.509
LIG_BRCT_BRCA1_1	54	58	PF00533	0.526
LIG_FHA_1	101	107	PF00498	0.429
LIG_FHA_1	205	211	PF00498	0.500
LIG_FHA_1	219	225	PF00498	0.350
LIG_FHA_1	253	259	PF00498	0.772
LIG_FHA_1	366	372	PF00498	0.533
LIG_FHA_2	185	191	PF00498	0.559
LIG_FHA_2	240	246	PF00498	0.777
LIG_LIR_Apic_2	184	188	PF02991	0.559
LIG_LIR_Gen_1	109	117	PF02991	0.400
LIG_LIR_Gen_1	325	332	PF02991	0.458
LIG_LIR_Gen_1	334	343	PF02991	0.362
LIG_LIR_Gen_1	83	91	PF02991	0.491
LIG_LIR_Nem_3	109	113	PF02991	0.364
LIG_LIR_Nem_3	325	331	PF02991	0.465
LIG_LIR_Nem_3	334	340	PF02991	0.375
LIG_LIR_Nem_3	385	391	PF02991	0.469
LIG_LIR_Nem_3	55	61	PF02991	0.417
LIG_LIR_Nem_3	83	89	PF02991	0.468
LIG_SH2_CRK	185	189	PF00017	0.566
LIG_SH2_NCK_1	185	189	PF00017	0.575
LIG_SH2_STAP1	195	199	PF00017	0.579
LIG_SH2_STAP1	308	312	PF00017	0.525
LIG_SH2_STAT5	185	188	PF00017	0.513
LIG_SH2_STAT5	195	198	PF00017	0.439
LIG_SH2_STAT5	25	28	PF00017	0.432
LIG_SH3_3	221	227	PF00018	0.525
LIG_SH3_4	410	417	PF00018	0.535
LIG_SH3_4	50	57	PF00018	0.512
MOD_CK1_1	120	126	PF00069	0.469
MOD_CK1_1	184	190	PF00069	0.581
MOD_CK1_1	259	265	PF00069	0.675
MOD_CK1_1	300	306	PF00069	0.678
MOD_CK1_1	37	43	PF00069	0.477
MOD_CK1_1	44	50	PF00069	0.467
MOD_CK1_1	74	80	PF00069	0.566
MOD_CK2_1	184	190	PF00069	0.498
MOD_CK2_1	360	366	PF00069	0.494
MOD_CK2_1	384	390	PF00069	0.511
MOD_GlcNHglycan	119	122	PF01048	0.502
MOD_GlcNHglycan	261	264	PF01048	0.719
MOD_GlcNHglycan	266	269	PF01048	0.408
MOD_GlcNHglycan	304	307	PF01048	0.579
MOD_GlcNHglycan	324	327	PF01048	0.493
MOD_GlcNHglycan	357	360	PF01048	0.473
MOD_GlcNHglycan	36	39	PF01048	0.500
MOD_GlcNHglycan	46	49	PF01048	0.453
MOD_GlcNHglycan	54	57	PF01048	0.441
MOD_GSK3_1	248	255	PF00069	0.772
MOD_GSK3_1	264	271	PF00069	0.718
MOD_GSK3_1	281	288	PF00069	0.296
MOD_GSK3_1	316	323	PF00069	0.396
MOD_GSK3_1	327	334	PF00069	0.395
MOD_GSK3_1	33	40	PF00069	0.492
MOD_GSK3_1	390	397	PF00069	0.527
MOD_GSK3_1	80	87	PF00069	0.466
MOD_N-GLC_1	264	269	PF02516	0.762
MOD_N-GLC_1	281	286	PF02516	0.296
MOD_NEK2_1	117	122	PF00069	0.469
MOD_NEK2_1	125	130	PF00069	0.365
MOD_NEK2_1	154	159	PF00069	0.552
MOD_NEK2_1	181	186	PF00069	0.548
MOD_NEK2_1	191	196	PF00069	0.527
MOD_NEK2_1	218	223	PF00069	0.415
MOD_NEK2_1	320	325	PF00069	0.502
MOD_NEK2_1	42	47	PF00069	0.453
MOD_NEK2_1	52	57	PF00069	0.397
MOD_NEK2_1	81	86	PF00069	0.544
MOD_NEK2_2	349	354	PF00069	0.519
MOD_NEK2_2	384	389	PF00069	0.516
MOD_PIKK_1	154	160	PF00454	0.454
MOD_PIKK_1	171	177	PF00454	0.543
MOD_PIKK_1	256	262	PF00454	0.735
MOD_PKA_2	349	355	PF00069	0.540
MOD_PKA_2	81	87	PF00069	0.562
MOD_Plk_1	154	160	PF00069	0.487
MOD_Plk_1	234	240	PF00069	0.718
MOD_Plk_1	281	287	PF00069	0.535
MOD_Plk_4	120	126	PF00069	0.415
MOD_Plk_4	17	23	PF00069	0.478
MOD_Plk_4	218	224	PF00069	0.411
MOD_Plk_4	37	43	PF00069	0.465
MOD_Plk_4	394	400	PF00069	0.536
MOD_ProDKin_1	184	190	PF00069	0.561
MOD_ProDKin_1	252	258	PF00069	0.776
MOD_ProDKin_1	297	303	PF00069	0.590
MOD_SUMO_rev_2	243	249	PF00179	0.789
MOD_SUMO_rev_2	271	280	PF00179	0.649
TRG_ENDOCYTIC_2	147	150	PF00928	0.436
TRG_ENDOCYTIC_2	25	28	PF00928	0.397
TRG_NES_CRM1_1	390	403	PF08389	0.541

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJS3	Leptomonas seymouri	53%	100%
A0A0S4KFQ7	Bodo saltans	27%	100%
A0A1X0NYM7	Trypanosomatidae	30%	87%
A0A3R7KQG6	Trypanosoma rangeli	38%	95%
A4I3A5	Leishmania infantum	99%	100%
D0A828	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AZK3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q8M8	Leishmania major	91%	100%
V5B0U4	Trypanosoma cruzi	34%	90%