Katanin p60 ATPase-containing subunit A1

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

katanin, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X163_LEIDO

TriTrypDb:

LdBPK_280390.1 , LdCL_280008900 , LDHU3_28.0510

Length:

530

Annotations

LeishMANIAdb annotations

A large and likely artifical grouping of protease domain carrying proteins related to proteasomal proteases. Only a tiny subgroup (the AFG3-related mitochondrail proteins) seem to have a TM segment.. Localization: Cytoplasmic (by homology) / Mitochondrial (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0005874	microtubule	6	11
GO:0099080	supramolecular complex	2	11
GO:0099081	supramolecular polymer	3	11
GO:0099512	supramolecular fiber	4	11
GO:0099513	polymeric cytoskeletal fiber	5	11
GO:0110165	cellular anatomical entity	1	11
GO:0005856	cytoskeleton	5	1
GO:0015630	microtubule cytoskeleton	6	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1

Expansion

Sequence features

A0A3S7X163

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X163

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	11
GO:0006996	organelle organization	4	11
GO:0007010	cytoskeleton organization	5	11
GO:0007017	microtubule-based process	2	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0051013	microtubule severing	4	11
GO:0071840	cellular component organization or biogenesis	2	11

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0005524	ATP binding	5	11
GO:0008017	microtubule binding	5	11
GO:0008092	cytoskeletal protein binding	3	11
GO:0008568	microtubule severing ATPase activity	2	11
GO:0015631	tubulin binding	4	11
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0016853	isomerase activity	2	11
GO:0016887	ATP hydrolysis activity	7	11
GO:0017076	purine nucleotide binding	4	11
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:0140657	ATP-dependent activity	1	11
GO:0140776	protein-containing complex destabilizing activity	1	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	345	349	PF00656	0.266
CLV_NRD_NRD_1	276	278	PF00675	0.350
CLV_NRD_NRD_1	364	366	PF00675	0.232
CLV_NRD_NRD_1	403	405	PF00675	0.285
CLV_NRD_NRD_1	468	470	PF00675	0.241
CLV_NRD_NRD_1	86	88	PF00675	0.607
CLV_PCSK_KEX2_1	255	257	PF00082	0.453
CLV_PCSK_KEX2_1	276	278	PF00082	0.350
CLV_PCSK_KEX2_1	364	366	PF00082	0.232
CLV_PCSK_KEX2_1	402	404	PF00082	0.283
CLV_PCSK_KEX2_1	407	409	PF00082	0.296
CLV_PCSK_KEX2_1	468	470	PF00082	0.241
CLV_PCSK_KEX2_1	85	87	PF00082	0.632
CLV_PCSK_PC1ET2_1	255	257	PF00082	0.453
CLV_PCSK_PC1ET2_1	407	409	PF00082	0.289
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.564
CLV_PCSK_PC7_1	403	409	PF00082	0.285
CLV_PCSK_SKI1_1	255	259	PF00082	0.312
CLV_PCSK_SKI1_1	26	30	PF00082	0.461
CLV_PCSK_SKI1_1	280	284	PF00082	0.241
CLV_PCSK_SKI1_1	292	296	PF00082	0.255
CLV_PCSK_SKI1_1	328	332	PF00082	0.241
CLV_PCSK_SKI1_1	364	368	PF00082	0.241
CLV_PCSK_SKI1_1	428	432	PF00082	0.397
CLV_PCSK_SKI1_1	469	473	PF00082	0.374
DEG_APCC_DBOX_1	418	426	PF00400	0.311
DEG_APCC_KENBOX_2	479	483	PF00400	0.374
DEG_Nend_UBRbox_3	1	3	PF02207	0.435
DEG_SPOP_SBC_1	172	176	PF00917	0.613
DOC_CYCLIN_RxL_1	325	332	PF00134	0.241
DOC_MAPK_gen_1	402	413	PF00069	0.259
DOC_MAPK_gen_1	428	438	PF00069	0.373
DOC_MAPK_gen_1	523	530	PF00069	0.477
DOC_MAPK_MEF2A_6	404	413	PF00069	0.241
DOC_PP1_RVXF_1	326	332	PF00149	0.241
DOC_PP4_FxxP_1	78	81	PF00568	0.509
DOC_USP7_MATH_1	158	162	PF00917	0.607
DOC_USP7_MATH_1	172	176	PF00917	0.655
DOC_USP7_MATH_1	196	200	PF00917	0.603
DOC_USP7_MATH_1	298	302	PF00917	0.274
DOC_USP7_UBL2_3	11	15	PF12436	0.348
DOC_USP7_UBL2_3	424	428	PF12436	0.438
DOC_USP7_UBL2_3	472	476	PF12436	0.255
DOC_WW_Pin1_4	167	172	PF00397	0.543
DOC_WW_Pin1_4	308	313	PF00397	0.247
LIG_14-3-3_CanoR_1	116	122	PF00244	0.720
LIG_14-3-3_CanoR_1	160	169	PF00244	0.630
LIG_14-3-3_CanoR_1	96	106	PF00244	0.707
LIG_APCC_ABBA_1	75	80	PF00400	0.469
LIG_BRCT_BRCA1_1	169	173	PF00533	0.537
LIG_BRCT_BRCA1_1	339	343	PF00533	0.241
LIG_CtBP_PxDLS_1	494	498	PF00389	0.262
LIG_deltaCOP1_diTrp_1	520	526	PF00928	0.241
LIG_FHA_1	339	345	PF00498	0.241
LIG_FHA_1	379	385	PF00498	0.326
LIG_FHA_1	41	47	PF00498	0.404
LIG_FHA_1	425	431	PF00498	0.356
LIG_FHA_1	454	460	PF00498	0.241
LIG_FHA_2	242	248	PF00498	0.483
LIG_FHA_2	476	482	PF00498	0.385
LIG_FHA_2	69	75	PF00498	0.425
LIG_GBD_Chelix_1	228	236	PF00786	0.333
LIG_Integrin_RGD_1	320	322	PF01839	0.241
LIG_LIR_Gen_1	164	173	PF02991	0.547
LIG_LIR_Gen_1	244	251	PF02991	0.334
LIG_LIR_Gen_1	435	445	PF02991	0.259
LIG_LIR_Gen_1	52	61	PF02991	0.464
LIG_LIR_Nem_3	164	169	PF02991	0.558
LIG_LIR_Nem_3	244	248	PF02991	0.347
LIG_LIR_Nem_3	270	275	PF02991	0.383
LIG_LIR_Nem_3	305	310	PF02991	0.243
LIG_LIR_Nem_3	435	441	PF02991	0.241
LIG_LIR_Nem_3	52	57	PF02991	0.477
LIG_LYPXL_S_1	263	267	PF13949	0.318
LIG_LYPXL_yS_3	264	267	PF13949	0.322
LIG_MYND_1	265	269	PF01753	0.333
LIG_NRBOX	440	446	PF00104	0.306
LIG_PDZ_Class_2	525	530	PF00595	0.505
LIG_Pex14_1	522	526	PF04695	0.241
LIG_SH2_CRK	166	170	PF00017	0.675
LIG_SH2_CRK	272	276	PF00017	0.382
LIG_SH2_CRK	285	289	PF00017	0.201
LIG_SH2_CRK	32	36	PF00017	0.455
LIG_SH2_NCK_1	166	170	PF00017	0.557
LIG_SH2_PTP2	410	413	PF00017	0.241
LIG_SH2_SRC	337	340	PF00017	0.259
LIG_SH2_STAT5	22	25	PF00017	0.467
LIG_SH2_STAT5	410	413	PF00017	0.241
LIG_SH3_3	146	152	PF00018	0.546
LIG_SH3_3	166	172	PF00018	0.705
LIG_SH3_3	177	183	PF00018	0.593
LIG_SH3_3	259	265	PF00018	0.305
LIG_TRAF2_1	223	226	PF00917	0.390
LIG_TYR_ITIM	262	267	PF00017	0.314
LIG_UBA3_1	422	428	PF00899	0.350
LIG_UBA3_1	464	472	PF00899	0.303
MOD_CK1_1	124	130	PF00069	0.574
MOD_CK1_1	161	167	PF00069	0.509
MOD_CK1_1	199	205	PF00069	0.658
MOD_CK1_1	214	220	PF00069	0.531
MOD_CK1_1	311	317	PF00069	0.259
MOD_CK1_1	4	10	PF00069	0.433
MOD_CK1_1	97	103	PF00069	0.642
MOD_CK2_1	475	481	PF00069	0.306
MOD_CK2_1	68	74	PF00069	0.473
MOD_CK2_1	96	102	PF00069	0.707
MOD_GlcNHglycan	123	126	PF01048	0.585
MOD_GlcNHglycan	160	163	PF01048	0.565
MOD_GlcNHglycan	175	178	PF01048	0.636
MOD_GlcNHglycan	199	202	PF01048	0.642
MOD_GlcNHglycan	213	216	PF01048	0.616
MOD_GlcNHglycan	450	453	PF01048	0.402
MOD_GlcNHglycan	99	102	PF01048	0.640
MOD_GSK3_1	117	124	PF00069	0.587
MOD_GSK3_1	158	165	PF00069	0.681
MOD_GSK3_1	167	174	PF00069	0.485
MOD_GSK3_1	298	305	PF00069	0.259
MOD_GSK3_1	49	56	PF00069	0.499
MOD_N-GLC_1	127	132	PF02516	0.672
MOD_N-GLC_1	303	308	PF02516	0.250
MOD_N-GLC_1	495	500	PF02516	0.262
MOD_N-GLC_1	94	99	PF02516	0.634
MOD_NEK2_1	1	6	PF00069	0.497
MOD_NEK2_1	121	126	PF00069	0.639
MOD_NEK2_1	173	178	PF00069	0.495
MOD_NEK2_1	388	393	PF00069	0.241
MOD_NEK2_1	500	505	PF00069	0.131
MOD_NEK2_2	303	308	PF00069	0.241
MOD_NEK2_2	31	36	PF00069	0.448
MOD_NEK2_2	463	468	PF00069	0.241
MOD_PIKK_1	439	445	PF00454	0.354
MOD_PIKK_1	49	55	PF00454	0.481
MOD_PIKK_1	68	74	PF00454	0.415
MOD_PKA_2	68	74	PF00069	0.415
MOD_PKA_2	95	101	PF00069	0.676
MOD_Plk_1	127	133	PF00069	0.671
MOD_Plk_1	303	309	PF00069	0.284
MOD_Plk_1	474	480	PF00069	0.306
MOD_Plk_2-3	475	481	PF00069	0.306
MOD_Plk_4	290	296	PF00069	0.268
MOD_Plk_4	303	309	PF00069	0.241
MOD_Plk_4	338	344	PF00069	0.241
MOD_Plk_4	366	372	PF00069	0.241
MOD_Plk_4	53	59	PF00069	0.481
MOD_ProDKin_1	167	173	PF00069	0.547
MOD_ProDKin_1	308	314	PF00069	0.247
MOD_SUMO_rev_2	247	257	PF00179	0.344
TRG_DiLeu_BaEn_1	227	232	PF01217	0.381
TRG_DiLeu_BaEn_1	253	258	PF01217	0.359
TRG_DiLeu_BaEn_2	73	79	PF01217	0.524
TRG_DiLeu_LyEn_5	253	258	PF01217	0.449
TRG_ENDOCYTIC_2	166	169	PF00928	0.559
TRG_ENDOCYTIC_2	264	267	PF00928	0.322
TRG_ENDOCYTIC_2	272	275	PF00928	0.358
TRG_ENDOCYTIC_2	32	35	PF00928	0.313
TRG_ENDOCYTIC_2	410	413	PF00928	0.241
TRG_ER_diArg_1	207	210	PF00400	0.648
TRG_ER_diArg_1	275	277	PF00400	0.371
TRG_ER_diArg_1	401	404	PF00400	0.281
TRG_ER_diArg_1	467	469	PF00400	0.241
TRG_NLS_MonoCore_2	112	117	PF00514	0.666
TRG_NLS_MonoExtC_3	111	116	PF00514	0.615
TRG_NLS_MonoExtN_4	112	117	PF00514	0.617
TRG_Pf-PMV_PEXEL_1	255	259	PF00026	0.325
TRG_Pf-PMV_PEXEL_1	328	332	PF00026	0.241
TRG_Pf-PMV_PEXEL_1	44	48	PF00026	0.424

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRH8	Leptomonas seymouri	70%	97%
A0A0S4IR32	Bodo saltans	40%	99%
A0A0S4IUM1	Bodo saltans	51%	89%
A0A1X0NYV7	Trypanosomatidae	56%	94%
A0A3Q8IHU1	Leishmania donovani	33%	100%
A0A3Q8IJS0	Leishmania donovani	34%	100%
A0A3S7X2R4	Leishmania donovani	42%	100%
A0A422P1K0	Trypanosoma rangeli	57%	95%
A4H6T6	Leishmania braziliensis	36%	100%
A4HG81	Leishmania braziliensis	88%	98%
A4HME8	Leishmania braziliensis	35%	100%
A4I3C0	Leishmania infantum	100%	100%
A4I4W4	Leishmania infantum	42%	100%
A4IB20	Leishmania infantum	33%	100%
A4IE38	Leishmania infantum	34%	100%
A9RA82	Papio anubis	50%	100%
B2RYN7	Rattus norvegicus	38%	91%
B3EX35	Sorex araneus	49%	100%
B3M301	Drosophila ananassae	41%	69%
B4NBP4	Drosophila willistoni	42%	68%
B4PL32	Drosophila yakuba	39%	70%
B4USW8	Otolemur garnettii	51%	100%
B7NZ88	Oryctolagus cuniculus	50%	100%
B7PXE3	Ixodes scapularis	39%	82%
C9ZKZ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
D0A833	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	96%
E9AEB2	Leishmania major	42%	100%
E9AEU9	Leishmania major	33%	100%
E9AZK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	99%
E9B605	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
O75449	Homo sapiens	41%	100%
P51327	Porphyra purpurea	34%	84%
Q05AS3	Xenopus tropicalis	39%	88%
Q09803	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	100%
Q0IIR9	Xenopus tropicalis	42%	100%
Q1HGK7	Gallus gallus	43%	100%
Q4Q8N0	Leishmania major	95%	100%
Q4R407	Macaca fascicularis	41%	100%
Q5RII9	Danio rerio	43%	100%
Q5U3S1	Danio rerio	42%	100%
Q5XIK7	Rattus norvegicus	49%	100%
Q5ZK92	Gallus gallus	40%	86%
Q6AZT2	Xenopus laevis	39%	88%
Q6E0V2	Rattus norvegicus	41%	100%
Q6PIW4	Homo sapiens	38%	79%
Q8K0T4	Mus musculus	50%	100%
Q9BW62	Homo sapiens	50%	100%
Q9ERZ6	Mus musculus	30%	70%
Q9PUL2	Xenopus laevis	42%	100%
Q9SEX2	Arabidopsis thaliana	42%	100%
V5B0U7	Trypanosoma cruzi	56%	95%