C2H2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X161_LEIDO

TriTrypDb:

LdBPK_280350.1 , LdCL_280009000 , LDHU3_28.0520

Length:

655

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X161

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X161

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	340	344	PF00656	0.842
CLV_C14_Caspase3-7	590	594	PF00656	0.715
CLV_NRD_NRD_1	203	205	PF00675	0.521
CLV_NRD_NRD_1	250	252	PF00675	0.551
CLV_NRD_NRD_1	265	267	PF00675	0.573
CLV_NRD_NRD_1	412	414	PF00675	0.762
CLV_NRD_NRD_1	506	508	PF00675	0.655
CLV_NRD_NRD_1	599	601	PF00675	0.751
CLV_NRD_NRD_1	651	653	PF00675	0.613
CLV_PCSK_KEX2_1	203	205	PF00082	0.521
CLV_PCSK_KEX2_1	250	252	PF00082	0.551
CLV_PCSK_KEX2_1	265	267	PF00082	0.573
CLV_PCSK_KEX2_1	506	508	PF00082	0.655
CLV_PCSK_KEX2_1	599	601	PF00082	0.751
CLV_PCSK_KEX2_1	650	652	PF00082	0.607
CLV_PCSK_SKI1_1	183	187	PF00082	0.621
CLV_PCSK_SKI1_1	25	29	PF00082	0.690
CLV_PCSK_SKI1_1	366	370	PF00082	0.776
DEG_APCC_DBOX_1	203	211	PF00400	0.627
DEG_APCC_DBOX_1	269	277	PF00400	0.618
DEG_APCC_DBOX_1	365	373	PF00400	0.776
DEG_APCC_DBOX_1	453	461	PF00400	0.592
DEG_SPOP_SBC_1	400	404	PF00917	0.719
DEG_SPOP_SBC_1	493	497	PF00917	0.720
DEG_SPOP_SBC_1	53	57	PF00917	0.725
DEG_SPOP_SBC_1	62	66	PF00917	0.709
DOC_CKS1_1	286	291	PF01111	0.726
DOC_CYCLIN_RxL_1	363	373	PF00134	0.769
DOC_CYCLIN_yClb5_NLxxxL_5	566	575	PF00134	0.642
DOC_CYCLIN_yCln2_LP_2	368	371	PF00134	0.682
DOC_MAPK_gen_1	413	420	PF00069	0.699
DOC_MAPK_gen_1	506	514	PF00069	0.668
DOC_MAPK_gen_1	611	619	PF00069	0.644
DOC_MAPK_MEF2A_6	161	170	PF00069	0.614
DOC_MAPK_MEF2A_6	519	527	PF00069	0.689
DOC_PP2B_LxvP_1	368	371	PF13499	0.682
DOC_PP4_FxxP_1	239	242	PF00568	0.509
DOC_PP4_FxxP_1	97	100	PF00568	0.782
DOC_USP7_MATH_1	133	137	PF00917	0.714
DOC_USP7_MATH_1	337	341	PF00917	0.862
DOC_USP7_MATH_1	395	399	PF00917	0.696
DOC_USP7_MATH_1	400	404	PF00917	0.703
DOC_USP7_MATH_1	46	50	PF00917	0.759
DOC_USP7_MATH_1	485	489	PF00917	0.642
DOC_USP7_MATH_1	53	57	PF00917	0.798
DOC_USP7_MATH_1	589	593	PF00917	0.720
DOC_USP7_MATH_1	61	65	PF00917	0.649
DOC_USP7_MATH_1	72	76	PF00917	0.588
DOC_USP7_UBL2_3	157	161	PF12436	0.635
DOC_USP7_UBL2_3	90	94	PF12436	0.770
DOC_WW_Pin1_4	135	140	PF00397	0.631
DOC_WW_Pin1_4	285	290	PF00397	0.685
DOC_WW_Pin1_4	317	322	PF00397	0.744
DOC_WW_Pin1_4	345	350	PF00397	0.712
DOC_WW_Pin1_4	462	467	PF00397	0.706
DOC_WW_Pin1_4	48	53	PF00397	0.728
DOC_WW_Pin1_4	514	519	PF00397	0.584
DOC_WW_Pin1_4	536	541	PF00397	0.590
LIG_14-3-3_CanoR_1	119	127	PF00244	0.709
LIG_14-3-3_CanoR_1	394	400	PF00244	0.723
LIG_14-3-3_CanoR_1	413	418	PF00244	0.483
LIG_14-3-3_CanoR_1	474	482	PF00244	0.797
LIG_14-3-3_CanoR_1	599	608	PF00244	0.688
LIG_14-3-3_CanoR_1	611	617	PF00244	0.466
LIG_BIR_II_1	1	5	PF00653	0.726
LIG_BIR_III_4	588	592	PF00653	0.725
LIG_BRCT_BRCA1_1	296	300	PF00533	0.746
LIG_DLG_GKlike_1	413	420	PF00625	0.707
LIG_FHA_1	163	169	PF00498	0.544
LIG_FHA_1	18	24	PF00498	0.551
LIG_FHA_1	30	36	PF00498	0.611
LIG_FHA_1	346	352	PF00498	0.685
LIG_FHA_1	407	413	PF00498	0.789
LIG_FHA_1	57	63	PF00498	0.756
LIG_FHA_1	596	602	PF00498	0.737
LIG_FHA_2	200	206	PF00498	0.500
LIG_FHA_2	270	276	PF00498	0.616
LIG_FHA_2	297	303	PF00498	0.823
LIG_FHA_2	371	377	PF00498	0.784
LIG_FHA_2	463	469	PF00498	0.701
LIG_FHA_2	495	501	PF00498	0.587
LIG_LIR_Apic_2	19	24	PF02991	0.551
LIG_LIR_Apic_2	238	242	PF02991	0.506
LIG_LIR_Apic_2	96	100	PF02991	0.781
LIG_LIR_Gen_1	416	421	PF02991	0.521
LIG_LIR_Gen_1	431	440	PF02991	0.503
LIG_LIR_Nem_3	220	226	PF02991	0.631
LIG_LIR_Nem_3	228	234	PF02991	0.498
LIG_LIR_Nem_3	391	396	PF02991	0.684
LIG_LIR_Nem_3	416	420	PF02991	0.528
LIG_LIR_Nem_3	563	568	PF02991	0.548
LIG_LIR_Nem_3	602	608	PF02991	0.623
LIG_LIR_Nem_3	621	626	PF02991	0.475
LIG_LIR_Nem_3	88	92	PF02991	0.667
LIG_LYPXL_yS_3	605	608	PF13949	0.612
LIG_MYND_1	367	371	PF01753	0.678
LIG_Pex14_2	196	200	PF04695	0.519
LIG_PTAP_UEV_1	323	328	PF05743	0.679
LIG_PTAP_UEV_1	42	47	PF05743	0.752
LIG_Rb_LxCxE_1	557	573	PF01857	0.654
LIG_SH2_CRK	223	227	PF00017	0.604
LIG_SH2_CRK	231	235	PF00017	0.506
LIG_SH2_CRK	552	556	PF00017	0.532
LIG_SH2_CRK	568	572	PF00017	0.535
LIG_SH2_GRB2like	219	222	PF00017	0.733
LIG_SH2_NCK_1	92	96	PF00017	0.776
LIG_SH2_PTP2	21	24	PF00017	0.544
LIG_SH2_PTP2	417	420	PF00017	0.578
LIG_SH2_STAP1	219	223	PF00017	0.728
LIG_SH2_STAP1	562	566	PF00017	0.639
LIG_SH2_STAT5	201	204	PF00017	0.513
LIG_SH2_STAT5	206	209	PF00017	0.515
LIG_SH2_STAT5	21	24	PF00017	0.544
LIG_SH2_STAT5	223	226	PF00017	0.397
LIG_SH2_STAT5	417	420	PF00017	0.539
LIG_SH2_STAT5	449	452	PF00017	0.560
LIG_SH2_STAT5	630	633	PF00017	0.538
LIG_SH3_2	181	186	PF14604	0.640
LIG_SH3_2	324	329	PF14604	0.681
LIG_SH3_3	10	16	PF00018	0.712
LIG_SH3_3	124	130	PF00018	0.594
LIG_SH3_3	178	184	PF00018	0.523
LIG_SH3_3	207	213	PF00018	0.517
LIG_SH3_3	318	324	PF00018	0.765
LIG_SH3_3	344	350	PF00018	0.696
LIG_SH3_3	364	370	PF00018	0.664
LIG_SH3_3	40	46	PF00018	0.773
LIG_SH3_3	458	464	PF00018	0.635
LIG_SH3_3	47	53	PF00018	0.711
LIG_SH3_3	512	518	PF00018	0.587
LIG_SUMO_SIM_anti_2	520	526	PF11976	0.583
LIG_SUMO_SIM_par_1	487	497	PF11976	0.666
LIG_TYR_ITIM	229	234	PF00017	0.542
LIG_TYR_ITIM	566	571	PF00017	0.638
MOD_CDK_SPK_2	514	519	PF00069	0.685
MOD_CDK_SPxK_1	135	141	PF00069	0.598
MOD_CDK_SPxxK_3	285	292	PF00069	0.574
MOD_CK1_1	162	168	PF00069	0.512
MOD_CK1_1	296	302	PF00069	0.824
MOD_CK1_1	304	310	PF00069	0.650
MOD_CK1_1	317	323	PF00069	0.731
MOD_CK1_1	358	364	PF00069	0.723
MOD_CK1_1	402	408	PF00069	0.777
MOD_CK1_1	470	476	PF00069	0.716
MOD_CK1_1	517	523	PF00069	0.516
MOD_CK1_1	55	61	PF00069	0.750
MOD_CK1_1	592	598	PF00069	0.761
MOD_CK1_1	64	70	PF00069	0.657
MOD_CK2_1	41	47	PF00069	0.731
MOD_CK2_1	428	434	PF00069	0.651
MOD_CK2_1	462	468	PF00069	0.690
MOD_CK2_1	626	632	PF00069	0.585
MOD_GlcNHglycan	101	104	PF01048	0.732
MOD_GlcNHglycan	121	124	PF01048	0.475
MOD_GlcNHglycan	160	164	PF01048	0.539
MOD_GlcNHglycan	302	306	PF01048	0.704
MOD_GlcNHglycan	339	342	PF01048	0.844
MOD_GlcNHglycan	357	360	PF01048	0.515
MOD_GlcNHglycan	386	389	PF01048	0.784
MOD_GlcNHglycan	390	393	PF01048	0.804
MOD_GlcNHglycan	43	46	PF01048	0.817
MOD_GlcNHglycan	468	472	PF01048	0.814
MOD_GlcNHglycan	487	490	PF01048	0.686
MOD_GlcNHglycan	59	62	PF01048	0.515
MOD_GlcNHglycan	632	635	PF01048	0.620
MOD_GlcNHglycan	66	69	PF01048	0.691
MOD_GSK3_1	217	224	PF00069	0.640
MOD_GSK3_1	294	301	PF00069	0.730
MOD_GSK3_1	304	311	PF00069	0.740
MOD_GSK3_1	380	387	PF00069	0.707
MOD_GSK3_1	395	402	PF00069	0.644
MOD_GSK3_1	440	447	PF00069	0.580
MOD_GSK3_1	470	477	PF00069	0.763
MOD_GSK3_1	48	55	PF00069	0.716
MOD_GSK3_1	513	520	PF00069	0.685
MOD_GSK3_1	532	539	PF00069	0.591
MOD_GSK3_1	57	64	PF00069	0.724
MOD_GSK3_1	575	582	PF00069	0.586
MOD_GSK3_1	595	602	PF00069	0.433
MOD_GSK3_1	626	633	PF00069	0.584
MOD_GSK3_1	72	79	PF00069	0.627
MOD_N-GLC_1	217	222	PF02516	0.731
MOD_N-GLC_1	293	298	PF02516	0.747
MOD_N-GLC_2	147	149	PF02516	0.540
MOD_NEK2_1	148	153	PF00069	0.556
MOD_NEK2_1	159	164	PF00069	0.632
MOD_NEK2_1	17	22	PF00069	0.609
MOD_NEK2_1	27	32	PF00069	0.522
MOD_NEK2_1	300	305	PF00069	0.787
MOD_NEK2_1	308	313	PF00069	0.716
MOD_NEK2_1	380	385	PF00069	0.793
MOD_NEK2_1	428	433	PF00069	0.542
MOD_NEK2_1	492	497	PF00069	0.630
MOD_NEK2_1	575	580	PF00069	0.578
MOD_PIKK_1	395	401	PF00454	0.716
MOD_PIKK_1	474	480	PF00454	0.683
MOD_PKA_1	413	419	PF00069	0.719
MOD_PKA_1	599	605	PF00069	0.735
MOD_PKA_2	118	124	PF00069	0.705
MOD_PKA_2	269	275	PF00069	0.622
MOD_PKA_2	473	479	PF00069	0.801
MOD_PKA_2	599	605	PF00069	0.660
MOD_PKB_1	39	47	PF00069	0.720
MOD_Plk_1	104	110	PF00069	0.692
MOD_Plk_1	380	386	PF00069	0.792
MOD_Plk_1	46	52	PF00069	0.725
MOD_Plk_1	592	598	PF00069	0.707
MOD_Plk_2-3	88	94	PF00069	0.687
MOD_Plk_4	17	23	PF00069	0.556
MOD_Plk_4	358	364	PF00069	0.680
MOD_Plk_4	413	419	PF00069	0.563
MOD_ProDKin_1	135	141	PF00069	0.627
MOD_ProDKin_1	285	291	PF00069	0.691
MOD_ProDKin_1	317	323	PF00069	0.746
MOD_ProDKin_1	345	351	PF00069	0.705
MOD_ProDKin_1	462	468	PF00069	0.710
MOD_ProDKin_1	48	54	PF00069	0.728
MOD_ProDKin_1	514	520	PF00069	0.582
MOD_ProDKin_1	536	542	PF00069	0.594
MOD_SUMO_for_1	185	188	PF00179	0.616
TRG_DiLeu_BaLyEn_6	364	369	PF01217	0.664
TRG_DiLeu_BaLyEn_6	487	492	PF01217	0.550
TRG_ENDOCYTIC_2	197	200	PF00928	0.528
TRG_ENDOCYTIC_2	223	226	PF00928	0.613
TRG_ENDOCYTIC_2	231	234	PF00928	0.500
TRG_ENDOCYTIC_2	417	420	PF00928	0.520
TRG_ENDOCYTIC_2	562	565	PF00928	0.538
TRG_ENDOCYTIC_2	568	571	PF00928	0.534
TRG_ENDOCYTIC_2	605	608	PF00928	0.616
TRG_ER_diArg_1	174	177	PF00400	0.598
TRG_ER_diArg_1	249	251	PF00400	0.532
TRG_ER_diArg_1	505	507	PF00400	0.664
TRG_ER_diArg_1	599	601	PF00400	0.751
TRG_ER_diArg_1	649	652	PF00400	0.606
TRG_Pf-PMV_PEXEL_1	394	399	PF00026	0.723

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3E5	Leptomonas seymouri	50%	96%
A4HG82	Leishmania braziliensis	83%	100%
A4I3A7	Leishmania infantum	100%	100%
E9AZK2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q8M9	Leishmania major	96%	100%