Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7X148_LEIDO

TriTrypDb:

LdBPK_280190.1 , LdCL_280006800 , LDHU3_28.0240

Length:

517

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X148

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X148

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	266	270	PF00656	0.635
CLV_MEL_PAP_1	231	237	PF00089	0.534
CLV_NRD_NRD_1	114	116	PF00675	0.582
CLV_NRD_NRD_1	122	124	PF00675	0.645
CLV_NRD_NRD_1	171	173	PF00675	0.840
CLV_NRD_NRD_1	228	230	PF00675	0.665
CLV_NRD_NRD_1	243	245	PF00675	0.669
CLV_NRD_NRD_1	247	249	PF00675	0.676
CLV_NRD_NRD_1	317	319	PF00675	0.643
CLV_NRD_NRD_1	346	348	PF00675	0.626
CLV_NRD_NRD_1	37	39	PF00675	0.564
CLV_PCSK_KEX2_1	114	116	PF00082	0.582
CLV_PCSK_KEX2_1	171	173	PF00082	0.840
CLV_PCSK_KEX2_1	228	230	PF00082	0.665
CLV_PCSK_KEX2_1	243	245	PF00082	0.669
CLV_PCSK_KEX2_1	317	319	PF00082	0.658
CLV_PCSK_KEX2_1	322	324	PF00082	0.611
CLV_PCSK_KEX2_1	346	348	PF00082	0.626
CLV_PCSK_KEX2_1	357	359	PF00082	0.667
CLV_PCSK_KEX2_1	37	39	PF00082	0.508
CLV_PCSK_KEX2_1	82	84	PF00082	0.548
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.635
CLV_PCSK_PC1ET2_1	357	359	PF00082	0.769
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.548
CLV_PCSK_PC7_1	313	319	PF00082	0.665
CLV_PCSK_PC7_1	78	84	PF00082	0.539
CLV_PCSK_SKI1_1	103	107	PF00082	0.507
CLV_PCSK_SKI1_1	133	137	PF00082	0.567
CLV_PCSK_SKI1_1	229	233	PF00082	0.655
CLV_PCSK_SKI1_1	244	248	PF00082	0.670
CLV_PCSK_SKI1_1	285	289	PF00082	0.677
CLV_PCSK_SKI1_1	317	321	PF00082	0.674
CLV_PCSK_SKI1_1	346	350	PF00082	0.731
CLV_PCSK_SKI1_1	511	515	PF00082	0.741
CLV_PCSK_SKI1_1	65	69	PF00082	0.584
CLV_PCSK_SKI1_1	82	86	PF00082	0.374
DEG_APCC_DBOX_1	233	241	PF00400	0.650
DEG_Nend_Nbox_1	1	3	PF02207	0.655
DEG_SCF_FBW7_1	230	236	PF00400	0.619
DEG_SPOP_SBC_1	143	147	PF00917	0.617
DOC_CKS1_1	230	235	PF01111	0.660
DOC_CYCLIN_yCln2_LP_2	302	305	PF00134	0.692
DOC_CYCLIN_yCln2_LP_2	386	392	PF00134	0.691
DOC_MAPK_gen_1	82	92	PF00069	0.452
DOC_MAPK_MEF2A_6	228	237	PF00069	0.664
DOC_MAPK_MEF2A_6	86	94	PF00069	0.452
DOC_PP2B_LxvP_1	176	179	PF13499	0.726
DOC_PP2B_LxvP_1	302	305	PF13499	0.692
DOC_PP2B_LxvP_1	386	389	PF13499	0.678
DOC_PP4_FxxP_1	432	435	PF00568	0.714
DOC_USP7_MATH_1	143	147	PF00917	0.593
DOC_USP7_MATH_1	204	208	PF00917	0.745
DOC_USP7_MATH_1	233	237	PF00917	0.616
DOC_USP7_MATH_1	253	257	PF00917	0.689
DOC_USP7_MATH_1	279	283	PF00917	0.577
DOC_USP7_MATH_1	444	448	PF00917	0.787
DOC_USP7_MATH_1	462	466	PF00917	0.564
DOC_USP7_MATH_2	279	285	PF00917	0.655
DOC_WW_Pin1_4	229	234	PF00397	0.660
DOC_WW_Pin1_4	288	293	PF00397	0.682
DOC_WW_Pin1_4	296	301	PF00397	0.684
DOC_WW_Pin1_4	427	432	PF00397	0.657
DOC_WW_Pin1_4	442	447	PF00397	0.772
DOC_WW_Pin1_4	450	455	PF00397	0.704
LIG_14-3-3_CanoR_1	114	118	PF00244	0.641
LIG_14-3-3_CanoR_1	234	238	PF00244	0.633
LIG_14-3-3_CanoR_1	37	42	PF00244	0.721
LIG_14-3-3_CanoR_1	420	427	PF00244	0.714
LIG_14-3-3_CanoR_1	492	496	PF00244	0.775
LIG_Actin_WH2_2	87	105	PF00022	0.508
LIG_BRCT_BRCA1_1	145	149	PF00533	0.588
LIG_BRCT_BRCA1_1	283	287	PF00533	0.658
LIG_BRCT_BRCA1_1	338	342	PF00533	0.630
LIG_BRCT_BRCA1_1	394	398	PF00533	0.721
LIG_BRCT_BRCA1_1	428	432	PF00533	0.700
LIG_BRCT_BRCA1_2	394	400	PF00533	0.720
LIG_DCNL_PONY_1	1	4	PF03556	0.649
LIG_EVH1_2	388	392	PF00568	0.695
LIG_FHA_1	230	236	PF00498	0.639
LIG_FHA_1	413	419	PF00498	0.704
LIG_FHA_1	51	57	PF00498	0.711
LIG_FHA_2	264	270	PF00498	0.617
LIG_FHA_2	376	382	PF00498	0.682
LIG_HP1_1	233	237	PF01393	0.538
LIG_LIR_Apic_2	382	388	PF02991	0.660
LIG_LIR_Apic_2	429	435	PF02991	0.705
LIG_LIR_Gen_1	497	507	PF02991	0.693
LIG_LIR_Nem_3	284	290	PF02991	0.683
LIG_MYND_1	300	304	PF01753	0.713
LIG_MYND_1	431	435	PF01753	0.668
LIG_Pex14_2	149	153	PF04695	0.610
LIG_PTAP_UEV_1	445	450	PF05743	0.582
LIG_PTB_Apo_2	30	37	PF02174	0.654
LIG_SH2_CRK	15	19	PF00017	0.768
LIG_SH2_SRC	385	388	PF00017	0.591
LIG_SH2_SRC	457	460	PF00017	0.562
LIG_SH2_STAP1	457	461	PF00017	0.778
LIG_SH2_STAP1	95	99	PF00017	0.632
LIG_SH2_STAT3	41	44	PF00017	0.609
LIG_SH2_STAT3	479	482	PF00017	0.605
LIG_SH2_STAT5	385	388	PF00017	0.743
LIG_SH2_STAT5	467	470	PF00017	0.640
LIG_SH2_STAT5	55	58	PF00017	0.709
LIG_SH3_1	172	178	PF00018	0.668
LIG_SH3_2	239	244	PF14604	0.662
LIG_SH3_3	172	178	PF00018	0.668
LIG_SH3_3	198	204	PF00018	0.711
LIG_SH3_3	236	242	PF00018	0.717
LIG_SH3_3	294	300	PF00018	0.685
LIG_SH3_3	443	449	PF00018	0.736
LIG_SH3_3	470	476	PF00018	0.763
LIG_SUMO_SIM_par_1	414	419	PF11976	0.570
LIG_SUMO_SIM_par_1	503	510	PF11976	0.654
LIG_TRAF2_1	20	23	PF00917	0.687
LIG_TRAF2_1	506	509	PF00917	0.761
LIG_UBA3_1	106	111	PF00899	0.488
LIG_WW_1	454	457	PF00397	0.655
LIG_WW_3	240	244	PF00397	0.662
MOD_CDK_SPK_2	229	234	PF00069	0.646
MOD_CK1_1	129	135	PF00069	0.607
MOD_CK1_1	181	187	PF00069	0.771
MOD_CK1_1	199	205	PF00069	0.606
MOD_CK1_1	261	267	PF00069	0.739
MOD_CK1_1	296	302	PF00069	0.732
MOD_CK1_1	331	337	PF00069	0.597
MOD_CK1_1	375	381	PF00069	0.714
MOD_CK1_1	391	397	PF00069	0.735
MOD_CK1_1	414	420	PF00069	0.678
MOD_CK1_1	465	471	PF00069	0.603
MOD_CK1_1	494	500	PF00069	0.777
MOD_CK2_1	16	22	PF00069	0.646
MOD_CK2_1	503	509	PF00069	0.770
MOD_Cter_Amidation	169	172	PF01082	0.786
MOD_Cter_Amidation	226	229	PF01082	0.718
MOD_GlcNHglycan	146	149	PF01048	0.674
MOD_GlcNHglycan	260	263	PF01048	0.693
MOD_GlcNHglycan	266	269	PF01048	0.649
MOD_GlcNHglycan	351	354	PF01048	0.737
MOD_GlcNHglycan	407	410	PF01048	0.663
MOD_GlcNHglycan	446	449	PF01048	0.772
MOD_GSK3_1	113	120	PF00069	0.584
MOD_GSK3_1	125	132	PF00069	0.618
MOD_GSK3_1	133	140	PF00069	0.583
MOD_GSK3_1	177	184	PF00069	0.801
MOD_GSK3_1	229	236	PF00069	0.619
MOD_GSK3_1	253	260	PF00069	0.630
MOD_GSK3_1	279	286	PF00069	0.625
MOD_GSK3_1	333	340	PF00069	0.627
MOD_GSK3_1	342	349	PF00069	0.625
MOD_GSK3_1	368	375	PF00069	0.699
MOD_GSK3_1	388	395	PF00069	0.768
MOD_GSK3_1	412	419	PF00069	0.682
MOD_GSK3_1	422	429	PF00069	0.644
MOD_GSK3_1	461	468	PF00069	0.664
MOD_GSK3_1	474	481	PF00069	0.730
MOD_NEK2_1	257	262	PF00069	0.751
MOD_NEK2_1	283	288	PF00069	0.707
MOD_NEK2_1	337	342	PF00069	0.578
MOD_NEK2_1	36	41	PF00069	0.612
MOD_NEK2_1	392	397	PF00069	0.720
MOD_NEK2_1	74	79	PF00069	0.542
MOD_NEK2_2	137	142	PF00069	0.566
MOD_NEK2_2	436	441	PF00069	0.798
MOD_PIKK_1	178	184	PF00454	0.828
MOD_PIKK_1	331	337	PF00454	0.519
MOD_PIKK_1	379	385	PF00454	0.605
MOD_PIKK_1	420	426	PF00454	0.625
MOD_PIKK_1	478	484	PF00454	0.647
MOD_PKA_1	346	352	PF00069	0.735
MOD_PKA_1	37	43	PF00069	0.580
MOD_PKA_2	113	119	PF00069	0.633
MOD_PKA_2	233	239	PF00069	0.605
MOD_PKA_2	346	352	PF00069	0.735
MOD_PKA_2	36	42	PF00069	0.637
MOD_PKA_2	491	497	PF00069	0.741
MOD_PKA_2	74	80	PF00069	0.552
MOD_Plk_1	125	131	PF00069	0.605
MOD_Plk_1	50	56	PF00069	0.660
MOD_Plk_4	137	143	PF00069	0.566
MOD_Plk_4	220	226	PF00069	0.627
MOD_Plk_4	253	259	PF00069	0.727
MOD_Plk_4	328	334	PF00069	0.679
MOD_Plk_4	337	343	PF00069	0.574
MOD_Plk_4	375	381	PF00069	0.791
MOD_Plk_4	494	500	PF00069	0.661
MOD_ProDKin_1	229	235	PF00069	0.661
MOD_ProDKin_1	288	294	PF00069	0.683
MOD_ProDKin_1	296	302	PF00069	0.688
MOD_ProDKin_1	427	433	PF00069	0.660
MOD_ProDKin_1	442	448	PF00069	0.773
MOD_ProDKin_1	450	456	PF00069	0.703
MOD_SUMO_for_1	109	112	PF00179	0.565
MOD_SUMO_for_1	404	407	PF00179	0.583
MOD_SUMO_for_1	56	59	PF00179	0.723
MOD_SUMO_rev_2	506	513	PF00179	0.661
TRG_DiLeu_BaEn_1	321	326	PF01217	0.654
TRG_DiLeu_BaEn_4	51	57	PF01217	0.711
TRG_DiLeu_BaLyEn_6	62	67	PF01217	0.660
TRG_ENDOCYTIC_2	15	18	PF00928	0.659
TRG_ER_diArg_1	113	115	PF00400	0.574
TRG_ER_diArg_1	228	230	PF00400	0.676
TRG_ER_diArg_1	242	244	PF00400	0.704
TRG_ER_diArg_1	317	319	PF00400	0.680
TRG_ER_diArg_1	36	38	PF00400	0.518
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.718
TRG_Pf-PMV_PEXEL_1	323	328	PF00026	0.632
TRG_Pf-PMV_PEXEL_1	420	424	PF00026	0.605

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P724	Leptomonas seymouri	48%	71%
A4HG60	Leishmania braziliensis	60%	100%
A4I392	Leishmania infantum	98%	100%
E9AZI0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q8Q1	Leishmania major	89%	100%