Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X145_LEIDO

TriTrypDb:

LdBPK_280200.1 , LdCL_280006900 , LDHU3_28.0260

Length:

619

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X145

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X145

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	153	157	PF00656	0.657
CLV_NRD_NRD_1	109	111	PF00675	0.770
CLV_NRD_NRD_1	129	131	PF00675	0.612
CLV_NRD_NRD_1	385	387	PF00675	0.381
CLV_NRD_NRD_1	510	512	PF00675	0.414
CLV_NRD_NRD_1	593	595	PF00675	0.470
CLV_PCSK_KEX2_1	10	12	PF00082	0.559
CLV_PCSK_KEX2_1	111	113	PF00082	0.687
CLV_PCSK_KEX2_1	510	512	PF00082	0.326
CLV_PCSK_KEX2_1	553	555	PF00082	0.367
CLV_PCSK_KEX2_1	79	81	PF00082	0.370
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.515
CLV_PCSK_PC1ET2_1	111	113	PF00082	0.687
CLV_PCSK_PC1ET2_1	553	555	PF00082	0.367
CLV_PCSK_PC1ET2_1	79	81	PF00082	0.400
CLV_PCSK_SKI1_1	249	253	PF00082	0.338
CLV_PCSK_SKI1_1	79	83	PF00082	0.368
CLV_Separin_Metazoa	242	246	PF03568	0.389
DEG_APCC_DBOX_1	248	256	PF00400	0.330
DEG_SPOP_SBC_1	362	366	PF00917	0.356
DOC_CKS1_1	568	573	PF01111	0.371
DOC_CYCLIN_yCln2_LP_2	471	477	PF00134	0.351
DOC_MAPK_gen_1	381	390	PF00069	0.420
DOC_MAPK_gen_1	510	521	PF00069	0.399
DOC_MAPK_MEF2A_6	249	256	PF00069	0.343
DOC_MAPK_NFAT4_5	249	257	PF00069	0.368
DOC_PP2B_LxvP_1	471	474	PF13499	0.351
DOC_PP2B_LxvP_1	91	94	PF13499	0.641
DOC_PP4_FxxP_1	423	426	PF00568	0.346
DOC_PP4_MxPP_1	92	95	PF00568	0.502
DOC_USP7_MATH_1	123	127	PF00917	0.651
DOC_USP7_MATH_1	201	205	PF00917	0.530
DOC_USP7_MATH_1	41	45	PF00917	0.557
DOC_USP7_MATH_1	506	510	PF00917	0.417
DOC_USP7_MATH_1	517	521	PF00917	0.289
DOC_USP7_MATH_1	98	102	PF00917	0.610
DOC_WW_Pin1_4	104	109	PF00397	0.725
DOC_WW_Pin1_4	11	16	PF00397	0.500
DOC_WW_Pin1_4	207	212	PF00397	0.386
DOC_WW_Pin1_4	422	427	PF00397	0.389
DOC_WW_Pin1_4	567	572	PF00397	0.345
DOC_WW_Pin1_4	588	593	PF00397	0.483
LIG_14-3-3_CanoR_1	562	568	PF00244	0.321
LIG_Actin_WH2_2	548	564	PF00022	0.447
LIG_BRCT_BRCA1_1	203	207	PF00533	0.480
LIG_BRCT_BRCA1_1	427	431	PF00533	0.338
LIG_EVH1_2	70	74	PF00568	0.373
LIG_FHA_1	149	155	PF00498	0.759
LIG_FHA_1	278	284	PF00498	0.347
LIG_FHA_1	299	305	PF00498	0.375
LIG_FHA_1	341	347	PF00498	0.357
LIG_FHA_1	353	359	PF00498	0.337
LIG_FHA_1	363	369	PF00498	0.309
LIG_FHA_1	372	378	PF00498	0.209
LIG_FHA_2	134	140	PF00498	0.690
LIG_FHA_2	153	159	PF00498	0.425
LIG_FHA_2	568	574	PF00498	0.368
LIG_LIR_Apic_2	65	71	PF02991	0.467
LIG_LIR_Gen_1	165	176	PF02991	0.565
LIG_LIR_Gen_1	300	310	PF02991	0.351
LIG_LIR_Gen_1	469	477	PF02991	0.371
LIG_LIR_Gen_1	572	582	PF02991	0.355
LIG_LIR_Nem_3	165	171	PF02991	0.579
LIG_LIR_Nem_3	300	306	PF02991	0.351
LIG_LIR_Nem_3	400	406	PF02991	0.449
LIG_LIR_Nem_3	428	434	PF02991	0.324
LIG_LIR_Nem_3	44	49	PF02991	0.511
LIG_LIR_Nem_3	464	470	PF02991	0.354
LIG_LIR_Nem_3	572	577	PF02991	0.356
LIG_LRP6_Inhibitor_1	16	22	PF00058	0.332
LIG_NRBOX	26	32	PF00104	0.526
LIG_PTB_Apo_2	275	282	PF02174	0.342
LIG_REV1ctd_RIR_1	429	439	PF16727	0.447
LIG_SH2_CRK	68	72	PF00017	0.426
LIG_SH2_NCK_1	568	572	PF00017	0.359
LIG_SH2_PTP2	574	577	PF00017	0.425
LIG_SH2_SRC	235	238	PF00017	0.500
LIG_SH2_STAP1	235	239	PF00017	0.360
LIG_SH2_STAP1	257	261	PF00017	0.370
LIG_SH2_STAP1	598	602	PF00017	0.324
LIG_SH2_STAT5	303	306	PF00017	0.363
LIG_SH2_STAT5	361	364	PF00017	0.292
LIG_SH2_STAT5	470	473	PF00017	0.348
LIG_SH2_STAT5	491	494	PF00017	0.431
LIG_SH2_STAT5	537	540	PF00017	0.399
LIG_SH2_STAT5	560	563	PF00017	0.339
LIG_SH2_STAT5	574	577	PF00017	0.313
LIG_SH3_3	271	277	PF00018	0.365
LIG_SH3_3	519	525	PF00018	0.360
LIG_SH3_3	545	551	PF00018	0.436
LIG_SH3_3	586	592	PF00018	0.542
LIG_SUMO_SIM_par_1	252	258	PF11976	0.331
LIG_SUMO_SIM_par_1	355	360	PF11976	0.351
LIG_SUMO_SIM_par_1	520	526	PF11976	0.370
LIG_SUMO_SIM_par_1	579	586	PF11976	0.494
LIG_TYR_ITSM	299	306	PF00017	0.371
LIG_WRC_WIRS_1	168	173	PF05994	0.512
LIG_WRC_WIRS_1	49	54	PF05994	0.465
MOD_CDC14_SPxK_1	107	110	PF00782	0.611
MOD_CDC14_SPxK_1	14	17	PF00782	0.476
MOD_CDC14_SPxK_1	591	594	PF00782	0.505
MOD_CDK_SPK_2	422	427	PF00069	0.389
MOD_CDK_SPxK_1	104	110	PF00069	0.618
MOD_CDK_SPxK_1	11	17	PF00069	0.495
MOD_CDK_SPxK_1	588	594	PF00069	0.498
MOD_CDK_SPxxK_3	104	111	PF00069	0.615
MOD_CDK_SPxxK_3	588	595	PF00069	0.448
MOD_CK1_1	163	169	PF00069	0.699
MOD_CK1_1	410	416	PF00069	0.388
MOD_CK1_1	425	431	PF00069	0.308
MOD_CK1_1	51	57	PF00069	0.454
MOD_CK1_1	531	537	PF00069	0.523
MOD_CK1_1	9	15	PF00069	0.560
MOD_CK2_1	110	116	PF00069	0.649
MOD_CK2_1	129	135	PF00069	0.705
MOD_CK2_1	317	323	PF00069	0.391
MOD_CK2_1	41	47	PF00069	0.497
MOD_CK2_1	517	523	PF00069	0.342
MOD_CK2_1	567	573	PF00069	0.343
MOD_CK2_1	80	86	PF00069	0.434
MOD_DYRK1A_RPxSP_1	11	15	PF00069	0.392
MOD_GlcNHglycan	104	107	PF01048	0.510
MOD_GlcNHglycan	143	146	PF01048	0.788
MOD_GlcNHglycan	177	180	PF01048	0.542
MOD_GlcNHglycan	365	368	PF01048	0.376
MOD_GlcNHglycan	427	430	PF01048	0.449
MOD_GlcNHglycan	497	500	PF01048	0.375
MOD_GlcNHglycan	563	566	PF01048	0.321
MOD_GSK3_1	106	113	PF00069	0.747
MOD_GSK3_1	129	136	PF00069	0.655
MOD_GSK3_1	148	155	PF00069	0.660
MOD_GSK3_1	156	163	PF00069	0.672
MOD_GSK3_1	31	38	PF00069	0.520
MOD_GSK3_1	421	428	PF00069	0.328
MOD_GSK3_1	441	448	PF00069	0.247
MOD_GSK3_1	490	497	PF00069	0.500
MOD_GSK3_1	98	105	PF00069	0.707
MOD_N-GLC_1	148	153	PF02516	0.509
MOD_N-GLC_1	207	212	PF02516	0.444
MOD_N-GLC_1	277	282	PF02516	0.348
MOD_N-GLC_1	352	357	PF02516	0.500
MOD_N-GLC_1	41	46	PF02516	0.439
MOD_NEK2_1	129	134	PF00069	0.610
MOD_NEK2_1	221	226	PF00069	0.317
MOD_NEK2_1	495	500	PF00069	0.355
MOD_NEK2_1	528	533	PF00069	0.499
MOD_NEK2_1	561	566	PF00069	0.422
MOD_NEK2_2	41	46	PF00069	0.524
MOD_NEK2_2	48	53	PF00069	0.451
MOD_OFUCOSY	162	167	PF10250	0.439
MOD_PIKK_1	407	413	PF00454	0.470
MOD_PK_1	17	23	PF00069	0.581
MOD_PK_1	441	447	PF00069	0.528
MOD_PKA_1	110	116	PF00069	0.742
MOD_PKA_2	129	135	PF00069	0.700
MOD_PKA_2	561	567	PF00069	0.322
MOD_PKA_2	600	606	PF00069	0.577
MOD_Plk_1	163	169	PF00069	0.549
MOD_Plk_1	277	283	PF00069	0.320
MOD_Plk_1	337	343	PF00069	0.452
MOD_Plk_1	35	41	PF00069	0.532
MOD_Plk_1	352	358	PF00069	0.250
MOD_Plk_1	64	70	PF00069	0.552
MOD_Plk_2-3	152	158	PF00069	0.617
MOD_Plk_2-3	160	166	PF00069	0.493
MOD_Plk_4	221	227	PF00069	0.399
MOD_Plk_4	353	359	PF00069	0.362
MOD_Plk_4	41	47	PF00069	0.591
MOD_Plk_4	410	416	PF00069	0.340
MOD_Plk_4	441	447	PF00069	0.415
MOD_Plk_4	466	472	PF00069	0.377
MOD_Plk_4	517	523	PF00069	0.342
MOD_Plk_4	528	534	PF00069	0.367
MOD_ProDKin_1	104	110	PF00069	0.724
MOD_ProDKin_1	11	17	PF00069	0.495
MOD_ProDKin_1	207	213	PF00069	0.381
MOD_ProDKin_1	422	428	PF00069	0.398
MOD_ProDKin_1	567	573	PF00069	0.343
MOD_ProDKin_1	588	594	PF00069	0.481
MOD_SUMO_rev_2	400	406	PF00179	0.437
TRG_DiLeu_BaEn_2	241	247	PF01217	0.448
TRG_DiLeu_LyEn_5	250	255	PF01217	0.392
TRG_ENDOCYTIC_2	303	306	PF00928	0.363
TRG_ENDOCYTIC_2	307	310	PF00928	0.352
TRG_ENDOCYTIC_2	470	473	PF00928	0.323
TRG_ENDOCYTIC_2	560	563	PF00928	0.323
TRG_ENDOCYTIC_2	574	577	PF00928	0.352
TRG_ER_diArg_1	380	383	PF00400	0.369
TRG_ER_diArg_1	510	512	PF00400	0.326
TRG_NLS_MonoExtC_3	109	114	PF00514	0.749
TRG_NLS_MonoExtC_3	129	135	PF00514	0.609
TRG_NLS_MonoExtN_4	108	115	PF00514	0.733
TRG_Pf-PMV_PEXEL_1	232	236	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	264	269	PF00026	0.358
TRG_Pf-PMV_PEXEL_1	328	332	PF00026	0.499

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7G6	Leptomonas seymouri	67%	95%
A0A1X0NVS7	Trypanosomatidae	65%	100%
A0A3R7RDE4	Trypanosoma rangeli	62%	100%
A4HG61	Leishmania braziliensis	77%	100%
E9AZI1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q8Q0	Leishmania major	92%	100%
Q9LGZ2	Oryza sativa subsp. japonica	25%	100%
Q9M1R1	Arabidopsis thaliana	27%	100%
V5D807	Trypanosoma cruzi	65%	100%