Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X140_LEIDO

TriTrypDb:

LdBPK_280180.1 , LdCL_280006700 , LDHU3_28.0230

Length:

206

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	6
GO:0016020	membrane	2	5

Expansion

Sequence features

A0A3S7X140

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X140

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	34	36	PF00675	0.489
CLV_NRD_NRD_1	40	42	PF00675	0.539
CLV_PCSK_KEX2_1	34	36	PF00082	0.492
CLV_PCSK_KEX2_1	40	42	PF00082	0.543
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.619
CLV_PCSK_SKI1_1	149	153	PF00082	0.445
CLV_PCSK_SKI1_1	7	11	PF00082	0.470
DEG_APCC_DBOX_1	148	156	PF00400	0.422
DEG_SCF_FBW7_1	166	172	PF00400	0.386
DOC_CKS1_1	166	171	PF01111	0.470
DOC_PP2B_LxvP_1	189	192	PF13499	0.431
DOC_USP7_MATH_1	179	183	PF00917	0.462
DOC_USP7_MATH_1	44	48	PF00917	0.565
DOC_WW_Pin1_4	104	109	PF00397	0.278
DOC_WW_Pin1_4	165	170	PF00397	0.477
DOC_WW_Pin1_4	40	45	PF00397	0.556
DOC_WW_Pin1_4	90	95	PF00397	0.461
LIG_14-3-3_CanoR_1	122	128	PF00244	0.469
LIG_14-3-3_CanoR_1	180	185	PF00244	0.511
LIG_BIR_II_1	1	5	PF00653	0.376
LIG_BRCT_BRCA1_1	181	185	PF00533	0.448
LIG_BRCT_BRCA1_1	186	190	PF00533	0.397
LIG_FHA_1	105	111	PF00498	0.350
LIG_FHA_1	91	97	PF00498	0.427
LIG_FHA_2	14	20	PF00498	0.460
LIG_LIR_Apic_2	172	178	PF02991	0.433
LIG_LIR_Gen_1	113	121	PF02991	0.488
LIG_LIR_Nem_3	163	167	PF02991	0.348
LIG_LYPXL_yS_3	158	161	PF13949	0.504
LIG_MLH1_MIPbox_1	181	185	PF16413	0.357
LIG_PDZ_Class_3	201	206	PF00595	0.493
LIG_Pex14_1	6	10	PF04695	0.425
LIG_SH2_CRK	167	171	PF00017	0.447
LIG_SH2_GRB2like	114	117	PF00017	0.351
LIG_SH2_PTP2	175	178	PF00017	0.466
LIG_SH2_STAP1	4	8	PF00017	0.421
LIG_SH2_STAP1	77	81	PF00017	0.495
LIG_SH2_STAT5	114	117	PF00017	0.476
LIG_SH2_STAT5	167	170	PF00017	0.368
LIG_SH2_STAT5	175	178	PF00017	0.411
LIG_SH3_3	163	169	PF00018	0.353
LIG_SUMO_SIM_par_1	107	113	PF11976	0.476
LIG_SUMO_SIM_par_1	158	163	PF11976	0.460
LIG_TYR_ITIM	9	14	PF00017	0.481
LIG_UBA3_1	51	57	PF00899	0.569
LIG_WW_3	177	181	PF00397	0.393
MOD_CDK_SPK_2	40	45	PF00069	0.556
MOD_CK1_1	126	132	PF00069	0.556
MOD_CK1_1	13	19	PF00069	0.407
MOD_GlcNHglycan	36	39	PF01048	0.561
MOD_GlcNHglycan	46	49	PF01048	0.367
MOD_GSK3_1	165	172	PF00069	0.410
MOD_GSK3_1	179	186	PF00069	0.482
MOD_GSK3_1	40	47	PF00069	0.530
MOD_GSK3_1	86	93	PF00069	0.470
MOD_NEK2_1	10	15	PF00069	0.454
MOD_NEK2_1	160	165	PF00069	0.369
MOD_NEK2_1	184	189	PF00069	0.522
MOD_NEK2_1	66	71	PF00069	0.373
MOD_NEK2_2	61	66	PF00069	0.430
MOD_PIKK_1	197	203	PF00454	0.366
MOD_PKA_1	34	40	PF00069	0.571
MOD_PKA_2	179	185	PF00069	0.566
MOD_PKA_2	34	40	PF00069	0.571
MOD_PKA_2	44	50	PF00069	0.414
MOD_Plk_1	132	138	PF00069	0.622
MOD_Plk_2-3	143	149	PF00069	0.482
MOD_Plk_4	10	16	PF00069	0.394
MOD_Plk_4	126	132	PF00069	0.548
MOD_Plk_4	180	186	PF00069	0.515
MOD_Plk_4	61	67	PF00069	0.440
MOD_ProDKin_1	104	110	PF00069	0.272
MOD_ProDKin_1	165	171	PF00069	0.476
MOD_ProDKin_1	40	46	PF00069	0.545
MOD_ProDKin_1	90	96	PF00069	0.464
TRG_DiLeu_BaLyEn_6	105	110	PF01217	0.466
TRG_DiLeu_BaLyEn_6	156	161	PF01217	0.488
TRG_ENDOCYTIC_2	11	14	PF00928	0.475
TRG_ENDOCYTIC_2	158	161	PF00928	0.447
TRG_ENDOCYTIC_2	167	170	PF00928	0.347
TRG_ENDOCYTIC_2	77	80	PF00928	0.452

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5Y0	Leptomonas seymouri	74%	100%
A0A1X0NVB8	Trypanosomatidae	40%	95%
A0A422N4D7	Trypanosoma rangeli	43%	98%
A4HG59	Leishmania braziliensis	77%	100%
A4I391	Leishmania infantum	100%	100%
D0A7R7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	98%
E9AZH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q8Q2	Leishmania major	93%	100%
V5AS20	Trypanosoma cruzi	46%	98%