LeishMANIAdb
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Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical_protein_conserved
Gene product:
hypothetical protein, unknown function
Species:
Leishmania donovani
UniProt:
A0A3S7X132_LEIDO
TriTrypDb:
LdBPK_272330.1 * , LdCL_270031700 , LDHU3_27.3560
Length:
113

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7

Expansion

Sequence features

A0A3S7X132
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X132

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 33 37 PF00082 0.274
DEG_MDM2_SWIB_1 67 74 PF02201 0.310
DEG_Nend_Nbox_1 1 3 PF02207 0.299
DOC_MAPK_MEF2A_6 92 99 PF00069 0.526
DOC_USP7_MATH_1 80 84 PF00917 0.654
DOC_WW_Pin1_4 81 86 PF00397 0.587
LIG_14-3-3_CanoR_1 92 98 PF00244 0.481
LIG_deltaCOP1_diTrp_1 54 61 PF00928 0.290
LIG_FHA_1 13 19 PF00498 0.277
LIG_FHA_1 2 8 PF00498 0.388
LIG_FHA_1 45 51 PF00498 0.344
LIG_FHA_1 94 100 PF00498 0.282
LIG_LIR_Gen_1 88 98 PF02991 0.473
LIG_LIR_Nem_3 88 93 PF02991 0.580
LIG_Pex14_2 107 111 PF04695 0.320
LIG_Pex14_2 12 16 PF04695 0.310
LIG_Pex14_2 67 71 PF04695 0.310
LIG_SH2_SRC 98 101 PF00017 0.310
LIG_SH2_STAP1 3 7 PF00017 0.445
LIG_SH2_STAP1 39 43 PF00017 0.320
LIG_SH2_STAT3 106 109 PF00017 0.383
LIG_SH2_STAT5 106 109 PF00017 0.310
LIG_SH2_STAT5 3 6 PF00017 0.304
LIG_SH2_STAT5 90 93 PF00017 0.574
LIG_SH2_STAT5 98 101 PF00017 0.310
LIG_SH3_3 88 94 PF00018 0.575
LIG_SUMO_SIM_anti_2 47 52 PF11976 0.310
LIG_SUMO_SIM_anti_2 6 11 PF11976 0.324
LIG_SUMO_SIM_par_1 4 11 PF11976 0.308
LIG_WRC_WIRS_1 9 14 PF05994 0.310
MOD_CDC14_SPxK_1 84 87 PF00782 0.606
MOD_CDK_SPxK_1 81 87 PF00069 0.610
MOD_CK1_1 83 89 PF00069 0.648
MOD_GlcNHglycan 30 33 PF01048 0.376
MOD_GSK3_1 8 15 PF00069 0.277
MOD_NEK2_1 1 6 PF00069 0.350
MOD_NEK2_1 12 17 PF00069 0.304
MOD_NEK2_1 28 33 PF00069 0.658
MOD_NEK2_1 46 51 PF00069 0.310
MOD_Plk_4 12 18 PF00069 0.444
MOD_Plk_4 37 43 PF00069 0.320
MOD_Plk_4 46 52 PF00069 0.344
MOD_Plk_4 93 99 PF00069 0.333
MOD_ProDKin_1 81 87 PF00069 0.587
TRG_ENDOCYTIC_2 90 93 PF00928 0.574

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I817 Leptomonas seymouri 60% 92%
A4HG18 Leishmania braziliensis 84% 100%
E9ACV8 Leishmania major 94% 100%
E9AHG3 Leishmania infantum 100% 100%
E9AZE7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS