RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X131_LEIDO

TriTrypDb:

LdBPK_280070.1 , LdCL_280005600 , LDHU3_28.0090

Length:

524

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X131

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X131

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	127	129	PF00675	0.565
CLV_NRD_NRD_1	13	15	PF00675	0.731
CLV_NRD_NRD_1	347	349	PF00675	0.542
CLV_NRD_NRD_1	455	457	PF00675	0.582
CLV_PCSK_FUR_1	388	392	PF00082	0.474
CLV_PCSK_FUR_1	453	457	PF00082	0.495
CLV_PCSK_KEX2_1	127	129	PF00082	0.667
CLV_PCSK_KEX2_1	13	15	PF00082	0.731
CLV_PCSK_KEX2_1	266	268	PF00082	0.481
CLV_PCSK_KEX2_1	390	392	PF00082	0.482
CLV_PCSK_KEX2_1	455	457	PF00082	0.582
CLV_PCSK_PC1ET2_1	266	268	PF00082	0.512
CLV_PCSK_PC1ET2_1	390	392	PF00082	0.482
CLV_PCSK_SKI1_1	127	131	PF00082	0.566
CLV_PCSK_SKI1_1	257	261	PF00082	0.485
CLV_PCSK_SKI1_1	267	271	PF00082	0.365
CLV_PCSK_SKI1_1	337	341	PF00082	0.505
CLV_PCSK_SKI1_1	344	348	PF00082	0.531
DEG_APCC_DBOX_1	266	274	PF00400	0.496
DEG_APCC_KENBOX_2	329	333	PF00400	0.574
DEG_SPOP_SBC_1	310	314	PF00917	0.577
DOC_CYCLIN_RxL_1	124	133	PF00134	0.498
DOC_MAPK_DCC_7	179	189	PF00069	0.483
DOC_MAPK_gen_1	238	246	PF00069	0.583
DOC_MAPK_gen_1	266	272	PF00069	0.465
DOC_MAPK_gen_1	451	459	PF00069	0.434
DOC_PP2B_LxvP_1	356	359	PF13499	0.491
DOC_USP7_MATH_1	101	105	PF00917	0.708
DOC_USP7_MATH_1	156	160	PF00917	0.405
DOC_USP7_MATH_1	225	229	PF00917	0.637
DOC_USP7_MATH_1	310	314	PF00917	0.577
DOC_USP7_MATH_1	467	471	PF00917	0.507
DOC_USP7_UBL2_3	226	230	PF12436	0.648
DOC_WW_Pin1_4	22	27	PF00397	0.591
DOC_WW_Pin1_4	311	316	PF00397	0.609
DOC_WW_Pin1_4	483	488	PF00397	0.594
LIG_14-3-3_CanoR_1	120	126	PF00244	0.461
LIG_14-3-3_CanoR_1	13	23	PF00244	0.649
LIG_14-3-3_CanoR_1	147	156	PF00244	0.387
LIG_14-3-3_CanoR_1	196	205	PF00244	0.423
LIG_14-3-3_CanoR_1	348	353	PF00244	0.518
LIG_14-3-3_CanoR_1	391	399	PF00244	0.529
LIG_14-3-3_CanoR_1	427	431	PF00244	0.521
LIG_14-3-3_CanoR_1	57	61	PF00244	0.559
LIG_Actin_WH2_2	243	259	PF00022	0.380
LIG_Actin_WH2_2	349	364	PF00022	0.361
LIG_BRCT_BRCA1_1	424	428	PF00533	0.343
LIG_BRCT_BRCA1_1	49	53	PF00533	0.667
LIG_Clathr_ClatBox_1	129	133	PF01394	0.467
LIG_CSL_BTD_1	23	26	PF09270	0.675
LIG_eIF4E_1	148	154	PF01652	0.495
LIG_FHA_1	103	109	PF00498	0.621
LIG_FHA_1	163	169	PF00498	0.470
LIG_FHA_1	320	326	PF00498	0.494
LIG_FHA_1	43	49	PF00498	0.620
LIG_FHA_1	452	458	PF00498	0.489
LIG_FHA_1	77	83	PF00498	0.666
LIG_FHA_2	411	417	PF00498	0.593
LIG_FHA_2	470	476	PF00498	0.582
LIG_LIR_Apic_2	478	483	PF02991	0.542
LIG_LIR_Apic_2	69	74	PF02991	0.698
LIG_LIR_Gen_1	149	157	PF02991	0.482
LIG_LIR_Gen_1	167	174	PF02991	0.240
LIG_LIR_Gen_1	195	205	PF02991	0.593
LIG_LIR_Gen_1	297	307	PF02991	0.529
LIG_LIR_Gen_1	429	439	PF02991	0.500
LIG_LIR_Nem_3	115	121	PF02991	0.534
LIG_LIR_Nem_3	149	153	PF02991	0.416
LIG_LIR_Nem_3	167	173	PF02991	0.392
LIG_LIR_Nem_3	181	186	PF02991	0.447
LIG_LIR_Nem_3	195	201	PF02991	0.509
LIG_LIR_Nem_3	297	302	PF02991	0.565
LIG_LIR_Nem_3	429	435	PF02991	0.491
LIG_LIR_Nem_3	475	480	PF02991	0.602
LIG_LIR_Nem_3	50	56	PF02991	0.662
LIG_PDZ_Class_3	519	524	PF00595	0.783
LIG_Pex14_2	428	432	PF04695	0.373
LIG_SH2_CRK	299	303	PF00017	0.558
LIG_SH2_SRC	382	385	PF00017	0.329
LIG_SH2_STAP1	382	386	PF00017	0.484
LIG_SH2_STAP1	477	481	PF00017	0.614
LIG_SH2_STAP1	54	58	PF00017	0.628
LIG_SH2_STAT5	188	191	PF00017	0.424
LIG_SH2_STAT5	288	291	PF00017	0.611
LIG_SH2_STAT5	360	363	PF00017	0.502
LIG_SH2_STAT5	480	483	PF00017	0.575
LIG_SH2_STAT5	496	499	PF00017	0.521
LIG_SH2_STAT5	517	520	PF00017	0.605
LIG_SH3_3	400	406	PF00018	0.576
LIG_SH3_3	58	64	PF00018	0.602
LIG_SUMO_SIM_par_1	44	51	PF11976	0.669
LIG_UBA3_1	252	257	PF00899	0.575
MOD_CDC14_SPxK_1	314	317	PF00782	0.595
MOD_CDK_SPxK_1	311	317	PF00069	0.583
MOD_CK1_1	123	129	PF00069	0.546
MOD_CK1_1	15	21	PF00069	0.717
MOD_CK1_1	178	184	PF00069	0.578
MOD_CK1_1	233	239	PF00069	0.658
MOD_CK2_1	22	28	PF00069	0.589
MOD_CK2_1	320	326	PF00069	0.602
MOD_CK2_1	362	368	PF00069	0.486
MOD_CK2_1	410	416	PF00069	0.595
MOD_CK2_1	469	475	PF00069	0.579
MOD_GlcNHglycan	133	137	PF01048	0.498
MOD_GlcNHglycan	14	17	PF01048	0.725
MOD_GlcNHglycan	143	146	PF01048	0.464
MOD_GlcNHglycan	180	183	PF01048	0.521
MOD_GlcNHglycan	198	201	PF01048	0.518
MOD_GlcNHglycan	227	230	PF01048	0.672
MOD_GlcNHglycan	322	325	PF01048	0.616
MOD_GlcNHglycan	399	402	PF01048	0.570
MOD_GSK3_1	119	126	PF00069	0.489
MOD_GSK3_1	14	21	PF00069	0.664
MOD_GSK3_1	204	211	PF00069	0.456
MOD_GSK3_1	230	237	PF00069	0.664
MOD_GSK3_1	410	417	PF00069	0.529
MOD_GSK3_1	422	429	PF00069	0.540
MOD_NEK2_1	119	124	PF00069	0.510
MOD_NEK2_1	12	17	PF00069	0.734
MOD_NEK2_1	146	151	PF00069	0.445
MOD_NEK2_1	208	213	PF00069	0.536
MOD_NEK2_1	335	340	PF00069	0.437
MOD_NEK2_1	347	352	PF00069	0.525
MOD_NEK2_1	4	9	PF00069	0.720
MOD_NEK2_1	430	435	PF00069	0.493
MOD_NEK2_1	460	465	PF00069	0.519
MOD_NEK2_1	56	61	PF00069	0.660
MOD_NEK2_2	288	293	PF00069	0.532
MOD_PIKK_1	362	368	PF00454	0.452
MOD_PIKK_1	422	428	PF00454	0.440
MOD_PKA_1	348	354	PF00069	0.522
MOD_PKA_1	390	396	PF00069	0.503
MOD_PKA_2	119	125	PF00069	0.566
MOD_PKA_2	12	18	PF00069	0.729
MOD_PKA_2	146	152	PF00069	0.422
MOD_PKA_2	178	184	PF00069	0.586
MOD_PKA_2	239	245	PF00069	0.458
MOD_PKA_2	347	353	PF00069	0.524
MOD_PKA_2	390	396	PF00069	0.503
MOD_PKA_2	426	432	PF00069	0.476
MOD_PKA_2	56	62	PF00069	0.539
MOD_Plk_1	132	138	PF00069	0.508
MOD_Plk_1	294	300	PF00069	0.514
MOD_Plk_1	513	519	PF00069	0.765
MOD_Plk_2-3	490	496	PF00069	0.667
MOD_Plk_4	114	120	PF00069	0.517
MOD_Plk_4	138	144	PF00069	0.459
MOD_Plk_4	164	170	PF00069	0.438
MOD_Plk_4	204	210	PF00069	0.471
MOD_Plk_4	255	261	PF00069	0.567
MOD_Plk_4	348	354	PF00069	0.390
MOD_Plk_4	374	380	PF00069	0.484
MOD_Plk_4	460	466	PF00069	0.526
MOD_Plk_4	56	62	PF00069	0.582
MOD_ProDKin_1	22	28	PF00069	0.589
MOD_ProDKin_1	311	317	PF00069	0.616
MOD_ProDKin_1	483	489	PF00069	0.598
MOD_SUMO_for_1	292	295	PF00179	0.534
TRG_DiLeu_BaEn_1	394	399	PF01217	0.542
TRG_DiLeu_BaEn_1	77	82	PF01217	0.717
TRG_DiLeu_BaLyEn_6	182	187	PF01217	0.463
TRG_ENDOCYTIC_2	188	191	PF00928	0.393
TRG_ENDOCYTIC_2	202	205	PF00928	0.486
TRG_ENDOCYTIC_2	299	302	PF00928	0.558
TRG_ENDOCYTIC_2	382	385	PF00928	0.489
TRG_ER_diArg_1	12	14	PF00400	0.740
TRG_ER_diArg_1	127	129	PF00400	0.589
TRG_ER_diArg_1	453	456	PF00400	0.438
TRG_NES_CRM1_1	37	51	PF08389	0.615

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ13	Leptomonas seymouri	54%	100%
A0A3R7L246	Trypanosoma rangeli	24%	100%
A4HG50	Leishmania braziliensis	71%	100%
A4I380	Leishmania infantum	99%	100%
E9AZG8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q8R3	Leishmania major	87%	100%
V5BGK7	Trypanosoma cruzi	23%	100%