Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X122_LEIDO

TriTrypDb:

LdBPK_272400.1 , LdCL_270032400 , LDHU3_27.3630

Length:

447

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X122

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X122

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	194	198	PF00656	0.603
CLV_NRD_NRD_1	11	13	PF00675	0.547
CLV_NRD_NRD_1	115	117	PF00675	0.630
CLV_NRD_NRD_1	131	133	PF00675	0.367
CLV_NRD_NRD_1	192	194	PF00675	0.782
CLV_NRD_NRD_1	260	262	PF00675	0.555
CLV_NRD_NRD_1	318	320	PF00675	0.520
CLV_NRD_NRD_1	323	325	PF00675	0.519
CLV_NRD_NRD_1	378	380	PF00675	0.564
CLV_PCSK_KEX2_1	11	13	PF00082	0.547
CLV_PCSK_KEX2_1	115	117	PF00082	0.622
CLV_PCSK_KEX2_1	192	194	PF00082	0.636
CLV_PCSK_KEX2_1	260	262	PF00082	0.509
CLV_PCSK_KEX2_1	318	320	PF00082	0.501
CLV_PCSK_KEX2_1	323	325	PF00082	0.487
CLV_PCSK_KEX2_1	378	380	PF00082	0.570
CLV_PCSK_PC7_1	314	320	PF00082	0.446
CLV_PCSK_SKI1_1	292	296	PF00082	0.494
CLV_PCSK_SKI1_1	72	76	PF00082	0.388
DEG_APCC_DBOX_1	343	351	PF00400	0.527
DEG_Nend_UBRbox_3	1	3	PF02207	0.641
DEG_SPOP_SBC_1	243	247	PF00917	0.599
DOC_MAPK_gen_1	11	17	PF00069	0.538
DOC_MAPK_gen_1	367	376	PF00069	0.634
DOC_MAPK_HePTP_8	364	376	PF00069	0.441
DOC_MAPK_MEF2A_6	202	209	PF00069	0.641
DOC_MAPK_MEF2A_6	367	376	PF00069	0.646
DOC_PP4_FxxP_1	228	231	PF00568	0.551
DOC_USP7_MATH_1	183	187	PF00917	0.648
DOC_USP7_MATH_1	242	246	PF00917	0.764
DOC_USP7_MATH_1	249	253	PF00917	0.713
DOC_USP7_MATH_1	356	360	PF00917	0.583
DOC_USP7_MATH_1	398	402	PF00917	0.691
DOC_USP7_MATH_1	420	424	PF00917	0.674
DOC_USP7_UBL2_3	113	117	PF12436	0.463
DOC_WW_Pin1_4	227	232	PF00397	0.740
DOC_WW_Pin1_4	352	357	PF00397	0.610
DOC_WW_Pin1_4	393	398	PF00397	0.744
LIG_14-3-3_CanoR_1	115	123	PF00244	0.455
LIG_14-3-3_CanoR_1	260	270	PF00244	0.623
LIG_14-3-3_CanoR_1	318	325	PF00244	0.551
LIG_14-3-3_CanoR_1	341	351	PF00244	0.537
LIG_14-3-3_CanoR_1	367	376	PF00244	0.539
LIG_14-3-3_CanoR_1	410	415	PF00244	0.596
LIG_14-3-3_CanoR_1	85	91	PF00244	0.492
LIG_BRCT_BRCA1_1	275	279	PF00533	0.643
LIG_deltaCOP1_diTrp_1	439	443	PF00928	0.616
LIG_FHA_1	85	91	PF00498	0.440
LIG_FHA_2	368	374	PF00498	0.545
LIG_FHA_2	434	440	PF00498	0.573
LIG_LIR_Apic_2	227	231	PF02991	0.552
LIG_LIR_Gen_1	276	285	PF02991	0.610
LIG_LIR_Gen_1	355	365	PF02991	0.531
LIG_LIR_Gen_1	415	426	PF02991	0.598
LIG_LIR_Gen_1	438	447	PF02991	0.567
LIG_LIR_Nem_3	239	243	PF02991	0.555
LIG_LIR_Nem_3	276	282	PF02991	0.631
LIG_LIR_Nem_3	415	421	PF02991	0.596
LIG_NRBOX	346	352	PF00104	0.577
LIG_PCNA_PIPBox_1	340	349	PF02747	0.459
LIG_PCNA_yPIPBox_3	29	38	PF02747	0.502
LIG_SH2_PTP2	281	284	PF00017	0.468
LIG_SH2_PTP2	418	421	PF00017	0.598
LIG_SH2_SRC	281	284	PF00017	0.468
LIG_SH2_SRC	91	94	PF00017	0.421
LIG_SH2_STAP1	137	141	PF00017	0.443
LIG_SH2_STAP1	38	42	PF00017	0.435
LIG_SH2_STAP1	414	418	PF00017	0.524
LIG_SH2_STAT3	160	163	PF00017	0.701
LIG_SH2_STAT5	143	146	PF00017	0.386
LIG_SH2_STAT5	281	284	PF00017	0.468
LIG_SH2_STAT5	418	421	PF00017	0.666
LIG_SH3_3	416	422	PF00018	0.552
LIG_SUMO_SIM_anti_2	172	179	PF11976	0.482
LIG_SUMO_SIM_anti_2	54	59	PF11976	0.529
LIG_SUMO_SIM_par_1	203	214	PF11976	0.559
LIG_TRAF2_1	170	173	PF00917	0.634
LIG_TRAF2_1	284	287	PF00917	0.583
LIG_TYR_ITIM	416	421	PF00017	0.555
LIG_UBA3_1	66	75	PF00899	0.432
MOD_CK1_1	159	165	PF00069	0.523
MOD_CK1_1	227	233	PF00069	0.732
MOD_CK1_1	245	251	PF00069	0.586
MOD_CK1_1	252	258	PF00069	0.625
MOD_CK1_1	329	335	PF00069	0.488
MOD_CK1_1	386	392	PF00069	0.553
MOD_CK1_1	412	418	PF00069	0.566
MOD_CK1_1	424	430	PF00069	0.539
MOD_CK1_1	73	79	PF00069	0.473
MOD_CK2_1	213	219	PF00069	0.618
MOD_CK2_1	356	362	PF00069	0.570
MOD_CK2_1	367	373	PF00069	0.489
MOD_CK2_1	433	439	PF00069	0.621
MOD_GlcNHglycan	185	188	PF01048	0.580
MOD_GlcNHglycan	211	216	PF01048	0.620
MOD_GlcNHglycan	253	257	PF01048	0.678
MOD_GlcNHglycan	309	312	PF01048	0.479
MOD_GlcNHglycan	40	43	PF01048	0.576
MOD_GlcNHglycan	402	405	PF01048	0.583
MOD_GlcNHglycan	423	426	PF01048	0.595
MOD_GlcNHglycan	431	434	PF01048	0.552
MOD_GSK3_1	183	190	PF00069	0.692
MOD_GSK3_1	220	227	PF00069	0.661
MOD_GSK3_1	244	251	PF00069	0.699
MOD_GSK3_1	296	303	PF00069	0.577
MOD_GSK3_1	352	359	PF00069	0.529
MOD_GSK3_1	363	370	PF00069	0.503
MOD_GSK3_1	383	390	PF00069	0.369
MOD_GSK3_1	400	407	PF00069	0.634
MOD_GSK3_1	410	417	PF00069	0.537
MOD_GSK3_1	420	427	PF00069	0.447
MOD_GSK3_1	429	436	PF00069	0.565
MOD_N-GLC_1	249	254	PF02516	0.553
MOD_N-GLC_1	30	35	PF02516	0.508
MOD_NEK2_1	270	275	PF00069	0.677
MOD_NEK2_1	30	35	PF00069	0.559
MOD_NEK2_1	350	355	PF00069	0.566
MOD_NEK2_1	70	75	PF00069	0.422
MOD_PIKK_1	149	155	PF00454	0.473
MOD_PIKK_1	159	165	PF00454	0.469
MOD_PIKK_1	24	30	PF00454	0.466
MOD_PIKK_1	270	276	PF00454	0.574
MOD_PIKK_1	317	323	PF00454	0.474
MOD_PIKK_1	350	356	PF00454	0.494
MOD_PIKK_1	398	404	PF00454	0.597
MOD_PIKK_1	65	71	PF00454	0.440
MOD_PIKK_1	93	99	PF00454	0.513
MOD_PKA_1	115	121	PF00069	0.446
MOD_PKA_2	115	121	PF00069	0.545
MOD_PKA_2	191	197	PF00069	0.743
MOD_PKA_2	317	323	PF00069	0.579
MOD_PKA_2	409	415	PF00069	0.497
MOD_PKA_2	84	90	PF00069	0.517
MOD_Plk_1	149	155	PF00069	0.596
MOD_Plk_1	18	24	PF00069	0.564
MOD_Plk_1	30	36	PF00069	0.522
MOD_Plk_4	18	24	PF00069	0.564
MOD_Plk_4	224	230	PF00069	0.690
MOD_Plk_4	300	306	PF00069	0.586
MOD_Plk_4	414	420	PF00069	0.755
MOD_Plk_4	51	57	PF00069	0.558
MOD_Plk_4	62	68	PF00069	0.371
MOD_Plk_4	86	92	PF00069	0.474
MOD_ProDKin_1	227	233	PF00069	0.737
MOD_ProDKin_1	352	358	PF00069	0.613
MOD_ProDKin_1	393	399	PF00069	0.745
TRG_DiLeu_BaEn_1	286	291	PF01217	0.582
TRG_DiLeu_BaEn_1	52	57	PF01217	0.541
TRG_DiLeu_BaEn_4	286	292	PF01217	0.586
TRG_ENDOCYTIC_2	109	112	PF00928	0.441
TRG_ENDOCYTIC_2	418	421	PF00928	0.598
TRG_ER_diArg_1	11	14	PF00400	0.539
TRG_ER_diArg_1	192	195	PF00400	0.734
TRG_ER_diArg_1	260	262	PF00400	0.626
TRG_ER_diArg_1	322	324	PF00400	0.558
TRG_ER_diArg_1	378	380	PF00400	0.502
TRG_NES_CRM1_1	362	375	PF08389	0.470
TRG_Pf-PMV_PEXEL_1	124	129	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	146	150	PF00026	0.453

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IB83	Leptomonas seymouri	48%	100%
A0A1X0NF90	Trypanosomatidae	28%	100%
A0A3R7KL96	Trypanosoma rangeli	27%	100%
A4HG25	Leishmania braziliensis	73%	99%
A4I346	Leishmania infantum	100%	100%
C9ZJL9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9ACW5	Leishmania major	92%	100%
E9AZF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BB13	Trypanosoma cruzi	28%	100%