CPL domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X117_LEIDO

TriTrypDb:

LdBPK_272310.1 , LdCL_270031500 , LDHU3_27.3540

Length:

384

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X117

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X117

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	299	305	PF00089	0.370
CLV_NRD_NRD_1	305	307	PF00675	0.485
CLV_PCSK_KEX2_1	329	331	PF00082	0.623
CLV_PCSK_KEX2_1	337	339	PF00082	0.577
CLV_PCSK_KEX2_1	380	382	PF00082	0.638
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.570
CLV_PCSK_PC1ET2_1	337	339	PF00082	0.503
CLV_PCSK_PC1ET2_1	380	382	PF00082	0.638
CLV_PCSK_SKI1_1	107	111	PF00082	0.545
CLV_PCSK_SKI1_1	139	143	PF00082	0.463
CLV_PCSK_SKI1_1	158	162	PF00082	0.272
CLV_PCSK_SKI1_1	198	202	PF00082	0.454
CLV_PCSK_SKI1_1	33	37	PF00082	0.449
DOC_CYCLIN_RxL_1	195	202	PF00134	0.446
DOC_PP1_RVXF_1	196	202	PF00149	0.439
DOC_PP1_RVXF_1	341	347	PF00149	0.560
DOC_PP4_FxxP_1	151	154	PF00568	0.472
DOC_PP4_FxxP_1	201	204	PF00568	0.515
DOC_USP7_MATH_1	318	322	PF00917	0.515
DOC_USP7_MATH_1	349	353	PF00917	0.633
DOC_USP7_MATH_1	53	57	PF00917	0.530
DOC_USP7_UBL2_3	107	111	PF12436	0.559
DOC_USP7_UBL2_3	139	143	PF12436	0.547
DOC_USP7_UBL2_3	178	182	PF12436	0.377
DOC_USP7_UBL2_3	222	226	PF12436	0.565
LIG_14-3-3_CanoR_1	330	339	PF00244	0.577
LIG_14-3-3_CanoR_1	77	87	PF00244	0.539
LIG_CaM_NSCaTE_8	14	21	PF13499	0.518
LIG_deltaCOP1_diTrp_1	95	101	PF00928	0.519
LIG_EH1_1	269	277	PF00400	0.525
LIG_FHA_1	108	114	PF00498	0.531
LIG_FHA_1	13	19	PF00498	0.498
LIG_FHA_1	166	172	PF00498	0.523
LIG_FHA_1	21	27	PF00498	0.381
LIG_FHA_1	298	304	PF00498	0.402
LIG_FHA_1	334	340	PF00498	0.549
LIG_FHA_1	34	40	PF00498	0.479
LIG_FHA_1	371	377	PF00498	0.665
LIG_FHA_1	4	10	PF00498	0.554
LIG_FHA_1	71	77	PF00498	0.377
LIG_FHA_1	79	85	PF00498	0.371
LIG_FHA_2	256	262	PF00498	0.558
LIG_LIR_Apic_2	148	154	PF02991	0.492
LIG_LIR_Gen_1	129	138	PF02991	0.500
LIG_LIR_Gen_1	194	204	PF02991	0.386
LIG_LIR_Gen_1	266	276	PF02991	0.401
LIG_LIR_Gen_1	96	105	PF02991	0.373
LIG_LIR_Nem_3	129	134	PF02991	0.504
LIG_LIR_Nem_3	194	199	PF02991	0.399
LIG_LIR_Nem_3	211	217	PF02991	0.420
LIG_LIR_Nem_3	266	271	PF02991	0.407
LIG_NRBOX	112	118	PF00104	0.482
LIG_PAM2_1	5	17	PF00658	0.532
LIG_PCNA_yPIPBox_3	283	293	PF02747	0.538
LIG_SH2_CRK	131	135	PF00017	0.417
LIG_SH2_SRC	268	271	PF00017	0.516
LIG_SH2_STAP1	268	272	PF00017	0.401
LIG_SH2_STAP1	323	327	PF00017	0.527
LIG_SH3_3	41	47	PF00018	0.557
LIG_SUMO_SIM_par_1	5	10	PF11976	0.482
LIG_TRAF2_1	192	195	PF00917	0.509
LIG_UBA3_1	134	143	PF00899	0.428
LIG_UBA3_1	313	320	PF00899	0.431
LIG_UBA3_1	361	367	PF00899	0.544
LIG_WRC_WIRS_1	98	103	PF05994	0.515
MOD_CK1_1	145	151	PF00069	0.508
MOD_CK1_1	28	34	PF00069	0.413
MOD_CK1_1	3	9	PF00069	0.580
MOD_CK1_1	352	358	PF00069	0.655
MOD_CK1_1	370	376	PF00069	0.616
MOD_CK1_1	40	46	PF00069	0.474
MOD_CK1_1	70	76	PF00069	0.393
MOD_CK1_1	89	95	PF00069	0.392
MOD_CK2_1	169	175	PF00069	0.517
MOD_CK2_1	255	261	PF00069	0.538
MOD_GlcNHglycan	2	5	PF01048	0.664
MOD_GlcNHglycan	27	30	PF01048	0.414
MOD_GlcNHglycan	91	94	PF01048	0.345
MOD_GSK3_1	107	114	PF00069	0.526
MOD_GSK3_1	142	149	PF00069	0.427
MOD_GSK3_1	165	172	PF00069	0.345
MOD_GSK3_1	319	326	PF00069	0.518
MOD_GSK3_1	33	40	PF00069	0.461
MOD_GSK3_1	349	356	PF00069	0.635
MOD_GSK3_1	367	374	PF00069	0.531
MOD_N-GLC_1	33	38	PF02516	0.509
MOD_N-GLC_1	347	352	PF02516	0.533
MOD_NEK2_1	146	151	PF00069	0.385
MOD_NEK2_1	180	185	PF00069	0.460
MOD_NEK2_1	217	222	PF00069	0.455
MOD_NEK2_1	331	336	PF00069	0.569
MOD_NEK2_1	368	373	PF00069	0.624
MOD_PIKK_1	331	337	PF00454	0.574
MOD_PIKK_1	347	353	PF00454	0.483
MOD_PIKK_1	354	360	PF00454	0.609
MOD_PKA_1	142	148	PF00069	0.506
MOD_PKA_2	264	270	PF00069	0.447
MOD_Plk_1	33	39	PF00069	0.487
MOD_Plk_4	142	148	PF00069	0.405
MOD_Plk_4	67	73	PF00069	0.405
MOD_SUMO_for_1	105	108	PF00179	0.539
MOD_SUMO_rev_2	220	227	PF00179	0.522
TRG_DiLeu_BaEn_3	194	200	PF01217	0.437
TRG_DiLeu_BaLyEn_6	271	276	PF01217	0.489
TRG_ENDOCYTIC_2	131	134	PF00928	0.419
TRG_ENDOCYTIC_2	268	271	PF00928	0.385
TRG_Pf-PMV_PEXEL_1	198	202	PF00026	0.456

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1A8	Leptomonas seymouri	67%	100%
A0A0S4J8X0	Bodo saltans	29%	100%
A0A1X0NG17	Trypanosomatidae	35%	99%
A0A422NDW9	Trypanosoma rangeli	35%	99%
A4HG16	Leishmania braziliensis	83%	100%
A4I338	Leishmania infantum	99%	100%
C9ZJL0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	98%
E9ACV6	Leishmania major	91%	100%
E9AZE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BB08	Trypanosoma cruzi	35%	99%