Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X110_LEIDO

TriTrypDb:

LdBPK_272380.1 , LdCL_270032200 , LDHU3_27.3610

Length:

570

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X110

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X110

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.609
CLV_NRD_NRD_1	147	149	PF00675	0.636
CLV_NRD_NRD_1	186	188	PF00675	0.705
CLV_NRD_NRD_1	206	208	PF00675	0.395
CLV_NRD_NRD_1	404	406	PF00675	0.807
CLV_NRD_NRD_1	555	557	PF00675	0.866
CLV_NRD_NRD_1	60	62	PF00675	0.691
CLV_PCSK_KEX2_1	146	148	PF00082	0.633
CLV_PCSK_KEX2_1	186	188	PF00082	0.705
CLV_PCSK_KEX2_1	206	208	PF00082	0.395
CLV_PCSK_KEX2_1	336	338	PF00082	0.819
CLV_PCSK_KEX2_1	380	382	PF00082	0.762
CLV_PCSK_KEX2_1	555	557	PF00082	0.866
CLV_PCSK_KEX2_1	60	62	PF00082	0.691
CLV_PCSK_PC1ET2_1	336	338	PF00082	0.819
CLV_PCSK_PC1ET2_1	380	382	PF00082	0.762
CLV_PCSK_SKI1_1	129	133	PF00082	0.622
CLV_PCSK_SKI1_1	248	252	PF00082	0.593
CLV_PCSK_SKI1_1	356	360	PF00082	0.794
CLV_PCSK_SKI1_1	95	99	PF00082	0.708
DEG_SIAH_1	319	327	PF03145	0.758
DEG_SPOP_SBC_1	109	113	PF00917	0.670
DEG_SPOP_SBC_1	130	134	PF00917	0.614
DEG_SPOP_SBC_1	416	420	PF00917	0.699
DEG_SPOP_SBC_1	560	564	PF00917	0.858
DOC_CKS1_1	463	468	PF01111	0.766
DOC_CYCLIN_yClb3_PxF_3	507	513	PF00134	0.719
DOC_PP2B_LxvP_1	250	253	PF13499	0.767
DOC_PP2B_LxvP_1	506	509	PF13499	0.729
DOC_USP7_MATH_1	109	113	PF00917	0.782
DOC_USP7_MATH_1	257	261	PF00917	0.799
DOC_USP7_MATH_1	281	285	PF00917	0.801
DOC_USP7_MATH_1	291	295	PF00917	0.716
DOC_USP7_MATH_1	313	317	PF00917	0.751
DOC_USP7_MATH_1	318	322	PF00917	0.748
DOC_USP7_MATH_1	327	331	PF00917	0.614
DOC_USP7_MATH_1	386	390	PF00917	0.806
DOC_USP7_MATH_1	426	430	PF00917	0.866
DOC_USP7_MATH_1	497	501	PF00917	0.851
DOC_USP7_MATH_1	72	76	PF00917	0.637
DOC_WW_Pin1_4	123	128	PF00397	0.750
DOC_WW_Pin1_4	178	183	PF00397	0.723
DOC_WW_Pin1_4	219	224	PF00397	0.801
DOC_WW_Pin1_4	316	321	PF00397	0.823
DOC_WW_Pin1_4	322	327	PF00397	0.739
DOC_WW_Pin1_4	328	333	PF00397	0.626
DOC_WW_Pin1_4	382	387	PF00397	0.795
DOC_WW_Pin1_4	408	413	PF00397	0.850
DOC_WW_Pin1_4	418	423	PF00397	0.679
DOC_WW_Pin1_4	439	444	PF00397	0.841
DOC_WW_Pin1_4	448	453	PF00397	0.716
DOC_WW_Pin1_4	456	461	PF00397	0.589
DOC_WW_Pin1_4	462	467	PF00397	0.629
DOC_WW_Pin1_4	484	489	PF00397	0.721
DOC_WW_Pin1_4	539	544	PF00397	0.753
LIG_14-3-3_CanoR_1	129	136	PF00244	0.778
LIG_14-3-3_CanoR_1	25	29	PF00244	0.632
LIG_14-3-3_CanoR_1	280	286	PF00244	0.739
LIG_14-3-3_CanoR_1	344	350	PF00244	0.834
LIG_14-3-3_CanoR_1	367	372	PF00244	0.714
LIG_14-3-3_CanoR_1	54	62	PF00244	0.686
LIG_14-3-3_CanoR_1	68	76	PF00244	0.527
LIG_BIR_II_1	1	5	PF00653	0.609
LIG_EVH1_1	506	510	PF00568	0.728
LIG_EVH1_2	509	513	PF00568	0.801
LIG_FHA_1	130	136	PF00498	0.605
LIG_FHA_1	193	199	PF00498	0.400
LIG_FHA_1	238	244	PF00498	0.561
LIG_FHA_1	267	273	PF00498	0.776
LIG_FHA_1	47	53	PF00498	0.672
LIG_FHA_1	96	102	PF00498	0.693
LIG_FHA_2	137	143	PF00498	0.672
LIG_FHA_2	32	38	PF00498	0.679
LIG_FHA_2	385	391	PF00498	0.769
LIG_FHA_2	561	567	PF00498	0.849
LIG_LIR_Gen_1	151	160	PF02991	0.637
LIG_LIR_Gen_1	19	28	PF02991	0.680
LIG_LIR_Nem_3	19	24	PF02991	0.666
LIG_PROFILIN_1	466	472	PF00235	0.759
LIG_PROFILIN_1	490	496	PF00235	0.717
LIG_SH2_CRK	481	485	PF00017	0.763
LIG_SH2_NCK_1	481	485	PF00017	0.763
LIG_SH2_SRC	481	484	PF00017	0.667
LIG_SH2_SRC	8	11	PF00017	0.588
LIG_SH2_STAP1	199	203	PF00017	0.673
LIG_SH2_STAT5	152	155	PF00017	0.702
LIG_SH2_STAT5	8	11	PF00017	0.588
LIG_SH3_1	449	455	PF00018	0.682
LIG_SH3_2	551	556	PF14604	0.854
LIG_SH3_3	162	168	PF00018	0.759
LIG_SH3_3	246	252	PF00018	0.745
LIG_SH3_3	258	264	PF00018	0.568
LIG_SH3_3	269	275	PF00018	0.665
LIG_SH3_3	282	288	PF00018	0.618
LIG_SH3_3	407	413	PF00018	0.764
LIG_SH3_3	449	455	PF00018	0.746
LIG_SH3_3	457	463	PF00018	0.673
LIG_SH3_3	464	470	PF00018	0.684
LIG_SH3_3	482	488	PF00018	0.568
LIG_SH3_3	489	495	PF00018	0.697
LIG_SH3_3	502	508	PF00018	0.579
LIG_SH3_3	532	538	PF00018	0.678
LIG_SH3_3	548	554	PF00018	0.668
LIG_TRAF2_1	112	115	PF00917	0.727
LIG_WW_3	421	425	PF00397	0.817
LIG_WW_3	552	556	PF00397	0.734
MOD_CDC14_SPxK_1	126	129	PF00782	0.696
MOD_CDC14_SPxK_1	421	424	PF00782	0.773
MOD_CDK_SPxK_1	123	129	PF00069	0.694
MOD_CDK_SPxK_1	418	424	PF00069	0.821
MOD_CDK_SPxxK_3	322	329	PF00069	0.765
MOD_CDK_SPxxK_3	539	546	PF00069	0.646
MOD_CK1_1	121	127	PF00069	0.831
MOD_CK1_1	134	140	PF00069	0.568
MOD_CK1_1	3	9	PF00069	0.633
MOD_CK1_1	307	313	PF00069	0.835
MOD_CK1_1	316	322	PF00069	0.681
MOD_CK1_1	361	367	PF00069	0.836
MOD_CK1_1	370	376	PF00069	0.678
MOD_CK1_1	385	391	PF00069	0.606
MOD_CK1_1	394	400	PF00069	0.705
MOD_CK1_1	427	433	PF00069	0.754
MOD_CK1_1	437	443	PF00069	0.693
MOD_CK1_1	454	460	PF00069	0.565
MOD_CK1_1	55	61	PF00069	0.687
MOD_CK1_1	562	568	PF00069	0.847
MOD_CK2_1	108	114	PF00069	0.782
MOD_CK2_1	136	142	PF00069	0.684
MOD_CK2_1	156	162	PF00069	0.640
MOD_CK2_1	31	37	PF00069	0.554
MOD_GlcNHglycan	243	246	PF01048	0.780
MOD_GlcNHglycan	253	256	PF01048	0.662
MOD_GlcNHglycan	293	296	PF01048	0.655
MOD_GlcNHglycan	311	314	PF01048	0.720
MOD_GlcNHglycan	315	318	PF01048	0.760
MOD_GlcNHglycan	320	323	PF01048	0.683
MOD_GlcNHglycan	347	350	PF01048	0.841
MOD_GlcNHglycan	372	375	PF01048	0.828
MOD_GlcNHglycan	426	429	PF01048	0.832
MOD_GlcNHglycan	436	439	PF01048	0.727
MOD_GlcNHglycan	474	477	PF01048	0.784
MOD_GlcNHglycan	499	502	PF01048	0.776
MOD_GlcNHglycan	518	521	PF01048	0.528
MOD_GlcNHglycan	539	542	PF01048	0.759
MOD_GlcNHglycan	54	57	PF01048	0.468
MOD_GSK3_1	117	124	PF00069	0.772
MOD_GSK3_1	130	137	PF00069	0.600
MOD_GSK3_1	237	244	PF00069	0.751
MOD_GSK3_1	287	294	PF00069	0.654
MOD_GSK3_1	304	311	PF00069	0.738
MOD_GSK3_1	312	319	PF00069	0.694
MOD_GSK3_1	328	335	PF00069	0.579
MOD_GSK3_1	358	365	PF00069	0.840
MOD_GSK3_1	382	389	PF00069	0.761
MOD_GSK3_1	390	397	PF00069	0.726
MOD_GSK3_1	426	433	PF00069	0.817
MOD_GSK3_1	447	454	PF00069	0.665
MOD_GSK3_1	533	540	PF00069	0.781
MOD_GSK3_1	63	70	PF00069	0.546
MOD_NEK2_1	131	136	PF00069	0.738
MOD_NEK2_1	191	196	PF00069	0.527
MOD_NEK2_1	24	29	PF00069	0.593
MOD_NEK2_1	243	248	PF00069	0.600
MOD_NEK2_1	305	310	PF00069	0.840
MOD_NEK2_1	358	363	PF00069	0.842
MOD_NEK2_1	415	420	PF00069	0.814
MOD_NEK2_1	514	519	PF00069	0.836
MOD_PIKK_1	430	436	PF00454	0.736
MOD_PIKK_1	63	69	PF00454	0.672
MOD_PIKK_1	84	90	PF00454	0.654
MOD_PK_1	367	373	PF00069	0.713
MOD_PKA_2	24	30	PF00069	0.625
MOD_PKA_2	67	73	PF00069	0.663
MOD_Plk_1	3	9	PF00069	0.628
MOD_Plk_4	281	287	PF00069	0.734
MOD_Plk_4	3	9	PF00069	0.589
MOD_Plk_4	442	448	PF00069	0.634
MOD_ProDKin_1	123	129	PF00069	0.753
MOD_ProDKin_1	178	184	PF00069	0.726
MOD_ProDKin_1	219	225	PF00069	0.801
MOD_ProDKin_1	316	322	PF00069	0.826
MOD_ProDKin_1	328	334	PF00069	0.627
MOD_ProDKin_1	382	388	PF00069	0.798
MOD_ProDKin_1	408	414	PF00069	0.846
MOD_ProDKin_1	418	424	PF00069	0.682
MOD_ProDKin_1	439	445	PF00069	0.841
MOD_ProDKin_1	448	454	PF00069	0.718
MOD_ProDKin_1	456	462	PF00069	0.587
MOD_ProDKin_1	484	490	PF00069	0.717
MOD_ProDKin_1	539	545	PF00069	0.755
MOD_SUMO_for_1	297	300	PF00179	0.767
TRG_DiLeu_BaEn_4	12	18	PF01217	0.696
TRG_ENDOCYTIC_2	152	155	PF00928	0.624
TRG_ER_diArg_1	145	148	PF00400	0.624
TRG_ER_diArg_1	186	188	PF00400	0.705
TRG_ER_diArg_1	554	556	PF00400	0.862
TRG_ER_diArg_1	60	62	PF00400	0.691

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HG23	Leishmania braziliensis	69%	100%
A4I344	Leishmania infantum	99%	100%
E9ACW3	Leishmania major	91%	100%
E9AZF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%