Tat binding protein 1(TBP-1)-interacting protein (TBPIP), putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X109_LEIDO

TriTrypDb:

LdBPK_272370.1 , LdCL_270032100 , LDHU3_27.3600

Length:

280

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	12
GO:0000228	nuclear chromosome	6	1
GO:0000793	condensed chromosome	6	1
GO:0000794	condensed nuclear chromosome	7	1
GO:0005694	chromosome	5	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	3
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0120231	DNA recombinase auxiliary factor complex	3	1
GO:0150005	enzyme activator complex	2	1
GO:0000502	proteasome complex	3	2
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1905368	peptidase complex	3	2
GO:1905369	endopeptidase complex	4	2

Expansion

Sequence features

A0A3S7X109

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X109

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006310	DNA recombination	5	11
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0007131	reciprocal meiotic recombination	3	11
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0022402	cell cycle process	2	12
GO:0022414	reproductive process	1	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0035825	homologous recombination	6	11
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:0140527	reciprocal homologous recombination	7	11
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1903046	meiotic cell cycle process	2	12
GO:0000708	meiotic strand invasion	4	1
GO:0000709	meiotic joint molecule formation	3	1
GO:0006996	organelle organization	4	1
GO:0007129	homologous chromosome pairing at meiosis	4	1
GO:0010774	meiotic strand invasion involved in reciprocal meiotic recombination	5	1
GO:0016043	cellular component organization	3	1
GO:0042148	strand invasion	5	1
GO:0051276	chromosome organization	5	1
GO:0061982	meiosis I cell cycle process	3	1
GO:0070192	chromosome organization involved in meiotic cell cycle	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003690	double-stranded DNA binding	5	1
GO:0005488	binding	1	1
GO:0008047	enzyme activator activity	3	1
GO:0030234	enzyme regulator activity	2	1
GO:0097159	organic cyclic compound binding	2	1
GO:0098772	molecular function regulator activity	1	1
GO:0120230	recombinase activator activity	4	1
GO:0140677	molecular function activator activity	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.627
CLV_C14_Caspase3-7	234	238	PF00656	0.557
CLV_C14_Caspase3-7	36	40	PF00656	0.289
CLV_NRD_NRD_1	150	152	PF00675	0.559
CLV_NRD_NRD_1	207	209	PF00675	0.444
CLV_NRD_NRD_1	214	216	PF00675	0.404
CLV_NRD_NRD_1	217	219	PF00675	0.382
CLV_NRD_NRD_1	222	224	PF00675	0.400
CLV_PCSK_FUR_1	148	152	PF00082	0.414
CLV_PCSK_FUR_1	205	209	PF00082	0.462
CLV_PCSK_FUR_1	212	216	PF00082	0.434
CLV_PCSK_KEX2_1	150	152	PF00082	0.507
CLV_PCSK_KEX2_1	207	209	PF00082	0.444
CLV_PCSK_KEX2_1	214	216	PF00082	0.404
CLV_PCSK_KEX2_1	217	219	PF00082	0.386
CLV_PCSK_SKI1_1	150	154	PF00082	0.579
CLV_PCSK_SKI1_1	164	168	PF00082	0.464
CLV_PCSK_SKI1_1	30	34	PF00082	0.414
CLV_PCSK_SKI1_1	44	48	PF00082	0.367
CLV_PCSK_SKI1_1	66	70	PF00082	0.274
DEG_APCC_DBOX_1	178	186	PF00400	0.546
DEG_Nend_UBRbox_1	1	4	PF02207	0.533
DOC_CKS1_1	31	36	PF01111	0.417
DOC_CYCLIN_RxL_1	270	278	PF00134	0.426
DOC_CYCLIN_RxL_1	72	83	PF00134	0.486
DOC_MAPK_gen_1	223	230	PF00069	0.460
DOC_MAPK_gen_1	69	78	PF00069	0.405
DOC_PP2B_LxvP_1	267	270	PF13499	0.535
DOC_USP7_MATH_1	190	194	PF00917	0.680
DOC_USP7_MATH_1	256	260	PF00917	0.460
DOC_USP7_MATH_1	40	44	PF00917	0.274
DOC_USP7_UBL2_3	5	9	PF12436	0.495
DOC_USP7_UBL2_3	62	66	PF12436	0.283
DOC_WW_Pin1_4	123	128	PF00397	0.517
DOC_WW_Pin1_4	237	242	PF00397	0.484
DOC_WW_Pin1_4	30	35	PF00397	0.417
LIG_14-3-3_CanoR_1	179	183	PF00244	0.476
LIG_BIR_III_4	109	113	PF00653	0.514
LIG_BIR_III_4	39	43	PF00653	0.274
LIG_BIR_III_4	83	87	PF00653	0.566
LIG_CaM_IQ_9	140	156	PF13499	0.472
LIG_FHA_1	16	22	PF00498	0.333
LIG_FHA_1	201	207	PF00498	0.476
LIG_FHA_2	101	107	PF00498	0.616
LIG_FHA_2	120	126	PF00498	0.400
LIG_FHA_2	232	238	PF00498	0.550
LIG_FHA_2	250	256	PF00498	0.269
LIG_FHA_2	86	92	PF00498	0.527
LIG_Integrin_RGD_1	107	109	PF01839	0.554
LIG_SH2_STAP1	168	172	PF00017	0.412
LIG_SH2_STAT5	75	78	PF00017	0.388
LIG_SH3_3	108	114	PF00018	0.574
LIG_SH3_3	262	268	PF00018	0.565
LIG_SH3_3	28	34	PF00018	0.417
LIG_SH3_3	42	48	PF00018	0.302
LIG_SH3_4	47	54	PF00018	0.400
LIG_SUMO_SIM_par_1	18	23	PF11976	0.269
LIG_UBA3_1	53	62	PF00899	0.350
MOD_CK1_1	146	152	PF00069	0.451
MOD_CK1_1	15	21	PF00069	0.448
MOD_CK1_1	198	204	PF00069	0.614
MOD_CK2_1	100	106	PF00069	0.642
MOD_CK2_1	119	125	PF00069	0.438
MOD_CK2_1	157	163	PF00069	0.605
MOD_CK2_1	249	255	PF00069	0.446
MOD_CK2_1	85	91	PF00069	0.641
MOD_CMANNOS	155	158	PF00535	0.575
MOD_GlcNHglycan	140	143	PF01048	0.536
MOD_GlcNHglycan	192	195	PF01048	0.617
MOD_GlcNHglycan	197	200	PF01048	0.454
MOD_GSK3_1	119	126	PF00069	0.671
MOD_GSK3_1	12	19	PF00069	0.369
MOD_GSK3_1	146	153	PF00069	0.446
MOD_GSK3_1	256	263	PF00069	0.415
MOD_GSK3_1	87	94	PF00069	0.726
MOD_NEK2_1	231	236	PF00069	0.490
MOD_NEK2_1	260	265	PF00069	0.408
MOD_NEK2_1	275	280	PF00069	0.460
MOD_OFUCOSY	117	123	PF10250	0.553
MOD_PKA_1	150	156	PF00069	0.537
MOD_PKA_2	150	156	PF00069	0.530
MOD_PKA_2	178	184	PF00069	0.455
MOD_PKB_1	148	156	PF00069	0.490
MOD_Plk_1	15	21	PF00069	0.417
MOD_Plk_1	260	266	PF00069	0.430
MOD_Plk_1	273	279	PF00069	0.383
MOD_Plk_2-3	91	97	PF00069	0.539
MOD_Plk_4	16	22	PF00069	0.274
MOD_ProDKin_1	123	129	PF00069	0.509
MOD_ProDKin_1	237	243	PF00069	0.485
MOD_ProDKin_1	30	36	PF00069	0.417
MOD_SUMO_rev_2	55	63	PF00179	0.368
TRG_DiLeu_BaEn_1	16	21	PF01217	0.422
TRG_DiLeu_BaLyEn_6	267	272	PF01217	0.359
TRG_DiLeu_BaLyEn_6	45	50	PF01217	0.302
TRG_ENDOCYTIC_2	168	171	PF00928	0.601
TRG_ENDOCYTIC_2	75	78	PF00928	0.466
TRG_ER_diArg_1	148	151	PF00400	0.591
TRG_ER_diArg_1	205	208	PF00400	0.442
TRG_ER_diArg_1	213	215	PF00400	0.407
TRG_NLS_MonoExtN_4	66	73	PF00514	0.274

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9H7	Leptomonas seymouri	50%	100%
A0A0S4J6Z3	Bodo saltans	30%	100%
A0A1X0NFH4	Trypanosomatidae	34%	100%
A0A3R7MDB5	Trypanosoma rangeli	34%	100%
A4HG22	Leishmania braziliensis	78%	100%
A4I343	Leishmania infantum	100%	100%
C9ZJL5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9ACW2	Leishmania major	93%	100%
E9AZF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5D720	Trypanosoma cruzi	31%	100%