LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7X108_LEIDO
TriTrypDb:
LdBPK_272190.1 , LdCL_270029300 , LDHU3_27.3330
Length:
657

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X108
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X108

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 168 172 PF00656 0.706
CLV_C14_Caspase3-7 401 405 PF00656 0.792
CLV_C14_Caspase3-7 541 545 PF00656 0.471
CLV_C14_Caspase3-7 580 584 PF00656 0.559
CLV_NRD_NRD_1 160 162 PF00675 0.674
CLV_NRD_NRD_1 224 226 PF00675 0.720
CLV_NRD_NRD_1 274 276 PF00675 0.642
CLV_NRD_NRD_1 3 5 PF00675 0.632
CLV_NRD_NRD_1 360 362 PF00675 0.812
CLV_NRD_NRD_1 379 381 PF00675 0.526
CLV_NRD_NRD_1 411 413 PF00675 0.812
CLV_NRD_NRD_1 418 420 PF00675 0.676
CLV_NRD_NRD_1 436 438 PF00675 0.790
CLV_PCSK_FUR_1 272 276 PF00082 0.641
CLV_PCSK_KEX2_1 160 162 PF00082 0.847
CLV_PCSK_KEX2_1 2 4 PF00082 0.637
CLV_PCSK_KEX2_1 224 226 PF00082 0.720
CLV_PCSK_KEX2_1 274 276 PF00082 0.642
CLV_PCSK_KEX2_1 379 381 PF00082 0.669
CLV_PCSK_KEX2_1 411 413 PF00082 0.812
CLV_PCSK_KEX2_1 418 420 PF00082 0.676
CLV_PCSK_KEX2_1 436 438 PF00082 0.790
CLV_PCSK_KEX2_1 577 579 PF00082 0.687
CLV_PCSK_KEX2_1 74 76 PF00082 0.773
CLV_PCSK_PC1ET2_1 2 4 PF00082 0.692
CLV_PCSK_PC1ET2_1 577 579 PF00082 0.687
CLV_PCSK_PC1ET2_1 74 76 PF00082 0.725
CLV_PCSK_SKI1_1 457 461 PF00082 0.572
DEG_APCC_DBOX_1 160 168 PF00400 0.604
DEG_Nend_UBRbox_1 1 4 PF02207 0.716
DEG_SPOP_SBC_1 386 390 PF00917 0.603
DEG_SPOP_SBC_1 469 473 PF00917 0.738
DOC_CKS1_1 80 85 PF01111 0.715
DOC_CYCLIN_RxL_1 157 168 PF00134 0.601
DOC_CYCLIN_RxL_1 187 199 PF00134 0.581
DOC_MAPK_DCC_7 160 169 PF00069 0.720
DOC_MAPK_gen_1 187 195 PF00069 0.582
DOC_MAPK_gen_1 361 369 PF00069 0.778
DOC_MAPK_gen_1 415 425 PF00069 0.695
DOC_MAPK_MEF2A_6 160 169 PF00069 0.720
DOC_MAPK_MEF2A_6 361 369 PF00069 0.778
DOC_MAPK_MEF2A_6 418 427 PF00069 0.696
DOC_PP2B_LxvP_1 162 165 PF13499 0.720
DOC_PP2B_LxvP_1 451 454 PF13499 0.609
DOC_USP7_MATH_1 132 136 PF00917 0.746
DOC_USP7_MATH_1 228 232 PF00917 0.607
DOC_USP7_MATH_1 257 261 PF00917 0.723
DOC_USP7_MATH_1 282 286 PF00917 0.779
DOC_USP7_MATH_1 310 314 PF00917 0.675
DOC_USP7_MATH_1 321 325 PF00917 0.606
DOC_USP7_MATH_1 365 369 PF00917 0.653
DOC_USP7_MATH_1 386 390 PF00917 0.773
DOC_USP7_MATH_1 482 486 PF00917 0.522
DOC_WW_Pin1_4 153 158 PF00397 0.666
DOC_WW_Pin1_4 18 23 PF00397 0.637
DOC_WW_Pin1_4 238 243 PF00397 0.764
DOC_WW_Pin1_4 313 318 PF00397 0.662
DOC_WW_Pin1_4 382 387 PF00397 0.630
DOC_WW_Pin1_4 40 45 PF00397 0.756
DOC_WW_Pin1_4 439 444 PF00397 0.751
DOC_WW_Pin1_4 446 451 PF00397 0.660
DOC_WW_Pin1_4 470 475 PF00397 0.614
DOC_WW_Pin1_4 558 563 PF00397 0.662
DOC_WW_Pin1_4 568 573 PF00397 0.667
DOC_WW_Pin1_4 606 611 PF00397 0.663
DOC_WW_Pin1_4 615 620 PF00397 0.644
DOC_WW_Pin1_4 641 646 PF00397 0.607
DOC_WW_Pin1_4 79 84 PF00397 0.673
LIG_14-3-3_CanoR_1 122 132 PF00244 0.561
LIG_14-3-3_CanoR_1 160 165 PF00244 0.651
LIG_14-3-3_CanoR_1 189 194 PF00244 0.595
LIG_14-3-3_CanoR_1 236 242 PF00244 0.697
LIG_14-3-3_CanoR_1 259 263 PF00244 0.705
LIG_14-3-3_CanoR_1 272 278 PF00244 0.647
LIG_14-3-3_CanoR_1 364 370 PF00244 0.656
LIG_14-3-3_CanoR_1 418 425 PF00244 0.654
LIG_BIR_III_2 144 148 PF00653 0.719
LIG_BIR_III_2 550 554 PF00653 0.653
LIG_Clathr_ClatBox_1 65 69 PF01394 0.712
LIG_EVH1_2 10 14 PF00568 0.549
LIG_FHA_1 296 302 PF00498 0.652
LIG_FHA_1 35 41 PF00498 0.681
LIG_FHA_1 418 424 PF00498 0.775
LIG_FHA_1 470 476 PF00498 0.728
LIG_FHA_1 535 541 PF00498 0.439
LIG_FHA_1 634 640 PF00498 0.697
LIG_FHA_2 207 213 PF00498 0.702
LIG_FHA_2 238 244 PF00498 0.659
LIG_FHA_2 493 499 PF00498 0.460
LIG_FHA_2 591 597 PF00498 0.742
LIG_FHA_2 80 86 PF00498 0.780
LIG_NRBOX 507 513 PF00104 0.452
LIG_PCNA_yPIPBox_3 102 112 PF02747 0.486
LIG_PTB_Apo_2 60 67 PF02174 0.699
LIG_SH3_3 241 247 PF00018 0.829
LIG_SH3_3 364 370 PF00018 0.647
LIG_SH3_3 38 44 PF00018 0.632
LIG_SH3_3 447 453 PF00018 0.636
LIG_SH3_3 609 615 PF00018 0.655
LIG_SH3_3 636 642 PF00018 0.628
LIG_SUMO_SIM_anti_2 192 197 PF11976 0.578
LIG_SUMO_SIM_anti_2 596 603 PF11976 0.656
LIG_SUMO_SIM_par_1 532 538 PF11976 0.404
LIG_SUMO_SIM_par_1 600 605 PF11976 0.681
LIG_TRAF2_1 552 555 PF00917 0.588
LIG_TRAF2_1 594 597 PF00917 0.711
LIG_WRC_WIRS_1 302 307 PF05994 0.721
LIG_WW_3 157 161 PF00397 0.582
MOD_CDK_SPxK_1 617 623 PF00069 0.666
MOD_CDK_SPxxK_3 153 160 PF00069 0.667
MOD_CDK_SPxxK_3 238 245 PF00069 0.670
MOD_CDK_SPxxK_3 470 477 PF00069 0.658
MOD_CK1_1 135 141 PF00069 0.748
MOD_CK1_1 194 200 PF00069 0.634
MOD_CK1_1 237 243 PF00069 0.662
MOD_CK1_1 268 274 PF00069 0.637
MOD_CK1_1 313 319 PF00069 0.700
MOD_CK1_1 34 40 PF00069 0.634
MOD_CK1_1 385 391 PF00069 0.657
MOD_CK1_1 449 455 PF00069 0.618
MOD_CK1_1 567 573 PF00069 0.692
MOD_CK1_1 88 94 PF00069 0.720
MOD_CK2_1 206 212 PF00069 0.706
MOD_CK2_1 492 498 PF00069 0.464
MOD_CK2_1 532 538 PF00069 0.572
MOD_CK2_1 590 596 PF00069 0.746
MOD_CMANNOS 46 49 PF00535 0.682
MOD_Cter_Amidation 222 225 PF01082 0.680
MOD_Cter_Amidation 272 275 PF01082 0.639
MOD_DYRK1A_RPxSP_1 238 242 PF00069 0.736
MOD_GlcNHglycan 133 137 PF01048 0.642
MOD_GlcNHglycan 196 199 PF01048 0.763
MOD_GlcNHglycan 230 233 PF01048 0.631
MOD_GlcNHglycan 267 270 PF01048 0.618
MOD_GlcNHglycan 277 280 PF01048 0.661
MOD_GlcNHglycan 325 328 PF01048 0.697
MOD_GlcNHglycan 376 379 PF01048 0.710
MOD_GlcNHglycan 390 393 PF01048 0.601
MOD_GlcNHglycan 454 457 PF01048 0.574
MOD_GlcNHglycan 51 55 PF01048 0.772
MOD_GlcNHglycan 540 543 PF01048 0.511
MOD_GlcNHglycan 625 628 PF01048 0.612
MOD_GlcNHglycan 95 98 PF01048 0.584
MOD_GSK3_1 170 177 PF00069 0.690
MOD_GSK3_1 181 188 PF00069 0.525
MOD_GSK3_1 194 201 PF00069 0.621
MOD_GSK3_1 202 209 PF00069 0.790
MOD_GSK3_1 230 237 PF00069 0.677
MOD_GSK3_1 323 330 PF00069 0.687
MOD_GSK3_1 365 372 PF00069 0.651
MOD_GSK3_1 382 389 PF00069 0.664
MOD_GSK3_1 402 409 PF00069 0.612
MOD_GSK3_1 417 424 PF00069 0.669
MOD_GSK3_1 439 446 PF00069 0.770
MOD_GSK3_1 464 471 PF00069 0.581
MOD_GSK3_1 478 485 PF00069 0.567
MOD_GSK3_1 534 541 PF00069 0.443
MOD_GSK3_1 554 561 PF00069 0.535
MOD_GSK3_1 563 570 PF00069 0.735
MOD_GSK3_1 602 609 PF00069 0.629
MOD_GSK3_1 85 92 PF00069 0.700
MOD_N-GLC_1 605 610 PF02516 0.765
MOD_N-GLC_1 632 637 PF02516 0.650
MOD_NEK2_1 185 190 PF00069 0.754
MOD_NEK2_1 196 201 PF00069 0.625
MOD_NEK2_1 251 256 PF00069 0.681
MOD_NEK2_1 258 263 PF00069 0.582
MOD_NEK2_1 587 592 PF00069 0.601
MOD_NEK2_1 68 73 PF00069 0.712
MOD_NEK2_1 87 92 PF00069 0.562
MOD_NEK2_2 198 203 PF00069 0.698
MOD_OFUCOSY 631 637 PF10250 0.585
MOD_PIKK_1 482 488 PF00454 0.506
MOD_PIKK_1 492 498 PF00454 0.541
MOD_PK_1 329 335 PF00069 0.760
MOD_PK_1 532 538 PF00069 0.587
MOD_PK_1 89 95 PF00069 0.728
MOD_PKA_1 160 166 PF00069 0.605
MOD_PKA_2 123 129 PF00069 0.545
MOD_PKA_2 152 158 PF00069 0.760
MOD_PKA_2 160 166 PF00069 0.659
MOD_PKA_2 175 181 PF00069 0.686
MOD_PKA_2 237 243 PF00069 0.636
MOD_PKA_2 258 264 PF00069 0.615
MOD_PKA_2 265 271 PF00069 0.621
MOD_PKA_2 273 279 PF00069 0.651
MOD_PKA_2 402 408 PF00069 0.644
MOD_PKA_2 417 423 PF00069 0.681
MOD_PKA_2 492 498 PF00069 0.449
MOD_PKB_1 187 195 PF00069 0.641
MOD_Plk_1 554 560 PF00069 0.626
MOD_Plk_4 191 197 PF00069 0.744
MOD_Plk_4 301 307 PF00069 0.751
MOD_Plk_4 89 95 PF00069 0.784
MOD_ProDKin_1 153 159 PF00069 0.665
MOD_ProDKin_1 18 24 PF00069 0.630
MOD_ProDKin_1 238 244 PF00069 0.760
MOD_ProDKin_1 313 319 PF00069 0.664
MOD_ProDKin_1 382 388 PF00069 0.630
MOD_ProDKin_1 40 46 PF00069 0.758
MOD_ProDKin_1 439 445 PF00069 0.750
MOD_ProDKin_1 446 452 PF00069 0.654
MOD_ProDKin_1 470 476 PF00069 0.606
MOD_ProDKin_1 558 564 PF00069 0.663
MOD_ProDKin_1 568 574 PF00069 0.668
MOD_ProDKin_1 606 612 PF00069 0.663
MOD_ProDKin_1 615 621 PF00069 0.643
MOD_ProDKin_1 641 647 PF00069 0.611
MOD_ProDKin_1 79 85 PF00069 0.673
MOD_SUMO_for_1 427 430 PF00179 0.752
MOD_SUMO_rev_2 52 61 PF00179 0.758
TRG_DiLeu_BaEn_1 36 41 PF01217 0.532
TRG_DiLeu_BaEn_3 596 602 PF01217 0.689
TRG_DiLeu_BaLyEn_6 643 648 PF01217 0.741
TRG_ER_diArg_1 150 153 PF00400 0.715
TRG_ER_diArg_1 159 161 PF00400 0.641
TRG_ER_diArg_1 224 227 PF00400 0.705
TRG_ER_diArg_1 272 275 PF00400 0.635
TRG_ER_diArg_1 417 419 PF00400 0.770
TRG_ER_diArg_1 435 437 PF00400 0.729
TRG_NLS_MonoExtC_3 360 365 PF00514 0.647
TRG_NLS_MonoExtN_4 359 365 PF00514 0.645
TRG_Pf-PMV_PEXEL_1 275 280 PF00026 0.783
TRG_Pf-PMV_PEXEL_1 457 461 PF00026 0.572

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I823 Leptomonas seymouri 42% 93%
A4HG04 Leishmania braziliensis 72% 100%
A4I323 Leishmania infantum 99% 100%
E9ACU4 Leishmania major 90% 100%
E9AZD3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS