Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X103_LEIDO

TriTrypDb:

LdBPK_272160.1 , LdCL_270029000 , LDHU3_27.3290

Length:

558

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0000323	lytic vacuole	6	1
GO:0005768	endosome	7	1
GO:0005773	vacuole	5	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X103

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X103

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0035493	SNARE complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	107	111	PF00656	0.544
CLV_C14_Caspase3-7	494	498	PF00656	0.564
CLV_NRD_NRD_1	326	328	PF00675	0.527
CLV_NRD_NRD_1	378	380	PF00675	0.490
CLV_NRD_NRD_1	498	500	PF00675	0.538
CLV_NRD_NRD_1	537	539	PF00675	0.539
CLV_PCSK_FUR_1	324	328	PF00082	0.560
CLV_PCSK_FUR_1	376	380	PF00082	0.449
CLV_PCSK_KEX2_1	326	328	PF00082	0.527
CLV_PCSK_KEX2_1	378	380	PF00082	0.505
CLV_PCSK_KEX2_1	537	539	PF00082	0.539
CLV_PCSK_PC7_1	374	380	PF00082	0.461
CLV_PCSK_SKI1_1	249	253	PF00082	0.665
CLV_PCSK_SKI1_1	412	416	PF00082	0.515
CLV_PCSK_SKI1_1	537	541	PF00082	0.602
DEG_APCC_DBOX_1	148	156	PF00400	0.604
DEG_APCC_DBOX_1	368	376	PF00400	0.507
DEG_Nend_UBRbox_2	1	3	PF02207	0.692
DOC_CYCLIN_RxL_1	376	388	PF00134	0.486
DOC_CYCLIN_yCln2_LP_2	464	470	PF00134	0.415
DOC_CYCLIN_yCln2_LP_2	489	495	PF00134	0.665
DOC_MAPK_gen_1	376	385	PF00069	0.486
DOC_MAPK_MEF2A_6	130	139	PF00069	0.604
DOC_MAPK_MEF2A_6	292	300	PF00069	0.501
DOC_MAPK_MEF2A_6	412	419	PF00069	0.578
DOC_MAPK_MEF2A_6	545	554	PF00069	0.473
DOC_PP1_RVXF_1	132	139	PF00149	0.635
DOC_PP2B_LxvP_1	489	492	PF13499	0.663
DOC_PP4_FxxP_1	10	13	PF00568	0.573
DOC_PP4_FxxP_1	174	177	PF00568	0.741
DOC_USP7_MATH_1	185	189	PF00917	0.621
DOC_USP7_MATH_1	197	201	PF00917	0.467
DOC_USP7_MATH_1	22	26	PF00917	0.674
DOC_USP7_MATH_1	66	70	PF00917	0.751
DOC_USP7_UBL2_3	530	534	PF12436	0.522
DOC_WW_Pin1_4	344	349	PF00397	0.606
DOC_WW_Pin1_4	477	482	PF00397	0.485
DOC_WW_Pin1_4	69	74	PF00397	0.732
DOC_WW_Pin1_4	9	14	PF00397	0.668
LIG_14-3-3_CanoR_1	140	148	PF00244	0.557
LIG_14-3-3_CanoR_1	170	175	PF00244	0.780
LIG_14-3-3_CanoR_1	221	227	PF00244	0.762
LIG_14-3-3_CanoR_1	23	28	PF00244	0.638
LIG_14-3-3_CanoR_1	297	307	PF00244	0.542
LIG_14-3-3_CanoR_1	355	359	PF00244	0.545
LIG_BRCT_BRCA1_1	113	117	PF00533	0.568
LIG_deltaCOP1_diTrp_1	2	10	PF00928	0.590
LIG_EVH1_2	6	10	PF00568	0.586
LIG_FHA_1	131	137	PF00498	0.638
LIG_FHA_1	140	146	PF00498	0.537
LIG_FHA_1	158	164	PF00498	0.621
LIG_FHA_1	16	22	PF00498	0.558
LIG_FHA_1	309	315	PF00498	0.542
LIG_FHA_1	386	392	PF00498	0.571
LIG_FHA_1	74	80	PF00498	0.638
LIG_FHA_2	103	109	PF00498	0.500
LIG_FHA_2	177	183	PF00498	0.812
LIG_FHA_2	242	248	PF00498	0.635
LIG_FHA_2	355	361	PF00498	0.571
LIG_FHA_2	43	49	PF00498	0.537
LIG_FHA_2	433	439	PF00498	0.631
LIG_FHA_2	492	498	PF00498	0.563
LIG_LIR_Apic_2	171	177	PF02991	0.799
LIG_LIR_Apic_2	225	231	PF02991	0.730
LIG_LIR_Apic_2	8	13	PF02991	0.577
LIG_LIR_Gen_1	255	264	PF02991	0.545
LIG_LIR_Nem_3	255	261	PF02991	0.557
LIG_LIR_Nem_3	340	344	PF02991	0.650
LIG_LYPXL_yS_3	466	469	PF13949	0.485
LIG_NRBOX	545	551	PF00104	0.407
LIG_PCNA_yPIPBox_3	91	100	PF02747	0.622
LIG_RPA_C_Fungi	362	374	PF08784	0.617
LIG_SH2_GRB2like	395	398	PF00017	0.713
LIG_SH2_STAP1	17	21	PF00017	0.559
LIG_SH2_STAP1	387	391	PF00017	0.489
LIG_SH2_STAP1	395	399	PF00017	0.651
LIG_SH2_STAP1	460	464	PF00017	0.563
LIG_SH2_STAT5	141	144	PF00017	0.536
LIG_SH2_STAT5	17	20	PF00017	0.560
LIG_SH2_STAT5	344	347	PF00017	0.666
LIG_SH2_STAT5	387	390	PF00017	0.562
LIG_SH2_STAT5	493	496	PF00017	0.592
LIG_SH2_STAT5	53	56	PF00017	0.513
LIG_SH3_3	142	148	PF00018	0.435
LIG_SH3_CIN85_PxpxPR_1	232	237	PF14604	0.701
LIG_SUMO_SIM_par_1	310	315	PF11976	0.489
LIG_SUMO_SIM_par_1	387	393	PF11976	0.557
LIG_SUMO_SIM_par_1	451	457	PF11976	0.432
LIG_SUMO_SIM_par_1	466	472	PF11976	0.456
LIG_TRAF2_1	105	108	PF00917	0.591
LIG_TRAF2_1	213	216	PF00917	0.750
LIG_TYR_ITIM	464	469	PF00017	0.490
LIG_Vh1_VBS_1	539	557	PF01044	0.508
MOD_CK1_1	153	159	PF00069	0.628
MOD_CK1_1	354	360	PF00069	0.597
MOD_CK1_1	472	478	PF00069	0.505
MOD_CK1_1	69	75	PF00069	0.717
MOD_CK2_1	101	107	PF00069	0.593
MOD_CK2_1	176	182	PF00069	0.809
MOD_CK2_1	307	313	PF00069	0.525
MOD_CK2_1	354	360	PF00069	0.578
MOD_CK2_1	42	48	PF00069	0.552
MOD_CK2_1	431	437	PF00069	0.645
MOD_GlcNHglycan	154	158	PF01048	0.595
MOD_GlcNHglycan	30	33	PF01048	0.642
MOD_GlcNHglycan	300	303	PF01048	0.529
MOD_GlcNHglycan	471	474	PF01048	0.538
MOD_GlcNHglycan	483	486	PF01048	0.544
MOD_GlcNHglycan	66	69	PF01048	0.647
MOD_GSK3_1	126	133	PF00069	0.648
MOD_GSK3_1	153	160	PF00069	0.642
MOD_GSK3_1	185	192	PF00069	0.769
MOD_GSK3_1	198	205	PF00069	0.652
MOD_GSK3_1	217	224	PF00069	0.649
MOD_GSK3_1	385	392	PF00069	0.496
MOD_GSK3_1	454	461	PF00069	0.549
MOD_GSK3_1	477	484	PF00069	0.571
MOD_GSK3_1	5	12	PF00069	0.743
MOD_GSK3_1	56	63	PF00069	0.642
MOD_GSK3_1	64	71	PF00069	0.744
MOD_N-GLC_1	481	486	PF02516	0.666
MOD_N-GLC_2	411	413	PF02516	0.585
MOD_NEK2_1	241	246	PF00069	0.750
MOD_NEK2_1	307	312	PF00069	0.553
MOD_NEK2_1	431	436	PF00069	0.634
MOD_NEK2_1	51	56	PF00069	0.530
MOD_NEK2_1	64	69	PF00069	0.680
MOD_PIKK_1	390	396	PF00454	0.584
MOD_PIKK_1	42	48	PF00454	0.570
MOD_PIKK_1	472	478	PF00454	0.554
MOD_PKA_2	139	145	PF00069	0.579
MOD_PKA_2	22	28	PF00069	0.586
MOD_PKA_2	241	247	PF00069	0.742
MOD_PKA_2	354	360	PF00069	0.628
MOD_Plk_1	109	115	PF00069	0.639
MOD_Plk_1	351	357	PF00069	0.565
MOD_Plk_4	198	204	PF00069	0.767
MOD_Plk_4	454	460	PF00069	0.415
MOD_Plk_4	5	11	PF00069	0.684
MOD_Plk_4	60	66	PF00069	0.693
MOD_ProDKin_1	344	350	PF00069	0.603
MOD_ProDKin_1	477	483	PF00069	0.486
MOD_ProDKin_1	69	75	PF00069	0.731
MOD_ProDKin_1	9	15	PF00069	0.661
TRG_DiLeu_BaEn_4	441	447	PF01217	0.502
TRG_ENDOCYTIC_2	466	469	PF00928	0.485
TRG_ER_diArg_1	324	327	PF00400	0.586
TRG_ER_diArg_1	365	368	PF00400	0.565
TRG_ER_diArg_1	375	378	PF00400	0.433
TRG_ER_diArg_1	537	539	PF00400	0.539
TRG_NES_CRM1_1	382	394	PF08389	0.539
TRG_NES_CRM1_1	544	558	PF08389	0.510
TRG_Pf-PMV_PEXEL_1	326	331	PF00026	0.585

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PG49	Leptomonas seymouri	58%	73%
A4HG01	Leishmania braziliensis	83%	99%
A4I320	Leishmania infantum	100%	100%
C9ZJJ3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	97%
E9ACU1	Leishmania major	94%	100%
E9AZD0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5ANH3	Trypanosoma cruzi	25%	100%