Thioredoxin family protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

thioredoxin, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X0Z3_LEIDO

TriTrypDb:

LdBPK_272120.1 , LdCL_270028500 , LDHU3_27.3240

Length:

239

Annotations

Annotations by Jardim et al.

Redox homeostasis, thioredoxin, putative

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X0Z3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0Z3

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	158	160	PF00675	0.400
CLV_NRD_NRD_1	49	51	PF00675	0.583
CLV_NRD_NRD_1	94	96	PF00675	0.447
CLV_PCSK_KEX2_1	158	160	PF00082	0.400
CLV_PCSK_KEX2_1	49	51	PF00082	0.579
CLV_PCSK_KEX2_1	94	96	PF00082	0.444
CLV_PCSK_SKI1_1	165	169	PF00082	0.308
CLV_PCSK_SKI1_1	171	175	PF00082	0.262
CLV_PCSK_SKI1_1	50	54	PF00082	0.683
DEG_APCC_DBOX_1	94	102	PF00400	0.583
DEG_Nend_Nbox_1	1	3	PF02207	0.582
DOC_MAPK_gen_1	226	235	PF00069	0.448
DOC_MAPK_MEF2A_6	165	172	PF00069	0.356
DOC_PP1_RVXF_1	204	211	PF00149	0.412
DOC_USP7_UBL2_3	70	74	PF12436	0.573
DOC_WW_Pin1_4	177	182	PF00397	0.307
LIG_14-3-3_CanoR_1	158	167	PF00244	0.335
LIG_14-3-3_CanoR_1	186	196	PF00244	0.330
LIG_FHA_1	150	156	PF00498	0.307
LIG_FHA_1	22	28	PF00498	0.455
LIG_FHA_1	51	57	PF00498	0.666
LIG_LIR_Gen_1	125	132	PF02991	0.307
LIG_LIR_Nem_3	118	122	PF02991	0.389
LIG_LIR_Nem_3	125	131	PF02991	0.276
LIG_SH2_NCK_1	64	68	PF00017	0.514
LIG_SH2_SRC	64	67	PF00017	0.537
LIG_SH3_3	60	66	PF00018	0.517
LIG_TRAF2_1	103	106	PF00917	0.577
MOD_CK1_1	161	167	PF00069	0.438
MOD_CK1_1	4	10	PF00069	0.558
MOD_GlcNHglycan	3	6	PF01048	0.564
MOD_GlcNHglycan	7	10	PF01048	0.542
MOD_GSK3_1	1	8	PF00069	0.569
MOD_GSK3_1	212	219	PF00069	0.400
MOD_LATS_1	48	54	PF00433	0.640
MOD_N-GLC_1	21	26	PF02516	0.459
MOD_NEK2_1	1	6	PF00069	0.574
MOD_NEK2_1	163	168	PF00069	0.329
MOD_NEK2_1	187	192	PF00069	0.404
MOD_PIKK_1	120	126	PF00454	0.326
MOD_PKA_1	158	164	PF00069	0.400
MOD_PKA_2	158	164	PF00069	0.327
MOD_PKA_2	187	193	PF00069	0.360
MOD_PKA_2	35	41	PF00069	0.636
MOD_PKB_1	186	194	PF00069	0.358
MOD_Plk_2-3	216	222	PF00069	0.394
MOD_ProDKin_1	177	183	PF00069	0.307
TRG_DiLeu_BaEn_2	177	183	PF01217	0.291
TRG_ENDOCYTIC_2	119	122	PF00928	0.367
TRG_ER_diArg_1	158	160	PF00400	0.400
TRG_ER_diArg_1	186	189	PF00400	0.358
TRG_ER_diArg_1	49	51	PF00400	0.686
TRG_ER_diArg_1	93	95	PF00400	0.438
TRG_ER_diLys_1	234	239	PF00400	0.402
TRG_NES_CRM1_1	88	99	PF08389	0.564
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.385
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.376

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMI4	Leptomonas seymouri	79%	99%
A0A0S4J4Q7	Bodo saltans	61%	97%
A0A1X0NR32	Trypanosomatidae	67%	98%
A0A3R7KUG1	Trypanosoma rangeli	64%	97%
A0A3S7X612	Leishmania donovani	33%	100%
A4HFZ7	Leishmania braziliensis	91%	100%
A4HKU1	Leishmania braziliensis	33%	100%
A4I316	Leishmania infantum	100%	100%
A4I8C0	Leishmania infantum	33%	100%
C9ZJI5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	95%
E9ACT7	Leishmania major	95%	100%
E9AZC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9B379	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
O64628	Arabidopsis thaliana	37%	100%
Q9U1D8	Leishmania major	34%	100%
V5DF31	Trypanosoma cruzi	68%	98%