RNA-binding protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X0Y2_LEIDO

TriTrypDb:

LdBPK_272020.1 , LdCL_270027500 , LDHU3_27.3100

Length:

453

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016604	nuclear body	2	1
GO:0016607	nuclear speck	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X0Y2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0Y2

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0005488	binding	1	10
GO:0008270	zinc ion binding	6	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0046914	transition metal ion binding	5	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	218	222	PF00656	0.792
CLV_NRD_NRD_1	127	129	PF00675	0.691
CLV_NRD_NRD_1	219	221	PF00675	0.765
CLV_NRD_NRD_1	224	226	PF00675	0.807
CLV_NRD_NRD_1	237	239	PF00675	0.425
CLV_NRD_NRD_1	318	320	PF00675	0.554
CLV_NRD_NRD_1	339	341	PF00675	0.716
CLV_NRD_NRD_1	348	350	PF00675	0.699
CLV_NRD_NRD_1	363	365	PF00675	0.541
CLV_NRD_NRD_1	373	375	PF00675	0.703
CLV_NRD_NRD_1	383	385	PF00675	0.655
CLV_NRD_NRD_1	393	395	PF00675	0.539
CLV_NRD_NRD_1	403	405	PF00675	0.543
CLV_NRD_NRD_1	413	415	PF00675	0.582
CLV_NRD_NRD_1	425	427	PF00675	0.683
CLV_NRD_NRD_1	437	439	PF00675	0.525
CLV_PCSK_FUR_1	344	348	PF00082	0.766
CLV_PCSK_FUR_1	357	361	PF00082	0.616
CLV_PCSK_FUR_1	370	374	PF00082	0.688
CLV_PCSK_FUR_1	380	384	PF00082	0.663
CLV_PCSK_FUR_1	390	394	PF00082	0.490
CLV_PCSK_FUR_1	400	404	PF00082	0.446
CLV_PCSK_FUR_1	410	414	PF00082	0.546
CLV_PCSK_FUR_1	420	424	PF00082	0.586
CLV_PCSK_FUR_1	435	439	PF00082	0.803
CLV_PCSK_KEX2_1	127	129	PF00082	0.656
CLV_PCSK_KEX2_1	219	221	PF00082	0.721
CLV_PCSK_KEX2_1	224	226	PF00082	0.774
CLV_PCSK_KEX2_1	236	238	PF00082	0.454
CLV_PCSK_KEX2_1	292	294	PF00082	0.395
CLV_PCSK_KEX2_1	318	320	PF00082	0.554
CLV_PCSK_KEX2_1	338	340	PF00082	0.725
CLV_PCSK_KEX2_1	344	346	PF00082	0.696
CLV_PCSK_KEX2_1	347	349	PF00082	0.691
CLV_PCSK_KEX2_1	359	361	PF00082	0.567
CLV_PCSK_KEX2_1	362	364	PF00082	0.449
CLV_PCSK_KEX2_1	372	374	PF00082	0.651
CLV_PCSK_KEX2_1	382	384	PF00082	0.592
CLV_PCSK_KEX2_1	392	394	PF00082	0.566
CLV_PCSK_KEX2_1	402	404	PF00082	0.569
CLV_PCSK_KEX2_1	412	414	PF00082	0.572
CLV_PCSK_KEX2_1	422	424	PF00082	0.650
CLV_PCSK_KEX2_1	425	427	PF00082	0.691
CLV_PCSK_KEX2_1	435	437	PF00082	0.625
CLV_PCSK_KEX2_1	451	453	PF00082	0.702
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.390
CLV_PCSK_PC7_1	220	226	PF00082	0.714
CLV_PCSK_PC7_1	340	346	PF00082	0.759
CLV_PCSK_PC7_1	357	363	PF00082	0.537
CLV_PCSK_PC7_1	420	426	PF00082	0.637
CLV_PCSK_PC7_1	431	437	PF00082	0.711
CLV_PCSK_PC7_1	447	453	PF00082	0.664
CLV_PCSK_SKI1_1	155	159	PF00082	0.308
CLV_PCSK_SKI1_1	188	192	PF00082	0.364
CLV_PCSK_SKI1_1	220	224	PF00082	0.681
CLV_PCSK_SKI1_1	255	259	PF00082	0.288
DEG_APCC_DBOX_1	150	158	PF00400	0.595
DOC_CYCLIN_RxL_1	185	193	PF00134	0.561
DOC_MAPK_gen_1	134	142	PF00069	0.533
DOC_MAPK_gen_1	236	244	PF00069	0.628
DOC_MAPK_gen_1	306	315	PF00069	0.675
DOC_MAPK_MEF2A_6	236	244	PF00069	0.620
DOC_MAPK_MEF2A_6	275	282	PF00069	0.551
DOC_PP2B_PxIxI_1	275	281	PF00149	0.590
DOC_PP4_FxxP_1	261	264	PF00568	0.561
DOC_PP4_FxxP_1	273	276	PF00568	0.561
DOC_PP4_FxxP_1	54	57	PF00568	0.561
DOC_USP7_MATH_1	114	118	PF00917	0.694
DOC_USP7_MATH_1	284	288	PF00917	0.533
DOC_WW_Pin1_4	156	161	PF00397	0.531
DOC_WW_Pin1_4	260	265	PF00397	0.590
DOC_WW_Pin1_4	429	434	PF00397	0.626
DOC_WW_Pin1_4	439	444	PF00397	0.663
DOC_WW_Pin1_4	445	450	PF00397	0.645
LIG_BIR_II_1	1	5	PF00653	0.597
LIG_FHA_1	3	9	PF00498	0.338
LIG_FHA_2	14	20	PF00498	0.493
LIG_FHA_2	179	185	PF00498	0.538
LIG_FHA_2	284	290	PF00498	0.571
LIG_LIR_Apic_2	270	276	PF02991	0.561
LIG_LIR_Apic_2	51	57	PF02991	0.590
LIG_LIR_Gen_1	166	175	PF02991	0.524
LIG_LIR_Gen_1	18	27	PF02991	0.504
LIG_LIR_Nem_3	166	170	PF02991	0.561
LIG_LIR_Nem_3	18	24	PF02991	0.504
LIG_MAD2	139	147	PF02301	0.443
LIG_NRP_CendR_1	451	453	PF00754	0.758
LIG_REV1ctd_RIR_1	21	30	PF16727	0.490
LIG_SH2_STAT5	180	183	PF00017	0.561
LIG_SH2_STAT5	7	10	PF00017	0.494
LIG_SH2_STAT5	78	81	PF00017	0.612
LIG_SH3_3	154	160	PF00018	0.531
LIG_SH3_3	200	206	PF00018	0.690
LIG_SH3_3	30	36	PF00018	0.561
LIG_TRAF2_1	181	184	PF00917	0.531
LIG_TRFH_1	167	171	PF08558	0.490
LIG_WW_3	207	211	PF00397	0.722
LIG_WW_3	432	436	PF00397	0.778
LIG_WW_3	442	446	PF00397	0.602
LIG_WW_3	448	452	PF00397	0.679
MOD_CDC14_SPxK_1	432	435	PF00782	0.643
MOD_CDC14_SPxK_1	442	445	PF00782	0.659
MOD_CDC14_SPxK_1	448	451	PF00782	0.641
MOD_CDK_SPxK_1	429	435	PF00069	0.631
MOD_CDK_SPxK_1	439	445	PF00069	0.663
MOD_CDK_SPxxK_3	429	436	PF00069	0.705
MOD_CDK_SPxxK_3	445	452	PF00069	0.663
MOD_CK1_1	2	8	PF00069	0.555
MOD_CK1_1	251	257	PF00069	0.585
MOD_CK1_1	334	340	PF00069	0.743
MOD_CK1_1	350	356	PF00069	0.620
MOD_CK1_1	62	68	PF00069	0.536
MOD_CK2_1	11	17	PF00069	0.563
MOD_CK2_1	178	184	PF00069	0.509
MOD_CK2_1	283	289	PF00069	0.554
MOD_DYRK1A_RPxSP_1	429	433	PF00069	0.629
MOD_DYRK1A_RPxSP_1	445	449	PF00069	0.656
MOD_GlcNHglycan	1	4	PF01048	0.617
MOD_GlcNHglycan	116	119	PF01048	0.703
MOD_GlcNHglycan	128	131	PF01048	0.752
MOD_GlcNHglycan	13	16	PF01048	0.364
MOD_GlcNHglycan	232	235	PF01048	0.694
MOD_GlcNHglycan	286	289	PF01048	0.323
MOD_GlcNHglycan	297	300	PF01048	0.282
MOD_GlcNHglycan	36	39	PF01048	0.358
MOD_GlcNHglycan	43	46	PF01048	0.396
MOD_GlcNHglycan	61	64	PF01048	0.235
MOD_GlcNHglycan	66	69	PF01048	0.585
MOD_GlcNHglycan	79	82	PF01048	0.582
MOD_GSK3_1	2	9	PF00069	0.556
MOD_GSK3_1	226	233	PF00069	0.729
MOD_GSK3_1	334	341	PF00069	0.673
MOD_GSK3_1	347	354	PF00069	0.709
MOD_GSK3_1	425	432	PF00069	0.691
MOD_GSK3_1	439	446	PF00069	0.724
MOD_GSK3_1	62	69	PF00069	0.561
MOD_GSK3_1	82	89	PF00069	0.395
MOD_N-GLC_1	226	231	PF02516	0.667
MOD_N-GLC_1	94	99	PF02516	0.581
MOD_NEK2_1	302	307	PF00069	0.524
MOD_PKA_1	338	344	PF00069	0.694
MOD_PKA_1	347	353	PF00069	0.750
MOD_PKA_1	362	368	PF00069	0.549
MOD_PKA_1	372	378	PF00069	0.677
MOD_PKA_1	382	388	PF00069	0.664
MOD_PKA_1	392	398	PF00069	0.641
MOD_PKA_1	402	408	PF00069	0.520
MOD_PKA_1	412	418	PF00069	0.496
MOD_PKA_1	425	431	PF00069	0.681
MOD_PKA_1	437	443	PF00069	0.585
MOD_PKA_2	126	132	PF00069	0.685
MOD_PKA_2	133	139	PF00069	0.598
MOD_PKA_2	338	344	PF00069	0.712
MOD_PKA_2	347	353	PF00069	0.704
MOD_PKA_2	362	368	PF00069	0.549
MOD_PKA_2	372	378	PF00069	0.695
MOD_PKA_2	382	388	PF00069	0.441
MOD_PKA_2	392	398	PF00069	0.641
MOD_PKA_2	402	408	PF00069	0.520
MOD_PKA_2	412	418	PF00069	0.496
MOD_PKA_2	425	431	PF00069	0.681
MOD_PKA_2	437	443	PF00069	0.585
MOD_PKB_1	345	353	PF00069	0.756
MOD_PKB_1	360	368	PF00069	0.560
MOD_PKB_1	370	378	PF00069	0.688
MOD_PKB_1	380	388	PF00069	0.628
MOD_PKB_1	390	398	PF00069	0.533
MOD_PKB_1	400	408	PF00069	0.385
MOD_PKB_1	410	418	PF00069	0.447
MOD_PKB_1	423	431	PF00069	0.684
MOD_PKB_1	435	443	PF00069	0.714
MOD_Plk_4	141	147	PF00069	0.590
MOD_Plk_4	2	8	PF00069	0.555
MOD_ProDKin_1	156	162	PF00069	0.531
MOD_ProDKin_1	260	266	PF00069	0.590
MOD_ProDKin_1	429	435	PF00069	0.631
MOD_ProDKin_1	439	445	PF00069	0.663
MOD_SUMO_for_1	274	277	PF00179	0.561
TRG_DiLeu_BaLyEn_6	311	316	PF01217	0.651
TRG_ER_diArg_1	126	128	PF00400	0.688
TRG_ER_diArg_1	235	238	PF00400	0.434
TRG_ER_diArg_1	306	309	PF00400	0.540
TRG_ER_diArg_1	338	340	PF00400	0.745
TRG_ER_diArg_1	344	347	PF00400	0.718
TRG_ER_diArg_1	359	362	PF00400	0.639
TRG_ER_diArg_1	372	374	PF00400	0.644
TRG_ER_diArg_1	382	384	PF00400	0.577
TRG_ER_diArg_1	392	394	PF00400	0.531
TRG_ER_diArg_1	402	404	PF00400	0.531
TRG_ER_diArg_1	412	414	PF00400	0.581
TRG_ER_diArg_1	422	425	PF00400	0.650
TRG_ER_diArg_1	434	437	PF00400	0.761
TRG_ER_diArg_1	444	447	PF00400	0.532
TRG_ER_diArg_1	450	453	PF00400	0.677

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMB5	Leptomonas seymouri	51%	100%
A0A1X0NSK5	Trypanosomatidae	30%	98%
A0A3R7LQ31	Trypanosoma rangeli	32%	100%
A4HFY7	Leishmania braziliensis	81%	100%
A4I2Y0	Leishmania infantum	99%	100%
C9ZJH0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9ADJ0	Leishmania major	98%	100%
E9AZB6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%