Ribonucleotide reductase, small chain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribonucleoside-diphosphate reductase small chain, putative (fragment)

Species:

Leishmania donovani

UniProt:

A0A3S7X0X6_LEIDO

TriTrypDb:

LdBPK_221112.1 , LdCL_270027000 , LDHU3_27.3040

Length:

388

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 35

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A0A3S7X0X6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0X6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	18
GO:0006725	cellular aromatic compound metabolic process	3	18
GO:0006753	nucleoside phosphate metabolic process	4	18
GO:0006793	phosphorus metabolic process	3	18
GO:0006796	phosphate-containing compound metabolic process	4	18
GO:0006807	nitrogen compound metabolic process	2	18
GO:0008152	metabolic process	1	18
GO:0009058	biosynthetic process	2	18
GO:0009117	nucleotide metabolic process	5	18
GO:0009165	nucleotide biosynthetic process	6	18
GO:0009262	deoxyribonucleotide metabolic process	4	18
GO:0009263	deoxyribonucleotide biosynthetic process	5	18
GO:0009987	cellular process	1	18
GO:0018130	heterocycle biosynthetic process	4	18
GO:0019438	aromatic compound biosynthetic process	4	18
GO:0019637	organophosphate metabolic process	3	18
GO:0034641	cellular nitrogen compound metabolic process	3	18
GO:0034654	nucleobase-containing compound biosynthetic process	4	18
GO:0044237	cellular metabolic process	2	18
GO:0044238	primary metabolic process	2	18
GO:0044249	cellular biosynthetic process	3	18
GO:0044271	cellular nitrogen compound biosynthetic process	4	18
GO:0044281	small molecule metabolic process	2	18
GO:0046483	heterocycle metabolic process	3	18
GO:0055086	nucleobase-containing small molecule metabolic process	3	18
GO:0071704	organic substance metabolic process	2	18
GO:0090407	organophosphate biosynthetic process	4	18
GO:1901135	carbohydrate derivative metabolic process	3	18
GO:1901137	carbohydrate derivative biosynthetic process	4	18
GO:1901293	nucleoside phosphate biosynthetic process	5	18
GO:1901360	organic cyclic compound metabolic process	3	18
GO:1901362	organic cyclic compound biosynthetic process	4	18
GO:1901576	organic substance biosynthetic process	3	18

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	18
GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	6	11
GO:0016491	oxidoreductase activity	2	18
GO:0016725	oxidoreductase activity, acting on CH or CH2 groups	3	11
GO:0016728	oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor	4	11
GO:0061731	ribonucleoside-diphosphate reductase activity	5	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	116	120	PF00656	0.470
CLV_NRD_NRD_1	89	91	PF00675	0.343
CLV_PCSK_KEX2_1	13	15	PF00082	0.581
CLV_PCSK_KEX2_1	245	247	PF00082	0.465
CLV_PCSK_KEX2_1	362	364	PF00082	0.530
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.581
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.465
CLV_PCSK_PC1ET2_1	362	364	PF00082	0.530
CLV_PCSK_SKI1_1	126	130	PF00082	0.265
CLV_PCSK_SKI1_1	77	81	PF00082	0.325
DEG_APCC_DBOX_1	76	84	PF00400	0.533
DEG_COP1_1	149	156	PF00400	0.499
DOC_MAPK_gen_1	281	290	PF00069	0.276
DOC_MAPK_MEF2A_6	245	254	PF00069	0.265
DOC_MAPK_MEF2A_6	284	292	PF00069	0.357
DOC_PP1_RVXF_1	219	226	PF00149	0.465
DOC_PP1_RVXF_1	75	82	PF00149	0.465
DOC_WW_Pin1_4	24	29	PF00397	0.613
LIG_14-3-3_CanoR_1	146	154	PF00244	0.499
LIG_14-3-3_CanoR_1	328	334	PF00244	0.299
LIG_14-3-3_CanoR_1	340	344	PF00244	0.299
LIG_BIR_III_2	304	308	PF00653	0.275
LIG_BRCT_BRCA1_1	214	218	PF00533	0.549
LIG_BRCT_BRCA1_1	233	237	PF00533	0.157
LIG_BRCT_BRCA1_1	378	382	PF00533	0.503
LIG_BRCT_BRCA1_1	384	388	PF00533	0.499
LIG_deltaCOP1_diTrp_1	206	211	PF00928	0.481
LIG_EH_1	73	77	PF12763	0.656
LIG_FHA_1	171	177	PF00498	0.465
LIG_FHA_1	37	43	PF00498	0.748
LIG_FHA_2	114	120	PF00498	0.448
LIG_FHA_2	181	187	PF00498	0.515
LIG_FHA_2	25	31	PF00498	0.797
LIG_FHA_2	61	67	PF00498	0.696
LIG_FHA_2	99	105	PF00498	0.470
LIG_GBD_Chelix_1	325	333	PF00786	0.465
LIG_LIR_Gen_1	113	121	PF02991	0.467
LIG_LIR_Gen_1	171	182	PF02991	0.465
LIG_LIR_Gen_1	234	243	PF02991	0.317
LIG_LIR_Gen_1	267	274	PF02991	0.265
LIG_LIR_Gen_1	342	353	PF02991	0.354
LIG_LIR_Nem_3	113	117	PF02991	0.485
LIG_LIR_Nem_3	171	177	PF02991	0.465
LIG_LIR_Nem_3	234	240	PF02991	0.317
LIG_LIR_Nem_3	267	272	PF02991	0.265
LIG_LIR_Nem_3	73	79	PF02991	0.559
LIG_LIR_Nem_3	87	92	PF02991	0.464
LIG_PDZ_Class_3	383	388	PF00595	0.541
LIG_Pex14_2	233	237	PF04695	0.317
LIG_REV1ctd_RIR_1	357	367	PF16727	0.409
LIG_SH2_CRK	174	178	PF00017	0.465
LIG_SH2_STAP1	174	178	PF00017	0.465
LIG_SH2_STAT3	160	163	PF00017	0.465
LIG_SH2_STAT3	92	95	PF00017	0.557
LIG_SH2_STAT5	181	184	PF00017	0.465
LIG_SH2_STAT5	321	324	PF00017	0.265
LIG_SH2_STAT5	78	81	PF00017	0.465
LIG_SH3_3	148	154	PF00018	0.465
LIG_SH3_3	40	46	PF00018	0.789
LIG_SH3_3	76	82	PF00018	0.498
LIG_SUMO_SIM_par_1	329	336	PF11976	0.370
LIG_TRAF2_1	101	104	PF00917	0.475
LIG_TRAF2_1	15	18	PF00917	0.676
LIG_TRAF2_1	217	220	PF00917	0.557
LIG_TRAF2_1	65	68	PF00917	0.705
LIG_TRAF2_2	82	87	PF00917	0.570
LIG_TRFH_1	78	82	PF08558	0.533
LIG_TYR_ITIM	83	88	PF00017	0.457
LIG_UBA3_1	240	245	PF00899	0.317
LIG_UBA3_1	329	337	PF00899	0.357
LIG_UBA3_1	350	356	PF00899	0.389
MOD_CK1_1	214	220	PF00069	0.466
MOD_CK2_1	180	186	PF00069	0.515
MOD_CK2_1	214	220	PF00069	0.515
MOD_CK2_1	257	263	PF00069	0.265
MOD_CK2_1	329	335	PF00069	0.352
MOD_CK2_1	380	386	PF00069	0.545
MOD_CK2_1	60	66	PF00069	0.693
MOD_CK2_1	98	104	PF00069	0.470
MOD_GlcNHglycan	214	217	PF01048	0.350
MOD_GlcNHglycan	233	236	PF01048	0.157
MOD_GSK3_1	168	175	PF00069	0.465
MOD_GSK3_1	371	378	PF00069	0.446
MOD_GSK3_1	94	101	PF00069	0.465
MOD_NEK2_1	177	182	PF00069	0.465
MOD_NEK2_1	233	238	PF00069	0.317
MOD_NEK2_1	273	278	PF00069	0.357
MOD_NEK2_1	329	334	PF00069	0.284
MOD_PIKK_1	339	345	PF00454	0.357
MOD_PKA_1	380	386	PF00069	0.545
MOD_PKA_2	339	345	PF00069	0.245
MOD_Plk_2-3	113	119	PF00069	0.543
MOD_Plk_4	172	178	PF00069	0.465
MOD_ProDKin_1	24	30	PF00069	0.614
MOD_SUMO_for_1	37	40	PF00179	0.662
MOD_SUMO_rev_2	149	154	PF00179	0.570
MOD_SUMO_rev_2	184	189	PF00179	0.557
TRG_DiLeu_BaEn_1	187	192	PF01217	0.486
TRG_DiLeu_BaLyEn_6	218	223	PF01217	0.557
TRG_DiLeu_BaLyEn_6	306	311	PF01217	0.274
TRG_DiLeu_BaLyEn_6	325	330	PF01217	0.192
TRG_DiLeu_LyEn_5	187	192	PF01217	0.486
TRG_ENDOCYTIC_2	174	177	PF00928	0.465
TRG_ENDOCYTIC_2	321	324	PF00928	0.265
TRG_ENDOCYTIC_2	78	81	PF00928	0.465
TRG_ENDOCYTIC_2	85	88	PF00928	0.432
TRG_NES_CRM1_1	141	155	PF08389	0.465
TRG_NES_CRM1_1	320	335	PF08389	0.370

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8G9	Leptomonas seymouri	86%	100%
A0A0S4JI02	Bodo saltans	68%	96%
A0A1X0NN82	Trypanosomatidae	80%	100%
A0A3Q8IAS1	Leishmania donovani	94%	100%
A0A3R7N6N4	Trypanosoma rangeli	77%	100%
A4HCG7	Leishmania braziliensis	91%	100%
A4HFY2	Leishmania braziliensis	94%	100%
A4I2X5	Leishmania infantum	100%	100%
D0A9F7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	79%	100%
D0A9F8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	79%	100%
D0A9F9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	78%	100%
E9ADI5	Leishmania major	99%	100%
E9AGZ9	Leishmania infantum	94%	100%
E9AVW1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9AZB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
O15910	Trypanosoma brucei brucei	79%	100%
O30601	Bacillus subtilis (strain 168)	25%	100%
O36410	Alcelaphine herpesvirus 1 (strain C500)	29%	100%
O46310	Leishmania amazonensis	99%	100%
O57175	Vaccinia virus (strain Ankara)	65%	100%
O64174	Bacillus phage SPbeta	25%	100%
O83092	Treponema pallidum (strain Nichols)	24%	100%
O84835	Chlamydia trachomatis (strain D/UW-3/Cx)	29%	100%
P06474	Human herpesvirus 1 (strain KOS)	31%	100%
P07201	Spisula solidissima	64%	100%
P09247	Varicella-zoster virus (strain Dumas)	30%	100%
P09938	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	62%	97%
P0C701	Epstein-Barr virus (strain GD1)	32%	100%
P0C8I0	African swine fever virus (isolate Pig/Kenya/KEN-50/1950)	39%	100%
P0C8I1	African swine fever virus (isolate Tick/South Africa/Pretoriuskop Pr4/1996)	40%	100%
P0C8I2	African swine fever virus (isolate Warthog/Namibia/Wart80/1980)	39%	100%
P0CAP6	Epstein-Barr virus (strain B95-8)	32%	100%
P0CAP7	Epstein-Barr virus (strain AG876)	32%	100%
P0DKH3	Arabidopsis thaliana	65%	100%
P0DSS7	Variola virus (isolate Human/India/Ind3/1967)	64%	100%
P0DSS8	Variola virus	65%	100%
P10224	Human herpesvirus 1 (strain 17)	31%	100%
P11157	Mus musculus	64%	99%
P11158	Vaccinia virus (strain Western Reserve)	65%	100%
P20493	Vaccinia virus (strain Copenhagen)	65%	100%
P26713	African swine fever virus (isolate Tick/Malawi/Lil 20-1/1983)	41%	100%
P28847	Equine herpesvirus 1 (strain Ab4p)	29%	100%
P29883	Vaccinia virus (strain L-IVP)	64%	100%
P31350	Homo sapiens	64%	100%
P32209	Swinepox virus (strain Kasza)	63%	100%
P36603	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	62%	99%
P42170	Caenorhabditis elegans	60%	100%
P42492	African swine fever virus (strain Badajoz 1971 Vero-adapted)	39%	100%
P42521	Dictyostelium discoideum	64%	100%
P48592	Drosophila melanogaster	65%	99%
P49723	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	44%	100%
P49730	Nicotiana tabacum	67%	100%
P50644	Equine herpesvirus 4 (strain 1942)	29%	100%
P50645	Suid herpesvirus 1 (strain Kaplan)	31%	100%
P50649	Plasmodium falciparum (isolate FCR-3 / Gambia)	58%	100%
P50650	Plasmodium falciparum (isolate Dd2)	55%	100%
P50651	Arabidopsis thaliana	65%	100%
P55983	Helicobacter pylori (strain ATCC 700392 / 26695)	25%	100%
P69520	Human herpesvirus 2 (strain 333)	29%	100%
P69521	Human herpesvirus 2 (strain HG52)	29%	100%
P69924	Escherichia coli (strain K12)	24%	100%
P69925	Escherichia coli O157:H7	24%	100%
P79733	Danio rerio	65%	100%
Q01038	Saimiriine herpesvirus 2 (strain 11)	29%	100%
Q01319	Bovine herpesvirus 1.1 (strain Cooper)	28%	100%
Q4JQV7	Varicella-zoster virus (strain Oka vaccine)	30%	100%
Q4KLN6	Rattus norvegicus	64%	99%
Q4QBL8	Leishmania major	93%	100%
Q4R741	Macaca fascicularis	59%	100%
Q4R7Q7	Macaca fascicularis	60%	100%
Q5R9G0	Pongo abelii	59%	100%
Q60561	Mesocricetus auratus	60%	100%
Q66662	Equine herpesvirus 2 (strain 86/87)	29%	100%
Q6PEE3	Mus musculus	59%	100%
Q6R7K3	Ostreid herpesvirus 1 (isolate France)	28%	67%
Q6UDJ1	Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997)	31%	100%
Q77MS0	Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987)	30%	100%
Q7LG56	Homo sapiens	59%	100%
Q7T6Y9	Acanthamoeba polyphaga mimivirus	46%	93%
Q8SRR2	Encephalitozoon cuniculi (strain GB-M1)	60%	100%
Q91FE8	Invertebrate iridescent virus 6	23%	100%
Q9C167	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	68%	95%
Q9DHU2	Yaba-like disease virus	61%	100%
Q9KFH7	Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)	22%	100%
Q9LSD0	Arabidopsis thaliana	67%	100%
Q9PL92	Chlamydia muridarum (strain MoPn / Nigg)	29%	100%
Q9QTF2	Red sea bream iridovirus	51%	100%
Q9Z6S4	Chlamydia pneumoniae	28%	100%
Q9ZKC3	Helicobacter pylori (strain J99 / ATCC 700824)	25%	100%
V5ASN2	Trypanosoma cruzi	77%	100%