PrgI family protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

PrgI family protein

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X0X5_LEIDO

TriTrypDb:

LdBPK_272010.1 , LdCL_270027400 , LDHU3_27.3090

Length:

148

Annotations

LeishMANIAdb annotations

Relatively conserved in Kinetoplastids but not seen beyond.

Annotations by Jardim et al.

Tricarboxylic acid cycle, Succinate dehydrogenase (SDH8)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A0A3S7X0X5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0X5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	111	113	PF00675	0.363
CLV_NRD_NRD_1	26	28	PF00675	0.401
CLV_NRD_NRD_1	43	45	PF00675	0.248
CLV_NRD_NRD_1	68	70	PF00675	0.586
CLV_PCSK_FUR_1	40	44	PF00082	0.399
CLV_PCSK_KEX2_1	111	113	PF00082	0.363
CLV_PCSK_KEX2_1	26	28	PF00082	0.399
CLV_PCSK_KEX2_1	42	44	PF00082	0.271
CLV_PCSK_KEX2_1	67	69	PF00082	0.592
CLV_PCSK_SKI1_1	44	48	PF00082	0.317
DEG_Nend_UBRbox_3	1	3	PF02207	0.772
DOC_CYCLIN_RxL_1	40	51	PF00134	0.580
DOC_MAPK_gen_1	40	48	PF00069	0.575
DOC_MAPK_gen_1	67	76	PF00069	0.387
DOC_PP1_RVXF_1	109	116	PF00149	0.565
DOC_PP1_RVXF_1	42	49	PF00149	0.575
DOC_USP7_MATH_1	3	7	PF00917	0.778
DOC_USP7_UBL2_3	117	121	PF12436	0.582
LIG_14-3-3_CanoR_1	132	138	PF00244	0.707
LIG_14-3-3_CanoR_1	43	49	PF00244	0.485
LIG_14-3-3_CanoR_1	67	73	PF00244	0.413
LIG_FHA_1	45	51	PF00498	0.513
LIG_FHA_1	54	60	PF00498	0.378
LIG_FHA_1	69	75	PF00498	0.361
LIG_LIR_Gen_1	124	131	PF02991	0.634
LIG_LIR_Gen_1	71	79	PF02991	0.313
LIG_LIR_Gen_1	80	89	PF02991	0.364
LIG_LIR_Nem_3	124	128	PF02991	0.637
LIG_LIR_Nem_3	61	65	PF02991	0.408
LIG_LIR_Nem_3	71	76	PF02991	0.287
LIG_LIR_Nem_3	77	82	PF02991	0.324
LIG_Pex14_1	133	137	PF04695	0.609
LIG_Pex14_1	35	39	PF04695	0.592
LIG_SH2_CRK	125	129	PF00017	0.647
LIG_SH2_GRB2like	98	101	PF00017	0.594
LIG_SH2_NCK_1	125	129	PF00017	0.630
LIG_SH2_NCK_1	98	102	PF00017	0.622
LIG_SH2_SRC	98	101	PF00017	0.594
LIG_SH2_STAP1	98	102	PF00017	0.589
LIG_SH2_STAT5	63	66	PF00017	0.420
LIG_SH2_STAT5	72	75	PF00017	0.367
LIG_TYR_ITIM	96	101	PF00017	0.418
LIG_WRC_WIRS_1	76	81	PF05994	0.355
MOD_CK1_1	53	59	PF00069	0.381
MOD_CK1_1	77	83	PF00069	0.398
MOD_GlcNHglycan	52	55	PF01048	0.398
MOD_GlcNHglycan	79	82	PF01048	0.428
MOD_GSK3_1	44	51	PF00069	0.492
MOD_GSK3_1	54	61	PF00069	0.300
MOD_N-GLC_1	3	8	PF02516	0.552
MOD_NEK2_1	48	53	PF00069	0.378
MOD_NEK2_1	58	63	PF00069	0.335
MOD_NEK2_1	75	80	PF00069	0.369
MOD_PIKK_1	123	129	PF00454	0.607
MOD_PKA_1	68	74	PF00069	0.386
MOD_PKA_2	68	74	PF00069	0.388
MOD_PKB_1	42	50	PF00069	0.553
MOD_Plk_1	105	111	PF00069	0.555
MOD_Plk_1	123	129	PF00069	0.607
MOD_Plk_4	105	111	PF00069	0.564
MOD_Plk_4	54	60	PF00069	0.340
MOD_Plk_4	68	74	PF00069	0.406
TRG_ENDOCYTIC_2	125	128	PF00928	0.622
TRG_ENDOCYTIC_2	63	66	PF00928	0.464
TRG_ENDOCYTIC_2	72	75	PF00928	0.386
TRG_ENDOCYTIC_2	98	101	PF00928	0.539
TRG_ER_diArg_1	110	112	PF00400	0.552
TRG_ER_diArg_1	25	27	PF00400	0.606
TRG_ER_diArg_1	39	42	PF00400	0.482
TRG_ER_diArg_1	66	69	PF00400	0.451
TRG_ER_diLys_1	145	148	PF00400	0.718

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDZ2	Leptomonas seymouri	82%	100%
A0A0S4IJ67	Bodo saltans	52%	100%
A0A1X0NST1	Trypanosomatidae	74%	100%
A0A3S5IQM8	Trypanosoma rangeli	67%	100%
A4HFY6	Leishmania braziliensis	89%	100%
A4I2X9	Leishmania infantum	100%	100%
C9ZJG9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	98%
E9ADI9	Leishmania major	95%	100%
E9AZB5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%