Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X0W4_LEIDO

TriTrypDb:

LdBPK_271850.1 , LdCL_270025700 , LDHU3_27.2820

Length:

259

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X0W4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0W4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	121	123	PF00675	0.648
CLV_NRD_NRD_1	156	158	PF00675	0.518
CLV_NRD_NRD_1	166	168	PF00675	0.471
CLV_NRD_NRD_1	19	21	PF00675	0.552
CLV_NRD_NRD_1	190	192	PF00675	0.550
CLV_PCSK_FUR_1	119	123	PF00082	0.655
CLV_PCSK_KEX2_1	121	123	PF00082	0.648
CLV_PCSK_KEX2_1	156	158	PF00082	0.518
CLV_PCSK_KEX2_1	166	168	PF00082	0.470
CLV_PCSK_KEX2_1	190	192	PF00082	0.559
CLV_PCSK_PC7_1	152	158	PF00082	0.467
CLV_PCSK_SKI1_1	173	177	PF00082	0.471
DEG_Nend_Nbox_1	1	3	PF02207	0.572
DOC_USP7_MATH_1	53	57	PF00917	0.717
DOC_USP7_MATH_1	71	75	PF00917	0.510
DOC_USP7_MATH_1	97	101	PF00917	0.559
DOC_WW_Pin1_4	67	72	PF00397	0.708
DOC_WW_Pin1_4	77	82	PF00397	0.590
LIG_14-3-3_CanoR_1	227	235	PF00244	0.559
LIG_14-3-3_CanoR_1	244	254	PF00244	0.472
LIG_14-3-3_CanoR_1	64	70	PF00244	0.603
LIG_FHA_1	253	259	PF00498	0.636
LIG_LIR_Gen_1	248	258	PF02991	0.590
LIG_LIR_Nem_3	248	254	PF02991	0.591
LIG_SH2_CRK	16	20	PF00017	0.601
LIG_SH2_CRK	251	255	PF00017	0.494
LIG_SH2_STAP1	216	220	PF00017	0.562
LIG_SH2_STAT5	216	219	PF00017	0.576
LIG_SH3_1	33	39	PF00018	0.637
LIG_SH3_3	102	108	PF00018	0.675
LIG_SH3_3	33	39	PF00018	0.637
LIG_TRFH_1	9	13	PF08558	0.651
LIG_TYR_ITIM	14	19	PF00017	0.654
LIG_WW_1	30	33	PF00397	0.559
MOD_CK1_1	63	69	PF00069	0.611
MOD_CK1_1	70	76	PF00069	0.612
MOD_CK1_1	77	83	PF00069	0.585
MOD_CK1_1	85	91	PF00069	0.591
MOD_CK2_1	198	204	PF00069	0.626
MOD_CK2_1	41	47	PF00069	0.618
MOD_GlcNHglycan	123	126	PF01048	0.692
MOD_GlcNHglycan	43	46	PF01048	0.675
MOD_GlcNHglycan	53	56	PF01048	0.627
MOD_GlcNHglycan	65	68	PF01048	0.569
MOD_GlcNHglycan	76	79	PF01048	0.566
MOD_GlcNHglycan	99	102	PF01048	0.621
MOD_GSK3_1	169	176	PF00069	0.505
MOD_GSK3_1	226	233	PF00069	0.548
MOD_GSK3_1	51	58	PF00069	0.668
MOD_GSK3_1	63	70	PF00069	0.626
MOD_GSK3_1	76	83	PF00069	0.649
MOD_N-GLC_1	246	251	PF02516	0.591
MOD_NEK2_1	177	182	PF00069	0.543
MOD_NEK2_1	46	51	PF00069	0.587
MOD_NEK2_1	62	67	PF00069	0.642
MOD_NEK2_1	84	89	PF00069	0.567
MOD_PKA_1	121	127	PF00069	0.642
MOD_PKA_2	121	127	PF00069	0.642
MOD_PKA_2	226	232	PF00069	0.536
MOD_PKA_2	51	57	PF00069	0.625
MOD_PKA_2	63	69	PF00069	0.571
MOD_PKB_1	119	127	PF00069	0.648
MOD_PKB_1	167	175	PF00069	0.453
MOD_Plk_1	173	179	PF00069	0.518
MOD_Plk_1	46	52	PF00069	0.662
MOD_ProDKin_1	67	73	PF00069	0.708
MOD_ProDKin_1	77	83	PF00069	0.592
TRG_DiLeu_BaEn_1	219	224	PF01217	0.494
TRG_ENDOCYTIC_2	16	19	PF00928	0.655
TRG_ENDOCYTIC_2	251	254	PF00928	0.500
TRG_ER_diArg_1	118	121	PF00400	0.657
TRG_ER_diArg_1	190	192	PF00400	0.593
TRG_ER_diArg_1	231	234	PF00400	0.658
TRG_ER_diArg_1	238	241	PF00400	0.515
TRG_NLS_MonoExtN_4	156	161	PF00514	0.403
TRG_Pf-PMV_PEXEL_1	240	245	PF00026	0.510

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NR64	Trypanosomatidae	29%	100%
A4HFW8	Leishmania braziliensis	74%	98%
A4I301	Leishmania infantum	99%	100%
E9ADH3	Leishmania major	93%	100%
E9AZ97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%