Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X0W2_LEIDO

TriTrypDb:

LdBPK_271830.1 , LdCL_270025500 , LDHU3_27.2790

Length:

672

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A0A3S7X0W2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0W2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	516	520	PF00656	0.491
CLV_NRD_NRD_1	170	172	PF00675	0.699
CLV_NRD_NRD_1	265	267	PF00675	0.506
CLV_NRD_NRD_1	336	338	PF00675	0.534
CLV_NRD_NRD_1	366	368	PF00675	0.725
CLV_NRD_NRD_1	389	391	PF00675	0.688
CLV_NRD_NRD_1	428	430	PF00675	0.689
CLV_NRD_NRD_1	437	439	PF00675	0.752
CLV_NRD_NRD_1	482	484	PF00675	0.735
CLV_NRD_NRD_1	525	527	PF00675	0.696
CLV_NRD_NRD_1	571	573	PF00675	0.497
CLV_NRD_NRD_1	601	603	PF00675	0.553
CLV_NRD_NRD_1	613	615	PF00675	0.494
CLV_NRD_NRD_1	631	633	PF00675	0.428
CLV_PCSK_FUR_1	426	430	PF00082	0.740
CLV_PCSK_FUR_1	599	603	PF00082	0.612
CLV_PCSK_FUR_1	611	615	PF00082	0.488
CLV_PCSK_KEX2_1	170	172	PF00082	0.699
CLV_PCSK_KEX2_1	265	267	PF00082	0.506
CLV_PCSK_KEX2_1	336	338	PF00082	0.534
CLV_PCSK_KEX2_1	428	430	PF00082	0.689
CLV_PCSK_KEX2_1	437	439	PF00082	0.752
CLV_PCSK_KEX2_1	482	484	PF00082	0.735
CLV_PCSK_KEX2_1	525	527	PF00082	0.696
CLV_PCSK_KEX2_1	571	573	PF00082	0.497
CLV_PCSK_KEX2_1	601	603	PF00082	0.551
CLV_PCSK_KEX2_1	613	615	PF00082	0.487
CLV_PCSK_KEX2_1	631	633	PF00082	0.428
CLV_PCSK_KEX2_1	91	93	PF00082	0.650
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.650
CLV_PCSK_SKI1_1	315	319	PF00082	0.625
CLV_PCSK_SKI1_1	476	480	PF00082	0.750
CLV_PCSK_SKI1_1	562	566	PF00082	0.454
DEG_APCC_DBOX_1	279	287	PF00400	0.690
DEG_APCC_DBOX_1	389	397	PF00400	0.483
DEG_APCC_DBOX_1	561	569	PF00400	0.518
DEG_MDM2_SWIB_1	566	574	PF02201	0.482
DEG_Nend_UBRbox_3	1	3	PF02207	0.786
DOC_CDC14_PxL_1	329	337	PF14671	0.518
DOC_CYCLIN_yCln2_LP_2	52	58	PF00134	0.752
DOC_MAPK_gen_1	140	149	PF00069	0.673
DOC_MAPK_gen_1	170	180	PF00069	0.395
DOC_MAPK_gen_1	278	285	PF00069	0.697
DOC_MAPK_gen_1	515	523	PF00069	0.434
DOC_MAPK_MEF2A_6	143	151	PF00069	0.627
DOC_MAPK_MEF2A_6	53	62	PF00069	0.732
DOC_MAPK_MEF2A_6	544	553	PF00069	0.427
DOC_MAPK_RevD_3	469	483	PF00069	0.552
DOC_PP1_RVXF_1	560	567	PF00149	0.390
DOC_PP2B_LxvP_1	471	474	PF13499	0.594
DOC_PP4_FxxP_1	184	187	PF00568	0.575
DOC_PP4_FxxP_1	330	333	PF00568	0.518
DOC_USP7_MATH_1	18	22	PF00917	0.812
DOC_USP7_MATH_1	188	192	PF00917	0.515
DOC_USP7_MATH_1	225	229	PF00917	0.520
DOC_USP7_MATH_1	28	32	PF00917	0.715
DOC_USP7_MATH_1	410	414	PF00917	0.564
DOC_USP7_MATH_1	458	462	PF00917	0.588
DOC_USP7_MATH_1	472	476	PF00917	0.480
DOC_USP7_MATH_1	633	637	PF00917	0.808
DOC_WW_Pin1_4	179	184	PF00397	0.577
DOC_WW_Pin1_4	21	26	PF00397	0.764
DOC_WW_Pin1_4	252	257	PF00397	0.592
DOC_WW_Pin1_4	37	42	PF00397	0.702
DOC_WW_Pin1_4	375	380	PF00397	0.526
DOC_WW_Pin1_4	438	443	PF00397	0.570
DOC_WW_Pin1_4	463	468	PF00397	0.613
DOC_WW_Pin1_4	626	631	PF00397	0.845
DOC_WW_Pin1_4	641	646	PF00397	0.658
LIG_14-3-3_CanoR_1	174	179	PF00244	0.542
LIG_14-3-3_CanoR_1	280	286	PF00244	0.692
LIG_14-3-3_CanoR_1	371	376	PF00244	0.533
LIG_14-3-3_CanoR_1	418	422	PF00244	0.563
LIG_14-3-3_CanoR_1	459	467	PF00244	0.572
LIG_14-3-3_CanoR_1	525	534	PF00244	0.388
LIG_14-3-3_CanoR_1	632	641	PF00244	0.840
LIG_Actin_RPEL_3	332	351	PF02755	0.454
LIG_ActinCP_TwfCPI_2	184	193	PF01115	0.580
LIG_APCC_ABBA_1	402	407	PF00400	0.487
LIG_APCC_ABBAyCdc20_2	518	524	PF00400	0.426
LIG_BRCT_BRCA1_1	180	184	PF00533	0.583
LIG_EH1_1	545	553	PF00400	0.427
LIG_eIF4E_1	141	147	PF01652	0.624
LIG_eIF4E_1	546	552	PF01652	0.518
LIG_eIF4E_1	72	78	PF01652	0.518
LIG_EVH1_1	42	46	PF00568	0.796
LIG_FHA_1	1	7	PF00498	0.741
LIG_FHA_1	302	308	PF00498	0.518
LIG_FHA_1	322	328	PF00498	0.199
LIG_FHA_1	384	390	PF00498	0.379
LIG_FHA_1	508	514	PF00498	0.515
LIG_FHA_1	543	549	PF00498	0.427
LIG_FHA_1	646	652	PF00498	0.768
LIG_FHA_1	77	83	PF00498	0.518
LIG_GBD_Chelix_1	117	125	PF00786	0.454
LIG_LIR_Apic_2	181	187	PF02991	0.580
LIG_LIR_Gen_1	116	126	PF02991	0.518
LIG_LIR_Gen_1	355	366	PF02991	0.593
LIG_LIR_Gen_1	420	427	PF02991	0.532
LIG_LIR_Gen_1	545	554	PF02991	0.427
LIG_LIR_Nem_3	116	122	PF02991	0.518
LIG_LIR_Nem_3	261	267	PF02991	0.693
LIG_LIR_Nem_3	338	344	PF02991	0.712
LIG_LIR_Nem_3	355	361	PF02991	0.247
LIG_LIR_Nem_3	420	424	PF02991	0.536
LIG_LIR_Nem_3	494	498	PF02991	0.507
LIG_LIR_Nem_3	500	504	PF02991	0.399
LIG_LIR_Nem_3	541	546	PF02991	0.474
LIG_PDZ_Class_1	667	672	PF00595	0.758
LIG_Pex14_2	566	570	PF04695	0.472
LIG_PTB_Apo_2	124	131	PF02174	0.518
LIG_REV1ctd_RIR_1	520	530	PF16727	0.493
LIG_RPA_C_Fungi	608	620	PF08784	0.671
LIG_SH2_CRK	358	362	PF00017	0.518
LIG_SH2_CRK	546	550	PF00017	0.518
LIG_SH2_PTP2	67	70	PF00017	0.502
LIG_SH2_PTP2	72	75	PF00017	0.454
LIG_SH2_SRC	394	397	PF00017	0.607
LIG_SH2_STAP1	134	138	PF00017	0.560
LIG_SH2_STAP1	358	362	PF00017	0.518
LIG_SH2_STAP1	381	385	PF00017	0.588
LIG_SH2_STAP1	394	398	PF00017	0.426
LIG_SH2_STAP1	546	550	PF00017	0.518
LIG_SH2_STAT3	603	606	PF00017	0.714
LIG_SH2_STAT5	163	166	PF00017	0.518
LIG_SH2_STAT5	301	304	PF00017	0.518
LIG_SH2_STAT5	329	332	PF00017	0.518
LIG_SH2_STAT5	385	388	PF00017	0.530
LIG_SH2_STAT5	491	494	PF00017	0.608
LIG_SH2_STAT5	501	504	PF00017	0.415
LIG_SH2_STAT5	658	661	PF00017	0.584
LIG_SH2_STAT5	67	70	PF00017	0.502
LIG_SH2_STAT5	72	75	PF00017	0.454
LIG_SH3_3	109	115	PF00018	0.622
LIG_SH3_3	184	190	PF00018	0.708
LIG_SH3_3	216	222	PF00018	0.738
LIG_SH3_3	226	232	PF00018	0.539
LIG_SH3_3	250	256	PF00018	0.518
LIG_SH3_3	3	9	PF00018	0.692
LIG_SH3_3	38	44	PF00018	0.595
LIG_SH3_3	627	633	PF00018	0.759
LIG_SUMO_SIM_anti_2	81	86	PF11976	0.511
LIG_SUMO_SIM_par_1	315	321	PF11976	0.518
LIG_SUMO_SIM_par_1	350	355	PF11976	0.515
LIG_SUMO_SIM_par_1	54	59	PF11976	0.686
LIG_SUMO_SIM_par_1	552	559	PF11976	0.518
LIG_SUMO_SIM_par_1	74	79	PF11976	0.199
LIG_SUMO_SIM_par_1	83	89	PF11976	0.374
LIG_TRAF2_1	514	517	PF00917	0.677
LIG_TRAF2_1	604	607	PF00917	0.727
LIG_TRFH_1	329	333	PF08558	0.518
LIG_TYR_ITIM	327	332	PF00017	0.518
LIG_TYR_ITIM	419	424	PF00017	0.673
LIG_TYR_ITIM	70	75	PF00017	0.518
LIG_UBA3_1	56	65	PF00899	0.571
LIG_Vh1_VBS_1	62	80	PF01044	0.454
LIG_WRC_WIRS_1	259	264	PF05994	0.605
LIG_WRC_WIRS_1	322	327	PF05994	0.518
LIG_WRC_WIRS_1	87	92	PF05994	0.567
LIG_WW_2	43	46	PF00397	0.752
MOD_CDC14_SPxK_1	629	632	PF00782	0.824
MOD_CDK_SPK_2	626	631	PF00069	0.824
MOD_CDK_SPxK_1	626	632	PF00069	0.824
MOD_CDK_SPxxK_3	179	186	PF00069	0.670
MOD_CK1_1	182	188	PF00069	0.679
MOD_CK1_1	199	205	PF00069	0.652
MOD_CK1_1	21	27	PF00069	0.680
MOD_CK1_1	240	246	PF00069	0.441
MOD_CK1_1	252	258	PF00069	0.471
MOD_CK1_1	374	380	PF00069	0.559
MOD_CK1_1	462	468	PF00069	0.744
MOD_CK1_1	93	99	PF00069	0.578
MOD_CK2_1	208	214	PF00069	0.700
MOD_CK2_1	93	99	PF00069	0.578
MOD_CMANNOS	570	573	PF00535	0.618
MOD_GlcNHglycan	20	23	PF01048	0.810
MOD_GlcNHglycan	205	208	PF01048	0.701
MOD_GlcNHglycan	210	213	PF01048	0.635
MOD_GlcNHglycan	29	33	PF01048	0.683
MOD_GlcNHglycan	354	357	PF01048	0.518
MOD_GlcNHglycan	37	40	PF01048	0.537
MOD_GlcNHglycan	395	399	PF01048	0.557
MOD_GlcNHglycan	407	411	PF01048	0.488
MOD_GlcNHglycan	461	464	PF01048	0.720
MOD_GlcNHglycan	476	479	PF01048	0.500
MOD_GlcNHglycan	558	561	PF01048	0.518
MOD_GlcNHglycan	641	644	PF01048	0.803
MOD_GSK3_1	17	24	PF00069	0.771
MOD_GSK3_1	174	181	PF00069	0.686
MOD_GSK3_1	199	206	PF00069	0.762
MOD_GSK3_1	237	244	PF00069	0.511
MOD_GSK3_1	281	288	PF00069	0.600
MOD_GSK3_1	371	378	PF00069	0.565
MOD_GSK3_1	379	386	PF00069	0.419
MOD_GSK3_1	406	413	PF00069	0.685
MOD_GSK3_1	458	465	PF00069	0.745
MOD_GSK3_1	487	494	PF00069	0.574
MOD_GSK3_1	620	627	PF00069	0.770
MOD_GSK3_1	633	640	PF00069	0.649
MOD_GSK3_1	641	648	PF00069	0.666
MOD_GSK3_1	664	671	PF00069	0.746
MOD_GSK3_1	86	93	PF00069	0.636
MOD_N-GLC_1	485	490	PF02516	0.673
MOD_N-GLC_1	507	512	PF02516	0.616
MOD_NEK2_1	117	122	PF00069	0.518
MOD_NEK2_1	173	178	PF00069	0.540
MOD_NEK2_1	234	239	PF00069	0.518
MOD_NEK2_1	249	254	PF00069	0.279
MOD_NEK2_1	307	312	PF00069	0.605
MOD_NEK2_1	318	323	PF00069	0.343
MOD_NEK2_1	335	340	PF00069	0.386
MOD_NEK2_1	417	422	PF00069	0.671
MOD_NEK2_1	555	560	PF00069	0.518
MOD_NEK2_1	78	83	PF00069	0.514
MOD_NEK2_1	90	95	PF00069	0.470
MOD_NEK2_2	301	306	PF00069	0.518
MOD_NEK2_2	507	512	PF00069	0.616
MOD_NEK2_2	86	91	PF00069	0.495
MOD_PIKK_1	452	458	PF00454	0.662
MOD_PIKK_1	624	630	PF00454	0.815
MOD_PIKK_1	645	651	PF00454	0.782
MOD_PK_1	174	180	PF00069	0.559
MOD_PK_1	371	377	PF00069	0.670
MOD_PKA_2	173	179	PF00069	0.673
MOD_PKA_2	196	202	PF00069	0.761
MOD_PKA_2	281	287	PF00069	0.604
MOD_PKA_2	335	341	PF00069	0.654
MOD_PKA_2	417	423	PF00069	0.671
MOD_PKA_2	458	464	PF00069	0.723
MOD_PKA_2	93	99	PF00069	0.515
MOD_Plk_1	406	412	PF00069	0.556
MOD_Plk_1	507	513	PF00069	0.625
MOD_Plk_1	637	643	PF00069	0.748
MOD_Plk_4	174	180	PF00069	0.559
MOD_Plk_4	199	205	PF00069	0.760
MOD_Plk_4	225	231	PF00069	0.642
MOD_Plk_4	243	249	PF00069	0.269
MOD_Plk_4	281	287	PF00069	0.604
MOD_Plk_4	301	307	PF00069	0.199
MOD_Plk_4	400	406	PF00069	0.430
MOD_Plk_4	487	493	PF00069	0.628
MOD_Plk_4	78	84	PF00069	0.518
MOD_ProDKin_1	179	185	PF00069	0.730
MOD_ProDKin_1	21	27	PF00069	0.706
MOD_ProDKin_1	252	258	PF00069	0.586
MOD_ProDKin_1	37	43	PF00069	0.619
MOD_ProDKin_1	375	381	PF00069	0.658
MOD_ProDKin_1	438	444	PF00069	0.718
MOD_ProDKin_1	463	469	PF00069	0.777
MOD_ProDKin_1	626	632	PF00069	0.824
MOD_ProDKin_1	641	647	PF00069	0.558
TRG_DiLeu_BaEn_1	142	147	PF01217	0.506
TRG_DiLeu_BaLyEn_6	340	345	PF01217	0.632
TRG_DiLeu_BaLyEn_6	52	57	PF01217	0.694
TRG_ENDOCYTIC_2	163	166	PF00928	0.518
TRG_ENDOCYTIC_2	259	262	PF00928	0.592
TRG_ENDOCYTIC_2	329	332	PF00928	0.518
TRG_ENDOCYTIC_2	358	361	PF00928	0.518
TRG_ENDOCYTIC_2	421	424	PF00928	0.643
TRG_ENDOCYTIC_2	501	504	PF00928	0.574
TRG_ENDOCYTIC_2	546	549	PF00928	0.518
TRG_ENDOCYTIC_2	67	70	PF00928	0.518
TRG_ENDOCYTIC_2	72	75	PF00928	0.438
TRG_ER_diArg_1	264	266	PF00400	0.623
TRG_ER_diArg_1	279	282	PF00400	0.376
TRG_ER_diArg_1	335	337	PF00400	0.655
TRG_ER_diArg_1	426	429	PF00400	0.704
TRG_ER_diArg_1	436	438	PF00400	0.661
TRG_ER_diArg_1	481	483	PF00400	0.663
TRG_ER_diArg_1	525	527	PF00400	0.614
TRG_ER_diArg_1	570	572	PF00400	0.618
TRG_ER_diArg_1	599	602	PF00400	0.665
TRG_ER_diArg_1	611	614	PF00400	0.600
TRG_ER_diArg_1	630	632	PF00400	0.506
TRG_ER_diArg_1	92	95	PF00400	0.597
TRG_NES_CRM1_1	281	293	PF08389	0.583
TRG_NES_CRM1_1	59	71	PF08389	0.526
TRG_Pf-PMV_PEXEL_1	391	395	PF00026	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4I2Z9	Leishmania infantum	99%	100%
E9ADH1	Leishmania major	90%	100%
E9AZ95	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	99%