Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X0V6_LEIDO

TriTrypDb:

LdBPK_271800.1 , LdCL_270025200 , LDHU3_27.2760

Length:

1181

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X0V6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0V6

PDB structure(s): 7ane_ab

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1017	1021	PF00656	0.530
CLV_C14_Caspase3-7	202	206	PF00656	0.598
CLV_C14_Caspase3-7	333	337	PF00656	0.586
CLV_C14_Caspase3-7	832	836	PF00656	0.422
CLV_C14_Caspase3-7	853	857	PF00656	0.433
CLV_NRD_NRD_1	1030	1032	PF00675	0.448
CLV_NRD_NRD_1	331	333	PF00675	0.613
CLV_NRD_NRD_1	341	343	PF00675	0.488
CLV_NRD_NRD_1	362	364	PF00675	0.626
CLV_NRD_NRD_1	386	388	PF00675	0.475
CLV_NRD_NRD_1	399	401	PF00675	0.363
CLV_NRD_NRD_1	418	420	PF00675	0.453
CLV_NRD_NRD_1	511	513	PF00675	0.382
CLV_NRD_NRD_1	534	536	PF00675	0.414
CLV_NRD_NRD_1	690	692	PF00675	0.414
CLV_NRD_NRD_1	868	870	PF00675	0.461
CLV_NRD_NRD_1	930	932	PF00675	0.427
CLV_NRD_NRD_1	944	946	PF00675	0.453
CLV_NRD_NRD_1	95	97	PF00675	0.509
CLV_NRD_NRD_1	952	954	PF00675	0.455
CLV_PCSK_FUR_1	688	692	PF00082	0.486
CLV_PCSK_FUR_1	865	869	PF00082	0.416
CLV_PCSK_KEX2_1	1030	1032	PF00082	0.449
CLV_PCSK_KEX2_1	330	332	PF00082	0.631
CLV_PCSK_KEX2_1	362	364	PF00082	0.503
CLV_PCSK_KEX2_1	386	388	PF00082	0.591
CLV_PCSK_KEX2_1	399	401	PF00082	0.343
CLV_PCSK_KEX2_1	418	420	PF00082	0.453
CLV_PCSK_KEX2_1	511	513	PF00082	0.389
CLV_PCSK_KEX2_1	534	536	PF00082	0.413
CLV_PCSK_KEX2_1	690	692	PF00082	0.419
CLV_PCSK_KEX2_1	776	778	PF00082	0.484
CLV_PCSK_KEX2_1	867	869	PF00082	0.437
CLV_PCSK_KEX2_1	930	932	PF00082	0.433
CLV_PCSK_KEX2_1	944	946	PF00082	0.466
CLV_PCSK_KEX2_1	95	97	PF00082	0.508
CLV_PCSK_KEX2_1	952	954	PF00082	0.445
CLV_PCSK_PC1ET2_1	776	778	PF00082	0.559
CLV_PCSK_SKI1_1	1003	1007	PF00082	0.439
CLV_PCSK_SKI1_1	1097	1101	PF00082	0.450
CLV_PCSK_SKI1_1	1160	1164	PF00082	0.496
CLV_PCSK_SKI1_1	140	144	PF00082	0.615
CLV_PCSK_SKI1_1	363	367	PF00082	0.536
CLV_PCSK_SKI1_1	387	391	PF00082	0.576
CLV_PCSK_SKI1_1	535	539	PF00082	0.495
CLV_PCSK_SKI1_1	620	624	PF00082	0.391
CLV_PCSK_SKI1_1	633	637	PF00082	0.414
CLV_PCSK_SKI1_1	777	781	PF00082	0.577
CLV_PCSK_SKI1_1	905	909	PF00082	0.389
DEG_APCC_DBOX_1	1096	1104	PF00400	0.535
DEG_APCC_DBOX_1	510	518	PF00400	0.454
DEG_APCC_DBOX_1	534	542	PF00400	0.405
DEG_SPOP_SBC_1	12	16	PF00917	0.716
DEG_SPOP_SBC_1	178	182	PF00917	0.603
DOC_CYCLIN_RxL_1	531	540	PF00134	0.524
DOC_CYCLIN_RxL_1	616	625	PF00134	0.424
DOC_CYCLIN_yCln2_LP_2	36	42	PF00134	0.568
DOC_CYCLIN_yCln2_LP_2	804	810	PF00134	0.539
DOC_MAPK_DCC_7	776	784	PF00069	0.462
DOC_MAPK_gen_1	776	784	PF00069	0.456
DOC_MAPK_MEF2A_6	777	786	PF00069	0.440
DOC_PP1_RVXF_1	618	625	PF00149	0.512
DOC_PP2B_LxvP_1	804	807	PF13499	0.533
DOC_PP4_FxxP_1	1130	1133	PF00568	0.489
DOC_PP4_FxxP_1	770	773	PF00568	0.577
DOC_PP4_FxxP_1	899	902	PF00568	0.425
DOC_USP7_MATH_1	107	111	PF00917	0.536
DOC_USP7_MATH_1	12	16	PF00917	0.765
DOC_USP7_MATH_1	178	182	PF00917	0.589
DOC_USP7_MATH_1	188	192	PF00917	0.583
DOC_USP7_MATH_1	546	550	PF00917	0.411
DOC_USP7_MATH_1	85	89	PF00917	0.589
DOC_USP7_MATH_1	965	969	PF00917	0.710
DOC_USP7_UBL2_3	1110	1114	PF12436	0.452
DOC_USP7_UBL2_3	1154	1158	PF12436	0.523
DOC_USP7_UBL2_3	728	732	PF12436	0.590
DOC_WW_Pin1_4	1040	1045	PF00397	0.403
DOC_WW_Pin1_4	1104	1109	PF00397	0.462
DOC_WW_Pin1_4	35	40	PF00397	0.603
DOC_WW_Pin1_4	542	547	PF00397	0.408
DOC_WW_Pin1_4	574	579	PF00397	0.362
DOC_WW_Pin1_4	777	782	PF00397	0.573
DOC_WW_Pin1_4	847	852	PF00397	0.426
DOC_WW_Pin1_4	963	968	PF00397	0.707
LIG_14-3-3_CanoR_1	1139	1146	PF00244	0.460
LIG_14-3-3_CanoR_1	114	120	PF00244	0.558
LIG_14-3-3_CanoR_1	330	335	PF00244	0.586
LIG_14-3-3_CanoR_1	362	366	PF00244	0.648
LIG_14-3-3_CanoR_1	386	396	PF00244	0.523
LIG_14-3-3_CanoR_1	399	406	PF00244	0.350
LIG_14-3-3_CanoR_1	433	437	PF00244	0.580
LIG_14-3-3_CanoR_1	754	764	PF00244	0.704
LIG_14-3-3_CanoR_1	905	910	PF00244	0.467
LIG_14-3-3_CanoR_1	998	1005	PF00244	0.476
LIG_ActinCP_TwfCPI_2	1130	1139	PF01115	0.489
LIG_APCC_ABBA_1	465	470	PF00400	0.488
LIG_APCC_ABBA_1	477	482	PF00400	0.464
LIG_BIR_II_1	1	5	PF00653	0.622
LIG_BRCT_BRCA1_1	104	108	PF00533	0.533
LIG_BRCT_BRCA1_1	1069	1073	PF00533	0.471
LIG_Clathr_ClatBox_1	621	625	PF01394	0.432
LIG_deltaCOP1_diTrp_1	1009	1014	PF00928	0.494
LIG_deltaCOP1_diTrp_1	497	501	PF00928	0.369
LIG_eIF4E_1	617	623	PF01652	0.418
LIG_FHA_1	1000	1006	PF00498	0.443
LIG_FHA_1	1062	1068	PF00498	0.592
LIG_FHA_1	1154	1160	PF00498	0.570
LIG_FHA_1	241	247	PF00498	0.552
LIG_FHA_1	288	294	PF00498	0.543
LIG_FHA_1	318	324	PF00498	0.481
LIG_FHA_1	531	537	PF00498	0.367
LIG_FHA_1	634	640	PF00498	0.515
LIG_FHA_1	717	723	PF00498	0.487
LIG_FHA_1	793	799	PF00498	0.487
LIG_FHA_2	1004	1010	PF00498	0.459
LIG_FHA_2	1041	1047	PF00498	0.406
LIG_FHA_2	1115	1121	PF00498	0.468
LIG_FHA_2	306	312	PF00498	0.538
LIG_FHA_2	367	373	PF00498	0.518
LIG_FHA_2	386	392	PF00498	0.318
LIG_FHA_2	525	531	PF00498	0.438
LIG_FHA_2	543	549	PF00498	0.512
LIG_FHA_2	577	583	PF00498	0.399
LIG_FHA_2	737	743	PF00498	0.596
LIG_FHA_2	851	857	PF00498	0.436
LIG_FHA_2	936	942	PF00498	0.444
LIG_LIR_Apic_2	435	441	PF02991	0.547
LIG_LIR_Apic_2	463	467	PF02991	0.414
LIG_LIR_Apic_2	50	55	PF02991	0.445
LIG_LIR_Apic_2	768	773	PF02991	0.530
LIG_LIR_Gen_1	1009	1019	PF02991	0.483
LIG_LIR_Gen_1	1043	1053	PF02991	0.457
LIG_LIR_Gen_1	484	493	PF02991	0.399
LIG_LIR_Gen_1	497	506	PF02991	0.346
LIG_LIR_Nem_3	1009	1014	PF02991	0.468
LIG_LIR_Nem_3	1043	1048	PF02991	0.427
LIG_LIR_Nem_3	1070	1075	PF02991	0.485
LIG_LIR_Nem_3	1117	1121	PF02991	0.541
LIG_LIR_Nem_3	463	468	PF02991	0.413
LIG_LIR_Nem_3	484	489	PF02991	0.451
LIG_LIR_Nem_3	497	501	PF02991	0.283
LIG_LIR_Nem_3	681	686	PF02991	0.552
LIG_LIR_Nem_3	697	702	PF02991	0.557
LIG_LIR_Nem_3	768	772	PF02991	0.477
LIG_LIR_Nem_3	796	802	PF02991	0.479
LIG_LYPXL_yS_3	76	79	PF13949	0.575
LIG_MAD2	890	898	PF02301	0.543
LIG_MLH1_MIPbox_1	1069	1073	PF16413	0.471
LIG_PCNA_yPIPBox_3	443	457	PF02747	0.416
LIG_PDZ_Class_2	1176	1181	PF00595	0.473
LIG_Pex14_1	569	573	PF04695	0.379
LIG_Pex14_1	631	635	PF04695	0.513
LIG_Pex14_1	928	932	PF04695	0.417
LIG_Pex14_2	627	631	PF04695	0.489
LIG_SH2_CRK	438	442	PF00017	0.539
LIG_SH2_CRK	650	654	PF00017	0.518
LIG_SH2_CRK	707	711	PF00017	0.580
LIG_SH2_CRK	895	899	PF00017	0.513
LIG_SH2_GRB2like	1092	1095	PF00017	0.581
LIG_SH2_GRB2like	617	620	PF00017	0.339
LIG_SH2_NCK_1	192	196	PF00017	0.611
LIG_SH2_NCK_1	650	654	PF00017	0.588
LIG_SH2_NCK_1	89	93	PF00017	0.459
LIG_SH2_NCK_1	946	950	PF00017	0.529
LIG_SH2_PTP2	573	576	PF00017	0.477
LIG_SH2_PTP2	954	957	PF00017	0.461
LIG_SH2_SRC	912	915	PF00017	0.478
LIG_SH2_SRC	954	957	PF00017	0.445
LIG_SH2_STAP1	1092	1096	PF00017	0.550
LIG_SH2_STAP1	211	215	PF00017	0.620
LIG_SH2_STAP1	89	93	PF00017	0.504
LIG_SH2_STAT3	1033	1036	PF00017	0.538
LIG_SH2_STAT3	59	62	PF00017	0.444
LIG_SH2_STAT3	671	674	PF00017	0.518
LIG_SH2_STAT3	894	897	PF00017	0.426
LIG_SH2_STAT5	1033	1036	PF00017	0.453
LIG_SH2_STAT5	1038	1041	PF00017	0.403
LIG_SH2_STAT5	1042	1045	PF00017	0.398
LIG_SH2_STAT5	1071	1074	PF00017	0.467
LIG_SH2_STAT5	1088	1091	PF00017	0.408
LIG_SH2_STAT5	192	195	PF00017	0.667
LIG_SH2_STAT5	397	400	PF00017	0.480
LIG_SH2_STAT5	464	467	PF00017	0.405
LIG_SH2_STAT5	573	576	PF00017	0.441
LIG_SH2_STAT5	659	662	PF00017	0.552
LIG_SH2_STAT5	671	674	PF00017	0.276
LIG_SH2_STAT5	692	695	PF00017	0.583
LIG_SH2_STAT5	769	772	PF00017	0.551
LIG_SH2_STAT5	830	833	PF00017	0.375
LIG_SH2_STAT5	954	957	PF00017	0.445
LIG_SH3_2	860	865	PF14604	0.537
LIG_SH3_3	18	24	PF00018	0.536
LIG_SH3_3	269	275	PF00018	0.620
LIG_SH3_3	36	42	PF00018	0.580
LIG_SH3_3	5	11	PF00018	0.731
LIG_SH3_3	857	863	PF00018	0.477
LIG_SH3_3	954	960	PF00018	0.462
LIG_SUMO_SIM_anti_2	513	518	PF11976	0.530
LIG_SUMO_SIM_par_1	1023	1028	PF11976	0.431
LIG_SUMO_SIM_par_1	721	726	PF11976	0.515
LIG_TRAF2_1	278	281	PF00917	0.539
LIG_TRAF2_1	309	312	PF00917	0.574
LIG_TRAF2_1	843	846	PF00917	0.509
LIG_TRAF2_2	247	252	PF00917	0.463
LIG_WRPW_2	465	468	PF00400	0.442
MOD_CDK_SPxK_1	1104	1110	PF00069	0.477
MOD_CK1_1	181	187	PF00069	0.706
MOD_CK1_1	3	9	PF00069	0.799
MOD_CK1_1	401	407	PF00069	0.384
MOD_CK1_1	748	754	PF00069	0.790
MOD_CK1_1	757	763	PF00069	0.519
MOD_CK1_1	775	781	PF00069	0.571
MOD_CK1_1	788	794	PF00069	0.546
MOD_CK1_1	850	856	PF00069	0.437
MOD_CK1_1	966	972	PF00069	0.719
MOD_CK2_1	1040	1046	PF00069	0.420
MOD_CK2_1	1114	1120	PF00069	0.465
MOD_CK2_1	119	125	PF00069	0.559
MOD_CK2_1	196	202	PF00069	0.603
MOD_CK2_1	274	280	PF00069	0.522
MOD_CK2_1	305	311	PF00069	0.565
MOD_CK2_1	366	372	PF00069	0.507
MOD_CK2_1	442	448	PF00069	0.442
MOD_CK2_1	524	530	PF00069	0.438
MOD_CK2_1	576	582	PF00069	0.378
MOD_CK2_1	736	742	PF00069	0.588
MOD_Cter_Amidation	688	691	PF01082	0.513
MOD_GlcNHglycan	1140	1143	PF01048	0.586
MOD_GlcNHglycan	140	143	PF01048	0.611
MOD_GlcNHglycan	157	160	PF01048	0.387
MOD_GlcNHglycan	184	187	PF01048	0.663
MOD_GlcNHglycan	198	201	PF01048	0.623
MOD_GlcNHglycan	3	6	PF01048	0.801
MOD_GlcNHglycan	381	384	PF01048	0.401
MOD_GlcNHglycan	725	728	PF01048	0.506
MOD_GlcNHglycan	731	735	PF01048	0.603
MOD_GlcNHglycan	787	790	PF01048	0.496
MOD_GlcNHglycan	799	802	PF01048	0.420
MOD_GlcNHglycan	808	811	PF01048	0.506
MOD_GlcNHglycan	81	84	PF01048	0.697
MOD_GSK3_1	102	109	PF00069	0.591
MOD_GSK3_1	1067	1074	PF00069	0.454
MOD_GSK3_1	1149	1156	PF00069	0.457
MOD_GSK3_1	155	162	PF00069	0.532
MOD_GSK3_1	177	184	PF00069	0.608
MOD_GSK3_1	23	30	PF00069	0.520
MOD_GSK3_1	428	435	PF00069	0.510
MOD_GSK3_1	542	549	PF00069	0.389
MOD_GSK3_1	576	583	PF00069	0.547
MOD_GSK3_1	745	752	PF00069	0.790
MOD_GSK3_1	753	760	PF00069	0.613
MOD_GSK3_1	788	795	PF00069	0.572
MOD_GSK3_1	81	88	PF00069	0.655
MOD_GSK3_1	963	970	PF00069	0.675
MOD_GSK3_1	999	1006	PF00069	0.450
MOD_LATS_1	328	334	PF00433	0.644
MOD_N-GLC_1	1075	1080	PF02516	0.546
MOD_N-GLC_1	145	150	PF02516	0.515
MOD_N-GLC_1	306	311	PF02516	0.594
MOD_N-GLC_1	524	529	PF02516	0.461
MOD_NEK2_1	1	6	PF00069	0.729
MOD_NEK2_1	1014	1019	PF00069	0.479
MOD_NEK2_1	1025	1030	PF00069	0.415
MOD_NEK2_1	1075	1080	PF00069	0.546
MOD_NEK2_1	155	160	PF00069	0.546
MOD_NEK2_1	240	245	PF00069	0.541
MOD_NEK2_1	449	454	PF00069	0.531
MOD_NEK2_1	547	552	PF00069	0.483
MOD_NEK2_1	723	728	PF00069	0.500
MOD_NEK2_1	730	735	PF00069	0.526
MOD_NEK2_1	79	84	PF00069	0.680
MOD_PIKK_1	107	113	PF00454	0.513
MOD_PIKK_1	127	133	PF00454	0.486
MOD_PIKK_1	830	836	PF00454	0.381
MOD_PK_1	1023	1029	PF00069	0.434
MOD_PKA_1	330	336	PF00069	0.649
MOD_PKA_1	366	372	PF00069	0.507
MOD_PKA_1	399	405	PF00069	0.528
MOD_PKA_2	113	119	PF00069	0.526
MOD_PKA_2	1138	1144	PF00069	0.471
MOD_PKA_2	125	131	PF00069	0.494
MOD_PKA_2	155	161	PF00069	0.593
MOD_PKA_2	241	247	PF00069	0.515
MOD_PKA_2	330	336	PF00069	0.517
MOD_PKA_2	361	367	PF00069	0.655
MOD_PKA_2	385	391	PF00069	0.498
MOD_PKA_2	398	404	PF00069	0.454
MOD_PKA_2	432	438	PF00069	0.521
MOD_PKA_2	530	536	PF00069	0.516
MOD_PKA_2	753	759	PF00069	0.614
MOD_PKA_2	988	994	PF00069	0.569
MOD_PKA_2	999	1005	PF00069	0.444
MOD_Plk_1	1075	1081	PF00069	0.547
MOD_Plk_1	145	151	PF00069	0.510
MOD_Plk_1	935	941	PF00069	0.461
MOD_Plk_4	1067	1073	PF00069	0.475
MOD_Plk_4	576	582	PF00069	0.374
MOD_Plk_4	757	763	PF00069	0.612
MOD_Plk_4	765	771	PF00069	0.516
MOD_ProDKin_1	1040	1046	PF00069	0.404
MOD_ProDKin_1	1104	1110	PF00069	0.461
MOD_ProDKin_1	35	41	PF00069	0.603
MOD_ProDKin_1	542	548	PF00069	0.410
MOD_ProDKin_1	574	580	PF00069	0.362
MOD_ProDKin_1	777	783	PF00069	0.576
MOD_ProDKin_1	847	853	PF00069	0.431
MOD_ProDKin_1	963	969	PF00069	0.719
MOD_SUMO_rev_2	1147	1156	PF00179	0.505
MOD_SUMO_rev_2	158	166	PF00179	0.598
MOD_SUMO_rev_2	233	240	PF00179	0.574
MOD_SUMO_rev_2	310	315	PF00179	0.636
MOD_SUMO_rev_2	556	561	PF00179	0.537
TRG_DiLeu_BaEn_1	484	489	PF01217	0.389
TRG_DiLeu_BaLyEn_6	370	375	PF01217	0.558
TRG_DiLeu_BaLyEn_6	617	622	PF01217	0.431
TRG_ENDOCYTIC_2	1118	1121	PF00928	0.463
TRG_ENDOCYTIC_2	480	483	PF00928	0.379
TRG_ENDOCYTIC_2	699	702	PF00928	0.423
TRG_ENDOCYTIC_2	76	79	PF00928	0.575
TRG_ENDOCYTIC_2	769	772	PF00928	0.516
TRG_ENDOCYTIC_2	954	957	PF00928	0.468
TRG_ER_diArg_1	330	332	PF00400	0.641
TRG_ER_diArg_1	385	387	PF00400	0.592
TRG_ER_diArg_1	398	400	PF00400	0.501
TRG_ER_diArg_1	534	536	PF00400	0.470
TRG_ER_diArg_1	688	691	PF00400	0.433
TRG_ER_diArg_1	864	867	PF00400	0.403
TRG_ER_diArg_1	868	870	PF00400	0.456
TRG_ER_diArg_1	888	891	PF00400	0.521
TRG_ER_diArg_1	930	932	PF00400	0.433
TRG_ER_diArg_1	944	946	PF00400	0.466
TRG_ER_diArg_1	951	953	PF00400	0.430
TRG_NLS_Bipartite_1	330	346	PF00514	0.640
TRG_Pf-PMV_PEXEL_1	118	123	PF00026	0.633
TRG_Pf-PMV_PEXEL_1	387	391	PF00026	0.537
TRG_Pf-PMV_PEXEL_1	534	539	PF00026	0.495
TRG_Pf-PMV_PEXEL_1	620	625	PF00026	0.432
TRG_Pf-PMV_PEXEL_1	691	695	PF00026	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3K9	Leptomonas seymouri	75%	94%
A0A0S4JLH0	Bodo saltans	46%	100%
A0A1X0NRH4	Trypanosomatidae	59%	99%
A0A422NJT2	Trypanosoma rangeli	60%	100%
A4HFW4	Leishmania braziliensis	89%	100%
A4I2Z6	Leishmania infantum	100%	100%
C9ZJE4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9ADG8	Leishmania major	95%	100%
E9AZ92	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5BN80	Trypanosoma cruzi	60%	100%