Paraflagellar rod protein 5, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

paraflagellar rod protein 5, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X0V5_LEIDO

TriTrypDb:

LdBPK_271750.1 , LdCL_270024700 , LDHU3_27.2700

Length:

779

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 8
Forrest at al. (procyclic)	no	yes: 8
Silverman et al.	no	yes: 2
Pissara et al.	no	yes: 26

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 8

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 30
NetGPI	no	yes: 0, no: 30

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	31
GO:0031514	motile cilium	5	31
GO:0042995	cell projection	2	31
GO:0043226	organelle	2	31
GO:0043227	membrane-bounded organelle	3	31
GO:0110165	cellular anatomical entity	1	31
GO:0120025	plasma membrane bounded cell projection	3	31
GO:0005930	axoneme	2	1
GO:0005737	cytoplasm	2	3
GO:0031974	membrane-enclosed lumen	2	3
GO:0031981	nuclear lumen	5	3
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	3
GO:0043233	organelle lumen	3	3
GO:0070013	intracellular organelle lumen	4	3
GO:0097014	ciliary plasm	5	3
GO:0099568	cytoplasmic region	3	3

Expansion

Sequence features

A0A3S7X0V5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0V5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	31
GO:0005515	protein binding	2	31
GO:0005516	calmodulin binding	3	31

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	379	383	PF00656	0.319
CLV_C14_Caspase3-7	550	554	PF00656	0.418
CLV_NRD_NRD_1	129	131	PF00675	0.435
CLV_NRD_NRD_1	245	247	PF00675	0.440
CLV_NRD_NRD_1	292	294	PF00675	0.268
CLV_NRD_NRD_1	348	350	PF00675	0.350
CLV_NRD_NRD_1	359	361	PF00675	0.345
CLV_NRD_NRD_1	443	445	PF00675	0.270
CLV_NRD_NRD_1	447	449	PF00675	0.268
CLV_NRD_NRD_1	584	586	PF00675	0.582
CLV_NRD_NRD_1	88	90	PF00675	0.577
CLV_NRD_NRD_1	92	94	PF00675	0.619
CLV_PCSK_FUR_1	10	14	PF00082	0.462
CLV_PCSK_FUR_1	243	247	PF00082	0.466
CLV_PCSK_KEX2_1	12	14	PF00082	0.459
CLV_PCSK_KEX2_1	129	131	PF00082	0.420
CLV_PCSK_KEX2_1	211	213	PF00082	0.420
CLV_PCSK_KEX2_1	243	245	PF00082	0.525
CLV_PCSK_KEX2_1	294	296	PF00082	0.326
CLV_PCSK_KEX2_1	348	350	PF00082	0.342
CLV_PCSK_KEX2_1	359	361	PF00082	0.347
CLV_PCSK_KEX2_1	429	431	PF00082	0.283
CLV_PCSK_KEX2_1	447	449	PF00082	0.392
CLV_PCSK_KEX2_1	584	586	PF00082	0.533
CLV_PCSK_KEX2_1	88	90	PF00082	0.461
CLV_PCSK_KEX2_1	92	94	PF00082	0.503
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.459
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.505
CLV_PCSK_PC1ET2_1	294	296	PF00082	0.326
CLV_PCSK_PC1ET2_1	429	431	PF00082	0.268
CLV_PCSK_PC7_1	239	245	PF00082	0.437
CLV_PCSK_PC7_1	355	361	PF00082	0.395
CLV_PCSK_PC7_1	580	586	PF00082	0.542
CLV_PCSK_PC7_1	88	94	PF00082	0.596
CLV_PCSK_SKI1_1	167	171	PF00082	0.448
CLV_PCSK_SKI1_1	222	226	PF00082	0.404
CLV_PCSK_SKI1_1	255	259	PF00082	0.323
CLV_PCSK_SKI1_1	320	324	PF00082	0.402
CLV_PCSK_SKI1_1	447	451	PF00082	0.393
CLV_PCSK_SKI1_1	463	467	PF00082	0.222
CLV_PCSK_SKI1_1	483	487	PF00082	0.163
CLV_PCSK_SKI1_1	507	511	PF00082	0.384
CLV_PCSK_SKI1_1	68	72	PF00082	0.648
CLV_Separin_Metazoa	418	422	PF03568	0.252
CLV_Separin_Metazoa	494	498	PF03568	0.217
DEG_APCC_DBOX_1	759	767	PF00400	0.252
DEG_SPOP_SBC_1	678	682	PF00917	0.708
DOC_CKS1_1	123	128	PF01111	0.516
DOC_MAPK_gen_1	726	735	PF00069	0.235
DOC_MAPK_gen_1	88	97	PF00069	0.616
DOC_PP1_RVXF_1	138	145	PF00149	0.421
DOC_PP1_RVXF_1	512	519	PF00149	0.268
DOC_PP2B_PxIxI_1	525	531	PF00149	0.201
DOC_PP4_FxxP_1	123	126	PF00568	0.460
DOC_USP7_MATH_1	24	28	PF00917	0.410
DOC_USP7_MATH_1	3	7	PF00917	0.659
DOC_USP7_MATH_1	671	675	PF00917	0.620
DOC_USP7_MATH_1	701	705	PF00917	0.757
DOC_WW_Pin1_4	122	127	PF00397	0.472
DOC_WW_Pin1_4	181	186	PF00397	0.388
DOC_WW_Pin1_4	507	512	PF00397	0.384
DOC_WW_Pin1_4	626	631	PF00397	0.713
DOC_WW_Pin1_4	667	672	PF00397	0.521
LIG_14-3-3_CanoR_1	222	231	PF00244	0.399
LIG_14-3-3_CanoR_1	239	247	PF00244	0.461
LIG_14-3-3_CanoR_1	320	325	PF00244	0.442
LIG_14-3-3_CanoR_1	33	39	PF00244	0.429
LIG_14-3-3_CanoR_1	430	436	PF00244	0.286
LIG_14-3-3_CanoR_1	457	462	PF00244	0.310
LIG_14-3-3_CanoR_1	537	542	PF00244	0.252
LIG_APCC_ABBA_1	322	327	PF00400	0.290
LIG_BRCT_BRCA1_1	119	123	PF00533	0.602
LIG_BRCT_BRCA1_1	140	144	PF00533	0.488
LIG_BRCT_BRCA1_1	27	31	PF00533	0.403
LIG_BRCT_BRCA1_1	302	306	PF00533	0.219
LIG_BRCT_BRCA1_1	514	518	PF00533	0.252
LIG_FHA_1	151	157	PF00498	0.518
LIG_FHA_1	164	170	PF00498	0.430
LIG_FHA_1	2	8	PF00498	0.603
LIG_FHA_1	256	262	PF00498	0.318
LIG_FHA_1	508	514	PF00498	0.384
LIG_FHA_1	560	566	PF00498	0.615
LIG_FHA_1	621	627	PF00498	0.621
LIG_FHA_1	679	685	PF00498	0.519
LIG_FHA_2	177	183	PF00498	0.454
LIG_FHA_2	538	544	PF00498	0.315
LIG_FHA_2	710	716	PF00498	0.697
LIG_Integrin_RGD_1	569	571	PF01839	0.374
LIG_LIR_Apic_2	120	126	PF02991	0.584
LIG_LIR_Gen_1	215	224	PF02991	0.415
LIG_LIR_Gen_1	316	325	PF02991	0.350
LIG_LIR_Gen_1	536	544	PF02991	0.384
LIG_LIR_Gen_1	717	727	PF02991	0.386
LIG_LIR_Nem_3	215	220	PF02991	0.394
LIG_LIR_Nem_3	225	231	PF02991	0.439
LIG_LIR_Nem_3	316	321	PF02991	0.328
LIG_LIR_Nem_3	323	328	PF02991	0.320
LIG_LIR_Nem_3	515	521	PF02991	0.252
LIG_LIR_Nem_3	543	547	PF02991	0.271
LIG_LIR_Nem_3	717	722	PF02991	0.511
LIG_LIR_Nem_3	750	756	PF02991	0.268
LIG_LYPXL_yS_3	228	231	PF13949	0.389
LIG_PCNA_yPIPBox_3	408	420	PF02747	0.268
LIG_Pex14_1	318	322	PF04695	0.252
LIG_Pex14_2	31	35	PF04695	0.442
LIG_Pex14_2	719	723	PF04695	0.384
LIG_PTB_Apo_2	316	323	PF02174	0.252
LIG_SH2_CRK	544	548	PF00017	0.204
LIG_SH2_PTP2	523	526	PF00017	0.252
LIG_SH2_SRC	217	220	PF00017	0.424
LIG_SH2_SRC	235	238	PF00017	0.381
LIG_SH2_SRC	477	480	PF00017	0.290
LIG_SH2_SRC	523	526	PF00017	0.252
LIG_SH2_STAP1	217	221	PF00017	0.323
LIG_SH2_STAT3	409	412	PF00017	0.268
LIG_SH2_STAT5	15	18	PF00017	0.446
LIG_SH2_STAT5	435	438	PF00017	0.312
LIG_SH2_STAT5	441	444	PF00017	0.309
LIG_SH2_STAT5	477	480	PF00017	0.426
LIG_SH2_STAT5	523	526	PF00017	0.252
LIG_SH2_STAT5	768	771	PF00017	0.268
LIG_SH3_3	140	146	PF00018	0.541
LIG_SH3_3	61	67	PF00018	0.617
LIG_SH3_3	704	710	PF00018	0.691
LIG_SH3_3	773	779	PF00018	0.468
LIG_Sin3_3	699	706	PF02671	0.487
LIG_SUMO_SIM_par_1	2	9	PF11976	0.432
LIG_TRAF2_1	179	182	PF00917	0.511
LIG_TRAF2_1	270	273	PF00917	0.287
LIG_TRAF2_1	747	750	PF00917	0.253
LIG_TRAF2_1	775	778	PF00917	0.603
LIG_TYR_ITIM	542	547	PF00017	0.204
LIG_ULM_U2AF65_1	243	248	PF00076	0.450
LIG_WRC_WIRS_1	32	37	PF05994	0.536
MOD_CDK_SPK_2	122	127	PF00069	0.472
MOD_CDK_SPxxK_3	122	129	PF00069	0.462
MOD_CDK_SPxxK_3	507	514	PF00069	0.384
MOD_CK1_1	122	128	PF00069	0.543
MOD_CK1_1	238	244	PF00069	0.447
MOD_CK1_1	536	542	PF00069	0.372
MOD_CK1_1	554	560	PF00069	0.648
MOD_CK1_1	600	606	PF00069	0.692
MOD_CK1_1	657	663	PF00069	0.727
MOD_CK1_1	665	671	PF00069	0.806
MOD_CK1_1	687	693	PF00069	0.578
MOD_CK2_1	176	182	PF00069	0.468
MOD_CK2_1	3	9	PF00069	0.632
MOD_CK2_1	358	364	PF00069	0.309
MOD_CK2_1	709	715	PF00069	0.567
MOD_CK2_1	768	774	PF00069	0.368
MOD_Cter_Amidation	357	360	PF01082	0.252
MOD_DYRK1A_RPxSP_1	507	511	PF00069	0.384
MOD_GlcNHglycan	360	363	PF01048	0.252
MOD_GlcNHglycan	553	556	PF01048	0.669
MOD_GlcNHglycan	609	612	PF01048	0.647
MOD_GlcNHglycan	647	650	PF01048	0.731
MOD_GlcNHglycan	651	654	PF01048	0.682
MOD_GlcNHglycan	664	667	PF01048	0.516
MOD_GlcNHglycan	694	697	PF01048	0.711
MOD_GlcNHglycan	703	706	PF01048	0.638
MOD_GSK3_1	111	118	PF00069	0.494
MOD_GSK3_1	330	337	PF00069	0.424
MOD_GSK3_1	358	365	PF00069	0.290
MOD_GSK3_1	533	540	PF00069	0.322
MOD_GSK3_1	543	550	PF00069	0.239
MOD_GSK3_1	571	578	PF00069	0.545
MOD_GSK3_1	603	610	PF00069	0.578
MOD_GSK3_1	616	623	PF00069	0.641
MOD_GSK3_1	645	652	PF00069	0.642
MOD_GSK3_1	653	660	PF00069	0.567
MOD_GSK3_1	667	674	PF00069	0.562
MOD_GSK3_1	687	694	PF00069	0.529
MOD_LATS_1	427	433	PF00433	0.235
MOD_N-GLC_1	533	538	PF02516	0.314
MOD_N-GLC_1	654	659	PF02516	0.673
MOD_N-GLC_1	687	692	PF02516	0.641
MOD_NEK2_1	1	6	PF00069	0.637
MOD_NEK2_1	111	116	PF00069	0.448
MOD_NEK2_1	194	199	PF00069	0.398
MOD_NEK2_1	31	36	PF00069	0.475
MOD_NEK2_1	39	44	PF00069	0.424
MOD_NEK2_1	390	395	PF00069	0.346
MOD_NEK2_1	533	538	PF00069	0.384
MOD_NEK2_1	598	603	PF00069	0.743
MOD_NEK2_1	625	630	PF00069	0.529
MOD_NEK2_1	71	76	PF00069	0.493
MOD_NEK2_1	714	719	PF00069	0.413
MOD_NEK2_2	171	176	PF00069	0.349
MOD_NEK2_2	3	8	PF00069	0.505
MOD_NEK2_2	768	773	PF00069	0.351
MOD_PIKK_1	41	47	PF00454	0.536
MOD_PIKK_1	571	577	PF00454	0.508
MOD_PK_1	313	319	PF00069	0.280
MOD_PKA_1	429	435	PF00069	0.237
MOD_PKA_2	238	244	PF00069	0.448
MOD_PKA_2	358	364	PF00069	0.252
MOD_PKA_2	429	435	PF00069	0.252
MOD_PKA_2	536	542	PF00069	0.318
MOD_PKA_2	559	565	PF00069	0.497
MOD_PKA_2	603	609	PF00069	0.818
MOD_Plk_1	171	177	PF00069	0.502
MOD_Plk_1	194	200	PF00069	0.370
MOD_Plk_1	255	261	PF00069	0.293
MOD_Plk_1	39	45	PF00069	0.461
MOD_Plk_1	533	539	PF00069	0.461
MOD_Plk_1	654	660	PF00069	0.771
MOD_Plk_1	731	737	PF00069	0.252
MOD_Plk_2-3	731	737	PF00069	0.252
MOD_Plk_4	119	125	PF00069	0.554
MOD_Plk_4	138	144	PF00069	0.484
MOD_Plk_4	171	177	PF00069	0.508
MOD_Plk_4	3	9	PF00069	0.464
MOD_Plk_4	313	319	PF00069	0.280
MOD_Plk_4	34	40	PF00069	0.578
MOD_Plk_4	362	368	PF00069	0.315
MOD_Plk_4	537	543	PF00069	0.252
MOD_Plk_4	554	560	PF00069	0.424
MOD_Plk_4	621	627	PF00069	0.475
MOD_Plk_4	687	693	PF00069	0.734
MOD_ProDKin_1	122	128	PF00069	0.466
MOD_ProDKin_1	181	187	PF00069	0.379
MOD_ProDKin_1	507	513	PF00069	0.384
MOD_ProDKin_1	626	632	PF00069	0.708
MOD_ProDKin_1	667	673	PF00069	0.521
MOD_SUMO_rev_2	133	142	PF00179	0.418
MOD_SUMO_rev_2	17	22	PF00179	0.451
MOD_SUMO_rev_2	596	601	PF00179	0.456
TRG_DiLeu_BaEn_1	145	150	PF01217	0.451
TRG_DiLeu_BaEn_1	418	423	PF01217	0.259
TRG_DiLeu_BaEn_2	301	307	PF01217	0.384
TRG_DiLeu_BaEn_4	17	23	PF01217	0.561
TRG_DiLeu_BaLyEn_6	219	224	PF01217	0.504
TRG_ENDOCYTIC_2	217	220	PF00928	0.323
TRG_ENDOCYTIC_2	228	231	PF00928	0.435
TRG_ENDOCYTIC_2	544	547	PF00928	0.290
TRG_ER_diArg_1	129	131	PF00400	0.438
TRG_ER_diArg_1	243	246	PF00400	0.448
TRG_ER_diArg_1	293	296	PF00400	0.268
TRG_ER_diArg_1	348	350	PF00400	0.340
TRG_ER_diArg_1	447	449	PF00400	0.261
TRG_ER_diArg_1	496	499	PF00400	0.245
TRG_ER_diArg_1	725	728	PF00400	0.361
TRG_ER_diArg_1	88	90	PF00400	0.577
TRG_ER_diArg_1	91	93	PF00400	0.599
TRG_NES_CRM1_1	389	403	PF08389	0.209
TRG_Pf-PMV_PEXEL_1	130	134	PF00026	0.404
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.436
TRG_Pf-PMV_PEXEL_1	348	353	PF00026	0.318
TRG_Pf-PMV_PEXEL_1	447	451	PF00026	0.322
TRG_Pf-PMV_PEXEL_1	527	531	PF00026	0.268

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5J5	Leptomonas seymouri	73%	98%
A0A0N1IFZ5	Leptomonas seymouri	25%	100%
A0A0S4IZY8	Bodo saltans	24%	100%
A0A0S4JS20	Bodo saltans	25%	100%
A0A1X0NR57	Trypanosomatidae	56%	99%
A0A1X0NYU4	Trypanosomatidae	25%	100%
A0A381MH18	Leishmania infantum	24%	100%
A0A381MN58	Leishmania infantum	24%	100%
A0A3Q8IAP5	Leishmania donovani	24%	100%
A0A3Q8IEH2	Leishmania donovani	24%	100%
A0A3R7KDB9	Trypanosoma rangeli	25%	100%
A0A3S7X2K1	Leishmania donovani	24%	100%
A0A422NJR9	Trypanosoma rangeli	57%	100%
A4H8S1	Leishmania braziliensis	24%	100%
A4HFV9	Leishmania braziliensis	85%	100%
A4HIY0	Leishmania braziliensis	25%	100%
A4I2Z1	Leishmania infantum	100%	100%
C9ZJD8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
C9ZVV0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9ADG3	Leishmania major	95%	100%
E9AE36	Leishmania major	24%	100%
E9AE37	Leishmania major	24%	100%
E9AHJ2	Leishmania infantum	24%	100%
E9ALP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9ALP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AQV6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AZ87	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
P22225	Trypanosoma brucei brucei	24%	100%
Q4QEM2	Leishmania major	24%	100%
V5BIN9	Trypanosoma cruzi	58%	100%