Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X0V2_LEIDO

TriTrypDb:

LdBPK_271780.1 , LdCL_270025000 , LDHU3_27.2740

Length:

532

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3S7X0V2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0V2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.696
CLV_NRD_NRD_1	134	136	PF00675	0.543
CLV_NRD_NRD_1	191	193	PF00675	0.563
CLV_NRD_NRD_1	292	294	PF00675	0.635
CLV_NRD_NRD_1	320	322	PF00675	0.504
CLV_NRD_NRD_1	464	466	PF00675	0.647
CLV_NRD_NRD_1	68	70	PF00675	0.538
CLV_PCSK_KEX2_1	134	136	PF00082	0.538
CLV_PCSK_KEX2_1	191	193	PF00082	0.460
CLV_PCSK_KEX2_1	292	294	PF00082	0.635
CLV_PCSK_KEX2_1	320	322	PF00082	0.504
CLV_PCSK_KEX2_1	411	413	PF00082	0.478
CLV_PCSK_KEX2_1	524	526	PF00082	0.537
CLV_PCSK_KEX2_1	85	87	PF00082	0.601
CLV_PCSK_PC1ET2_1	411	413	PF00082	0.495
CLV_PCSK_PC1ET2_1	524	526	PF00082	0.537
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.571
CLV_PCSK_PC7_1	130	136	PF00082	0.419
CLV_PCSK_SKI1_1	266	270	PF00082	0.384
CLV_PCSK_SKI1_1	320	324	PF00082	0.609
CLV_PCSK_SKI1_1	346	350	PF00082	0.362
CLV_PCSK_SKI1_1	353	357	PF00082	0.328
CLV_PCSK_SKI1_1	371	375	PF00082	0.286
CLV_PCSK_SKI1_1	389	393	PF00082	0.594
CLV_PCSK_SKI1_1	400	404	PF00082	0.522
CLV_PCSK_SKI1_1	424	428	PF00082	0.624
CLV_PCSK_SKI1_1	442	446	PF00082	0.484
CLV_PCSK_SKI1_1	69	73	PF00082	0.457
DEG_APCC_DBOX_1	319	327	PF00400	0.518
DEG_APCC_DBOX_1	441	449	PF00400	0.549
DOC_CKS1_1	210	215	PF01111	0.414
DOC_CYCLIN_RxL_1	397	406	PF00134	0.481
DOC_CYCLIN_yCln2_LP_2	202	208	PF00134	0.388
DOC_CYCLIN_yCln2_LP_2	31	37	PF00134	0.435
DOC_CYCLIN_yCln2_LP_2	374	380	PF00134	0.533
DOC_CYCLIN_yCln2_LP_2	472	478	PF00134	0.656
DOC_MAPK_DCC_7	99	107	PF00069	0.569
DOC_MAPK_gen_1	85	93	PF00069	0.368
DOC_MAPK_MEF2A_6	353	361	PF00069	0.445
DOC_PP2B_LxvP_1	396	399	PF13499	0.473
DOC_PP2B_LxvP_1	472	475	PF13499	0.648
DOC_PP4_FxxP_1	107	110	PF00568	0.580
DOC_PP4_FxxP_1	140	143	PF00568	0.660
DOC_PP4_FxxP_1	3	6	PF00568	0.585
DOC_USP7_MATH_1	15	19	PF00917	0.488
DOC_USP7_MATH_1	222	226	PF00917	0.593
DOC_USP7_MATH_1	280	284	PF00917	0.584
DOC_USP7_MATH_1	287	291	PF00917	0.547
DOC_USP7_MATH_1	48	52	PF00917	0.498
DOC_USP7_MATH_1	493	497	PF00917	0.753
DOC_USP7_MATH_1	519	523	PF00917	0.579
DOC_WW_Pin1_4	106	111	PF00397	0.567
DOC_WW_Pin1_4	209	214	PF00397	0.630
DOC_WW_Pin1_4	226	231	PF00397	0.518
DOC_WW_Pin1_4	523	528	PF00397	0.533
LIG_14-3-3_CanoR_1	125	132	PF00244	0.635
LIG_14-3-3_CanoR_1	209	213	PF00244	0.450
LIG_14-3-3_CanoR_1	293	303	PF00244	0.627
LIG_14-3-3_CanoR_1	353	358	PF00244	0.424
LIG_14-3-3_CanoR_1	465	472	PF00244	0.581
LIG_Actin_WH2_1	412	430	PF00022	0.531
LIG_BRCT_BRCA1_1	12	16	PF00533	0.398
LIG_BRCT_BRCA1_1	180	184	PF00533	0.522
LIG_CtBP_PxDLS_1	179	183	PF00389	0.432
LIG_CtBP_PxDLS_1	95	99	PF00389	0.483
LIG_eIF4E_1	360	366	PF01652	0.367
LIG_FHA_1	198	204	PF00498	0.445
LIG_FHA_1	210	216	PF00498	0.486
LIG_FHA_1	354	360	PF00498	0.437
LIG_FHA_2	465	471	PF00498	0.566
LIG_FHA_2	47	53	PF00498	0.454
LIG_LIR_Apic_2	137	143	PF02991	0.599
LIG_LIR_Apic_2	2	6	PF02991	0.596
LIG_LIR_Apic_2	358	363	PF02991	0.338
LIG_LIR_Apic_2	375	381	PF02991	0.426
LIG_LIR_Gen_1	117	124	PF02991	0.511
LIG_LIR_Nem_3	117	121	PF02991	0.579
LIG_LIR_Nem_3	263	268	PF02991	0.383
LIG_LIR_Nem_3	29	35	PF02991	0.527
LIG_LIR_Nem_3	390	396	PF02991	0.569
LIG_LIR_Nem_3	479	483	PF02991	0.726
LIG_LYPXL_S_1	392	396	PF13949	0.524
LIG_LYPXL_yS_3	393	396	PF13949	0.524
LIG_MYND_1	394	398	PF01753	0.508
LIG_Pex14_2	12	16	PF04695	0.500
LIG_Pex14_2	369	373	PF04695	0.361
LIG_PTB_Apo_2	264	271	PF02174	0.316
LIG_PTB_Apo_2	349	356	PF02174	0.329
LIG_PTB_Phospho_1	264	270	PF10480	0.315
LIG_SH2_CRK	265	269	PF00017	0.312
LIG_SH2_CRK	480	484	PF00017	0.686
LIG_SH2_PTP2	360	363	PF00017	0.336
LIG_SH2_SRC	360	363	PF00017	0.365
LIG_SH2_SRC	507	510	PF00017	0.556
LIG_SH2_STAT5	186	189	PF00017	0.479
LIG_SH2_STAT5	360	363	PF00017	0.336
LIG_SH3_3	173	179	PF00018	0.684
LIG_SH3_3	210	216	PF00018	0.609
LIG_SH3_3	224	230	PF00018	0.526
LIG_SH3_3	305	311	PF00018	0.342
LIG_SH3_3	472	478	PF00018	0.644
LIG_SH3_3	497	503	PF00018	0.643
LIG_SH3_3	89	95	PF00018	0.403
LIG_SH3_3	98	104	PF00018	0.434
LIG_SUMO_SIM_anti_2	36	41	PF11976	0.471
LIG_SUMO_SIM_par_1	33	38	PF11976	0.570
LIG_SUMO_SIM_par_1	89	94	PF11976	0.326
LIG_TRAF2_1	453	456	PF00917	0.651
LIG_WW_3	397	401	PF00397	0.462
MOD_CK1_1	225	231	PF00069	0.553
MOD_CK1_1	281	287	PF00069	0.696
MOD_CK1_1	38	44	PF00069	0.502
MOD_CK2_1	398	404	PF00069	0.595
MOD_CK2_1	46	52	PF00069	0.465
MOD_CK2_1	464	470	PF00069	0.565
MOD_CK2_1	515	521	PF00069	0.641
MOD_Cter_Amidation	318	321	PF01082	0.494
MOD_Cter_Amidation	409	412	PF01082	0.507
MOD_GlcNHglycan	12	15	PF01048	0.553
MOD_GlcNHglycan	262	265	PF01048	0.395
MOD_GlcNHglycan	283	286	PF01048	0.691
MOD_GlcNHglycan	503	506	PF01048	0.796
MOD_GlcNHglycan	517	520	PF01048	0.509
MOD_GlcNHglycan	521	524	PF01048	0.476
MOD_GSK3_1	149	156	PF00069	0.664
MOD_GSK3_1	218	225	PF00069	0.615
MOD_GSK3_1	283	290	PF00069	0.710
MOD_GSK3_1	418	425	PF00069	0.501
MOD_GSK3_1	515	522	PF00069	0.601
MOD_N-GLC_1	351	356	PF02516	0.473
MOD_NEK2_1	148	153	PF00069	0.724
MOD_NEK2_1	184	189	PF00069	0.460
MOD_NEK2_1	218	223	PF00069	0.623
MOD_NEK2_1	291	296	PF00069	0.645
MOD_NEK2_1	351	356	PF00069	0.464
MOD_NEK2_2	287	292	PF00069	0.570
MOD_PIKK_1	23	29	PF00454	0.466
MOD_PIKK_1	294	300	PF00454	0.593
MOD_PIKK_1	418	424	PF00454	0.558
MOD_PKA_1	134	140	PF00069	0.466
MOD_PKA_2	124	130	PF00069	0.622
MOD_PKA_2	134	140	PF00069	0.505
MOD_PKA_2	208	214	PF00069	0.458
MOD_PKA_2	291	297	PF00069	0.643
MOD_PKA_2	339	345	PF00069	0.391
MOD_PKA_2	464	470	PF00069	0.578
MOD_PKA_2	8	14	PF00069	0.540
MOD_Plk_1	198	204	PF00069	0.455
MOD_Plk_1	35	41	PF00069	0.530
MOD_Plk_1	351	357	PF00069	0.460
MOD_Plk_2-3	117	123	PF00069	0.605
MOD_Plk_4	198	204	PF00069	0.447
MOD_Plk_4	35	41	PF00069	0.530
MOD_Plk_4	422	428	PF00069	0.621
MOD_ProDKin_1	106	112	PF00069	0.561
MOD_ProDKin_1	209	215	PF00069	0.627
MOD_ProDKin_1	226	232	PF00069	0.511
MOD_ProDKin_1	523	529	PF00069	0.536
MOD_SUMO_rev_2	342	348	PF00179	0.386
MOD_SUMO_rev_2	462	468	PF00179	0.588
TRG_DiLeu_BaEn_3	455	461	PF01217	0.626
TRG_DiLeu_BaEn_4	440	446	PF01217	0.564
TRG_DiLeu_BaLyEn_6	434	439	PF01217	0.551
TRG_ENDOCYTIC_2	265	268	PF00928	0.315
TRG_ENDOCYTIC_2	270	273	PF00928	0.324
TRG_ENDOCYTIC_2	32	35	PF00928	0.491
TRG_ENDOCYTIC_2	393	396	PF00928	0.524
TRG_ENDOCYTIC_2	480	483	PF00928	0.708
TRG_ER_diArg_1	134	136	PF00400	0.446
TRG_ER_diArg_1	19	22	PF00400	0.364
TRG_ER_diArg_1	291	293	PF00400	0.659
TRG_ER_diArg_1	320	322	PF00400	0.574
TRG_ER_diArg_1	6	9	PF00400	0.584
TRG_NES_CRM1_1	231	246	PF08389	0.377
TRG_Pf-PMV_PEXEL_1	192	196	PF00026	0.459
TRG_Pf-PMV_PEXEL_1	321	325	PF00026	0.418
TRG_Pf-PMV_PEXEL_1	400	404	PF00026	0.545
TRG_Pf-PMV_PEXEL_1	437	441	PF00026	0.603

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5J3	Leptomonas seymouri	65%	88%
A0A1X0NRT0	Trypanosomatidae	40%	100%
A0A422NJS3	Trypanosoma rangeli	36%	100%
A4HFW2	Leishmania braziliensis	82%	99%
A4I2Z4	Leishmania infantum	99%	100%
C9ZJE2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9ADG6	Leishmania major	93%	100%
E9AZ90	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5DEY5	Trypanosoma cruzi	45%	100%