Protein kinase domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

casein kinase I-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7X0V1_LEIDO

TriTrypDb:

LdBPK_271680.1 , LdCL_270023800 , LDHU3_27.2580

Length:

568

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3S7X0V1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0V1

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	13
GO:0006793	phosphorus metabolic process	3	13
GO:0006796	phosphate-containing compound metabolic process	4	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0009987	cellular process	1	13
GO:0016310	phosphorylation	5	13
GO:0019538	protein metabolic process	3	13
GO:0036211	protein modification process	4	13
GO:0043170	macromolecule metabolic process	3	13
GO:0043412	macromolecule modification	4	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0071704	organic substance metabolic process	2	13
GO:1901564	organonitrogen compound metabolic process	3	13
GO:0007165	signal transduction	2	2
GO:0018105	peptidyl-serine phosphorylation	6	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018209	peptidyl-serine modification	6	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0065007	biological regulation	1	2
GO:0006810	transport	3	1
GO:0006897	endocytosis	5	1
GO:0016192	vesicle-mediated transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003824	catalytic activity	1	13
GO:0004672	protein kinase activity	3	13
GO:0005488	binding	1	13
GO:0005524	ATP binding	5	13
GO:0016301	kinase activity	4	13
GO:0016740	transferase activity	2	13
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	13
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	13
GO:0017076	purine nucleotide binding	4	13
GO:0030554	adenyl nucleotide binding	5	13
GO:0032553	ribonucleotide binding	3	13
GO:0032555	purine ribonucleotide binding	4	13
GO:0032559	adenyl ribonucleotide binding	5	13
GO:0035639	purine ribonucleoside triphosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0097159	organic cyclic compound binding	2	13
GO:0097367	carbohydrate derivative binding	2	13
GO:0140096	catalytic activity, acting on a protein	2	13
GO:1901265	nucleoside phosphate binding	3	13
GO:1901363	heterocyclic compound binding	2	13
GO:0004674	protein serine/threonine kinase activity	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	362	366	PF00656	0.431
CLV_C14_Caspase3-7	418	422	PF00656	0.397
CLV_C14_Caspase3-7	494	498	PF00656	0.591
CLV_NRD_NRD_1	191	193	PF00675	0.548
CLV_NRD_NRD_1	302	304	PF00675	0.279
CLV_NRD_NRD_1	335	337	PF00675	0.329
CLV_PCSK_KEX2_1	191	193	PF00082	0.548
CLV_PCSK_KEX2_1	335	337	PF00082	0.329
CLV_PCSK_KEX2_1	369	371	PF00082	0.480
CLV_PCSK_PC1ET2_1	369	371	PF00082	0.480
CLV_PCSK_SKI1_1	392	396	PF00082	0.372
CLV_TASPASE1	495	501	PF01112	0.582
DEG_APCC_DBOX_1	125	133	PF00400	0.355
DOC_CKS1_1	317	322	PF01111	0.348
DOC_MAPK_DCC_7	126	134	PF00069	0.397
DOC_MAPK_MEF2A_6	126	134	PF00069	0.396
DOC_PP4_FxxP_1	548	551	PF00568	0.658
DOC_USP7_MATH_1	146	150	PF00917	0.480
DOC_USP7_MATH_1	435	439	PF00917	0.772
DOC_USP7_MATH_1	450	454	PF00917	0.443
DOC_USP7_MATH_1	47	51	PF00917	0.636
DOC_USP7_MATH_1	68	72	PF00917	0.588
DOC_WW_Pin1_4	316	321	PF00397	0.351
DOC_WW_Pin1_4	534	539	PF00397	0.745
DOC_WW_Pin1_4	546	551	PF00397	0.701
DOC_WW_Pin1_4	558	563	PF00397	0.599
LIG_14-3-3_CanoR_1	105	109	PF00244	0.432
LIG_14-3-3_CanoR_1	138	146	PF00244	0.575
LIG_14-3-3_CanoR_1	244	248	PF00244	0.325
LIG_14-3-3_CanoR_1	321	326	PF00244	0.398
LIG_14-3-3_CanoR_1	360	364	PF00244	0.320
LIG_Actin_WH2_2	347	362	PF00022	0.279
LIG_Actin_WH2_2	407	422	PF00022	0.391
LIG_BIR_III_2	532	536	PF00653	0.607
LIG_BIR_III_4	519	523	PF00653	0.588
LIG_BRCT_BRCA1_1	113	117	PF00533	0.424
LIG_BRCT_BRCA1_1	148	152	PF00533	0.437
LIG_BRCT_BRCA1_1	296	300	PF00533	0.329
LIG_eIF4E_1	344	350	PF01652	0.329
LIG_FHA_1	140	146	PF00498	0.469
LIG_FHA_1	248	254	PF00498	0.370
LIG_FHA_2	105	111	PF00498	0.438
LIG_FHA_2	202	208	PF00498	0.460
LIG_FHA_2	474	480	PF00498	0.615
LIG_Integrin_isoDGR_2	189	191	PF01839	0.517
LIG_IRF3_LxIS_1	355	362	PF10401	0.279
LIG_LIR_Gen_1	246	254	PF02991	0.332
LIG_LIR_Gen_1	319	329	PF02991	0.329
LIG_LIR_Gen_1	406	416	PF02991	0.336
LIG_LIR_Nem_3	114	120	PF02991	0.450
LIG_LIR_Nem_3	246	251	PF02991	0.375
LIG_LIR_Nem_3	319	325	PF02991	0.390
LIG_LIR_Nem_3	389	394	PF02991	0.371
LIG_LIR_Nem_3	406	412	PF02991	0.409
LIG_LYPXL_S_1	26	30	PF13949	0.601
LIG_LYPXL_yS_3	27	30	PF13949	0.600
LIG_MYND_1	24	28	PF01753	0.663
LIG_NRBOX	411	417	PF00104	0.384
LIG_NRP_CendR_1	565	568	PF00754	0.606
LIG_PCNA_yPIPBox_3	213	226	PF02747	0.309
LIG_Pex14_2	102	106	PF04695	0.462
LIG_PTB_Apo_2	310	317	PF02174	0.373
LIG_SH2_CRK	322	326	PF00017	0.329
LIG_SH2_CRK	409	413	PF00017	0.382
LIG_SH2_PTP2	344	347	PF00017	0.309
LIG_SH2_SRC	269	272	PF00017	0.329
LIG_SH2_STAP1	397	401	PF00017	0.444
LIG_SH2_STAT3	216	219	PF00017	0.309
LIG_SH2_STAT3	48	51	PF00017	0.639
LIG_SH2_STAT5	269	272	PF00017	0.337
LIG_SH2_STAT5	290	293	PF00017	0.390
LIG_SH2_STAT5	344	347	PF00017	0.388
LIG_SH2_STAT5	348	351	PF00017	0.380
LIG_SH2_STAT5	451	454	PF00017	0.471
LIG_SH3_3	19	25	PF00018	0.776
LIG_SH3_3	314	320	PF00018	0.287
LIG_SH3_3	41	47	PF00018	0.632
LIG_SH3_3	532	538	PF00018	0.576
LIG_SH3_3	544	550	PF00018	0.591
LIG_SH3_3	80	86	PF00018	0.633
LIG_SUMO_SIM_anti_2	223	229	PF11976	0.400
LIG_SUMO_SIM_par_1	249	255	PF11976	0.276
LIG_TRAF2_1	204	207	PF00917	0.483
LIG_TYR_ITIM	342	347	PF00017	0.283
LIG_UBA3_1	177	184	PF00899	0.440
LIG_WW_1	24	27	PF00397	0.620
MOD_CDK_SPK_2	316	321	PF00069	0.329
MOD_CDK_SPK_2	534	539	PF00069	0.576
MOD_CDK_SPxxK_3	558	565	PF00069	0.626
MOD_CK1_1	324	330	PF00069	0.329
MOD_CK1_1	508	514	PF00069	0.682
MOD_CK2_1	201	207	PF00069	0.471
MOD_CK2_1	419	425	PF00069	0.430
MOD_CK2_1	473	479	PF00069	0.620
MOD_Cter_Amidation	189	192	PF01082	0.521
MOD_GlcNHglycan	113	116	PF01048	0.446
MOD_GlcNHglycan	186	189	PF01048	0.567
MOD_GlcNHglycan	34	37	PF01048	0.654
MOD_GlcNHglycan	356	359	PF01048	0.359
MOD_GlcNHglycan	437	440	PF01048	0.731
MOD_GlcNHglycan	489	492	PF01048	0.622
MOD_GlcNHglycan	526	529	PF01048	0.665
MOD_GSK3_1	243	250	PF00069	0.370
MOD_GSK3_1	312	319	PF00069	0.436
MOD_GSK3_1	32	39	PF00069	0.609
MOD_GSK3_1	415	422	PF00069	0.570
MOD_GSK3_1	483	490	PF00069	0.802
MOD_GSK3_1	504	511	PF00069	0.604
MOD_GSK3_1	524	531	PF00069	0.628
MOD_N-GLC_1	312	317	PF02516	0.398
MOD_N-GLC_1	435	440	PF02516	0.579
MOD_N-GLC_1	528	533	PF02516	0.647
MOD_NEK2_1	1	6	PF00069	0.626
MOD_NEK2_1	226	231	PF00069	0.370
MOD_NEK2_1	247	252	PF00069	0.329
MOD_NEK2_1	294	299	PF00069	0.282
MOD_NEK2_1	329	334	PF00069	0.332
MOD_NEK2_1	415	420	PF00069	0.444
MOD_NEK2_1	504	509	PF00069	0.777
MOD_NEK2_2	243	248	PF00069	0.307
MOD_OFUCOSY	417	423	PF10250	0.373
MOD_PIKK_1	47	53	PF00454	0.811
MOD_PKA_2	104	110	PF00069	0.437
MOD_PKA_2	137	143	PF00069	0.468
MOD_PKA_2	243	249	PF00069	0.329
MOD_PKA_2	359	365	PF00069	0.320
MOD_PKA_2	419	425	PF00069	0.601
MOD_PKA_2	508	514	PF00069	0.649
MOD_Plk_1	146	152	PF00069	0.459
MOD_Plk_1	312	318	PF00069	0.309
MOD_Plk_1	376	382	PF00069	0.368
MOD_Plk_4	146	152	PF00069	0.459
MOD_Plk_4	243	249	PF00069	0.311
MOD_Plk_4	312	318	PF00069	0.376
MOD_Plk_4	97	103	PF00069	0.515
MOD_ProDKin_1	316	322	PF00069	0.351
MOD_ProDKin_1	534	540	PF00069	0.740
MOD_ProDKin_1	546	552	PF00069	0.706
MOD_ProDKin_1	558	564	PF00069	0.599
MOD_SUMO_for_1	134	137	PF00179	0.415
MOD_SUMO_for_1	374	377	PF00179	0.363
MOD_SUMO_rev_2	149	158	PF00179	0.405
TRG_DiLeu_BaEn_1	125	130	PF01217	0.416
TRG_DiLeu_BaEn_1	287	292	PF01217	0.329
TRG_DiLeu_BaLyEn_6	306	311	PF01217	0.347
TRG_ENDOCYTIC_2	27	30	PF00928	0.600
TRG_ENDOCYTIC_2	322	325	PF00928	0.390
TRG_ENDOCYTIC_2	344	347	PF00928	0.283
TRG_ENDOCYTIC_2	409	412	PF00928	0.331
TRG_ER_diArg_1	350	353	PF00400	0.329
TRG_NES_CRM1_1	220	233	PF08389	0.279
TRG_NES_CRM1_1	287	302	PF08389	0.329

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKB0	Leptomonas seymouri	59%	100%
A0A0S4IVY6	Bodo saltans	29%	100%
A0A3Q8ISA0	Leishmania donovani	32%	100%
A4HFV0	Leishmania braziliensis	76%	98%
A4HIT6	Leishmania braziliensis	31%	100%
A4I2Y4	Leishmania infantum	100%	100%
A4I638	Leishmania infantum	32%	100%
E9ADF5	Leishmania major	94%	99%
E9AZ78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9B1C3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
Q4Q6U1	Leishmania major	31%	100%