mRNA export factor MEX67

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mRNA export factor MEX67

Species:

Leishmania donovani

UniProt:

A0A3S7X0T8_LEIDO

TriTrypDb:

LdBPK_271590.1 , LdCL_270023000 , LDHU3_27.2450

Length:

616

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	19
GO:0042995	cell projection	2	19
GO:0043226	organelle	2	19
GO:0043227	membrane-bounded organelle	3	19
GO:0110165	cellular anatomical entity	1	19
GO:0120025	plasma membrane bounded cell projection	3	19
GO:0005634	nucleus	5	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0005643	nuclear pore	3	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A0A3S7X0T8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0T8

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0015931	nucleobase-containing compound transport	5	2
GO:0050657	nucleic acid transport	6	2
GO:0050658	RNA transport	4	2
GO:0051028	mRNA transport	5	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051236	establishment of RNA localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0006405	RNA export from nucleus	5	1
GO:0006406	mRNA export from nucleus	6	1
GO:0006913	nucleocytoplasmic transport	5	1
GO:0009987	cellular process	1	1
GO:0016973	poly(A)+ mRNA export from nucleus	7	1
GO:0046907	intracellular transport	3	1
GO:0051168	nuclear export	6	1
GO:0051169	nuclear transport	4	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	283	287	PF00656	0.527
CLV_MEL_PAP_1	585	591	PF00089	0.431
CLV_NRD_NRD_1	528	530	PF00675	0.451
CLV_NRD_NRD_1	601	603	PF00675	0.428
CLV_PCSK_KEX2_1	441	443	PF00082	0.402
CLV_PCSK_KEX2_1	521	523	PF00082	0.507
CLV_PCSK_KEX2_1	528	530	PF00082	0.464
CLV_PCSK_KEX2_1	601	603	PF00082	0.449
CLV_PCSK_PC1ET2_1	441	443	PF00082	0.496
CLV_PCSK_PC1ET2_1	521	523	PF00082	0.460
CLV_PCSK_SKI1_1	22	26	PF00082	0.539
CLV_PCSK_SKI1_1	259	263	PF00082	0.414
CLV_PCSK_SKI1_1	446	450	PF00082	0.397
CLV_PCSK_SKI1_1	70	74	PF00082	0.419
DEG_SCF_FBW7_1	309	315	PF00400	0.546
DOC_CDC14_PxL_1	275	283	PF14671	0.426
DOC_CKS1_1	17	22	PF01111	0.440
DOC_CKS1_1	309	314	PF01111	0.546
DOC_CKS1_1	496	501	PF01111	0.583
DOC_MAPK_MEF2A_6	531	539	PF00069	0.382
DOC_PP1_RVXF_1	198	204	PF00149	0.567
DOC_PP1_RVXF_1	68	74	PF00149	0.383
DOC_PP2B_LxvP_1	223	226	PF13499	0.539
DOC_PP4_FxxP_1	230	233	PF00568	0.643
DOC_USP7_MATH_1	307	311	PF00917	0.483
DOC_USP7_MATH_1	485	489	PF00917	0.784
DOC_USP7_MATH_1	490	494	PF00917	0.760
DOC_USP7_MATH_1	576	580	PF00917	0.471
DOC_USP7_UBL2_3	200	204	PF12436	0.567
DOC_WW_Pin1_4	123	128	PF00397	0.539
DOC_WW_Pin1_4	16	21	PF00397	0.466
DOC_WW_Pin1_4	308	313	PF00397	0.500
DOC_WW_Pin1_4	380	385	PF00397	0.530
DOC_WW_Pin1_4	495	500	PF00397	0.694
DOC_WW_Pin1_4	512	517	PF00397	0.519
LIG_14-3-3_CanoR_1	159	164	PF00244	0.374
LIG_14-3-3_CanoR_1	335	345	PF00244	0.445
LIG_14-3-3_CanoR_1	358	362	PF00244	0.412
LIG_14-3-3_CanoR_1	40	45	PF00244	0.691
LIG_14-3-3_CanoR_1	446	451	PF00244	0.379
LIG_14-3-3_CanoR_1	588	592	PF00244	0.343
LIG_APCC_ABBA_1	69	74	PF00400	0.508
LIG_BRCT_BRCA1_1	104	108	PF00533	0.388
LIG_CaM_NSCaTE_8	209	216	PF13499	0.347
LIG_deltaCOP1_diTrp_1	224	231	PF00928	0.670
LIG_EH1_1	458	466	PF00400	0.379
LIG_FHA_1	110	116	PF00498	0.369
LIG_FHA_1	297	303	PF00498	0.424
LIG_FHA_1	351	357	PF00498	0.490
LIG_FHA_1	521	527	PF00498	0.549
LIG_FHA_1	59	65	PF00498	0.465
LIG_FHA_1	75	81	PF00498	0.325
LIG_FHA_1	83	89	PF00498	0.444
LIG_FHA_2	167	173	PF00498	0.517
LIG_FHA_2	281	287	PF00498	0.549
LIG_FHA_2	568	574	PF00498	0.498
LIG_FHA_2	92	98	PF00498	0.540
LIG_LIR_Apic_2	14	20	PF02991	0.503
LIG_LIR_Gen_1	297	308	PF02991	0.533
LIG_LIR_Gen_1	606	614	PF02991	0.352
LIG_LIR_Gen_1	94	103	PF02991	0.457
LIG_LIR_Nem_3	224	230	PF02991	0.570
LIG_LIR_Nem_3	297	303	PF02991	0.488
LIG_LIR_Nem_3	606	610	PF02991	0.530
LIG_LIR_Nem_3	94	99	PF02991	0.437
LIG_PCNA_PIPBox_1	65	74	PF02747	0.398
LIG_PCNA_yPIPBox_3	252	265	PF02747	0.551
LIG_PCNA_yPIPBox_3	372	380	PF02747	0.444
LIG_Pex14_1	227	231	PF04695	0.679
LIG_PTB_Apo_2	388	395	PF02174	0.624
LIG_REV1ctd_RIR_1	21	30	PF16727	0.553
LIG_REV1ctd_RIR_1	70	79	PF16727	0.530
LIG_SH2_CRK	17	21	PF00017	0.493
LIG_SH2_CRK	510	514	PF00017	0.639
LIG_SH2_CRK	530	534	PF00017	0.211
LIG_SH2_SRC	36	39	PF00017	0.536
LIG_SH2_STAP1	292	296	PF00017	0.356
LIG_SH2_STAP1	510	514	PF00017	0.639
LIG_SH2_STAP1	565	569	PF00017	0.444
LIG_SH2_STAT5	36	39	PF00017	0.536
LIG_SH2_STAT5	379	382	PF00017	0.485
LIG_SH3_3	122	128	PF00018	0.447
LIG_SH3_3	186	192	PF00018	0.481
LIG_SH3_3	266	272	PF00018	0.501
LIG_SH3_3	306	312	PF00018	0.482
LIG_SH3_3	365	371	PF00018	0.477
LIG_SH3_3	493	499	PF00018	0.764
LIG_SH3_3	529	535	PF00018	0.571
LIG_SUMO_SIM_anti_2	385	390	PF11976	0.571
LIG_SUMO_SIM_anti_2	595	601	PF11976	0.414
LIG_SUMO_SIM_par_1	404	410	PF11976	0.420
LIG_SUMO_SIM_par_1	445	454	PF11976	0.498
LIG_SUMO_SIM_par_1	558	566	PF11976	0.485
LIG_TRAF2_1	148	151	PF00917	0.471
LIG_UBA3_1	346	350	PF00899	0.614
LIG_UBA3_1	68	75	PF00899	0.414
LIG_WRC_WIRS_1	540	545	PF05994	0.385
LIG_WRC_WIRS_1	93	98	PF05994	0.486
MOD_CDK_SPxK_1	16	22	PF00069	0.449
MOD_CDK_SPxK_1	308	314	PF00069	0.490
MOD_CK1_1	301	307	PF00069	0.456
MOD_CK1_1	310	316	PF00069	0.525
MOD_CK1_1	407	413	PF00069	0.465
MOD_CK1_1	515	521	PF00069	0.565
MOD_CK1_1	91	97	PF00069	0.495
MOD_CK2_1	471	477	PF00069	0.507
MOD_CK2_1	494	500	PF00069	0.723
MOD_CK2_1	543	549	PF00069	0.540
MOD_CK2_1	567	573	PF00069	0.488
MOD_GlcNHglycan	255	258	PF01048	0.532
MOD_GlcNHglycan	266	269	PF01048	0.462
MOD_GlcNHglycan	396	399	PF01048	0.635
MOD_GlcNHglycan	423	426	PF01048	0.687
MOD_GlcNHglycan	473	476	PF01048	0.590
MOD_GlcNHglycan	487	490	PF01048	0.700
MOD_GlcNHglycan	606	610	PF01048	0.500
MOD_GSK3_1	123	130	PF00069	0.430
MOD_GSK3_1	294	301	PF00069	0.337
MOD_GSK3_1	308	315	PF00069	0.436
MOD_GSK3_1	40	47	PF00069	0.656
MOD_GSK3_1	442	449	PF00069	0.346
MOD_GSK3_1	480	487	PF00069	0.648
MOD_GSK3_1	490	497	PF00069	0.568
MOD_GSK3_1	539	546	PF00069	0.449
MOD_GSK3_1	7	14	PF00069	0.673
MOD_GSK3_1	88	95	PF00069	0.439
MOD_GSK3_1	97	104	PF00069	0.425
MOD_LATS_1	165	171	PF00433	0.357
MOD_LATS_1	38	44	PF00433	0.639
MOD_N-GLC_1	181	186	PF02516	0.488
MOD_N-GLC_1	294	299	PF02516	0.500
MOD_N-GLC_1	40	45	PF02516	0.658
MOD_N-GLC_1	442	447	PF02516	0.421
MOD_N-GLC_1	58	63	PF02516	0.579
MOD_N-GLC_1	88	93	PF02516	0.427
MOD_NEK2_1	154	159	PF00069	0.415
MOD_NEK2_1	247	252	PF00069	0.664
MOD_NEK2_1	25	30	PF00069	0.602
MOD_NEK2_1	264	269	PF00069	0.430
MOD_NEK2_1	294	299	PF00069	0.423
MOD_NEK2_1	349	354	PF00069	0.508
MOD_NEK2_1	480	485	PF00069	0.594
MOD_NEK2_1	605	610	PF00069	0.352
MOD_NEK2_1	88	93	PF00069	0.447
MOD_NEK2_2	576	581	PF00069	0.484
MOD_NEK2_2	58	63	PF00069	0.518
MOD_OFUCOSY	114	120	PF10250	0.470
MOD_PIKK_1	74	80	PF00454	0.577
MOD_PIKK_1	88	94	PF00454	0.422
MOD_PKA_2	25	31	PF00069	0.553
MOD_PKA_2	336	342	PF00069	0.491
MOD_PKA_2	357	363	PF00069	0.512
MOD_PKA_2	587	593	PF00069	0.385
MOD_Plk_1	294	300	PF00069	0.495
MOD_Plk_1	40	46	PF00069	0.681
MOD_Plk_1	442	448	PF00069	0.419
MOD_Plk_1	605	611	PF00069	0.352
MOD_Plk_1	88	94	PF00069	0.408
MOD_Plk_1	97	103	PF00069	0.422
MOD_Plk_4	127	133	PF00069	0.423
MOD_Plk_4	40	46	PF00069	0.676
MOD_Plk_4	404	410	PF00069	0.493
MOD_Plk_4	429	435	PF00069	0.683
MOD_Plk_4	463	469	PF00069	0.396
MOD_Plk_4	539	545	PF00069	0.512
MOD_Plk_4	567	573	PF00069	0.428
MOD_Plk_4	576	582	PF00069	0.353
MOD_Plk_4	64	70	PF00069	0.425
MOD_ProDKin_1	123	129	PF00069	0.535
MOD_ProDKin_1	16	22	PF00069	0.463
MOD_ProDKin_1	308	314	PF00069	0.504
MOD_ProDKin_1	380	386	PF00069	0.525
MOD_ProDKin_1	495	501	PF00069	0.688
MOD_ProDKin_1	512	518	PF00069	0.523
MOD_SUMO_for_1	363	366	PF00179	0.498
MOD_SUMO_rev_2	135	142	PF00179	0.538
MOD_SUMO_rev_2	195	201	PF00179	0.520
MOD_SUMO_rev_2	385	394	PF00179	0.602
MOD_SUMO_rev_2	515	523	PF00179	0.493
TRG_DiLeu_BaEn_1	595	600	PF01217	0.404
TRG_ENDOCYTIC_2	36	39	PF00928	0.536
TRG_ENDOCYTIC_2	510	513	PF00928	0.636
TRG_ER_diArg_1	334	337	PF00400	0.508
TRG_ER_diArg_1	528	530	PF00400	0.488
TRG_ER_diArg_1	600	602	PF00400	0.456
TRG_NLS_MonoExtC_3	5	11	PF00514	0.556
TRG_NLS_MonoExtN_4	3	10	PF00514	0.679
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8E9	Leptomonas seymouri	69%	98%
A0A0N0P8S6	Leptomonas seymouri	25%	100%
A0A0S4IW66	Bodo saltans	30%	100%
A0A1X0P4A3	Trypanosomatidae	28%	100%
A0A1X0P4L1	Trypanosomatidae	44%	100%
A0A3R7NID6	Trypanosoma rangeli	45%	100%
A0A3S7X0T0	Leishmania donovani	25%	99%
A4HFU4	Leishmania braziliensis	86%	100%
A4I2W0	Leishmania infantum	26%	100%
A4I2W1	Leishmania infantum	100%	100%
D0A641	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D0A644	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9ADE8	Leishmania major	95%	100%
E9AZ71	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AZ72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5B0W6	Trypanosoma cruzi	46%	100%
V5BQG4	Trypanosoma cruzi	27%	100%