Acyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Acyltransferase

Gene product:

diacylglycerol acyltransferase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X0T2_LEIDO

TriTrypDb:

LdBPK_271460.1 , LdCL_270021700 , LDHU3_27.2220

Length:

331

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	4
GO:0016020	membrane	2	5
GO:0031090	organelle membrane	3	4
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A0A3S7X0T2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0T2

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	1
GO:0006638	neutral lipid metabolic process	4	1
GO:0006639	acylglycerol metabolic process	5	1
GO:0006641	triglyceride metabolic process	6	1
GO:0008152	metabolic process	1	1
GO:0008610	lipid biosynthetic process	4	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0019432	triglyceride biosynthetic process	6	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0045017	glycerolipid biosynthetic process	4	1
GO:0046460	neutral lipid biosynthetic process	4	1
GO:0046463	acylglycerol biosynthetic process	5	1
GO:0046486	glycerolipid metabolic process	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0008374	O-acyltransferase activity	5	6
GO:0016740	transferase activity	2	6
GO:0016746	acyltransferase activity	3	6
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	6
GO:0004144	diacylglycerol O-acyltransferase activity	7	1
GO:0016411	acylglycerol O-acyltransferase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	150	152	PF00675	0.254
CLV_NRD_NRD_1	276	278	PF00675	0.234
CLV_NRD_NRD_1	293	295	PF00675	0.234
CLV_NRD_NRD_1	313	315	PF00675	0.432
CLV_NRD_NRD_1	316	318	PF00675	0.446
CLV_PCSK_FUR_1	314	318	PF00082	0.312
CLV_PCSK_KEX2_1	150	152	PF00082	0.254
CLV_PCSK_KEX2_1	158	160	PF00082	0.194
CLV_PCSK_KEX2_1	276	278	PF00082	0.325
CLV_PCSK_KEX2_1	292	294	PF00082	0.234
CLV_PCSK_KEX2_1	315	317	PF00082	0.471
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.214
CLV_PCSK_PC1ET2_1	315	317	PF00082	0.471
CLV_PCSK_SKI1_1	182	186	PF00082	0.254
CLV_PCSK_SKI1_1	287	291	PF00082	0.260
CLV_Separin_Metazoa	172	176	PF03568	0.454
DEG_APCC_DBOX_1	199	207	PF00400	0.454
DEG_APCC_DBOX_1	224	232	PF00400	0.434
DEG_APCC_DBOX_1	249	257	PF00400	0.434
DEG_Nend_Nbox_1	1	3	PF02207	0.382
DOC_CKS1_1	249	254	PF01111	0.434
DOC_CYCLIN_yCln2_LP_2	231	237	PF00134	0.434
DOC_MAPK_DCC_7	200	209	PF00069	0.431
DOC_MAPK_FxFP_2	233	236	PF00069	0.434
DOC_MAPK_gen_1	158	166	PF00069	0.414
DOC_MAPK_gen_1	222	230	PF00069	0.454
DOC_MAPK_HePTP_8	197	209	PF00069	0.454
DOC_MAPK_MEF2A_6	200	209	PF00069	0.431
DOC_MAPK_MEF2A_6	222	230	PF00069	0.454
DOC_MAPK_MEF2A_6	242	249	PF00069	0.354
DOC_MAPK_MEF2A_6	250	257	PF00069	0.398
DOC_MAPK_NFAT4_5	242	250	PF00069	0.434
DOC_PP1_RVXF_1	227	234	PF00149	0.434
DOC_PP1_RVXF_1	45	52	PF00149	0.454
DOC_PP2B_LxvP_1	245	248	PF13499	0.434
DOC_PP2B_LxvP_1	261	264	PF13499	0.366
DOC_PP4_FxxP_1	131	134	PF00568	0.403
DOC_PP4_FxxP_1	233	236	PF00568	0.434
DOC_PP4_FxxP_1	243	246	PF00568	0.394
DOC_PP4_FxxP_1	249	252	PF00568	0.366
DOC_USP7_MATH_1	196	200	PF00917	0.454
DOC_USP7_MATH_1	322	326	PF00917	0.551
DOC_WW_Pin1_4	248	253	PF00397	0.434
LIG_14-3-3_CanoR_1	120	130	PF00244	0.454
LIG_14-3-3_CanoR_1	150	154	PF00244	0.454
LIG_14-3-3_CanoR_1	159	164	PF00244	0.435
LIG_14-3-3_CanoR_1	175	185	PF00244	0.485
LIG_14-3-3_CanoR_1	225	229	PF00244	0.454
LIG_14-3-3_CanoR_1	250	256	PF00244	0.434
LIG_14-3-3_CanoR_1	276	283	PF00244	0.493
LIG_14-3-3_CanoR_1	50	58	PF00244	0.584
LIG_Actin_WH2_2	99	115	PF00022	0.454
LIG_APCC_ABBAyCdc20_2	56	62	PF00400	0.454
LIG_BRCT_BRCA1_1	127	131	PF00533	0.414
LIG_BRCT_BRCA1_1	47	51	PF00533	0.454
LIG_eIF4E_1	299	305	PF01652	0.492
LIG_FHA_1	188	194	PF00498	0.591
LIG_FHA_1	252	258	PF00498	0.434
LIG_LIR_Apic_2	128	134	PF02991	0.414
LIG_LIR_Gen_1	100	111	PF02991	0.454
LIG_LIR_Gen_1	190	198	PF02991	0.454
LIG_LIR_Gen_1	280	291	PF02991	0.453
LIG_LIR_Gen_1	48	59	PF02991	0.454
LIG_LIR_LC3C_4	254	257	PF02991	0.434
LIG_LIR_Nem_3	100	106	PF02991	0.454
LIG_LIR_Nem_3	190	195	PF02991	0.454
LIG_LIR_Nem_3	280	286	PF02991	0.453
LIG_LIR_Nem_3	48	54	PF02991	0.454
LIG_LYPXL_yS_3	299	302	PF13949	0.488
LIG_SH2_GRB2like	66	69	PF00017	0.426
LIG_SH2_STAT5	121	124	PF00017	0.454
LIG_SH2_STAT5	282	285	PF00017	0.470
LIG_SH2_STAT5	32	35	PF00017	0.367
LIG_SH2_STAT5	58	61	PF00017	0.488
LIG_SH2_STAT5	66	69	PF00017	0.385
LIG_SH2_STAT5	87	90	PF00017	0.426
LIG_SH3_3	199	205	PF00018	0.438
LIG_SH3_3	2	8	PF00018	0.501
LIG_SH3_3	233	239	PF00018	0.434
LIG_SH3_3	253	259	PF00018	0.434
LIG_SH3_3	70	76	PF00018	0.571
LIG_SUMO_SIM_anti_2	162	167	PF11976	0.426
LIG_SUMO_SIM_anti_2	251	257	PF11976	0.434
LIG_SUMO_SIM_anti_2	303	309	PF11976	0.502
LIG_SUMO_SIM_par_1	162	167	PF11976	0.454
LIG_SUMO_SIM_par_1	179	187	PF11976	0.369
LIG_SUMO_SIM_par_1	259	265	PF11976	0.434
LIG_SUMO_SIM_par_1	303	309	PF11976	0.502
LIG_TYR_ITIM	30	35	PF00017	0.294
LIG_WRC_WIRS_1	88	93	PF05994	0.454
MOD_CK1_1	149	155	PF00069	0.526
MOD_CK1_1	45	51	PF00069	0.426
MOD_GlcNHglycan	36	39	PF01048	0.313
MOD_GSK3_1	121	128	PF00069	0.538
MOD_GSK3_1	149	156	PF00069	0.474
MOD_GSK3_1	173	180	PF00069	0.430
MOD_GSK3_1	45	52	PF00069	0.454
MOD_NEK2_1	102	107	PF00069	0.552
MOD_NEK2_1	146	151	PF00069	0.456
MOD_NEK2_1	164	169	PF00069	0.426
MOD_NEK2_1	173	178	PF00069	0.451
MOD_NEK2_2	282	287	PF00069	0.434
MOD_NEK2_2	87	92	PF00069	0.454
MOD_PIKK_1	173	179	PF00454	0.435
MOD_PIKK_1	184	190	PF00454	0.421
MOD_PIKK_1	42	48	PF00454	0.454
MOD_PIKK_1	82	88	PF00454	0.454
MOD_PK_1	159	165	PF00069	0.454
MOD_PKA_1	276	282	PF00069	0.434
MOD_PKA_2	149	155	PF00069	0.454
MOD_PKA_2	224	230	PF00069	0.454
MOD_PKA_2	276	282	PF00069	0.434
MOD_PKA_2	49	55	PF00069	0.454
MOD_Plk_1	153	159	PF00069	0.426
MOD_Plk_1	82	88	PF00069	0.454
MOD_Plk_4	125	131	PF00069	0.454
MOD_Plk_4	159	165	PF00069	0.426
MOD_Plk_4	251	257	PF00069	0.441
MOD_ProDKin_1	248	254	PF00069	0.434
TRG_DiLeu_BaEn_1	181	186	PF01217	0.434
TRG_DiLeu_BaLyEn_6	131	136	PF01217	0.454
TRG_DiLeu_BaLyEn_6	202	207	PF01217	0.454
TRG_ENDOCYTIC_2	299	302	PF00928	0.488
TRG_ENDOCYTIC_2	32	35	PF00928	0.326
TRG_ENDOCYTIC_2	66	69	PF00928	0.426
TRG_ER_diArg_1	275	277	PF00400	0.434
TRG_ER_diArg_1	291	294	PF00400	0.434
TRG_ER_diArg_1	314	317	PF00400	0.604
TRG_ER_diLys_1	328	331	PF00400	0.550
TRG_NLS_MonoCore_2	313	318	PF00514	0.550
TRG_NLS_MonoExtN_4	314	319	PF00514	0.553
TRG_Pf-PMV_PEXEL_1	70	74	PF00026	0.254

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IHU0	Bodo saltans	31%	80%
A0A0S4J1B8	Bodo saltans	26%	97%
A0A0S4JRA5	Bodo saltans	41%	100%
A0A0S4JT55	Bodo saltans	24%	72%
A0A3R7NQK7	Trypanosoma rangeli	29%	66%
A1A442	Ricinus communis	28%	97%
A2ADU8	Mus musculus	28%	98%
A2ADU9	Mus musculus	26%	100%
A4I2V0	Leishmania infantum	100%	100%
A6QP72	Bos taurus	28%	98%
C9ZK51	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	68%
E8NHG0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9ADD8	Leishmania major	96%	100%
K7K424	Glycine max	30%	100%
O74850	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	96%
Q08650	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	79%
Q28C88	Xenopus tropicalis	26%	99%
Q2KHS5	Xenopus laevis	26%	99%
Q3KPP4	Xenopus laevis	26%	99%
Q3SYC2	Homo sapiens	27%	99%
Q4V9F0	Danio rerio	30%	92%
Q54GC1	Dictyostelium discoideum	27%	100%
Q58HT5	Homo sapiens	25%	100%
Q5FVP8	Rattus norvegicus	26%	85%
Q5M7F4	Xenopus laevis	25%	99%
Q5M8H5	Xenopus tropicalis	27%	99%
Q6E1M8	Mus musculus	27%	99%
Q6E213	Homo sapiens	27%	99%
Q6P342	Xenopus tropicalis	26%	92%
Q6PAZ3	Xenopus laevis	27%	92%
Q6ZPD8	Homo sapiens	28%	98%
Q70VZ7	Bos taurus	27%	99%
Q70VZ8	Bos taurus	27%	92%
Q75BY0	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	32%	72%
Q80W94	Mus musculus	28%	99%
Q86VF5	Homo sapiens	29%	97%
Q91ZV4	Mus musculus	27%	99%
Q96PD6	Homo sapiens	25%	99%
Q96PD7	Homo sapiens	26%	85%
Q96UY1	Umbelopsis ramanniana	35%	95%
Q96UY2	Umbelopsis ramanniana	28%	93%
Q9ASU1	Arabidopsis thaliana	30%	100%
Q9DCV3	Mus musculus	29%	85%