Nuclear RNA export factor 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X0T0_LEIDO

TriTrypDb:

LdBPK_271580.1 , LdCL_270022900 , LDHU3_27.2420

Length:

537

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	21
GO:0042995	cell projection	2	21
GO:0043226	organelle	2	21
GO:0043227	membrane-bounded organelle	3	21
GO:0110165	cellular anatomical entity	1	21
GO:0120025	plasma membrane bounded cell projection	3	21
GO:0005634	nucleus	5	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0005643	nuclear pore	3	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A0A3S7X0T0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0T0

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	3
GO:0015931	nucleobase-containing compound transport	5	3
GO:0050657	nucleic acid transport	6	3
GO:0050658	RNA transport	4	3
GO:0051028	mRNA transport	5	3
GO:0051179	localization	1	3
GO:0051234	establishment of localization	2	3
GO:0051236	establishment of RNA localization	3	3
GO:0071702	organic substance transport	4	3
GO:0071705	nitrogen compound transport	4	3
GO:0006405	RNA export from nucleus	5	2
GO:0006406	mRNA export from nucleus	6	2
GO:0006913	nucleocytoplasmic transport	5	2
GO:0009987	cellular process	1	2
GO:0016973	poly(A)+ mRNA export from nucleus	7	2
GO:0046907	intracellular transport	3	2
GO:0051168	nuclear export	6	2
GO:0051169	nuclear transport	4	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	482	484	PF00675	0.560
CLV_PCSK_KEX2_1	117	119	PF00082	0.658
CLV_PCSK_KEX2_1	191	193	PF00082	0.529
CLV_PCSK_KEX2_1	481	483	PF00082	0.569
CLV_PCSK_KEX2_1	532	534	PF00082	0.549
CLV_PCSK_PC1ET2_1	117	119	PF00082	0.658
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.578
CLV_PCSK_PC1ET2_1	532	534	PF00082	0.520
CLV_PCSK_SKI1_1	153	157	PF00082	0.516
CLV_PCSK_SKI1_1	169	173	PF00082	0.465
CLV_PCSK_SKI1_1	233	237	PF00082	0.658
CLV_PCSK_SKI1_1	429	433	PF00082	0.466
CLV_PCSK_SKI1_1	532	536	PF00082	0.667
CLV_PCSK_SKI1_1	79	83	PF00082	0.519
CLV_Separin_Metazoa	132	136	PF03568	0.587
DOC_CYCLIN_RxL_1	137	151	PF00134	0.591
DOC_CYCLIN_RxL_1	153	160	PF00134	0.592
DOC_CYCLIN_RxL_1	76	83	PF00134	0.621
DOC_CYCLIN_yClb1_LxF_4	181	187	PF00134	0.584
DOC_CYCLIN_yCln2_LP_2	402	408	PF00134	0.487
DOC_MAPK_DCC_7	215	225	PF00069	0.673
DOC_MAPK_gen_1	135	144	PF00069	0.509
DOC_MAPK_MEF2A_6	218	225	PF00069	0.558
DOC_MAPK_MEF2A_6	363	371	PF00069	0.616
DOC_MAPK_MEF2A_6	507	515	PF00069	0.673
DOC_MAPK_MEF2A_6	79	86	PF00069	0.594
DOC_MAPK_NFAT4_5	79	87	PF00069	0.607
DOC_PP2B_LxvP_1	236	239	PF13499	0.643
DOC_PP2B_LxvP_1	514	517	PF13499	0.647
DOC_USP7_MATH_1	11	15	PF00917	0.604
DOC_USP7_MATH_1	241	245	PF00917	0.658
DOC_USP7_MATH_1	319	323	PF00917	0.703
DOC_USP7_MATH_1	334	338	PF00917	0.677
DOC_USP7_MATH_1	499	503	PF00917	0.618
DOC_USP7_MATH_1	523	527	PF00917	0.665
DOC_USP7_MATH_2	348	354	PF00917	0.475
DOC_WW_Pin1_4	106	111	PF00397	0.590
DOC_WW_Pin1_4	460	465	PF00397	0.602
DOC_WW_Pin1_4	470	475	PF00397	0.662
LIG_14-3-3_CanoR_1	325	333	PF00244	0.599
LIG_14-3-3_CanoR_1	429	434	PF00244	0.452
LIG_Actin_WH2_2	310	327	PF00022	0.540
LIG_APCC_ABBAyCdc20_2	455	461	PF00400	0.723
LIG_BIR_II_1	1	5	PF00653	0.653
LIG_BRCT_BRCA1_1	122	126	PF00533	0.493
LIG_BRCT_BRCA1_1	326	330	PF00533	0.513
LIG_BRCT_BRCA1_1	423	427	PF00533	0.518
LIG_BRCT_BRCA1_1	465	469	PF00533	0.643
LIG_BRCT_BRCA1_1	82	86	PF00533	0.557
LIG_BRCT_BRCA1_1	90	94	PF00533	0.544
LIG_BRCT_BRCA1_2	122	128	PF00533	0.512
LIG_BRCT_BRCA1_2	82	88	PF00533	0.605
LIG_FHA_1	304	310	PF00498	0.570
LIG_FHA_1	428	434	PF00498	0.422
LIG_FHA_1	487	493	PF00498	0.591
LIG_FHA_2	423	429	PF00498	0.538
LIG_FHA_2	498	504	PF00498	0.617
LIG_IRF3_LxIS_1	282	288	PF10401	0.603
LIG_LIR_Gen_1	120	129	PF02991	0.487
LIG_LIR_Gen_1	261	271	PF02991	0.627
LIG_LIR_Gen_1	280	287	PF02991	0.615
LIG_LIR_Gen_1	87	97	PF02991	0.620
LIG_LIR_Nem_3	120	124	PF02991	0.491
LIG_LIR_Nem_3	268	274	PF02991	0.565
LIG_LIR_Nem_3	280	285	PF02991	0.599
LIG_LIR_Nem_3	327	333	PF02991	0.608
LIG_LIR_Nem_3	87	93	PF02991	0.611
LIG_LRP6_Inhibitor_1	147	153	PF00058	0.472
LIG_MLH1_MIPbox_1	423	427	PF16413	0.546
LIG_MYND_1	110	114	PF01753	0.545
LIG_NRBOX	154	160	PF00104	0.504
LIG_NRBOX	195	201	PF00104	0.472
LIG_NRBOX	80	86	PF00104	0.493
LIG_PCNA_PIPBox_1	251	260	PF02747	0.577
LIG_Pex14_2	371	375	PF04695	0.648
LIG_PTB_Apo_2	369	376	PF02174	0.640
LIG_REV1ctd_RIR_1	424	433	PF16727	0.477
LIG_SH2_CRK	121	125	PF00017	0.601
LIG_SH2_CRK	193	197	PF00017	0.583
LIG_SH2_CRK	271	275	PF00017	0.545
LIG_SH2_CRK	90	94	PF00017	0.600
LIG_SH2_NCK_1	121	125	PF00017	0.601
LIG_SH2_NCK_1	271	275	PF00017	0.447
LIG_SH2_NCK_1	90	94	PF00017	0.576
LIG_SH2_SRC	276	279	PF00017	0.443
LIG_SH2_STAP1	212	216	PF00017	0.490
LIG_SH2_STAP1	90	94	PF00017	0.629
LIG_SH2_STAT3	257	260	PF00017	0.623
LIG_SH2_STAT3	278	281	PF00017	0.624
LIG_SH2_STAT5	257	260	PF00017	0.541
LIG_SH2_STAT5	276	279	PF00017	0.550
LIG_SH2_STAT5	401	404	PF00017	0.451
LIG_SH3_3	402	408	PF00018	0.487
LIG_SH3_3	410	416	PF00018	0.462
LIG_SH3_3	461	467	PF00018	0.717
LIG_SUMO_SIM_anti_2	198	203	PF11976	0.535
LIG_SUMO_SIM_par_1	428	434	PF11976	0.557
LIG_TRAF2_1	502	505	PF00917	0.763
LIG_TYR_ITIM	119	124	PF00017	0.598
LIG_UBA3_1	81	88	PF00899	0.493
LIG_WRC_WIRS_1	423	428	PF05994	0.595
MOD_CDK_SPxK_1	470	476	PF00069	0.703
MOD_CK1_1	185	191	PF00069	0.548
MOD_CK1_1	265	271	PF00069	0.582
MOD_CK1_1	280	286	PF00069	0.577
MOD_CK1_1	337	343	PF00069	0.674
MOD_CK1_1	69	75	PF00069	0.660
MOD_CK2_1	472	478	PF00069	0.521
MOD_CK2_1	498	504	PF00069	0.647
MOD_CK2_1	523	529	PF00069	0.611
MOD_Cter_Amidation	5	8	PF01082	0.681
MOD_GlcNHglycan	15	18	PF01048	0.775
MOD_GlcNHglycan	174	177	PF01048	0.491
MOD_GlcNHglycan	187	190	PF01048	0.491
MOD_GlcNHglycan	243	246	PF01048	0.754
MOD_GlcNHglycan	282	285	PF01048	0.577
MOD_GlcNHglycan	300	303	PF01048	0.524
MOD_GlcNHglycan	336	339	PF01048	0.744
MOD_GlcNHglycan	35	38	PF01048	0.887
MOD_GlcNHglycan	63	66	PF01048	0.750
MOD_GlcNHglycan	68	71	PF01048	0.759
MOD_GSK3_1	210	217	PF00069	0.664
MOD_GSK3_1	241	248	PF00069	0.667
MOD_GSK3_1	258	265	PF00069	0.484
MOD_GSK3_1	319	326	PF00069	0.625
MOD_GSK3_1	407	414	PF00069	0.596
MOD_GSK3_1	427	434	PF00069	0.473
MOD_GSK3_1	436	443	PF00069	0.506
MOD_GSK3_1	59	66	PF00069	0.801
MOD_N-GLC_1	101	106	PF02516	0.536
MOD_N-GLC_1	177	182	PF02516	0.654
MOD_N-GLC_1	497	502	PF02516	0.641
MOD_N-GLC_1	59	64	PF02516	0.815
MOD_N-GLC_1	66	71	PF02516	0.760
MOD_N-GLC_2	357	359	PF02516	0.408
MOD_NEK2_1	101	106	PF00069	0.565
MOD_NEK2_1	258	263	PF00069	0.514
MOD_NEK2_1	277	282	PF00069	0.549
MOD_NEK2_1	285	290	PF00069	0.496
MOD_NEK2_1	380	385	PF00069	0.576
MOD_NEK2_1	422	427	PF00069	0.462
MOD_NEK2_1	86	91	PF00069	0.509
MOD_NEK2_2	391	396	PF00069	0.445
MOD_PIKK_1	245	251	PF00454	0.575
MOD_PIKK_1	277	283	PF00454	0.654
MOD_PIKK_1	324	330	PF00454	0.655
MOD_PIKK_1	407	413	PF00454	0.598
MOD_PIKK_1	88	94	PF00454	0.664
MOD_PK_1	177	183	PF00069	0.430
MOD_PKA_2	214	220	PF00069	0.602
MOD_PKA_2	324	330	PF00069	0.580
MOD_Plk_1	148	154	PF00069	0.518
MOD_Plk_1	177	183	PF00069	0.565
MOD_Plk_1	258	264	PF00069	0.608
MOD_Plk_1	361	367	PF00069	0.632
MOD_Plk_1	380	386	PF00069	0.418
MOD_Plk_1	427	433	PF00069	0.496
MOD_Plk_1	86	92	PF00069	0.589
MOD_Plk_4	182	188	PF00069	0.561
MOD_Plk_4	250	256	PF00069	0.579
MOD_Plk_4	258	264	PF00069	0.468
MOD_Plk_4	422	428	PF00069	0.584
MOD_Plk_4	506	512	PF00069	0.629
MOD_Plk_4	80	86	PF00069	0.497
MOD_ProDKin_1	106	112	PF00069	0.583
MOD_ProDKin_1	460	466	PF00069	0.598
MOD_ProDKin_1	470	476	PF00069	0.655
MOD_SUMO_rev_2	501	509	PF00179	0.676
TRG_DiLeu_BaEn_1	96	101	PF01217	0.450
TRG_ENDOCYTIC_2	121	124	PF00928	0.598
TRG_ENDOCYTIC_2	193	196	PF00928	0.495
TRG_ENDOCYTIC_2	271	274	PF00928	0.549
TRG_ENDOCYTIC_2	90	93	PF00928	0.631
TRG_ER_diArg_1	141	144	PF00400	0.603
TRG_ER_diArg_1	480	483	PF00400	0.576
TRG_Pf-PMV_PEXEL_1	128	132	PF00026	0.577
TRG_Pf-PMV_PEXEL_1	143	148	PF00026	0.577
TRG_Pf-PMV_PEXEL_1	331	336	PF00026	0.621

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8E9	Leptomonas seymouri	24%	86%
A0A0N0P8S6	Leptomonas seymouri	75%	100%
A0A0S4IW66	Bodo saltans	28%	100%
A0A1X0P4A3	Trypanosomatidae	45%	100%
A0A1X0P4L1	Trypanosomatidae	26%	92%
A0A3R7NID6	Trypanosoma rangeli	27%	92%
A0A3S7X0T8	Leishmania donovani	25%	87%
A4HFU3	Leishmania braziliensis	87%	100%
A4HFU4	Leishmania braziliensis	26%	100%
A4I2W0	Leishmania infantum	100%	100%
A4I2W1	Leishmania infantum	25%	100%
D0A641	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
D0A644	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9ADE7	Leishmania major	97%	100%
E9ADE8	Leishmania major	25%	100%
E9AZ71	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9AZ72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
V5B0W6	Trypanosoma cruzi	26%	93%
V5BQG4	Trypanosoma cruzi	44%	100%