Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X0S8_LEIDO

TriTrypDb:

LdBPK_271400.1 , LdCL_270020800 , LDHU3_27.2140

Length:

157

Annotations

LeishMANIAdb annotations

No signal peptide, but transit signal possible

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A0A3S7X0S8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0S8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	22	26	PF00656	0.401
CLV_NRD_NRD_1	10	12	PF00675	0.465
CLV_NRD_NRD_1	14	16	PF00675	0.481
CLV_NRD_NRD_1	146	148	PF00675	0.500
CLV_NRD_NRD_1	4	6	PF00675	0.477
CLV_PCSK_KEX2_1	10	12	PF00082	0.451
CLV_PCSK_KEX2_1	14	16	PF00082	0.469
CLV_PCSK_KEX2_1	146	148	PF00082	0.498
CLV_PCSK_KEX2_1	4	6	PF00082	0.462
CLV_PCSK_KEX2_1	86	88	PF00082	0.404
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.422
CLV_PCSK_PC7_1	10	16	PF00082	0.526
DEG_Nend_UBRbox_3	1	3	PF02207	0.690
DOC_CYCLIN_RxL_1	93	104	PF00134	0.681
DOC_USP7_MATH_1	88	92	PF00917	0.668
LIG_14-3-3_CanoR_1	4	9	PF00244	0.639
LIG_deltaCOP1_diTrp_1	122	130	PF00928	0.629
LIG_FHA_1	126	132	PF00498	0.640
LIG_FHA_1	50	56	PF00498	0.437
LIG_Pex14_1	41	45	PF04695	0.462
LIG_Pex14_2	59	63	PF04695	0.405
LIG_Pex14_2	67	71	PF04695	0.314
LIG_SH2_CRK	16	20	PF00017	0.668
LIG_SH2_NCK_1	16	20	PF00017	0.686
LIG_SH2_STAT3	134	137	PF00017	0.713
LIG_SH2_STAT5	134	137	PF00017	0.642
LIG_SH3_3	135	141	PF00018	0.645
LIG_TYR_ITIM	107	112	PF00017	0.608
MOD_Cter_Amidation	84	87	PF01082	0.428
MOD_NEK2_1	130	135	PF00069	0.642
MOD_NEK2_1	71	76	PF00069	0.472
MOD_PIKK_1	50	56	PF00454	0.492
MOD_PKA_1	4	10	PF00069	0.653
MOD_PKA_2	4	10	PF00069	0.638
MOD_Plk_1	24	30	PF00069	0.408
MOD_Plk_1	71	77	PF00069	0.477
MOD_Plk_4	130	136	PF00069	0.639
MOD_Plk_4	4	10	PF00069	0.650
MOD_SUMO_for_1	107	110	PF00179	0.629
MOD_SUMO_rev_2	115	121	PF00179	0.632
TRG_ENDOCYTIC_2	109	112	PF00928	0.611
TRG_ENDOCYTIC_2	16	19	PF00928	0.667
TRG_ENDOCYTIC_2	68	71	PF00928	0.378
TRG_ER_diArg_1	14	16	PF00400	0.735
TRG_ER_diArg_1	145	147	PF00400	0.689
TRG_ER_diArg_1	78	81	PF00400	0.604
TRG_ER_diArg_1	9	11	PF00400	0.723
TRG_Pf-PMV_PEXEL_1	96	101	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5S2	Leptomonas seymouri	88%	100%
A0A0S4JKA8	Bodo saltans	57%	100%
A0A1X0P4E7	Trypanosomatidae	77%	100%
A4HFS6	Leishmania braziliensis	90%	100%
A4I366	Leishmania infantum	100%	100%
D0A618	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	77%	100%
E9ADC9	Leishmania major	99%	100%
E9AZ54	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%