LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

BRO1-like domain/ALIX V-shaped domain binding to HIV, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
BRO1-like domain/ALIX V-shaped domain binding to HIV, putative
Gene product:
BRO1-like domain/ALIX V-shaped domain binding to HIV, putative
Species:
Leishmania donovani
UniProt:
A0A3S7X0S6_LEIDO
TriTrypDb:
LdBPK_271540.1 * , LdCL_270022400 , LDHU3_27.2370
Length:
915

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 9
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005768 endosome 7 1
GO:0031410 cytoplasmic vesicle 6 1
GO:0031982 vesicle 4 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0097708 intracellular vesicle 5 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A0A3S7X0S6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0S6

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 11
GO:0016192 vesicle-mediated transport 4 11
GO:0051179 localization 1 11
GO:0051234 establishment of localization 2 11
GO:0071985 multivesicular body sorting pathway 5 11
GO:0006886 intracellular protein transport 4 1
GO:0007034 vacuolar transport 4 1
GO:0008104 protein localization 4 1
GO:0009987 cellular process 1 1
GO:0015031 protein transport 4 1
GO:0016197 endosomal transport 4 1
GO:0032509 endosome transport via multivesicular body sorting pathway 5 1
GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway 6 1
GO:0033036 macromolecule localization 2 1
GO:0033365 protein localization to organelle 5 1
GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway 5 1
GO:0045184 establishment of protein localization 3 1
GO:0045324 late endosome to vacuole transport 5 1
GO:0046907 intracellular transport 3 1
GO:0051641 cellular localization 2 1
GO:0051649 establishment of localization in cell 3 1
GO:0070727 cellular macromolecule localization 3 1
GO:0071702 organic substance transport 4 1
GO:0071705 nitrogen compound transport 4 1
GO:0072594 establishment of protein localization to organelle 4 1
GO:0072665 protein localization to vacuole 6 1
GO:0072666 establishment of protein localization to vacuole 5 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 298 300 PF00675 0.387
CLV_NRD_NRD_1 414 416 PF00675 0.435
CLV_NRD_NRD_1 506 508 PF00675 0.259
CLV_NRD_NRD_1 779 781 PF00675 0.475
CLV_PCSK_KEX2_1 194 196 PF00082 0.438
CLV_PCSK_KEX2_1 254 256 PF00082 0.229
CLV_PCSK_KEX2_1 506 508 PF00082 0.281
CLV_PCSK_KEX2_1 72 74 PF00082 0.361
CLV_PCSK_KEX2_1 778 780 PF00082 0.473
CLV_PCSK_PC1ET2_1 194 196 PF00082 0.438
CLV_PCSK_PC1ET2_1 254 256 PF00082 0.250
CLV_PCSK_PC1ET2_1 72 74 PF00082 0.365
CLV_PCSK_SKI1_1 107 111 PF00082 0.384
CLV_PCSK_SKI1_1 13 17 PF00082 0.384
CLV_PCSK_SKI1_1 299 303 PF00082 0.450
CLV_PCSK_SKI1_1 736 740 PF00082 0.282
CLV_Separin_Metazoa 446 450 PF03568 0.511
DEG_APCC_DBOX_1 194 202 PF00400 0.316
DEG_SCF_FBW7_2 548 554 PF00400 0.421
DOC_CKS1_1 548 553 PF01111 0.431
DOC_CYCLIN_RxL_1 101 115 PF00134 0.329
DOC_MAPK_gen_1 274 283 PF00069 0.384
DOC_MAPK_gen_1 299 308 PF00069 0.316
DOC_MAPK_gen_1 333 343 PF00069 0.384
DOC_MAPK_gen_1 397 406 PF00069 0.269
DOC_MAPK_MEF2A_6 274 283 PF00069 0.333
DOC_MAPK_NFAT4_5 276 284 PF00069 0.329
DOC_PP1_RVXF_1 105 112 PF00149 0.329
DOC_PP1_RVXF_1 566 572 PF00149 0.416
DOC_PP1_SILK_1 450 455 PF00149 0.438
DOC_USP7_MATH_1 337 341 PF00917 0.301
DOC_USP7_MATH_1 414 418 PF00917 0.395
DOC_USP7_MATH_1 447 451 PF00917 0.569
DOC_USP7_MATH_1 51 55 PF00917 0.384
DOC_USP7_MATH_1 75 79 PF00917 0.294
DOC_USP7_MATH_1 762 766 PF00917 0.472
DOC_USP7_MATH_1 838 842 PF00917 0.622
DOC_USP7_MATH_1 873 877 PF00917 0.525
DOC_USP7_MATH_1 901 905 PF00917 0.606
DOC_USP7_MATH_1 99 103 PF00917 0.413
DOC_USP7_UBL2_3 160 164 PF12436 0.251
DOC_USP7_UBL2_3 190 194 PF12436 0.384
DOC_USP7_UBL2_3 661 665 PF12436 0.550
DOC_WW_Pin1_4 524 529 PF00397 0.521
DOC_WW_Pin1_4 547 552 PF00397 0.481
DOC_WW_Pin1_4 7 12 PF00397 0.470
DOC_WW_Pin1_4 71 76 PF00397 0.378
LIG_14-3-3_CanoR_1 310 319 PF00244 0.385
LIG_14-3-3_CanoR_1 336 342 PF00244 0.452
LIG_14-3-3_CanoR_1 34 40 PF00244 0.471
LIG_14-3-3_CanoR_1 371 380 PF00244 0.293
LIG_14-3-3_CanoR_1 415 422 PF00244 0.424
LIG_14-3-3_CanoR_1 736 742 PF00244 0.528
LIG_Actin_WH2_2 479 494 PF00022 0.438
LIG_AP2alpha_2 379 381 PF02296 0.269
LIG_APCC_ABBA_1 549 554 PF00400 0.463
LIG_APCC_ABBA_1 579 584 PF00400 0.447
LIG_BIR_II_1 1 5 PF00653 0.532
LIG_BRCT_BRCA1_1 339 343 PF00533 0.269
LIG_BRCT_BRCA1_1 434 438 PF00533 0.504
LIG_Dynein_DLC8_1 414 420 PF01221 0.427
LIG_EH1_1 466 474 PF00400 0.438
LIG_EVH1_1 803 807 PF00568 0.498
LIG_EVH1_1 812 816 PF00568 0.465
LIG_FHA_1 175 181 PF00498 0.434
LIG_FHA_1 311 317 PF00498 0.300
LIG_FHA_1 422 428 PF00498 0.421
LIG_FHA_1 43 49 PF00498 0.264
LIG_FHA_1 464 470 PF00498 0.443
LIG_FHA_1 63 69 PF00498 0.129
LIG_FHA_1 687 693 PF00498 0.511
LIG_FHA_2 119 125 PF00498 0.331
LIG_FHA_2 187 193 PF00498 0.384
LIG_FHA_2 327 333 PF00498 0.293
LIG_FHA_2 373 379 PF00498 0.391
LIG_FHA_2 393 399 PF00498 0.129
LIG_FHA_2 44 50 PF00498 0.380
LIG_FHA_2 477 483 PF00498 0.445
LIG_FHA_2 556 562 PF00498 0.462
LIG_FHA_2 640 646 PF00498 0.427
LIG_FHA_2 65 71 PF00498 0.300
LIG_FHA_2 72 78 PF00498 0.263
LIG_LIR_Apic_2 841 847 PF02991 0.588
LIG_LIR_Apic_2 888 894 PF02991 0.631
LIG_LIR_Apic_2 908 912 PF02991 0.671
LIG_LIR_Gen_1 12 21 PF02991 0.257
LIG_LIR_Gen_1 142 151 PF02991 0.251
LIG_LIR_Gen_1 340 351 PF02991 0.270
LIG_LIR_Gen_1 368 373 PF02991 0.412
LIG_LIR_Gen_1 527 537 PF02991 0.470
LIG_LIR_Gen_1 708 718 PF02991 0.416
LIG_LIR_Gen_1 832 840 PF02991 0.573
LIG_LIR_Gen_1 865 873 PF02991 0.583
LIG_LIR_Nem_3 12 17 PF02991 0.314
LIG_LIR_Nem_3 142 146 PF02991 0.251
LIG_LIR_Nem_3 161 166 PF02991 0.251
LIG_LIR_Nem_3 340 346 PF02991 0.270
LIG_LIR_Nem_3 368 372 PF02991 0.303
LIG_LIR_Nem_3 378 384 PF02991 0.291
LIG_LIR_Nem_3 514 520 PF02991 0.465
LIG_LIR_Nem_3 527 533 PF02991 0.421
LIG_LIR_Nem_3 708 713 PF02991 0.416
LIG_LIR_Nem_3 865 869 PF02991 0.581
LIG_MLH1_MIPbox_1 339 343 PF16413 0.269
LIG_MYND_1 860 864 PF01753 0.577
LIG_PDZ_Class_2 910 915 PF00595 0.583
LIG_Pex14_1 113 117 PF04695 0.251
LIG_SH2_CRK 530 534 PF00017 0.439
LIG_SH2_CRK 801 805 PF00017 0.615
LIG_SH2_CRK 820 824 PF00017 0.503
LIG_SH2_CRK 844 848 PF00017 0.524
LIG_SH2_CRK 866 870 PF00017 0.581
LIG_SH2_CRK 87 91 PF00017 0.241
LIG_SH2_CRK 891 895 PF00017 0.704
LIG_SH2_CRK 909 913 PF00017 0.669
LIG_SH2_GRB2like 58 61 PF00017 0.316
LIG_SH2_NCK_1 137 141 PF00017 0.251
LIG_SH2_NCK_1 173 177 PF00017 0.251
LIG_SH2_PTP2 143 146 PF00017 0.312
LIG_SH2_SRC 143 146 PF00017 0.329
LIG_SH2_SRC 239 242 PF00017 0.269
LIG_SH2_SRC 508 511 PF00017 0.511
LIG_SH2_SRC 801 804 PF00017 0.595
LIG_SH2_SRC 824 827 PF00017 0.565
LIG_SH2_SRC 844 847 PF00017 0.569
LIG_SH2_SRC 891 894 PF00017 0.681
LIG_SH2_STAP1 239 243 PF00017 0.269
LIG_SH2_STAT5 143 146 PF00017 0.276
LIG_SH2_STAT5 214 217 PF00017 0.251
LIG_SH2_STAT5 342 345 PF00017 0.251
LIG_SH2_STAT5 35 38 PF00017 0.329
LIG_SH2_STAT5 508 511 PF00017 0.486
LIG_SH2_STAT5 530 533 PF00017 0.517
LIG_SH2_STAT5 741 744 PF00017 0.511
LIG_SH2_STAT5 87 90 PF00017 0.251
LIG_SH3_1 801 807 PF00018 0.557
LIG_SH3_3 347 353 PF00018 0.295
LIG_SH3_3 441 447 PF00018 0.329
LIG_SH3_3 801 807 PF00018 0.573
LIG_SH3_3 810 816 PF00018 0.535
LIG_SH3_3 857 863 PF00018 0.698
LIG_SH3_3 874 880 PF00018 0.510
LIG_TRAF2_1 558 561 PF00917 0.421
LIG_TRAF2_1 617 620 PF00917 0.449
LIG_TYR_ITIM 85 90 PF00017 0.384
LIG_UBA3_1 452 460 PF00899 0.511
LIG_WRC_WIRS_1 243 248 PF05994 0.316
LIG_WW_1 863 866 PF00397 0.561
LIG_WW_2 860 863 PF00397 0.576
MOD_CDK_SPxK_1 7 13 PF00069 0.401
MOD_CK1_1 125 131 PF00069 0.417
MOD_CK1_1 245 251 PF00069 0.323
MOD_CK1_1 30 36 PF00069 0.300
MOD_CK1_1 322 328 PF00069 0.303
MOD_CK1_1 417 423 PF00069 0.487
MOD_CK1_1 42 48 PF00069 0.200
MOD_CK1_1 463 469 PF00069 0.519
MOD_CK1_1 638 644 PF00069 0.539
MOD_CK1_1 71 77 PF00069 0.316
MOD_CK1_1 871 877 PF00069 0.622
MOD_CK2_1 113 119 PF00069 0.367
MOD_CK2_1 125 131 PF00069 0.279
MOD_CK2_1 152 158 PF00069 0.258
MOD_CK2_1 372 378 PF00069 0.335
MOD_CK2_1 392 398 PF00069 0.129
MOD_CK2_1 476 482 PF00069 0.442
MOD_CK2_1 535 541 PF00069 0.550
MOD_CK2_1 555 561 PF00069 0.329
MOD_CK2_1 634 640 PF00069 0.423
MOD_CK2_1 64 70 PF00069 0.291
MOD_CK2_1 643 649 PF00069 0.416
MOD_CK2_1 71 77 PF00069 0.243
MOD_GlcNHglycan 1 4 PF01048 0.659
MOD_GlcNHglycan 101 104 PF01048 0.413
MOD_GlcNHglycan 325 328 PF01048 0.316
MOD_GlcNHglycan 434 437 PF01048 0.447
MOD_GlcNHglycan 462 465 PF01048 0.354
MOD_GlcNHglycan 493 497 PF01048 0.374
MOD_GlcNHglycan 533 536 PF01048 0.274
MOD_GlcNHglycan 591 594 PF01048 0.328
MOD_GlcNHglycan 692 695 PF01048 0.360
MOD_GlcNHglycan 840 843 PF01048 0.616
MOD_GlcNHglycan 903 906 PF01048 0.682
MOD_GSK3_1 113 120 PF00069 0.290
MOD_GSK3_1 123 130 PF00069 0.326
MOD_GSK3_1 146 153 PF00069 0.434
MOD_GSK3_1 241 248 PF00069 0.253
MOD_GSK3_1 310 317 PF00069 0.296
MOD_GSK3_1 319 326 PF00069 0.239
MOD_GSK3_1 35 42 PF00069 0.264
MOD_GSK3_1 361 368 PF00069 0.255
MOD_GSK3_1 417 424 PF00069 0.545
MOD_GSK3_1 463 470 PF00069 0.469
MOD_GSK3_1 472 479 PF00069 0.421
MOD_GSK3_1 531 538 PF00069 0.559
MOD_GSK3_1 58 65 PF00069 0.293
MOD_GSK3_1 634 641 PF00069 0.478
MOD_GSK3_1 649 656 PF00069 0.446
MOD_GSK3_1 682 689 PF00069 0.534
MOD_GSK3_1 71 78 PF00069 0.331
MOD_GSK3_1 737 744 PF00069 0.431
MOD_GSK3_1 867 874 PF00069 0.702
MOD_GSK3_1 901 908 PF00069 0.601
MOD_GSK3_1 99 106 PF00069 0.385
MOD_LATS_1 413 419 PF00433 0.468
MOD_LATS_1 624 630 PF00433 0.438
MOD_N-GLC_1 337 342 PF02516 0.251
MOD_N-GLC_1 42 47 PF02516 0.269
MOD_N-GLC_1 458 463 PF02516 0.311
MOD_N-GLC_1 7 12 PF02516 0.344
MOD_N-GLC_1 75 80 PF02516 0.348
MOD_N-GLC_2 405 407 PF02516 0.482
MOD_N-GLC_2 478 480 PF02516 0.300
MOD_N-GLC_2 705 707 PF02516 0.229
MOD_NEK2_1 117 122 PF00069 0.286
MOD_NEK2_1 139 144 PF00069 0.286
MOD_NEK2_1 175 180 PF00069 0.384
MOD_NEK2_1 246 251 PF00069 0.330
MOD_NEK2_1 372 377 PF00069 0.471
MOD_NEK2_1 448 453 PF00069 0.500
MOD_NEK2_1 634 639 PF00069 0.428
MOD_NEK2_1 68 73 PF00069 0.353
MOD_NEK2_2 217 222 PF00069 0.316
MOD_NEK2_2 337 342 PF00069 0.329
MOD_PIKK_1 146 152 PF00454 0.387
MOD_PIKK_1 310 316 PF00454 0.366
MOD_PIKK_1 415 421 PF00454 0.504
MOD_PIKK_1 458 464 PF00454 0.396
MOD_PIKK_1 639 645 PF00454 0.448
MOD_PIKK_1 762 768 PF00454 0.559
MOD_PIKK_1 769 775 PF00454 0.494
MOD_PIKK_1 793 799 PF00454 0.625
MOD_PKA_1 194 200 PF00069 0.384
MOD_PKA_1 415 421 PF00069 0.504
MOD_PKA_2 194 200 PF00069 0.316
MOD_PKA_2 309 315 PF00069 0.293
MOD_PKA_2 414 420 PF00069 0.447
MOD_PKA_2 448 454 PF00069 0.530
MOD_PKA_2 643 649 PF00069 0.396
MOD_Plk_1 217 223 PF00069 0.338
MOD_Plk_1 27 33 PF00069 0.307
MOD_Plk_1 337 343 PF00069 0.251
MOD_Plk_1 43 49 PF00069 0.177
MOD_Plk_1 731 737 PF00069 0.511
MOD_Plk_1 75 81 PF00069 0.287
MOD_Plk_4 139 145 PF00069 0.298
MOD_Plk_4 175 181 PF00069 0.384
MOD_Plk_4 246 252 PF00069 0.323
MOD_Plk_4 314 320 PF00069 0.307
MOD_Plk_4 337 343 PF00069 0.317
MOD_Plk_4 365 371 PF00069 0.311
MOD_Plk_4 448 454 PF00069 0.486
MOD_Plk_4 58 64 PF00069 0.266
MOD_Plk_4 643 649 PF00069 0.472
MOD_Plk_4 705 711 PF00069 0.429
MOD_Plk_4 716 722 PF00069 0.525
MOD_Plk_4 75 81 PF00069 0.204
MOD_ProDKin_1 524 530 PF00069 0.521
MOD_ProDKin_1 547 553 PF00069 0.481
MOD_ProDKin_1 7 13 PF00069 0.469
MOD_ProDKin_1 71 77 PF00069 0.378
MOD_SUMO_for_1 215 218 PF00179 0.251
MOD_SUMO_for_1 674 677 PF00179 0.438
MOD_SUMO_rev_2 155 162 PF00179 0.303
MOD_SUMO_rev_2 326 334 PF00179 0.316
MOD_SUMO_rev_2 457 461 PF00179 0.463
MOD_SUMO_rev_2 482 491 PF00179 0.519
MOD_SUMO_rev_2 604 610 PF00179 0.451
MOD_SUMO_rev_2 613 623 PF00179 0.414
TRG_DiLeu_BaEn_2 364 370 PF01217 0.369
TRG_ENDOCYTIC_2 143 146 PF00928 0.329
TRG_ENDOCYTIC_2 163 166 PF00928 0.129
TRG_ENDOCYTIC_2 172 175 PF00928 0.215
TRG_ENDOCYTIC_2 239 242 PF00928 0.269
TRG_ENDOCYTIC_2 530 533 PF00928 0.421
TRG_ENDOCYTIC_2 710 713 PF00928 0.416
TRG_ENDOCYTIC_2 820 823 PF00928 0.667
TRG_ENDOCYTIC_2 833 836 PF00928 0.719
TRG_ENDOCYTIC_2 866 869 PF00928 0.566
TRG_ENDOCYTIC_2 87 90 PF00928 0.251
TRG_ER_diArg_1 441 444 PF00400 0.534
TRG_ER_diArg_1 506 508 PF00400 0.479
TRG_ER_diArg_1 778 780 PF00400 0.544
TRG_NES_CRM1_1 196 208 PF08389 0.356
TRG_NES_CRM1_1 867 879 PF08389 0.550
TRG_Pf-PMV_PEXEL_1 557 561 PF00026 0.249
TRG_Pf-PMV_PEXEL_1 603 607 PF00026 0.309
TRG_Pf-PMV_PEXEL_1 745 750 PF00026 0.311

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I2T8 Leptomonas seymouri 75% 100%
A0A1X0P4J9 Trypanosomatidae 49% 100%
A0A422N9P5 Trypanosoma rangeli 49% 100%
A4HFU0 Leishmania braziliensis 86% 100%
A4I2V6 Leishmania infantum 100% 100%
D0A635 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 100%
E9ADE3 Leishmania major 96% 100%
E9AZ67 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 98%
F4HXZ1 Arabidopsis thaliana 20% 100%
P79020 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 22% 100%
Q4X0Z5 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 21% 94%
Q8T7K0 Dictyostelium discoideum 21% 100%
Q8WUM4 Homo sapiens 24% 100%
Q9QZA2 Rattus norvegicus 24% 100%
Q9WU78 Mus musculus 24% 100%
V5BQH3 Trypanosoma cruzi 50% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS