Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X0S0_LEIDO

TriTrypDb:

LdBPK_271340.1 , LdCL_270020200 , LDHU3_27.2070

Length:

914

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X0S0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0S0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	278	280	PF00675	0.621
CLV_NRD_NRD_1	315	317	PF00675	0.632
CLV_NRD_NRD_1	395	397	PF00675	0.713
CLV_NRD_NRD_1	907	909	PF00675	0.518
CLV_PCSK_KEX2_1	270	272	PF00082	0.697
CLV_PCSK_KEX2_1	278	280	PF00082	0.620
CLV_PCSK_KEX2_1	315	317	PF00082	0.572
CLV_PCSK_KEX2_1	397	399	PF00082	0.715
CLV_PCSK_KEX2_1	907	909	PF00082	0.518
CLV_PCSK_PC1ET2_1	270	272	PF00082	0.614
CLV_PCSK_PC1ET2_1	397	399	PF00082	0.697
CLV_PCSK_PC7_1	266	272	PF00082	0.577
CLV_PCSK_PC7_1	393	399	PF00082	0.697
CLV_PCSK_SKI1_1	241	245	PF00082	0.572
CLV_PCSK_SKI1_1	278	282	PF00082	0.641
CLV_PCSK_SKI1_1	315	319	PF00082	0.625
CLV_PCSK_SKI1_1	424	428	PF00082	0.539
CLV_PCSK_SKI1_1	512	516	PF00082	0.560
CLV_PCSK_SKI1_1	74	78	PF00082	0.495
CLV_PCSK_SKI1_1	86	90	PF00082	0.505
CLV_PCSK_SKI1_1	908	912	PF00082	0.520
DEG_APCC_DBOX_1	171	179	PF00400	0.564
DEG_Nend_UBRbox_2	1	3	PF02207	0.497
DEG_SPOP_SBC_1	300	304	PF00917	0.587
DEG_SPOP_SBC_1	521	525	PF00917	0.638
DOC_CYCLIN_RxL_1	275	283	PF00134	0.615
DOC_CYCLIN_RxL_1	312	321	PF00134	0.622
DOC_MAPK_gen_1	117	126	PF00069	0.444
DOC_MAPK_gen_1	54	63	PF00069	0.526
DOC_MAPK_gen_1	684	693	PF00069	0.571
DOC_MAPK_MEF2A_6	119	128	PF00069	0.537
DOC_MAPK_MEF2A_6	54	63	PF00069	0.526
DOC_MAPK_MEF2A_6	755	763	PF00069	0.529
DOC_MAPK_MEF2A_6	90	97	PF00069	0.478
DOC_PP1_RVXF_1	232	238	PF00149	0.488
DOC_PP1_RVXF_1	797	804	PF00149	0.528
DOC_PP2B_LxvP_1	297	300	PF13499	0.646
DOC_PP4_FxxP_1	281	284	PF00568	0.631
DOC_PP4_FxxP_1	346	349	PF00568	0.528
DOC_USP7_MATH_1	111	115	PF00917	0.556
DOC_USP7_MATH_1	220	224	PF00917	0.614
DOC_USP7_MATH_1	258	262	PF00917	0.696
DOC_USP7_MATH_1	29	33	PF00917	0.437
DOC_USP7_MATH_1	399	403	PF00917	0.690
DOC_USP7_MATH_1	422	426	PF00917	0.616
DOC_USP7_MATH_1	43	47	PF00917	0.600
DOC_USP7_MATH_1	468	472	PF00917	0.600
DOC_USP7_MATH_1	52	56	PF00917	0.765
DOC_USP7_MATH_1	522	526	PF00917	0.663
DOC_USP7_MATH_1	552	556	PF00917	0.700
DOC_USP7_MATH_1	610	614	PF00917	0.612
DOC_USP7_MATH_1	655	659	PF00917	0.642
DOC_USP7_MATH_1	764	768	PF00917	0.416
DOC_USP7_MATH_1	811	815	PF00917	0.602
DOC_USP7_MATH_1	818	822	PF00917	0.569
DOC_USP7_MATH_1	851	855	PF00917	0.672
DOC_USP7_MATH_1	859	863	PF00917	0.640
DOC_WW_Pin1_4	102	107	PF00397	0.532
DOC_WW_Pin1_4	256	261	PF00397	0.623
DOC_WW_Pin1_4	280	285	PF00397	0.782
DOC_WW_Pin1_4	3	8	PF00397	0.480
DOC_WW_Pin1_4	356	361	PF00397	0.543
DOC_WW_Pin1_4	492	497	PF00397	0.660
DOC_WW_Pin1_4	542	547	PF00397	0.595
DOC_WW_Pin1_4	606	611	PF00397	0.747
DOC_WW_Pin1_4	612	617	PF00397	0.664
DOC_WW_Pin1_4	64	69	PF00397	0.486
DOC_WW_Pin1_4	650	655	PF00397	0.592
DOC_WW_Pin1_4	841	846	PF00397	0.648
LIG_14-3-3_CanoR_1	241	248	PF00244	0.563
LIG_14-3-3_CanoR_1	28	38	PF00244	0.374
LIG_14-3-3_CanoR_1	398	407	PF00244	0.776
LIG_14-3-3_CanoR_1	472	478	PF00244	0.736
LIG_14-3-3_CanoR_1	54	60	PF00244	0.559
LIG_14-3-3_CanoR_1	567	573	PF00244	0.755
LIG_14-3-3_CanoR_1	585	593	PF00244	0.435
LIG_14-3-3_CanoR_1	662	671	PF00244	0.458
LIG_14-3-3_CanoR_1	743	749	PF00244	0.607
LIG_14-3-3_CanoR_1	780	789	PF00244	0.604
LIG_14-3-3_CanoR_1	802	810	PF00244	0.566
LIG_14-3-3_CanoR_1	892	901	PF00244	0.548
LIG_Actin_WH2_2	671	688	PF00022	0.588
LIG_APCC_ABBAyCdc20_2	315	321	PF00400	0.551
LIG_BIR_III_4	383	387	PF00653	0.607
LIG_BRCT_BRCA1_1	104	108	PF00533	0.448
LIG_BRCT_BRCA1_1	26	30	PF00533	0.460
LIG_BRCT_BRCA1_1	482	486	PF00533	0.813
LIG_BRCT_BRCA1_1	5	9	PF00533	0.469
LIG_BRCT_BRCA1_1	678	682	PF00533	0.565
LIG_BRCT_BRCA1_2	678	684	PF00533	0.578
LIG_FHA_1	125	131	PF00498	0.414
LIG_FHA_1	210	216	PF00498	0.567
LIG_FHA_1	275	281	PF00498	0.700
LIG_FHA_1	496	502	PF00498	0.519
LIG_FHA_1	532	538	PF00498	0.623
LIG_FHA_1	58	64	PF00498	0.578
LIG_FHA_1	647	653	PF00498	0.612
LIG_FHA_1	793	799	PF00498	0.567
LIG_FHA_1	900	906	PF00498	0.506
LIG_FHA_2	172	178	PF00498	0.639
LIG_FHA_2	439	445	PF00498	0.583
LIG_FHA_2	569	575	PF00498	0.609
LIG_FHA_2	696	702	PF00498	0.560
LIG_GBD_Chelix_1	905	913	PF00786	0.572
LIG_LIR_Gen_1	250	260	PF02991	0.619
LIG_LIR_Gen_1	288	297	PF02991	0.620
LIG_LIR_Gen_1	335	346	PF02991	0.451
LIG_LIR_Gen_1	361	372	PF02991	0.447
LIG_LIR_Nem_3	250	256	PF02991	0.609
LIG_LIR_Nem_3	288	292	PF02991	0.613
LIG_LIR_Nem_3	335	341	PF02991	0.483
LIG_LIR_Nem_3	361	367	PF02991	0.450
LIG_LIR_Nem_3	571	575	PF02991	0.539
LIG_LIR_Nem_3	591	596	PF02991	0.401
LIG_LIR_Nem_3	668	674	PF02991	0.530
LIG_LIR_Nem_3	679	685	PF02991	0.573
LIG_LIR_Nem_3	89	95	PF02991	0.542
LIG_MLH1_MIPbox_1	5	9	PF16413	0.469
LIG_PCNA_yPIPBox_3	231	243	PF02747	0.555
LIG_PDZ_Class_3	909	914	PF00595	0.559
LIG_PTAP_UEV_1	477	482	PF05743	0.541
LIG_SH2_CRK	338	342	PF00017	0.414
LIG_SH2_CRK	671	675	PF00017	0.591
LIG_SH2_PTP2	340	343	PF00017	0.414
LIG_SH2_SRC	338	341	PF00017	0.414
LIG_SH2_STAP1	191	195	PF00017	0.595
LIG_SH2_STAP1	338	342	PF00017	0.417
LIG_SH2_STAP1	497	501	PF00017	0.604
LIG_SH2_STAP1	597	601	PF00017	0.594
LIG_SH2_STAT3	507	510	PF00017	0.517
LIG_SH2_STAT3	540	543	PF00017	0.619
LIG_SH2_STAT5	100	103	PF00017	0.464
LIG_SH2_STAT5	340	343	PF00017	0.446
LIG_SH2_STAT5	345	348	PF00017	0.520
LIG_SH2_STAT5	464	467	PF00017	0.558
LIG_SH2_STAT5	497	500	PF00017	0.514
LIG_SH2_STAT5	507	510	PF00017	0.414
LIG_SH3_1	475	481	PF00018	0.673
LIG_SH3_3	216	222	PF00018	0.570
LIG_SH3_3	254	260	PF00018	0.700
LIG_SH3_3	281	287	PF00018	0.600
LIG_SH3_3	475	481	PF00018	0.673
LIG_SH3_3	688	694	PF00018	0.542
LIG_SH3_3	826	832	PF00018	0.793
LIG_SH3_3	842	848	PF00018	0.561
LIG_Sin3_3	638	645	PF02671	0.604
LIG_SUMO_SIM_anti_2	498	505	PF11976	0.549
LIG_SUMO_SIM_anti_2	574	582	PF11976	0.574
LIG_SUMO_SIM_par_1	865	872	PF11976	0.450
LIG_TRAF2_1	227	230	PF00917	0.536
LIG_TRAF2_1	411	414	PF00917	0.657
LIG_WRC_WIRS_1	363	368	PF05994	0.516
MOD_CDC14_SPxK_1	283	286	PF00782	0.599
MOD_CDK_SPK_2	612	617	PF00069	0.553
MOD_CDK_SPxK_1	280	286	PF00069	0.601
MOD_CK1_1	210	216	PF00069	0.626
MOD_CK1_1	259	265	PF00069	0.632
MOD_CK1_1	358	364	PF00069	0.558
MOD_CK1_1	365	371	PF00069	0.504
MOD_CK1_1	495	501	PF00069	0.710
MOD_CK1_1	513	519	PF00069	0.688
MOD_CK1_1	525	531	PF00069	0.585
MOD_CK1_1	55	61	PF00069	0.544
MOD_CK1_1	627	633	PF00069	0.628
MOD_CK1_1	841	847	PF00069	0.579
MOD_CK2_1	409	415	PF00069	0.702
MOD_CK2_1	438	444	PF00069	0.582
MOD_CK2_1	662	668	PF00069	0.423
MOD_CMANNOS	137	140	PF00535	0.467
MOD_GlcNHglycan	112	116	PF01048	0.590
MOD_GlcNHglycan	132	135	PF01048	0.325
MOD_GlcNHglycan	203	206	PF01048	0.733
MOD_GlcNHglycan	207	210	PF01048	0.680
MOD_GlcNHglycan	266	269	PF01048	0.750
MOD_GlcNHglycan	297	300	PF01048	0.748
MOD_GlcNHglycan	31	34	PF01048	0.531
MOD_GlcNHglycan	378	381	PF01048	0.548
MOD_GlcNHglycan	401	404	PF01048	0.747
MOD_GlcNHglycan	512	515	PF01048	0.619
MOD_GlcNHglycan	524	527	PF01048	0.612
MOD_GlcNHglycan	554	557	PF01048	0.730
MOD_GlcNHglycan	612	615	PF01048	0.643
MOD_GlcNHglycan	627	630	PF01048	0.600
MOD_GlcNHglycan	724	727	PF01048	0.611
MOD_GlcNHglycan	784	787	PF01048	0.581
MOD_GlcNHglycan	804	807	PF01048	0.580
MOD_GlcNHglycan	820	823	PF01048	0.535
MOD_GlcNHglycan	840	843	PF01048	0.552
MOD_GlcNHglycan	853	856	PF01048	0.686
MOD_GlcNHglycan	861	864	PF01048	0.745
MOD_GSK3_1	201	208	PF00069	0.644
MOD_GSK3_1	210	217	PF00069	0.536
MOD_GSK3_1	295	302	PF00069	0.704
MOD_GSK3_1	304	311	PF00069	0.672
MOD_GSK3_1	351	358	PF00069	0.611
MOD_GSK3_1	476	483	PF00069	0.717
MOD_GSK3_1	521	528	PF00069	0.670
MOD_GSK3_1	606	613	PF00069	0.641
MOD_GSK3_1	64	71	PF00069	0.458
MOD_GSK3_1	646	653	PF00069	0.603
MOD_GSK3_1	672	679	PF00069	0.560
MOD_GSK3_1	718	725	PF00069	0.644
MOD_GSK3_1	895	902	PF00069	0.591
MOD_N-GLC_1	561	566	PF02516	0.632
MOD_N-GLC_1	721	726	PF02516	0.629
MOD_N-GLC_2	35	37	PF02516	0.476
MOD_NEK2_1	124	129	PF00069	0.461
MOD_NEK2_1	16	21	PF00069	0.544
MOD_NEK2_1	171	176	PF00069	0.636
MOD_NEK2_1	190	195	PF00069	0.613
MOD_NEK2_1	24	29	PF00069	0.398
MOD_NEK2_1	376	381	PF00069	0.575
MOD_NEK2_1	454	459	PF00069	0.482
MOD_NEK2_1	515	520	PF00069	0.656
MOD_NEK2_1	674	679	PF00069	0.589
MOD_NEK2_1	70	75	PF00069	0.525
MOD_NEK2_1	744	749	PF00069	0.465
MOD_NEK2_1	782	787	PF00069	0.533
MOD_NEK2_1	804	809	PF00069	0.565
MOD_NEK2_1	880	885	PF00069	0.600
MOD_PIKK_1	301	307	PF00454	0.590
MOD_PIKK_1	554	560	PF00454	0.564
MOD_PIKK_1	646	652	PF00454	0.635
MOD_PIKK_1	655	661	PF00454	0.557
MOD_PIKK_1	662	668	PF00454	0.530
MOD_PKA_2	171	177	PF00069	0.613
MOD_PKA_2	285	291	PF00069	0.623
MOD_PKA_2	399	405	PF00069	0.749
MOD_PKA_2	55	61	PF00069	0.530
MOD_PKA_2	579	585	PF00069	0.532
MOD_PKA_2	718	724	PF00069	0.644
MOD_PKA_2	744	750	PF00069	0.498
MOD_PKA_2	782	788	PF00069	0.502
MOD_Plk_1	191	197	PF00069	0.599
MOD_Plk_1	210	216	PF00069	0.615
MOD_Plk_1	561	567	PF00069	0.649
MOD_Plk_1	764	770	PF00069	0.364
MOD_Plk_2-3	173	179	PF00069	0.570
MOD_Plk_4	136	142	PF00069	0.510
MOD_Plk_4	308	314	PF00069	0.685
MOD_Plk_4	497	503	PF00069	0.525
MOD_Plk_4	574	580	PF00069	0.585
MOD_Plk_4	895	901	PF00069	0.593
MOD_ProDKin_1	102	108	PF00069	0.527
MOD_ProDKin_1	256	262	PF00069	0.626
MOD_ProDKin_1	280	286	PF00069	0.781
MOD_ProDKin_1	3	9	PF00069	0.480
MOD_ProDKin_1	356	362	PF00069	0.536
MOD_ProDKin_1	492	498	PF00069	0.654
MOD_ProDKin_1	542	548	PF00069	0.598
MOD_ProDKin_1	606	612	PF00069	0.749
MOD_ProDKin_1	64	70	PF00069	0.495
MOD_ProDKin_1	650	656	PF00069	0.587
MOD_ProDKin_1	841	847	PF00069	0.648
MOD_SUMO_rev_2	223	233	PF00179	0.561
MOD_SUMO_rev_2	706	715	PF00179	0.513
TRG_DiLeu_BaEn_1	326	331	PF01217	0.454
TRG_DiLeu_BaLyEn_6	313	318	PF01217	0.633
TRG_DiLeu_BaLyEn_6	65	70	PF01217	0.390
TRG_DiLeu_BaLyEn_6	659	664	PF01217	0.597
TRG_ENDOCYTIC_2	338	341	PF00928	0.414
TRG_ENDOCYTIC_2	671	674	PF00928	0.591
TRG_ER_diArg_1	278	280	PF00400	0.625
TRG_ER_diArg_1	314	316	PF00400	0.653
TRG_ER_diArg_1	395	398	PF00400	0.734
TRG_ER_diArg_1	907	909	PF00400	0.518
TRG_NES_CRM1_1	238	250	PF08389	0.578
TRG_NLS_MonoCore_2	396	401	PF00514	0.782
TRG_NLS_MonoExtC_3	395	400	PF00514	0.812
TRG_NLS_MonoExtN_4	393	400	PF00514	0.847
TRG_Pf-PMV_PEXEL_1	241	245	PF00026	0.572
TRG_Pf-PMV_PEXEL_1	278	282	PF00026	0.652
TRG_Pf-PMV_PEXEL_1	316	321	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	662	666	PF00026	0.690

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWA8	Leptomonas seymouri	48%	98%
A0A381ML15	Leishmania infantum	99%	100%
A4HFR9	Leishmania braziliensis	72%	100%
D0A612	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9ADC4	Leishmania major	89%	99%
E9AZ48	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%