Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X0R8_LEIDO

TriTrypDb:

LdBPK_271420.1 , LdCL_270021000 , LDHU3_27.2160

Length:

743

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X0R8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0R8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	352	356	PF00656	0.616
CLV_C14_Caspase3-7	458	462	PF00656	0.600
CLV_MEL_PAP_1	116	122	PF00089	0.447
CLV_NRD_NRD_1	332	334	PF00675	0.642
CLV_NRD_NRD_1	339	341	PF00675	0.657
CLV_NRD_NRD_1	342	344	PF00675	0.660
CLV_NRD_NRD_1	578	580	PF00675	0.558
CLV_NRD_NRD_1	676	678	PF00675	0.424
CLV_PCSK_FUR_1	329	333	PF00082	0.703
CLV_PCSK_FUR_1	340	344	PF00082	0.541
CLV_PCSK_KEX2_1	331	333	PF00082	0.647
CLV_PCSK_KEX2_1	338	340	PF00082	0.643
CLV_PCSK_KEX2_1	342	344	PF00082	0.631
CLV_PCSK_KEX2_1	676	678	PF00082	0.424
CLV_PCSK_KEX2_1	713	715	PF00082	0.476
CLV_PCSK_PC1ET2_1	338	340	PF00082	0.688
CLV_PCSK_PC1ET2_1	342	344	PF00082	0.726
CLV_PCSK_PC1ET2_1	713	715	PF00082	0.476
CLV_PCSK_PC7_1	340	346	PF00082	0.607
CLV_PCSK_SKI1_1	152	156	PF00082	0.386
CLV_PCSK_SKI1_1	33	37	PF00082	0.393
CLV_PCSK_SKI1_1	45	49	PF00082	0.361
CLV_PCSK_SKI1_1	530	534	PF00082	0.414
CLV_PCSK_SKI1_1	592	596	PF00082	0.483
CLV_PCSK_SKI1_1	612	616	PF00082	0.322
CLV_PCSK_SKI1_1	690	694	PF00082	0.378
CLV_PCSK_SKI1_1	724	728	PF00082	0.483
CLV_PCSK_SKI1_1	74	78	PF00082	0.335
DEG_APCC_DBOX_1	634	642	PF00400	0.494
DEG_APCC_DBOX_1	689	697	PF00400	0.371
DEG_APCC_DBOX_1	723	731	PF00400	0.479
DEG_APCC_DBOX_1	73	81	PF00400	0.356
DEG_ODPH_VHL_1	128	140	PF01847	0.380
DEG_SPOP_SBC_1	370	374	PF00917	0.619
DOC_CKS1_1	432	437	PF01111	0.414
DOC_CKS1_1	552	557	PF01111	0.448
DOC_CYCLIN_yCln2_LP_2	150	156	PF00134	0.391
DOC_CYCLIN_yCln2_LP_2	290	296	PF00134	0.516
DOC_CYCLIN_yCln2_LP_2	449	455	PF00134	0.528
DOC_CYCLIN_yCln2_LP_2	643	649	PF00134	0.465
DOC_MAPK_gen_1	132	140	PF00069	0.364
DOC_MAPK_gen_1	303	310	PF00069	0.523
DOC_MAPK_gen_1	527	537	PF00069	0.415
DOC_MAPK_MEF2A_6	530	539	PF00069	0.401
DOC_MAPK_MEF2A_6	650	658	PF00069	0.352
DOC_PP1_RVXF_1	31	37	PF00149	0.375
DOC_PP2B_LxvP_1	127	130	PF13499	0.362
DOC_PP4_MxPP_1	193	196	PF00568	0.433
DOC_USP7_MATH_1	189	193	PF00917	0.469
DOC_USP7_MATH_1	203	207	PF00917	0.411
DOC_USP7_MATH_1	3	7	PF00917	0.487
DOC_USP7_MATH_1	369	373	PF00917	0.675
DOC_USP7_MATH_1	393	397	PF00917	0.602
DOC_USP7_MATH_1	454	458	PF00917	0.587
DOC_USP7_MATH_1	548	552	PF00917	0.396
DOC_USP7_MATH_1	614	618	PF00917	0.437
DOC_USP7_MATH_1	684	688	PF00917	0.425
DOC_USP7_MATH_2	518	524	PF00917	0.410
DOC_USP7_UBL2_3	338	342	PF12436	0.661
DOC_WW_Pin1_4	17	22	PF00397	0.390
DOC_WW_Pin1_4	218	223	PF00397	0.490
DOC_WW_Pin1_4	23	28	PF00397	0.415
DOC_WW_Pin1_4	243	248	PF00397	0.560
DOC_WW_Pin1_4	260	265	PF00397	0.358
DOC_WW_Pin1_4	379	384	PF00397	0.644
DOC_WW_Pin1_4	414	419	PF00397	0.456
DOC_WW_Pin1_4	431	436	PF00397	0.409
DOC_WW_Pin1_4	514	519	PF00397	0.438
DOC_WW_Pin1_4	551	556	PF00397	0.452
DOC_WW_Pin1_4	661	666	PF00397	0.519
LIG_14-3-3_CanoR_1	119	128	PF00244	0.368
LIG_14-3-3_CanoR_1	132	141	PF00244	0.383
LIG_14-3-3_CanoR_1	19	29	PF00244	0.477
LIG_14-3-3_CanoR_1	270	278	PF00244	0.412
LIG_14-3-3_CanoR_1	45	51	PF00244	0.375
LIG_14-3-3_CanoR_1	596	601	PF00244	0.450
LIG_14-3-3_CanoR_1	612	621	PF00244	0.327
LIG_14-3-3_CanoR_1	645	654	PF00244	0.438
LIG_Actin_WH2_2	399	417	PF00022	0.479
LIG_EH1_1	648	656	PF00400	0.370
LIG_eIF4E_1	29	35	PF01652	0.378
LIG_EVH1_2	183	187	PF00568	0.440
LIG_FHA_1	122	128	PF00498	0.363
LIG_FHA_1	196	202	PF00498	0.558
LIG_FHA_1	248	254	PF00498	0.399
LIG_FHA_1	261	267	PF00498	0.402
LIG_FHA_1	279	285	PF00498	0.536
LIG_FHA_1	397	403	PF00498	0.665
LIG_FHA_1	63	69	PF00498	0.386
LIG_FHA_1	684	690	PF00498	0.397
LIG_FHA_2	134	140	PF00498	0.383
LIG_FHA_2	295	301	PF00498	0.496
LIG_FHA_2	350	356	PF00498	0.595
LIG_FHA_2	515	521	PF00498	0.426
LIG_FHA_2	554	560	PF00498	0.391
LIG_FHA_2	613	619	PF00498	0.443
LIG_FHA_2	7	13	PF00498	0.395
LIG_LIR_Gen_1	298	309	PF02991	0.495
LIG_LIR_Gen_1	556	566	PF02991	0.421
LIG_LIR_Gen_1	9	17	PF02991	0.378
LIG_LIR_Nem_3	298	304	PF02991	0.489
LIG_LIR_Nem_3	556	561	PF02991	0.306
LIG_LIR_Nem_3	71	76	PF02991	0.358
LIG_LIR_Nem_3	9	13	PF02991	0.382
LIG_NRBOX	252	258	PF00104	0.384
LIG_SH2_CRK	64	68	PF00017	0.387
LIG_SH2_CRK	698	702	PF00017	0.413
LIG_SH2_CRK	73	77	PF00017	0.350
LIG_SH2_STAP1	674	678	PF00017	0.409
LIG_SH2_STAT3	63	66	PF00017	0.390
LIG_SH2_STAT3	694	697	PF00017	0.370
LIG_SH2_STAT5	252	255	PF00017	0.376
LIG_SH2_STAT5	64	67	PF00017	0.398
LIG_SH2_STAT5	694	697	PF00017	0.370
LIG_SH2_STAT5	8	11	PF00017	0.386
LIG_SH3_3	34	40	PF00018	0.422
LIG_SH3_3	348	354	PF00018	0.645
LIG_SH3_3	380	386	PF00018	0.639
LIG_SH3_3	450	456	PF00018	0.523
LIG_SUMO_SIM_anti_2	136	142	PF11976	0.383
LIG_SUMO_SIM_par_1	46	51	PF11976	0.346
LIG_SUMO_SIM_par_1	639	644	PF11976	0.501
LIG_TRAF2_1	325	328	PF00917	0.586
LIG_UBA3_1	424	431	PF00899	0.388
LIG_UBA3_1	726	734	PF00899	0.424
MOD_CDK_SPxxK_3	260	267	PF00069	0.409
MOD_CK1_1	115	121	PF00069	0.392
MOD_CK1_1	20	26	PF00069	0.444
MOD_CK1_1	251	257	PF00069	0.376
MOD_CK1_1	288	294	PF00069	0.505
MOD_CK1_1	349	355	PF00069	0.670
MOD_CK1_1	372	378	PF00069	0.740
MOD_CK1_1	387	393	PF00069	0.517
MOD_CK1_1	396	402	PF00069	0.496
MOD_CK1_1	417	423	PF00069	0.416
MOD_CK1_1	551	557	PF00069	0.381
MOD_CK1_1	588	594	PF00069	0.549
MOD_CK1_1	6	12	PF00069	0.418
MOD_CK1_1	604	610	PF00069	0.425
MOD_CK2_1	294	300	PF00069	0.573
MOD_CK2_1	491	497	PF00069	0.342
MOD_CK2_1	514	520	PF00069	0.440
MOD_CK2_1	553	559	PF00069	0.392
MOD_CK2_1	612	618	PF00069	0.439
MOD_GlcNHglycan	164	167	PF01048	0.392
MOD_GlcNHglycan	205	208	PF01048	0.503
MOD_GlcNHglycan	313	316	PF01048	0.646
MOD_GlcNHglycan	322	325	PF01048	0.631
MOD_GlcNHglycan	335	338	PF01048	0.603
MOD_GlcNHglycan	348	351	PF01048	0.580
MOD_GlcNHglycan	457	460	PF01048	0.642
MOD_GlcNHglycan	5	8	PF01048	0.521
MOD_GlcNHglycan	510	513	PF01048	0.485
MOD_GlcNHglycan	548	551	PF01048	0.372
MOD_GlcNHglycan	603	606	PF01048	0.434
MOD_GSK3_1	111	118	PF00069	0.424
MOD_GSK3_1	195	202	PF00069	0.484
MOD_GSK3_1	226	233	PF00069	0.382
MOD_GSK3_1	243	250	PF00069	0.409
MOD_GSK3_1	256	263	PF00069	0.379
MOD_GSK3_1	309	316	PF00069	0.543
MOD_GSK3_1	345	352	PF00069	0.665
MOD_GSK3_1	369	376	PF00069	0.725
MOD_GSK3_1	396	403	PF00069	0.567
MOD_GSK3_1	473	480	PF00069	0.415
MOD_GSK3_1	581	588	PF00069	0.613
MOD_GSK3_1	604	611	PF00069	0.456
MOD_GSK3_1	626	633	PF00069	0.482
MOD_LATS_1	83	89	PF00433	0.469
MOD_N-GLC_1	377	382	PF02516	0.624
MOD_N-GLC_1	491	496	PF02516	0.332
MOD_N-GLC_1	678	683	PF02516	0.486
MOD_N-GLC_2	657	659	PF02516	0.350
MOD_NEK2_1	248	253	PF00069	0.377
MOD_NEK2_1	256	261	PF00069	0.406
MOD_NEK2_1	309	314	PF00069	0.536
MOD_NEK2_1	377	382	PF00069	0.643
MOD_NEK2_1	441	446	PF00069	0.434
MOD_NEK2_1	508	513	PF00069	0.467
MOD_NEK2_1	521	526	PF00069	0.393
MOD_NEK2_1	595	600	PF00069	0.388
MOD_NEK2_2	189	194	PF00069	0.470
MOD_PIKK_1	20	26	PF00454	0.426
MOD_PIKK_1	393	399	PF00454	0.524
MOD_PIKK_1	62	68	PF00454	0.381
MOD_PIKK_1	626	632	PF00454	0.553
MOD_PIKK_1	684	690	PF00454	0.418
MOD_PK_1	596	602	PF00069	0.443
MOD_PKA_1	338	344	PF00069	0.591
MOD_PKA_2	118	124	PF00069	0.376
MOD_PKA_2	269	275	PF00069	0.410
MOD_PKA_2	338	344	PF00069	0.591
MOD_PKA_2	508	514	PF00069	0.415
MOD_PKA_2	578	584	PF00069	0.482
MOD_PKA_2	595	601	PF00069	0.441
MOD_PKB_1	331	339	PF00069	0.694
MOD_PKB_1	343	351	PF00069	0.529
MOD_Plk_1	299	305	PF00069	0.547
MOD_Plk_1	377	383	PF00069	0.620
MOD_Plk_2-3	732	738	PF00069	0.441
MOD_Plk_4	226	232	PF00069	0.400
MOD_Plk_4	248	254	PF00069	0.554
MOD_Plk_4	521	527	PF00069	0.398
MOD_Plk_4	548	554	PF00069	0.503
MOD_Plk_4	604	610	PF00069	0.375
MOD_Plk_4	650	656	PF00069	0.351
MOD_ProDKin_1	17	23	PF00069	0.398
MOD_ProDKin_1	218	224	PF00069	0.483
MOD_ProDKin_1	243	249	PF00069	0.554
MOD_ProDKin_1	260	266	PF00069	0.360
MOD_ProDKin_1	379	385	PF00069	0.642
MOD_ProDKin_1	414	420	PF00069	0.451
MOD_ProDKin_1	431	437	PF00069	0.412
MOD_ProDKin_1	514	520	PF00069	0.440
MOD_ProDKin_1	551	557	PF00069	0.446
MOD_ProDKin_1	661	667	PF00069	0.514
MOD_SUMO_for_1	712	715	PF00179	0.420
MOD_SUMO_rev_2	259	268	PF00179	0.426
TRG_DiLeu_BaLyEn_6	123	128	PF01217	0.363
TRG_DiLeu_BaLyEn_6	181	186	PF01217	0.477
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.377
TRG_DiLeu_BaLyEn_6	537	542	PF01217	0.375
TRG_DiLeu_BaLyEn_6	725	730	PF01217	0.474
TRG_ENDOCYTIC_2	73	76	PF00928	0.353
TRG_ER_diArg_1	329	332	PF00400	0.699
TRG_ER_diArg_1	572	575	PF00400	0.426
TRG_ER_diArg_1	676	678	PF00400	0.424
TRG_NLS_MonoExtC_3	337	342	PF00514	0.684
TRG_Pf-PMV_PEXEL_1	527	531	PF00026	0.486
TRG_Pf-PMV_PEXEL_1	540	544	PF00026	0.318
TRG_Pf-PMV_PEXEL_1	728	732	PF00026	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5D1	Leptomonas seymouri	64%	100%
A4HFT0	Leishmania braziliensis	81%	100%
A4I368	Leishmania infantum	100%	100%
E9ADD1	Leishmania major	94%	100%
E9AZ56	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%