CBF/Mak21 family, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CBF/Mak21 family, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X0Q5_LEIDO

TriTrypDb:

LdBPK_271360.1 , LdCL_270020400 , LDHU3_27.2100

Length:

852

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0005730	nucleolus	5	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S7X0Q5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0Q5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	187	191	PF00656	0.323
CLV_C14_Caspase3-7	641	645	PF00656	0.576
CLV_C14_Caspase3-7	722	726	PF00656	0.699
CLV_MEL_PAP_1	833	839	PF00089	0.673
CLV_NRD_NRD_1	148	150	PF00675	0.407
CLV_NRD_NRD_1	184	186	PF00675	0.326
CLV_NRD_NRD_1	277	279	PF00675	0.389
CLV_NRD_NRD_1	314	316	PF00675	0.352
CLV_NRD_NRD_1	447	449	PF00675	0.288
CLV_NRD_NRD_1	790	792	PF00675	0.562
CLV_PCSK_KEX2_1	132	134	PF00082	0.392
CLV_PCSK_KEX2_1	163	165	PF00082	0.328
CLV_PCSK_KEX2_1	184	186	PF00082	0.328
CLV_PCSK_KEX2_1	314	316	PF00082	0.352
CLV_PCSK_KEX2_1	678	680	PF00082	0.757
CLV_PCSK_KEX2_1	790	792	PF00082	0.528
CLV_PCSK_KEX2_1	848	850	PF00082	0.679
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.380
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.328
CLV_PCSK_PC1ET2_1	678	680	PF00082	0.745
CLV_PCSK_PC1ET2_1	790	792	PF00082	0.536
CLV_PCSK_PC1ET2_1	848	850	PF00082	0.626
CLV_PCSK_PC7_1	180	186	PF00082	0.379
CLV_PCSK_SKI1_1	116	120	PF00082	0.410
CLV_PCSK_SKI1_1	129	133	PF00082	0.330
CLV_PCSK_SKI1_1	249	253	PF00082	0.373
CLV_PCSK_SKI1_1	279	283	PF00082	0.366
CLV_PCSK_SKI1_1	314	318	PF00082	0.357
CLV_PCSK_SKI1_1	346	350	PF00082	0.308
CLV_PCSK_SKI1_1	421	425	PF00082	0.339
CLV_PCSK_SKI1_1	448	452	PF00082	0.370
CLV_PCSK_SKI1_1	671	675	PF00082	0.763
CLV_PCSK_SKI1_1	77	81	PF00082	0.421
DEG_MDM2_SWIB_1	366	374	PF02201	0.279
DEG_ODPH_VHL_1	324	337	PF01847	0.385
DOC_CYCLIN_RxL_1	290	298	PF00134	0.484
DOC_CYCLIN_yClb5_NLxxxL_5	638	647	PF00134	0.602
DOC_CYCLIN_yCln2_LP_2	125	128	PF00134	0.440
DOC_CYCLIN_yCln2_LP_2	458	464	PF00134	0.222
DOC_MAPK_gen_1	11	18	PF00069	0.510
DOC_MAPK_gen_1	369	379	PF00069	0.295
DOC_MAPK_MEF2A_6	11	20	PF00069	0.512
DOC_MAPK_MEF2A_6	519	526	PF00069	0.362
DOC_MAPK_NFAT4_5	519	527	PF00069	0.473
DOC_PP1_RVXF_1	247	253	PF00149	0.324
DOC_PP1_RVXF_1	419	426	PF00149	0.279
DOC_PP1_RVXF_1	791	798	PF00149	0.577
DOC_PP2B_LxvP_1	125	128	PF13499	0.440
DOC_PP2B_LxvP_1	458	461	PF13499	0.222
DOC_PP4_FxxP_1	14	17	PF00568	0.515
DOC_USP7_MATH_1	217	221	PF00917	0.456
DOC_USP7_MATH_1	404	408	PF00917	0.408
DOC_USP7_MATH_1	479	483	PF00917	0.403
DOC_USP7_MATH_1	584	588	PF00917	0.440
DOC_USP7_MATH_1	664	668	PF00917	0.710
DOC_USP7_MATH_1	721	725	PF00917	0.770
DOC_USP7_MATH_1	803	807	PF00917	0.755
DOC_USP7_UBL2_3	275	279	PF12436	0.407
DOC_USP7_UBL2_3	785	789	PF12436	0.561
DOC_WW_Pin1_4	378	383	PF00397	0.294
DOC_WW_Pin1_4	538	543	PF00397	0.530
DOC_WW_Pin1_4	823	828	PF00397	0.717
LIG_14-3-3_CanoR_1	133	142	PF00244	0.383
LIG_14-3-3_CanoR_1	149	154	PF00244	0.342
LIG_14-3-3_CanoR_1	203	211	PF00244	0.423
LIG_14-3-3_CanoR_1	21	26	PF00244	0.416
LIG_14-3-3_CanoR_1	346	351	PF00244	0.279
LIG_14-3-3_CanoR_1	369	375	PF00244	0.370
LIG_14-3-3_CanoR_1	511	515	PF00244	0.314
LIG_14-3-3_CanoR_1	62	69	PF00244	0.484
LIG_14-3-3_CanoR_1	624	628	PF00244	0.500
LIG_14-3-3_CanoR_1	71	78	PF00244	0.377
LIG_Actin_WH2_2	298	316	PF00022	0.373
LIG_APCC_ABBA_1	523	528	PF00400	0.360
LIG_APCC_ABBA_1	546	551	PF00400	0.421
LIG_BIR_II_1	1	5	PF00653	0.541
LIG_BIR_III_4	190	194	PF00653	0.334
LIG_BIR_III_4	710	714	PF00653	0.717
LIG_BIR_III_4	757	761	PF00653	0.674
LIG_BRCT_BRCA1_1	135	139	PF00533	0.413
LIG_BRCT_BRCA1_1	240	244	PF00533	0.469
LIG_BRCT_BRCA1_1	64	68	PF00533	0.564
LIG_FHA_1	142	148	PF00498	0.415
LIG_FHA_1	149	155	PF00498	0.319
LIG_FHA_1	20	26	PF00498	0.546
LIG_FHA_1	28	34	PF00498	0.557
LIG_FHA_1	296	302	PF00498	0.425
LIG_FHA_1	304	310	PF00498	0.298
LIG_FHA_1	347	353	PF00498	0.286
LIG_FHA_1	699	705	PF00498	0.677
LIG_FHA_1	78	84	PF00498	0.430
LIG_FHA_2	185	191	PF00498	0.480
LIG_FHA_2	243	249	PF00498	0.424
LIG_FHA_2	624	630	PF00498	0.524
LIG_FHA_2	639	645	PF00498	0.455
LIG_FHA_2	651	657	PF00498	0.601
LIG_FHA_2	71	77	PF00498	0.394
LIG_FXI_DFP_1	716	720	PF00024	0.737
LIG_LIR_Gen_1	136	147	PF02991	0.389
LIG_LIR_Gen_1	165	172	PF02991	0.342
LIG_LIR_Gen_1	241	252	PF02991	0.433
LIG_LIR_Gen_1	287	296	PF02991	0.337
LIG_LIR_Gen_1	392	402	PF02991	0.313
LIG_LIR_Gen_1	95	104	PF02991	0.371
LIG_LIR_Nem_3	119	125	PF02991	0.472
LIG_LIR_Nem_3	136	142	PF02991	0.321
LIG_LIR_Nem_3	152	158	PF02991	0.298
LIG_LIR_Nem_3	165	169	PF02991	0.252
LIG_LIR_Nem_3	241	247	PF02991	0.428
LIG_LIR_Nem_3	287	291	PF02991	0.323
LIG_LIR_Nem_3	373	378	PF02991	0.343
LIG_LIR_Nem_3	392	398	PF02991	0.148
LIG_LIR_Nem_3	775	779	PF02991	0.556
LIG_LIR_Nem_3	87	93	PF02991	0.351
LIG_LIR_Nem_3	95	100	PF02991	0.337
LIG_MLH1_MIPbox_1	135	139	PF16413	0.413
LIG_MYND_1	123	127	PF01753	0.383
LIG_NRBOX	228	234	PF00104	0.361
LIG_NRBOX	351	357	PF00104	0.413
LIG_NRBOX	373	379	PF00104	0.295
LIG_NRBOX	519	525	PF00104	0.473
LIG_OCRL_FandH_1	394	406	PF00620	0.295
LIG_Pex14_2	366	370	PF04695	0.279
LIG_Pex14_2	545	549	PF04695	0.429
LIG_Pex14_2	97	101	PF04695	0.346
LIG_PTB_Apo_2	365	372	PF02174	0.295
LIG_PTB_Phospho_1	365	371	PF10480	0.295
LIG_SH2_CRK	371	375	PF00017	0.282
LIG_SH2_SRC	42	45	PF00017	0.500
LIG_SH2_SRC	93	96	PF00017	0.479
LIG_SH2_STAP1	111	115	PF00017	0.358
LIG_SH2_STAP1	166	170	PF00017	0.340
LIG_SH2_STAP1	263	267	PF00017	0.337
LIG_SH2_STAP1	64	68	PF00017	0.564
LIG_SH2_STAT3	609	612	PF00017	0.365
LIG_SH2_STAT3	64	67	PF00017	0.452
LIG_SH2_STAT5	138	141	PF00017	0.489
LIG_SH2_STAT5	157	160	PF00017	0.165
LIG_SH2_STAT5	161	164	PF00017	0.326
LIG_SH2_STAT5	288	291	PF00017	0.352
LIG_SH2_STAT5	590	593	PF00017	0.431
LIG_SH2_STAT5	93	96	PF00017	0.479
LIG_SH3_1	124	130	PF00018	0.364
LIG_SH3_2	127	132	PF14604	0.367
LIG_SH3_3	124	130	PF00018	0.375
LIG_SH3_3	13	19	PF00018	0.507
LIG_SUMO_SIM_anti_2	349	354	PF11976	0.296
LIG_SUMO_SIM_anti_2	521	526	PF11976	0.476
LIG_SUMO_SIM_par_1	376	381	PF11976	0.295
LIG_SUMO_SIM_par_1	433	439	PF11976	0.279
LIG_TRAF2_1	274	277	PF00917	0.495
LIG_TRAF2_1	326	329	PF00917	0.438
LIG_TYR_ITIM	153	158	PF00017	0.308
LIG_UBA3_1	243	249	PF00899	0.332
LIG_UBA3_1	352	360	PF00899	0.279
LIG_UBA3_1	377	383	PF00899	0.292
LIG_WRC_WIRS_1	28	33	PF05994	0.454
LIG_WW_3	126	130	PF00397	0.458
MOD_CDK_SPK_2	378	383	PF00069	0.279
MOD_CDK_SPxxK_3	823	830	PF00069	0.718
MOD_CK1_1	2	8	PF00069	0.505
MOD_CK1_1	234	240	PF00069	0.514
MOD_CK1_1	303	309	PF00069	0.403
MOD_CK1_1	478	484	PF00069	0.361
MOD_CK1_1	510	516	PF00069	0.333
MOD_CK1_1	582	588	PF00069	0.506
MOD_CK1_1	667	673	PF00069	0.758
MOD_CK1_1	70	76	PF00069	0.438
MOD_CK2_1	195	201	PF00069	0.346
MOD_CK2_1	242	248	PF00069	0.422
MOD_CK2_1	271	277	PF00069	0.440
MOD_CK2_1	627	633	PF00069	0.549
MOD_GlcNHglycan	387	390	PF01048	0.344
MOD_GlcNHglycan	477	480	PF01048	0.410
MOD_GlcNHglycan	481	484	PF01048	0.361
MOD_GlcNHglycan	594	597	PF01048	0.452
MOD_GlcNHglycan	629	633	PF01048	0.528
MOD_GlcNHglycan	650	653	PF01048	0.546
MOD_GlcNHglycan	709	714	PF01048	0.686
MOD_GlcNHglycan	761	764	PF01048	0.606
MOD_GlcNHglycan	801	804	PF01048	0.572
MOD_GlcNHglycan	805	808	PF01048	0.590
MOD_GlcNHglycan	809	812	PF01048	0.597
MOD_GSK3_1	231	238	PF00069	0.395
MOD_GSK3_1	27	34	PF00069	0.558
MOD_GSK3_1	300	307	PF00069	0.380
MOD_GSK3_1	385	392	PF00069	0.302
MOD_GSK3_1	471	478	PF00069	0.423
MOD_GSK3_1	579	586	PF00069	0.435
MOD_GSK3_1	618	625	PF00069	0.466
MOD_GSK3_1	63	70	PF00069	0.480
MOD_GSK3_1	667	674	PF00069	0.700
MOD_GSK3_1	799	806	PF00069	0.546
MOD_GSK3_1	819	826	PF00069	0.779
MOD_N-GLC_1	471	476	PF02516	0.359
MOD_N-GLC_1	592	597	PF02516	0.446
MOD_NEK2_1	1	6	PF00069	0.611
MOD_NEK2_1	100	105	PF00069	0.334
MOD_NEK2_1	162	167	PF00069	0.323
MOD_NEK2_1	172	177	PF00069	0.329
MOD_NEK2_1	195	200	PF00069	0.347
MOD_NEK2_1	233	238	PF00069	0.386
MOD_NEK2_1	295	300	PF00069	0.407
MOD_NEK2_1	337	342	PF00069	0.378
MOD_NEK2_1	638	643	PF00069	0.620
MOD_NEK2_1	759	764	PF00069	0.730
MOD_NEK2_2	257	262	PF00069	0.348
MOD_NEK2_2	370	375	PF00069	0.370
MOD_PIKK_1	133	139	PF00454	0.388
MOD_PIKK_1	438	444	PF00454	0.406
MOD_PIKK_1	618	624	PF00454	0.494
MOD_PIKK_1	63	69	PF00454	0.510
MOD_PKA_1	149	155	PF00069	0.450
MOD_PKA_1	184	190	PF00069	0.446
MOD_PKA_1	671	677	PF00069	0.679
MOD_PKA_2	148	154	PF00069	0.388
MOD_PKA_2	184	190	PF00069	0.506
MOD_PKA_2	202	208	PF00069	0.302
MOD_PKA_2	510	516	PF00069	0.331
MOD_PKA_2	623	629	PF00069	0.500
MOD_PKA_2	638	644	PF00069	0.489
MOD_PKA_2	667	673	PF00069	0.570
MOD_PKA_2	70	76	PF00069	0.403
MOD_PKA_2	835	841	PF00069	0.730
MOD_PKB_1	60	68	PF00069	0.508
MOD_PKB_1	834	842	PF00069	0.605
MOD_Plk_1	301	307	PF00069	0.369
MOD_Plk_2-3	44	50	PF00069	0.438
MOD_Plk_2-3	687	693	PF00069	0.644
MOD_Plk_4	149	155	PF00069	0.363
MOD_Plk_4	172	178	PF00069	0.470
MOD_Plk_4	184	190	PF00069	0.453
MOD_Plk_4	2	8	PF00069	0.490
MOD_Plk_4	238	244	PF00069	0.461
MOD_Plk_4	284	290	PF00069	0.330
MOD_Plk_4	348	354	PF00069	0.293
MOD_Plk_4	362	368	PF00069	0.279
MOD_Plk_4	44	50	PF00069	0.555
MOD_Plk_4	513	519	PF00069	0.342
MOD_ProDKin_1	378	384	PF00069	0.294
MOD_ProDKin_1	538	544	PF00069	0.529
MOD_ProDKin_1	823	829	PF00069	0.717
MOD_SUMO_rev_2	274	281	PF00179	0.389
MOD_SUMO_rev_2	47	56	PF00179	0.537
MOD_SUMO_rev_2	481	490	PF00179	0.401
MOD_SUMO_rev_2	556	564	PF00179	0.691
TRG_DiLeu_BaEn_1	775	780	PF01217	0.535
TRG_DiLeu_BaEn_2	247	253	PF01217	0.363
TRG_DiLeu_BaLyEn_6	121	126	PF01217	0.283
TRG_DiLeu_BaLyEn_6	414	419	PF01217	0.279
TRG_ENDOCYTIC_2	155	158	PF00928	0.308
TRG_ENDOCYTIC_2	166	169	PF00928	0.330
TRG_ENDOCYTIC_2	226	229	PF00928	0.335
TRG_ENDOCYTIC_2	288	291	PF00928	0.326
TRG_ENDOCYTIC_2	319	322	PF00928	0.493
TRG_ENDOCYTIC_2	371	374	PF00928	0.282
TRG_ENDOCYTIC_2	375	378	PF00928	0.275
TRG_ER_diArg_1	313	315	PF00400	0.353
TRG_ER_diArg_1	60	63	PF00400	0.580
TRG_ER_diArg_1	613	616	PF00400	0.398
TRG_ER_diArg_1	830	833	PF00400	0.619
TRG_ER_diArg_1	834	837	PF00400	0.612
TRG_ER_diArg_1	849	852	PF00400	0.446
TRG_NES_CRM1_1	538	551	PF08389	0.499
TRG_NES_CRM1_1	89	102	PF08389	0.338
TRG_NLS_MonoCore_2	788	793	PF00514	0.581
TRG_NLS_MonoExtC_3	788	793	PF00514	0.521
TRG_Pf-PMV_PEXEL_1	231	235	PF00026	0.499

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKJ4	Leptomonas seymouri	80%	100%
A0A0S4JS41	Bodo saltans	52%	100%
A0A1X0P4I0	Trypanosomatidae	60%	100%
A0A3R7MHJ2	Trypanosoma rangeli	58%	100%
A4HFS2	Leishmania braziliensis	85%	100%
A4I371	Leishmania infantum	100%	100%
D0A614	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9ADC6	Leishmania major	95%	100%
E9AZ50	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
G0SEQ5	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	27%	82%
O36021	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	99%
Q03701	Homo sapiens	26%	81%
Q12176	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	83%
V5DHD7	Trypanosoma cruzi	58%	100%