Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X0N8_LEIDO

TriTrypDb:

LdBPK_271180.1 , LdCL_270018300 , LDHU3_27.1850

Length:

442

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X0N8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0N8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	185	189	PF00656	0.598
CLV_MEL_PAP_1	105	111	PF00089	0.628
CLV_NRD_NRD_1	221	223	PF00675	0.535
CLV_NRD_NRD_1	23	25	PF00675	0.726
CLV_NRD_NRD_1	380	382	PF00675	0.637
CLV_NRD_NRD_1	391	393	PF00675	0.502
CLV_NRD_NRD_1	429	431	PF00675	0.659
CLV_PCSK_KEX2_1	107	109	PF00082	0.728
CLV_PCSK_KEX2_1	221	223	PF00082	0.535
CLV_PCSK_KEX2_1	225	227	PF00082	0.537
CLV_PCSK_KEX2_1	23	25	PF00082	0.612
CLV_PCSK_KEX2_1	306	308	PF00082	0.725
CLV_PCSK_KEX2_1	379	381	PF00082	0.652
CLV_PCSK_KEX2_1	391	393	PF00082	0.492
CLV_PCSK_KEX2_1	429	431	PF00082	0.676
CLV_PCSK_PC1ET2_1	107	109	PF00082	0.728
CLV_PCSK_PC1ET2_1	225	227	PF00082	0.555
CLV_PCSK_PC1ET2_1	306	308	PF00082	0.721
CLV_PCSK_PC7_1	221	227	PF00082	0.636
CLV_PCSK_SKI1_1	179	183	PF00082	0.612
CLV_PCSK_SKI1_1	221	225	PF00082	0.591
CLV_PCSK_SKI1_1	232	236	PF00082	0.455
CLV_PCSK_SKI1_1	263	267	PF00082	0.533
CLV_Separin_Metazoa	27	31	PF03568	0.689
DEG_APCC_DBOX_1	390	398	PF00400	0.563
DEG_Nend_UBRbox_3	1	3	PF02207	0.731
DEG_SCF_FBW7_1	85	90	PF00400	0.722
DOC_MAPK_FxFP_2	6	9	PF00069	0.717
DOC_MAPK_gen_1	137	147	PF00069	0.651
DOC_MAPK_gen_1	229	237	PF00069	0.621
DOC_MAPK_gen_1	404	413	PF00069	0.673
DOC_MAPK_gen_1	429	436	PF00069	0.590
DOC_PP2B_LxvP_1	411	414	PF13499	0.747
DOC_PP2B_LxvP_1	434	437	PF13499	0.644
DOC_PP4_FxxP_1	6	9	PF00568	0.717
DOC_USP7_MATH_1	139	143	PF00917	0.707
DOC_USP7_MATH_1	189	193	PF00917	0.607
DOC_USP7_MATH_1	350	354	PF00917	0.767
DOC_USP7_MATH_1	415	419	PF00917	0.781
DOC_USP7_MATH_1	87	91	PF00917	0.714
DOC_WW_Pin1_4	107	112	PF00397	0.605
DOC_WW_Pin1_4	132	137	PF00397	0.707
DOC_WW_Pin1_4	292	297	PF00397	0.659
DOC_WW_Pin1_4	30	35	PF00397	0.739
DOC_WW_Pin1_4	329	334	PF00397	0.723
DOC_WW_Pin1_4	341	346	PF00397	0.712
DOC_WW_Pin1_4	420	425	PF00397	0.764
DOC_WW_Pin1_4	64	69	PF00397	0.787
DOC_WW_Pin1_4	83	88	PF00397	0.726
DOC_WW_Pin1_4	91	96	PF00397	0.711
LIG_14-3-3_CanoR_1	116	121	PF00244	0.696
LIG_14-3-3_CanoR_1	124	133	PF00244	0.532
LIG_14-3-3_CanoR_1	256	265	PF00244	0.635
LIG_14-3-3_CanoR_1	274	279	PF00244	0.492
LIG_14-3-3_CanoR_1	30	34	PF00244	0.757
LIG_14-3-3_CanoR_1	369	376	PF00244	0.604
LIG_14-3-3_CanoR_1	37	43	PF00244	0.695
LIG_14-3-3_CanoR_1	391	395	PF00244	0.668
LIG_14-3-3_CanoR_1	416	420	PF00244	0.741
LIG_14-3-3_CanoR_1	78	83	PF00244	0.649
LIG_Actin_WH2_2	102	118	PF00022	0.651
LIG_BRCT_BRCA1_1	172	176	PF00533	0.417
LIG_BRCT_BRCA1_1	2	6	PF00533	0.659
LIG_BRCT_BRCA1_1	261	265	PF00533	0.574
LIG_BRCT_BRCA1_1	314	318	PF00533	0.707
LIG_BRCT_BRCA1_1	421	425	PF00533	0.699
LIG_Clathr_ClatBox_1	168	172	PF01394	0.612
LIG_FHA_1	104	110	PF00498	0.770
LIG_FHA_1	142	148	PF00498	0.717
LIG_LIR_Apic_2	3	9	PF02991	0.713
LIG_LIR_Gen_1	150	160	PF02991	0.647
LIG_LIR_Gen_1	188	197	PF02991	0.506
LIG_LIR_Gen_1	422	433	PF02991	0.702
LIG_LIR_Nem_3	150	155	PF02991	0.671
LIG_LIR_Nem_3	188	193	PF02991	0.501
LIG_LIR_Nem_3	422	428	PF02991	0.700
LIG_LIR_Nem_3	44	49	PF02991	0.636
LIG_MYND_1	433	437	PF01753	0.705
LIG_Pex14_2	176	180	PF04695	0.427
LIG_PTB_Apo_2	146	153	PF02174	0.572
LIG_SH2_CRK	49	53	PF00017	0.666
LIG_SH2_SRC	243	246	PF00017	0.482
LIG_SH2_SRC	49	52	PF00017	0.713
LIG_SH2_STAP1	239	243	PF00017	0.476
LIG_SH2_STAT5	100	103	PF00017	0.673
LIG_SH2_STAT5	356	359	PF00017	0.804
LIG_SH2_STAT5	7	10	PF00017	0.718
LIG_SH3_3	133	139	PF00018	0.661
LIG_SH3_3	344	350	PF00018	0.720
LIG_SH3_3	45	51	PF00018	0.708
LIG_SH3_3	70	76	PF00018	0.630
LIG_SH3_3	89	95	PF00018	0.738
LIG_Sin3_3	167	174	PF02671	0.561
LIG_SUMO_SIM_anti_2	191	198	PF11976	0.553
LIG_SUMO_SIM_anti_2	202	207	PF11976	0.464
LIG_SUMO_SIM_par_1	167	173	PF11976	0.609
LIG_SUMO_SIM_par_1	51	57	PF11976	0.599
LIG_TRAF2_1	406	409	PF00917	0.613
LIG_UBA3_1	193	201	PF00899	0.457
MOD_CDC14_SPxK_1	67	70	PF00782	0.824
MOD_CDC14_SPxK_1	94	97	PF00782	0.709
MOD_CDK_SPK_2	132	137	PF00069	0.672
MOD_CDK_SPK_2	341	346	PF00069	0.736
MOD_CDK_SPxK_1	64	70	PF00069	0.825
MOD_CDK_SPxK_1	91	97	PF00069	0.751
MOD_CDK_SPxxK_3	292	299	PF00069	0.730
MOD_CDK_SPxxK_3	30	37	PF00069	0.739
MOD_CK1_1	151	157	PF00069	0.570
MOD_CK1_1	192	198	PF00069	0.488
MOD_CK1_1	259	265	PF00069	0.655
MOD_CK1_1	273	279	PF00069	0.569
MOD_CK1_1	295	301	PF00069	0.711
MOD_CK1_1	331	337	PF00069	0.824
MOD_CK1_1	364	370	PF00069	0.717
MOD_CK1_1	38	44	PF00069	0.753
MOD_CK1_1	418	424	PF00069	0.697
MOD_CK1_1	54	60	PF00069	0.609
MOD_CK1_1	80	86	PF00069	0.668
MOD_DYRK1A_RPxSP_1	346	350	PF00069	0.731
MOD_GlcNHglycan	172	175	PF01048	0.439
MOD_GlcNHglycan	318	321	PF01048	0.699
MOD_GlcNHglycan	438	441	PF01048	0.668
MOD_GSK3_1	103	110	PF00069	0.783
MOD_GSK3_1	264	271	PF00069	0.579
MOD_GSK3_1	312	319	PF00069	0.723
MOD_GSK3_1	346	353	PF00069	0.768
MOD_GSK3_1	357	364	PF00069	0.755
MOD_GSK3_1	37	44	PF00069	0.743
MOD_GSK3_1	415	422	PF00069	0.782
MOD_GSK3_1	62	69	PF00069	0.776
MOD_GSK3_1	77	84	PF00069	0.653
MOD_GSK3_1	87	94	PF00069	0.606
MOD_N-GLC_1	148	153	PF02516	0.615
MOD_N-GLC_1	292	297	PF02516	0.730
MOD_NEK2_1	266	271	PF00069	0.547
MOD_NEK2_1	29	34	PF00069	0.754
MOD_NEK2_1	316	321	PF00069	0.714
MOD_NEK2_1	357	362	PF00069	0.745
MOD_NEK2_1	77	82	PF00069	0.616
MOD_NEK2_2	51	56	PF00069	0.670
MOD_PIKK_1	126	132	PF00454	0.682
MOD_PIKK_1	279	285	PF00454	0.672
MOD_PIKK_1	54	60	PF00454	0.609
MOD_PIKK_1	87	93	PF00454	0.768
MOD_PK_1	116	122	PF00069	0.663
MOD_PK_1	78	84	PF00069	0.626
MOD_PKA_2	19	25	PF00069	0.735
MOD_PKA_2	217	223	PF00069	0.534
MOD_PKA_2	273	279	PF00069	0.574
MOD_PKA_2	29	35	PF00069	0.595
MOD_PKA_2	328	334	PF00069	0.695
MOD_PKA_2	368	374	PF00069	0.616
MOD_PKA_2	38	44	PF00069	0.595
MOD_PKA_2	390	396	PF00069	0.630
MOD_PKA_2	415	421	PF00069	0.700
MOD_PKA_2	77	83	PF00069	0.682
MOD_PKB_1	272	280	PF00069	0.598
MOD_Plk_1	148	154	PF00069	0.583
MOD_Plk_4	151	157	PF00069	0.613
MOD_Plk_4	189	195	PF00069	0.609
MOD_Plk_4	312	318	PF00069	0.659
MOD_ProDKin_1	107	113	PF00069	0.604
MOD_ProDKin_1	132	138	PF00069	0.708
MOD_ProDKin_1	292	298	PF00069	0.657
MOD_ProDKin_1	30	36	PF00069	0.737
MOD_ProDKin_1	329	335	PF00069	0.724
MOD_ProDKin_1	341	347	PF00069	0.710
MOD_ProDKin_1	420	426	PF00069	0.630
MOD_ProDKin_1	64	70	PF00069	0.788
MOD_ProDKin_1	83	89	PF00069	0.726
MOD_ProDKin_1	91	97	PF00069	0.712
TRG_DiLeu_BaLyEn_6	159	164	PF01217	0.537
TRG_DiLeu_BaLyEn_6	430	435	PF01217	0.702
TRG_ENDOCYTIC_2	49	52	PF00928	0.713
TRG_ER_diArg_1	23	25	PF00400	0.612
TRG_ER_diArg_1	379	381	PF00400	0.645
TRG_ER_diArg_1	428	430	PF00400	0.658
TRG_ER_diArg_1	97	100	PF00400	0.790
TRG_Pf-PMV_PEXEL_1	222	227	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	253	257	PF00026	0.574

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCB3	Leptomonas seymouri	36%	96%
A4HFQ4	Leishmania braziliensis	62%	100%
A4I2S9	Leishmania infantum	99%	100%
E9ADA7	Leishmania major	87%	100%
E9AZ32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%