LeishMANIAdb
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Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical_protein_conserved
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7X0N0_LEIDO
TriTrypDb:
LdBPK_271100.1 , LdCL_270017500 , LDHU3_27.1730
Length:
411

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 3
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 7
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X0N0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0N0

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 194 198 PF00656 0.543
CLV_C14_Caspase3-7 308 312 PF00656 0.609
CLV_C14_Caspase3-7 49 53 PF00656 0.671
CLV_NRD_NRD_1 211 213 PF00675 0.551
CLV_NRD_NRD_1 232 234 PF00675 0.525
CLV_NRD_NRD_1 257 259 PF00675 0.495
CLV_NRD_NRD_1 368 370 PF00675 0.582
CLV_NRD_NRD_1 372 374 PF00675 0.495
CLV_NRD_NRD_1 408 410 PF00675 0.628
CLV_NRD_NRD_1 68 70 PF00675 0.740
CLV_PCSK_FUR_1 366 370 PF00082 0.533
CLV_PCSK_KEX2_1 232 234 PF00082 0.610
CLV_PCSK_KEX2_1 257 259 PF00082 0.495
CLV_PCSK_KEX2_1 34 36 PF00082 0.610
CLV_PCSK_KEX2_1 368 370 PF00082 0.582
CLV_PCSK_KEX2_1 372 374 PF00082 0.544
CLV_PCSK_KEX2_1 68 70 PF00082 0.736
CLV_PCSK_KEX2_1 91 93 PF00082 0.484
CLV_PCSK_PC1ET2_1 34 36 PF00082 0.661
CLV_PCSK_PC1ET2_1 91 93 PF00082 0.484
CLV_PCSK_PC7_1 228 234 PF00082 0.606
CLV_PCSK_PC7_1 368 374 PF00082 0.594
CLV_PCSK_PC7_1 64 70 PF00082 0.765
CLV_PCSK_SKI1_1 103 107 PF00082 0.516
CLV_PCSK_SKI1_1 109 113 PF00082 0.555
CLV_PCSK_SKI1_1 183 187 PF00082 0.515
CLV_PCSK_SKI1_1 258 262 PF00082 0.567
CLV_Separin_Metazoa 184 188 PF03568 0.577
DEG_APCC_DBOX_1 257 265 PF00400 0.545
DEG_APCC_DBOX_1 371 379 PF00400 0.580
DOC_CYCLIN_RxL_1 100 110 PF00134 0.519
DOC_MAPK_gen_1 152 161 PF00069 0.523
DOC_MAPK_gen_1 31 39 PF00069 0.587
DOC_MAPK_MEF2A_6 171 178 PF00069 0.519
DOC_USP7_MATH_1 356 360 PF00917 0.572
DOC_USP7_MATH_1 67 71 PF00917 0.759
DOC_USP7_UBL2_3 380 384 PF12436 0.515
LIG_BIR_II_1 1 5 PF00653 0.579
LIG_Clathr_ClatBox_1 13 17 PF01394 0.606
LIG_FHA_2 194 200 PF00498 0.656
LIG_FHA_2 212 218 PF00498 0.409
LIG_FHA_2 243 249 PF00498 0.633
LIG_FHA_2 298 304 PF00498 0.671
LIG_FHA_2 358 364 PF00498 0.583
LIG_LIR_Nem_3 127 133 PF02991 0.526
LIG_Rb_pABgroove_1 320 328 PF01858 0.581
LIG_SH2_STAP1 326 330 PF00017 0.581
LIG_SH2_STAT5 130 133 PF00017 0.567
LIG_SH2_STAT5 249 252 PF00017 0.598
LIG_SH2_STAT5 29 32 PF00017 0.631
LIG_SH2_STAT5 374 377 PF00017 0.496
LIG_SUMO_SIM_anti_2 204 211 PF11976 0.553
LIG_SUMO_SIM_par_1 5 10 PF11976 0.644
LIG_TRAF2_1 126 129 PF00917 0.515
LIG_UBA3_1 13 21 PF00899 0.599
MOD_CK1_1 2 8 PF00069 0.552
MOD_CK1_1 40 46 PF00069 0.657
MOD_CK1_1 53 59 PF00069 0.711
MOD_CK1_1 60 66 PF00069 0.677
MOD_CK1_1 98 104 PF00069 0.644
MOD_CK2_1 193 199 PF00069 0.621
MOD_CK2_1 2 8 PF00069 0.679
MOD_CK2_1 211 217 PF00069 0.400
MOD_CK2_1 357 363 PF00069 0.560
MOD_CK2_1 90 96 PF00069 0.616
MOD_GlcNHglycan 146 149 PF01048 0.668
MOD_GlcNHglycan 350 353 PF01048 0.627
MOD_GlcNHglycan 406 409 PF01048 0.651
MOD_GlcNHglycan 65 68 PF01048 0.731
MOD_GlcNHglycan 69 72 PF01048 0.713
MOD_GSK3_1 138 145 PF00069 0.561
MOD_GSK3_1 193 200 PF00069 0.572
MOD_GSK3_1 33 40 PF00069 0.575
MOD_GSK3_1 385 392 PF00069 0.517
MOD_GSK3_1 399 406 PF00069 0.413
MOD_GSK3_1 50 57 PF00069 0.599
MOD_GSK3_1 63 70 PF00069 0.638
MOD_LATS_1 355 361 PF00433 0.573
MOD_N-GLC_1 40 45 PF02516 0.643
MOD_NEK2_1 30 35 PF00069 0.544
MOD_NEK2_1 325 330 PF00069 0.514
MOD_NEK2_1 37 42 PF00069 0.581
MOD_NEK2_1 403 408 PF00069 0.487
MOD_NEK2_1 50 55 PF00069 0.455
MOD_NEK2_1 7 12 PF00069 0.535
MOD_PIKK_1 197 203 PF00454 0.598
MOD_PIKK_1 57 63 PF00454 0.673
MOD_PKA_2 211 217 PF00069 0.416
MOD_PKA_2 250 256 PF00069 0.552
MOD_PKA_2 30 36 PF00069 0.641
MOD_PKA_2 348 354 PF00069 0.494
MOD_PKA_2 385 391 PF00069 0.638
MOD_PKA_2 404 410 PF00069 0.594
MOD_PKA_2 50 56 PF00069 0.457
MOD_PKA_2 63 69 PF00069 0.758
MOD_Plk_1 357 363 PF00069 0.556
MOD_Plk_1 95 101 PF00069 0.572
MOD_Plk_4 2 8 PF00069 0.587
MOD_Plk_4 357 363 PF00069 0.636
MOD_Plk_4 389 395 PF00069 0.505
MOD_SUMO_for_1 117 120 PF00179 0.624
MOD_SUMO_rev_2 207 214 PF00179 0.526
MOD_SUMO_rev_2 38 48 PF00179 0.611
TRG_ENDOCYTIC_2 130 133 PF00928 0.605
TRG_ENDOCYTIC_2 280 283 PF00928 0.584
TRG_ER_diArg_1 257 259 PF00400 0.509
TRG_ER_diArg_1 366 369 PF00400 0.591
TRG_ER_diArg_1 372 374 PF00400 0.568
TRG_NES_CRM1_1 129 142 PF08389 0.589
TRG_NES_CRM1_1 284 297 PF08389 0.543
TRG_Pf-PMV_PEXEL_1 104 108 PF00026 0.401
TRG_Pf-PMV_PEXEL_1 373 377 PF00026 0.581

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IHJ5 Leptomonas seymouri 63% 96%
A0A1X0P450 Trypanosomatidae 30% 100%
A0A3R7M124 Trypanosoma rangeli 29% 100%
A4HFP7 Leishmania braziliensis 72% 100%
A4I2S2 Leishmania infantum 100% 100%
D0A5Y0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 100%
E9ADA0 Leishmania major 88% 100%
E9AZ25 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
V5AT73 Trypanosoma cruzi 29% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS