Pre-rRNA-processing protein TSR2 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X0M3_LEIDO

TriTrypDb:

LdBPK_270990.1 , LdCL_270016500 , LDHU3_27.1610

Length:

221

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X0M3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0M3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006364	rRNA processing	8	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016072	rRNA metabolic process	7	11
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0030490	maturation of SSU-rRNA	9	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	168	172	PF00656	0.661
CLV_NRD_NRD_1	202	204	PF00675	0.706
CLV_NRD_NRD_1	205	207	PF00675	0.693
CLV_PCSK_FUR_1	203	207	PF00082	0.743
CLV_PCSK_KEX2_1	205	207	PF00082	0.696
CLV_PCSK_KEX2_1	69	71	PF00082	0.427
CLV_PCSK_PC1ET2_1	205	207	PF00082	0.677
CLV_PCSK_PC1ET2_1	69	71	PF00082	0.427
DEG_Nend_UBRbox_3	1	3	PF02207	0.572
DOC_CKS1_1	192	197	PF01111	0.468
DOC_MAPK_gen_1	69	76	PF00069	0.647
DOC_WW_Pin1_4	191	196	PF00397	0.513
LIG_14-3-3_CanoR_1	15	19	PF00244	0.638
LIG_14-3-3_CanoR_1	206	212	PF00244	0.696
LIG_APCC_ABBA_1	79	84	PF00400	0.433
LIG_FHA_1	133	139	PF00498	0.685
LIG_FHA_1	30	36	PF00498	0.501
LIG_KLC1_Yacidic_2	73	77	PF13176	0.519
LIG_LIR_Gen_1	118	126	PF02991	0.465
LIG_LIR_Gen_1	25	35	PF02991	0.493
LIG_LIR_Gen_1	80	90	PF02991	0.467
LIG_LIR_Nem_3	118	122	PF02991	0.423
LIG_LIR_Nem_3	215	220	PF02991	0.534
LIG_LIR_Nem_3	25	31	PF02991	0.489
LIG_LIR_Nem_3	80	86	PF02991	0.454
LIG_Pex14_2	83	87	PF04695	0.413
LIG_SH2_STAT3	10	13	PF00017	0.620
LIG_SH2_STAT5	111	114	PF00017	0.426
LIG_SH2_STAT5	125	128	PF00017	0.468
LIG_SH2_STAT5	75	78	PF00017	0.616
LIG_SH2_STAT5	82	85	PF00017	0.380
LIG_SH3_3	182	188	PF00018	0.704
LIG_SH3_3	189	195	PF00018	0.705
LIG_TRAF2_1	99	102	PF00917	0.518
LIG_TYR_ITIM	59	64	PF00017	0.543
MOD_CDK_SPK_2	191	196	PF00069	0.502
MOD_CK1_1	17	23	PF00069	0.654
MOD_CK1_1	210	216	PF00069	0.623
MOD_CK2_1	117	123	PF00069	0.462
MOD_CK2_1	96	102	PF00069	0.494
MOD_GlcNHglycan	182	185	PF01048	0.761
MOD_GlcNHglycan	4	7	PF01048	0.599
MOD_GlcNHglycan	91	94	PF01048	0.536
MOD_GSK3_1	2	9	PF00069	0.546
MOD_N-GLC_1	207	212	PF02516	0.692
MOD_NEK2_1	14	19	PF00069	0.629
MOD_NEK2_1	180	185	PF00069	0.563
MOD_PK_1	207	213	PF00069	0.689
MOD_PKA_2	14	20	PF00069	0.560
MOD_Plk_1	117	123	PF00069	0.454
MOD_Plk_1	207	213	PF00069	0.696
MOD_Plk_1	96	102	PF00069	0.507
MOD_Plk_2-3	163	169	PF00069	0.525
MOD_Plk_2-3	96	102	PF00069	0.516
MOD_Plk_4	102	108	PF00069	0.501
MOD_Plk_4	127	133	PF00069	0.668
MOD_ProDKin_1	191	197	PF00069	0.508
TRG_ENDOCYTIC_2	61	64	PF00928	0.457
TRG_NLS_MonoCore_2	202	207	PF00514	0.683
TRG_NLS_MonoExtC_3	202	207	PF00514	0.622
TRG_NLS_MonoExtN_4	201	208	PF00514	0.613

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL48	Leptomonas seymouri	67%	100%
A0A0S4JFC4	Bodo saltans	35%	97%
A0A1X0P5J5	Trypanosomatidae	48%	100%
A0A422N5E3	Trypanosoma rangeli	48%	100%
A4HFN6	Leishmania braziliensis	78%	100%
A4I2R3	Leishmania infantum	100%	100%
D0A5W6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AD90	Leishmania major	91%	100%
E9AZ14	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%