Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X0M1_LEIDO

TriTrypDb:

LdBPK_270810.1 , LdCL_270014700 , LDHU3_27.1350

Length:

912

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X0M1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0M1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	290	294	PF00656	0.609
CLV_C14_Caspase3-7	513	517	PF00656	0.594
CLV_C14_Caspase3-7	623	627	PF00656	0.737
CLV_C14_Caspase3-7	80	84	PF00656	0.468
CLV_NRD_NRD_1	216	218	PF00675	0.732
CLV_NRD_NRD_1	329	331	PF00675	0.618
CLV_NRD_NRD_1	44	46	PF00675	0.742
CLV_NRD_NRD_1	463	465	PF00675	0.705
CLV_NRD_NRD_1	49	51	PF00675	0.699
CLV_NRD_NRD_1	518	520	PF00675	0.632
CLV_NRD_NRD_1	524	526	PF00675	0.629
CLV_NRD_NRD_1	806	808	PF00675	0.544
CLV_NRD_NRD_1	820	822	PF00675	0.622
CLV_NRD_NRD_1	880	882	PF00675	0.501
CLV_PCSK_FUR_1	818	822	PF00082	0.572
CLV_PCSK_KEX2_1	122	124	PF00082	0.522
CLV_PCSK_KEX2_1	216	218	PF00082	0.729
CLV_PCSK_KEX2_1	264	266	PF00082	0.610
CLV_PCSK_KEX2_1	329	331	PF00082	0.618
CLV_PCSK_KEX2_1	44	46	PF00082	0.758
CLV_PCSK_KEX2_1	462	464	PF00082	0.704
CLV_PCSK_KEX2_1	806	808	PF00082	0.544
CLV_PCSK_KEX2_1	820	822	PF00082	0.622
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.522
CLV_PCSK_PC1ET2_1	264	266	PF00082	0.610
CLV_PCSK_SKI1_1	122	126	PF00082	0.488
CLV_PCSK_SKI1_1	350	354	PF00082	0.699
CLV_PCSK_SKI1_1	51	55	PF00082	0.687
CLV_PCSK_SKI1_1	520	524	PF00082	0.663
CLV_PCSK_SKI1_1	685	689	PF00082	0.590
CLV_PCSK_SKI1_1	900	904	PF00082	0.427
DEG_APCC_DBOX_1	56	64	PF00400	0.472
DEG_Nend_UBRbox_2	1	3	PF02207	0.692
DEG_SPOP_SBC_1	223	227	PF00917	0.595
DEG_SPOP_SBC_1	480	484	PF00917	0.717
DEG_SPOP_SBC_1	529	533	PF00917	0.601
DOC_ANK_TNKS_1	376	383	PF00023	0.631
DOC_CDC14_PxL_1	186	194	PF14671	0.670
DOC_CKS1_1	351	356	PF01111	0.616
DOC_CKS1_1	53	58	PF01111	0.473
DOC_CKS1_1	556	561	PF01111	0.745
DOC_CYCLIN_yCln2_LP_2	641	647	PF00134	0.630
DOC_CYCLIN_yCln2_LP_2	736	742	PF00134	0.551
DOC_MAPK_gen_1	698	707	PF00069	0.496
DOC_MAPK_gen_1	755	763	PF00069	0.426
DOC_MAPK_gen_1	845	854	PF00069	0.425
DOC_MAPK_MEF2A_6	845	854	PF00069	0.402
DOC_PIKK_1	441	448	PF02985	0.582
DOC_PP2B_LxvP_1	400	403	PF13499	0.701
DOC_PP2B_LxvP_1	641	644	PF13499	0.653
DOC_PP2B_LxvP_1	889	892	PF13499	0.580
DOC_PP4_FxxP_1	344	347	PF00568	0.618
DOC_PP4_FxxP_1	581	584	PF00568	0.605
DOC_USP7_MATH_1	16	20	PF00917	0.632
DOC_USP7_MATH_1	253	257	PF00917	0.599
DOC_USP7_MATH_1	295	299	PF00917	0.766
DOC_USP7_MATH_1	365	369	PF00917	0.770
DOC_USP7_MATH_1	4	8	PF00917	0.633
DOC_USP7_MATH_1	426	430	PF00917	0.635
DOC_USP7_MATH_1	451	455	PF00917	0.681
DOC_USP7_MATH_1	456	460	PF00917	0.584
DOC_USP7_MATH_1	480	484	PF00917	0.635
DOC_USP7_MATH_1	49	53	PF00917	0.666
DOC_USP7_MATH_1	502	506	PF00917	0.653
DOC_USP7_MATH_1	510	514	PF00917	0.738
DOC_USP7_MATH_1	608	612	PF00917	0.721
DOC_USP7_MATH_1	645	649	PF00917	0.670
DOC_USP7_MATH_1	801	805	PF00917	0.645
DOC_USP7_UBL2_3	773	777	PF12436	0.401
DOC_WW_Pin1_4	350	355	PF00397	0.664
DOC_WW_Pin1_4	402	407	PF00397	0.634
DOC_WW_Pin1_4	52	57	PF00397	0.645
DOC_WW_Pin1_4	555	560	PF00397	0.628
DOC_WW_Pin1_4	575	580	PF00397	0.768
DOC_WW_Pin1_4	742	747	PF00397	0.430
LIG_14-3-3_CanoR_1	123	130	PF00244	0.524
LIG_14-3-3_CanoR_1	137	144	PF00244	0.559
LIG_14-3-3_CanoR_1	172	176	PF00244	0.687
LIG_14-3-3_CanoR_1	26	32	PF00244	0.610
LIG_14-3-3_CanoR_1	271	278	PF00244	0.604
LIG_14-3-3_CanoR_1	462	471	PF00244	0.709
LIG_14-3-3_CanoR_1	50	56	PF00244	0.597
LIG_14-3-3_CanoR_1	519	523	PF00244	0.583
LIG_14-3-3_CanoR_1	541	550	PF00244	0.656
LIG_14-3-3_CanoR_1	552	561	PF00244	0.672
LIG_14-3-3_CanoR_1	564	573	PF00244	0.628
LIG_14-3-3_CanoR_1	875	881	PF00244	0.450
LIG_APCC_ABBA_1	336	341	PF00400	0.611
LIG_APCC_ABBA_1	673	678	PF00400	0.515
LIG_BRCT_BRCA1_1	577	581	PF00533	0.613
LIG_BRCT_BRCA1_1	759	763	PF00533	0.527
LIG_Clathr_ClatBox_1	162	166	PF01394	0.577
LIG_FHA_1	157	163	PF00498	0.555
LIG_FHA_1	200	206	PF00498	0.673
LIG_FHA_1	22	28	PF00498	0.565
LIG_FHA_1	233	239	PF00498	0.678
LIG_FHA_1	357	363	PF00498	0.740
LIG_FHA_1	395	401	PF00498	0.608
LIG_FHA_1	490	496	PF00498	0.714
LIG_FHA_1	556	562	PF00498	0.782
LIG_FHA_1	638	644	PF00498	0.718
LIG_FHA_1	702	708	PF00498	0.420
LIG_FHA_1	742	748	PF00498	0.432
LIG_FHA_1	827	833	PF00498	0.556
LIG_FHA_1	834	840	PF00498	0.419
LIG_FHA_1	866	872	PF00498	0.479
LIG_FHA_2	194	200	PF00498	0.658
LIG_FHA_2	529	535	PF00498	0.706
LIG_FHA_2	53	59	PF00498	0.599
LIG_Integrin_isoDGR_2	570	572	PF01839	0.716
LIG_LIR_Apic_2	29	35	PF02991	0.662
LIG_LIR_Apic_2	341	347	PF02991	0.609
LIG_LIR_Apic_2	578	584	PF02991	0.753
LIG_LIR_Gen_1	183	192	PF02991	0.724
LIG_LIR_Gen_1	218	228	PF02991	0.672
LIG_LIR_Gen_1	235	242	PF02991	0.502
LIG_LIR_Gen_1	90	100	PF02991	0.594
LIG_LIR_Nem_3	125	130	PF02991	0.523
LIG_LIR_Nem_3	183	189	PF02991	0.718
LIG_LIR_Nem_3	218	223	PF02991	0.682
LIG_LIR_Nem_3	235	240	PF02991	0.570
LIG_LIR_Nem_3	409	413	PF02991	0.618
LIG_LIR_Nem_3	534	540	PF02991	0.541
LIG_LIR_Nem_3	663	669	PF02991	0.549
LIG_LIR_Nem_3	90	96	PF02991	0.584
LIG_LIR_Nem_3	99	103	PF02991	0.511
LIG_MYND_1	559	563	PF01753	0.692
LIG_MYND_1	735	739	PF01753	0.590
LIG_MYND_3	189	193	PF01753	0.670
LIG_NRBOX	706	712	PF00104	0.438
LIG_PCNA_yPIPBox_3	895	906	PF02747	0.483
LIG_PTB_Apo_2	545	552	PF02174	0.557
LIG_PTB_Apo_2	94	101	PF02174	0.541
LIG_PTB_Phospho_1	94	100	PF10480	0.537
LIG_SH2_NCK_1	198	202	PF00017	0.604
LIG_SH2_NCK_1	676	680	PF00017	0.670
LIG_SH2_SRC	676	679	PF00017	0.699
LIG_SH2_STAP1	676	680	PF00017	0.711
LIG_SH2_STAP1	72	76	PF00017	0.478
LIG_SH2_STAT5	105	108	PF00017	0.552
LIG_SH2_STAT5	301	304	PF00017	0.621
LIG_SH2_STAT5	32	35	PF00017	0.668
LIG_SH2_STAT5	62	65	PF00017	0.509
LIG_SH2_STAT5	788	791	PF00017	0.418
LIG_SH2_STAT5	828	831	PF00017	0.652
LIG_SH3_3	400	406	PF00018	0.694
LIG_SH3_3	420	426	PF00018	0.563
LIG_SH3_3	557	563	PF00018	0.718
LIG_SH3_3	573	579	PF00018	0.697
LIG_SH3_3	65	71	PF00018	0.417
LIG_SH3_3	729	735	PF00018	0.492
LIG_SUMO_SIM_par_1	738	745	PF11976	0.522
LIG_SUMO_SIM_par_1	867	873	PF11976	0.472
LIG_TRAF2_1	133	136	PF00917	0.543
LIG_TRAF2_1	273	276	PF00917	0.683
LIG_TRAF2_1	38	41	PF00917	0.658
LIG_TRAF2_1	661	664	PF00917	0.526
LIG_TRAF2_1	675	678	PF00917	0.555
LIG_UBA3_1	710	716	PF00899	0.387
LIG_WRC_WIRS_1	410	415	PF05994	0.677
LIG_WRC_WIRS_1	871	876	PF05994	0.555
LIG_WW_3	306	310	PF00397	0.741
MOD_CDC14_SPxK_1	745	748	PF00782	0.437
MOD_CDK_SPK_2	52	57	PF00069	0.487
MOD_CDK_SPK_2	559	564	PF00069	0.695
MOD_CDK_SPxK_1	742	748	PF00069	0.432
MOD_CDK_SPxxK_3	559	566	PF00069	0.637
MOD_CK1_1	20	26	PF00069	0.615
MOD_CK1_1	266	272	PF00069	0.616
MOD_CK1_1	395	401	PF00069	0.621
MOD_CK1_1	509	515	PF00069	0.556
MOD_CK1_1	52	58	PF00069	0.612
MOD_CK1_1	542	548	PF00069	0.669
MOD_CK1_1	555	561	PF00069	0.662
MOD_CK1_1	648	654	PF00069	0.679
MOD_CK1_1	870	876	PF00069	0.468
MOD_CK2_1	130	136	PF00069	0.661
MOD_CK2_1	193	199	PF00069	0.688
MOD_CK2_1	365	371	PF00069	0.739
MOD_CK2_1	52	58	PF00069	0.622
MOD_CK2_1	528	534	PF00069	0.772
MOD_CK2_1	750	756	PF00069	0.471
MOD_Cter_Amidation	523	526	PF01082	0.584
MOD_GlcNHglycan	119	122	PF01048	0.546
MOD_GlcNHglycan	139	142	PF01048	0.402
MOD_GlcNHglycan	14	17	PF01048	0.692
MOD_GlcNHglycan	253	256	PF01048	0.693
MOD_GlcNHglycan	257	260	PF01048	0.685
MOD_GlcNHglycan	284	287	PF01048	0.687
MOD_GlcNHglycan	293	296	PF01048	0.637
MOD_GlcNHglycan	371	374	PF01048	0.649
MOD_GlcNHglycan	397	400	PF01048	0.810
MOD_GlcNHglycan	435	438	PF01048	0.654
MOD_GlcNHglycan	449	452	PF01048	0.623
MOD_GlcNHglycan	45	48	PF01048	0.728
MOD_GlcNHglycan	495	498	PF01048	0.711
MOD_GlcNHglycan	508	511	PF01048	0.488
MOD_GlcNHglycan	591	595	PF01048	0.678
MOD_GlcNHglycan	618	622	PF01048	0.614
MOD_GlcNHglycan	647	650	PF01048	0.647
MOD_GlcNHglycan	856	859	PF01048	0.666
MOD_GlcNHglycan	907	910	PF01048	0.561
MOD_GSK3_1	12	19	PF00069	0.714
MOD_GSK3_1	171	178	PF00069	0.655
MOD_GSK3_1	218	225	PF00069	0.660
MOD_GSK3_1	228	235	PF00069	0.614
MOD_GSK3_1	247	254	PF00069	0.633
MOD_GSK3_1	255	262	PF00069	0.671
MOD_GSK3_1	263	270	PF00069	0.705
MOD_GSK3_1	291	298	PF00069	0.693
MOD_GSK3_1	365	372	PF00069	0.682
MOD_GSK3_1	402	409	PF00069	0.660
MOD_GSK3_1	447	454	PF00069	0.706
MOD_GSK3_1	476	483	PF00069	0.688
MOD_GSK3_1	489	496	PF00069	0.607
MOD_GSK3_1	502	509	PF00069	0.493
MOD_GSK3_1	528	535	PF00069	0.757
MOD_GSK3_1	551	558	PF00069	0.678
MOD_GSK3_1	595	602	PF00069	0.665
MOD_GSK3_1	633	640	PF00069	0.729
MOD_GSK3_1	645	652	PF00069	0.555
MOD_GSK3_1	797	804	PF00069	0.569
MOD_GSK3_1	816	823	PF00069	0.634
MOD_GSK3_1	826	833	PF00069	0.482
MOD_GSK3_1	870	877	PF00069	0.440
MOD_LATS_1	460	466	PF00433	0.764
MOD_N-GLC_1	148	153	PF02516	0.567
MOD_N-GLC_1	232	237	PF02516	0.617
MOD_N-GLC_1	282	287	PF02516	0.721
MOD_N-GLC_1	480	485	PF02516	0.684
MOD_N-GLC_1	489	494	PF02516	0.725
MOD_N-GLC_1	595	600	PF02516	0.723
MOD_N-GLC_1	701	706	PF02516	0.552
MOD_N-GLC_2	610	612	PF02516	0.623
MOD_NEK2_1	228	233	PF00069	0.612
MOD_NEK2_1	282	287	PF00069	0.613
MOD_NEK2_1	392	397	PF00069	0.601
MOD_NEK2_1	551	556	PF00069	0.707
MOD_NEK2_1	595	600	PF00069	0.729
MOD_NEK2_1	741	746	PF00069	0.429
MOD_NEK2_1	854	859	PF00069	0.515
MOD_NEK2_1	864	869	PF00069	0.444
MOD_NEK2_1	874	879	PF00069	0.287
MOD_NEK2_2	510	515	PF00069	0.626
MOD_NEK2_2	518	523	PF00069	0.581
MOD_NEK2_2	835	840	PF00069	0.506
MOD_PIKK_1	148	154	PF00454	0.563
MOD_PIKK_1	21	27	PF00454	0.664
MOD_PIKK_1	218	224	PF00454	0.673
MOD_PIKK_1	392	398	PF00454	0.594
MOD_PIKK_1	552	558	PF00454	0.663
MOD_PIKK_1	801	807	PF00454	0.654
MOD_PKA_1	122	128	PF00069	0.518
MOD_PKA_1	216	222	PF00069	0.641
MOD_PKA_1	462	468	PF00069	0.706
MOD_PKA_1	566	572	PF00069	0.635
MOD_PKA_1	820	826	PF00069	0.566
MOD_PKA_2	122	128	PF00069	0.522
MOD_PKA_2	171	177	PF00069	0.682
MOD_PKA_2	216	222	PF00069	0.619
MOD_PKA_2	266	272	PF00069	0.648
MOD_PKA_2	4	10	PF00069	0.766
MOD_PKA_2	43	49	PF00069	0.734
MOD_PKA_2	462	468	PF00069	0.706
MOD_PKA_2	518	524	PF00069	0.557
MOD_PKA_2	542	548	PF00069	0.622
MOD_PKA_2	551	557	PF00069	0.701
MOD_PKA_2	633	639	PF00069	0.688
MOD_PKA_2	820	826	PF00069	0.600
MOD_PKA_2	833	839	PF00069	0.346
MOD_PKA_2	874	880	PF00069	0.437
MOD_PKB_1	265	273	PF00069	0.616
MOD_PKB_1	539	547	PF00069	0.662
MOD_PKB_1	818	826	PF00069	0.566
MOD_Plk_1	148	154	PF00069	0.563
MOD_Plk_1	340	346	PF00069	0.604
MOD_Plk_1	590	596	PF00069	0.679
MOD_Plk_1	701	707	PF00069	0.548
MOD_Plk_1	750	756	PF00069	0.535
MOD_Plk_2-3	194	200	PF00069	0.644
MOD_Plk_2-3	725	731	PF00069	0.615
MOD_Plk_2-3	757	763	PF00069	0.541
MOD_Plk_4	171	177	PF00069	0.682
MOD_Plk_4	27	33	PF00069	0.616
MOD_Plk_4	295	301	PF00069	0.650
MOD_Plk_4	409	415	PF00069	0.678
MOD_Plk_4	532	538	PF00069	0.581
MOD_Plk_4	654	660	PF00069	0.613
MOD_Plk_4	668	674	PF00069	0.522
MOD_Plk_4	701	707	PF00069	0.551
MOD_Plk_4	808	814	PF00069	0.622
MOD_ProDKin_1	350	356	PF00069	0.664
MOD_ProDKin_1	402	408	PF00069	0.637
MOD_ProDKin_1	52	58	PF00069	0.639
MOD_ProDKin_1	555	561	PF00069	0.631
MOD_ProDKin_1	575	581	PF00069	0.769
MOD_ProDKin_1	742	748	PF00069	0.432
MOD_SUMO_rev_2	751	760	PF00179	0.544
TRG_DiLeu_BaLyEn_6	187	192	PF01217	0.671
TRG_DiLeu_BaLyEn_6	344	349	PF01217	0.633
TRG_DiLeu_BaLyEn_6	706	711	PF01217	0.476
TRG_DiLeu_BaLyEn_6	732	737	PF01217	0.625
TRG_ENDOCYTIC_2	100	103	PF00928	0.547
TRG_ENDOCYTIC_2	410	413	PF00928	0.686
TRG_ENDOCYTIC_2	676	679	PF00928	0.670
TRG_ENDOCYTIC_2	72	75	PF00928	0.482
TRG_ENDOCYTIC_2	93	96	PF00928	0.527
TRG_ER_diArg_1	215	217	PF00400	0.738
TRG_ER_diArg_1	462	464	PF00400	0.735
TRG_ER_diArg_1	540	543	PF00400	0.683
TRG_ER_diArg_1	806	808	PF00400	0.571
TRG_ER_diArg_1	818	821	PF00400	0.567
TRG_NES_CRM1_1	180	193	PF08389	0.717
TRG_Pf-PMV_PEXEL_1	179	183	PF00026	0.693
TRG_Pf-PMV_PEXEL_1	690	694	PF00026	0.530
TRG_Pf-PMV_PEXEL_1	721	725	PF00026	0.460
TRG_Pf-PMV_PEXEL_1	900	904	PF00026	0.445

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6J7	Leptomonas seymouri	41%	95%
A4HFL8	Leishmania braziliensis	60%	99%
A4I2P1	Leishmania infantum	100%	100%
E9AD72	Leishmania major	84%	97%
E9AYZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%