JmjC_domain_hydroxylase_putative/Pfam:PF02373

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

JmjC domain, hydroxylase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X0M0_LEIDO

TriTrypDb:

LdBPK_271030.1 , LdCL_270016800 , LDHU3_27.1650

Length:

486

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X0M0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0M0

Function

Biological processes
Term	Name	Level	Count
GO:0006417	regulation of translation	6	1
GO:0006449	regulation of translational termination	6	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009891	positive regulation of biosynthetic process	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010557	positive regulation of macromolecule biosynthetic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0010628	positive regulation of gene expression	6	1
GO:0010629	negative regulation of gene expression	6	1
GO:0018126	protein hydroxylation	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0019538	protein metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031328	positive regulation of cellular biosynthetic process	6	1
GO:0034248	regulation of amide metabolic process	5	1
GO:0034250	positive regulation of amide metabolic process	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043243	positive regulation of protein-containing complex disassembly	6	1
GO:0043244	regulation of protein-containing complex disassembly	5	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0045727	positive regulation of translation	7	1
GO:0045905	positive regulation of translational termination	7	1
GO:0048518	positive regulation of biological process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051128	regulation of cellular component organization	4	1
GO:0051130	positive regulation of cellular component organization	5	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0051247	positive regulation of protein metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003824	catalytic activity	1	1
GO:0005488	binding	1	1
GO:0016491	oxidoreductase activity	2	1
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	1
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	4	1
GO:0043565	sequence-specific DNA binding	5	1
GO:0051213	dioxygenase activity	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	179	183	PF00656	0.523
CLV_C14_Caspase3-7	194	198	PF00656	0.367
CLV_C14_Caspase3-7	408	412	PF00656	0.307
CLV_C14_Caspase3-7	447	451	PF00656	0.497
CLV_NRD_NRD_1	416	418	PF00675	0.395
CLV_NRD_NRD_1	47	49	PF00675	0.375
CLV_NRD_NRD_1	88	90	PF00675	0.590
CLV_PCSK_KEX2_1	416	418	PF00082	0.395
CLV_PCSK_KEX2_1	46	48	PF00082	0.457
CLV_PCSK_KEX2_1	484	486	PF00082	0.603
CLV_PCSK_KEX2_1	88	90	PF00082	0.605
CLV_PCSK_PC1ET2_1	46	48	PF00082	0.457
CLV_PCSK_PC1ET2_1	484	486	PF00082	0.603
CLV_PCSK_SKI1_1	295	299	PF00082	0.319
CLV_PCSK_SKI1_1	382	386	PF00082	0.332
DEG_Nend_Nbox_1	1	3	PF02207	0.440
DEG_SPOP_SBC_1	122	126	PF00917	0.429
DEG_SPOP_SBC_1	158	162	PF00917	0.500
DOC_CKS1_1	288	293	PF01111	0.480
DOC_PP2B_PxIxI_1	291	297	PF00149	0.437
DOC_PP4_FxxP_1	288	291	PF00568	0.514
DOC_USP7_MATH_1	123	127	PF00917	0.582
DOC_USP7_MATH_1	148	152	PF00917	0.403
DOC_USP7_MATH_1	163	167	PF00917	0.498
DOC_USP7_MATH_1	242	246	PF00917	0.513
DOC_USP7_MATH_1	68	72	PF00917	0.521
DOC_WW_Pin1_4	128	133	PF00397	0.625
DOC_WW_Pin1_4	244	249	PF00397	0.424
DOC_WW_Pin1_4	287	292	PF00397	0.503
DOC_WW_Pin1_4	78	83	PF00397	0.684
LIG_14-3-3_CanoR_1	392	400	PF00244	0.378
LIG_BIR_III_4	33	37	PF00653	0.347
LIG_BRCT_BRCA1_1	257	261	PF00533	0.514
LIG_DCNL_PONY_1	1	4	PF03556	0.434
LIG_deltaCOP1_diTrp_1	194	199	PF00928	0.302
LIG_deltaCOP1_diTrp_1	266	271	PF00928	0.422
LIG_EH1_1	377	385	PF00400	0.355
LIG_eIF4E_1	279	285	PF01652	0.514
LIG_EVH1_1	288	292	PF00568	0.493
LIG_FHA_1	109	115	PF00498	0.345
LIG_FHA_1	153	159	PF00498	0.576
LIG_FHA_1	325	331	PF00498	0.599
LIG_FHA_1	365	371	PF00498	0.401
LIG_FHA_1	375	381	PF00498	0.365
LIG_FHA_1	433	439	PF00498	0.490
LIG_FHA_1	70	76	PF00498	0.605
LIG_FHA_2	177	183	PF00498	0.366
LIG_FHA_2	288	294	PF00498	0.484
LIG_FHA_2	296	302	PF00498	0.442
LIG_FHA_2	74	80	PF00498	0.538
LIG_FHA_2	93	99	PF00498	0.703
LIG_LIR_Apic_2	182	188	PF02991	0.332
LIG_LIR_Apic_2	266	272	PF02991	0.422
LIG_LIR_Gen_1	234	243	PF02991	0.249
LIG_LIR_Gen_1	430	438	PF02991	0.453
LIG_LIR_Gen_1	475	481	PF02991	0.498
LIG_LIR_Nem_3	234	240	PF02991	0.258
LIG_LIR_Nem_3	245	249	PF02991	0.433
LIG_LIR_Nem_3	252	257	PF02991	0.477
LIG_LIR_Nem_3	282	288	PF02991	0.458
LIG_LIR_Nem_3	329	334	PF02991	0.438
LIG_LIR_Nem_3	412	418	PF02991	0.444
LIG_LIR_Nem_3	475	480	PF02991	0.500
LIG_LIR_Nem_3	8	14	PF02991	0.330
LIG_Pex14_1	195	199	PF04695	0.299
LIG_Pex14_1	374	378	PF04695	0.428
LIG_Pex14_2	314	318	PF04695	0.384
LIG_SH2_CRK	185	189	PF00017	0.356
LIG_SH2_CRK	320	324	PF00017	0.479
LIG_SH2_PTP2	239	242	PF00017	0.397
LIG_SH2_STAP1	257	261	PF00017	0.422
LIG_SH2_STAP1	477	481	PF00017	0.499
LIG_SH2_STAT5	139	142	PF00017	0.303
LIG_SH2_STAT5	239	242	PF00017	0.401
LIG_SH2_STAT5	270	273	PF00017	0.441
LIG_SH2_STAT5	279	282	PF00017	0.467
LIG_SH3_3	129	135	PF00018	0.452
LIG_SH3_3	18	24	PF00018	0.326
LIG_SH3_3	283	289	PF00018	0.508
LIG_SH3_3	303	309	PF00018	0.354
LIG_SH3_3	310	316	PF00018	0.402
LIG_SH3_3	349	355	PF00018	0.668
LIG_SH3_3	62	68	PF00018	0.459
LIG_SUMO_SIM_anti_2	401	409	PF11976	0.406
LIG_TRAF2_1	103	106	PF00917	0.472
LIG_TRFH_1	285	289	PF08558	0.192
LIG_WRC_WIRS_1	196	201	PF05994	0.373
MOD_CDK_SPxxK_3	78	85	PF00069	0.586
MOD_CK1_1	162	168	PF00069	0.566
MOD_CK1_1	174	180	PF00069	0.229
MOD_CK1_1	396	402	PF00069	0.412
MOD_CK1_1	430	436	PF00069	0.365
MOD_CK1_1	77	83	PF00069	0.681
MOD_CK2_1	295	301	PF00069	0.301
MOD_GlcNHglycan	125	128	PF01048	0.606
MOD_GlcNHglycan	161	164	PF01048	0.586
MOD_GlcNHglycan	176	179	PF01048	0.520
MOD_GlcNHglycan	33	37	PF01048	0.412
MOD_GlcNHglycan	362	365	PF01048	0.557
MOD_GlcNHglycan	411	414	PF01048	0.512
MOD_GlcNHglycan	446	449	PF01048	0.491
MOD_GSK3_1	117	124	PF00069	0.502
MOD_GSK3_1	148	155	PF00069	0.365
MOD_GSK3_1	158	165	PF00069	0.433
MOD_GSK3_1	217	224	PF00069	0.467
MOD_GSK3_1	253	260	PF00069	0.270
MOD_GSK3_1	360	367	PF00069	0.493
MOD_GSK3_1	69	76	PF00069	0.502
MOD_N-GLC_1	324	329	PF02516	0.369
MOD_N-GLC_1	424	429	PF02516	0.472
MOD_N-GLC_2	262	264	PF02516	0.283
MOD_N-GLC_2	29	31	PF02516	0.450
MOD_N-GLC_2	373	375	PF02516	0.284
MOD_NEK2_1	149	154	PF00069	0.558
MOD_NEK2_1	211	216	PF00069	0.657
MOD_NEK2_1	366	371	PF00069	0.320
MOD_NEK2_1	4	9	PF00069	0.465
MOD_NEK2_2	432	437	PF00069	0.309
MOD_PIKK_1	221	227	PF00454	0.376
MOD_PIKK_1	57	63	PF00454	0.423
MOD_PKA_2	174	180	PF00069	0.492
MOD_PKA_2	409	415	PF00069	0.455
MOD_Plk_1	427	433	PF00069	0.370
MOD_ProDKin_1	128	134	PF00069	0.621
MOD_ProDKin_1	244	250	PF00069	0.265
MOD_ProDKin_1	287	293	PF00069	0.377
MOD_ProDKin_1	78	84	PF00069	0.681
MOD_SUMO_rev_2	476	486	PF00179	0.363
TRG_DiLeu_BaEn_1	401	406	PF01217	0.509
TRG_DiLeu_BaEn_1	476	481	PF01217	0.538
TRG_DiLeu_BaLyEn_6	418	423	PF01217	0.256
TRG_ENDOCYTIC_2	11	14	PF00928	0.417
TRG_ENDOCYTIC_2	251	254	PF00928	0.421
TRG_ENDOCYTIC_2	320	323	PF00928	0.342
TRG_ENDOCYTIC_2	477	480	PF00928	0.501
TRG_ER_diArg_1	415	417	PF00400	0.392
TRG_ER_diArg_1	47	49	PF00400	0.448
TRG_NES_CRM1_1	293	303	PF08389	0.392
TRG_Pf-PMV_PEXEL_1	189	194	PF00026	0.371
TRG_Pf-PMV_PEXEL_1	56	61	PF00026	0.356

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I519	Leptomonas seymouri	51%	93%
A0A0S4JI40	Bodo saltans	31%	99%
A0A1X0P4A9	Trypanosomatidae	37%	100%
A0A3R7LP24	Trypanosoma rangeli	41%	100%
A4HFP0	Leishmania braziliensis	76%	100%
A4I2R6	Leishmania infantum	100%	100%
D0A5X2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AD93	Leishmania major	91%	100%
E9AZ18	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
Q08BY5	Danio rerio	26%	100%
Q67ZB6	Arabidopsis thaliana	25%	100%
V5BD54	Trypanosoma cruzi	40%	100%