Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X0L8_LEIDO

TriTrypDb:

LdBPK_270850.1 , LdCL_270015100 , LDHU3_27.1430

Length:

280

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X0L8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0L8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.476
CLV_C14_Caspase3-7	90	94	PF00656	0.614
CLV_NRD_NRD_1	252	254	PF00675	0.670
CLV_NRD_NRD_1	35	37	PF00675	0.527
CLV_PCSK_KEX2_1	2	4	PF00082	0.615
CLV_PCSK_KEX2_1	252	254	PF00082	0.670
CLV_PCSK_KEX2_1	35	37	PF00082	0.565
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.586
CLV_PCSK_SKI1_1	146	150	PF00082	0.475
CLV_PCSK_SKI1_1	36	40	PF00082	0.566
DEG_MDM2_SWIB_1	159	166	PF02201	0.479
DEG_Nend_UBRbox_1	1	4	PF02207	0.630
DEG_SPOP_SBC_1	26	30	PF00917	0.666
DOC_AGCK_PIF_2	68	73	PF00069	0.555
DOC_CYCLIN_RxL_1	143	153	PF00134	0.446
DOC_MAPK_gen_1	33	43	PF00069	0.525
DOC_MAPK_MEF2A_6	36	45	PF00069	0.540
DOC_USP7_MATH_1	196	200	PF00917	0.756
DOC_USP7_MATH_1	201	205	PF00917	0.793
DOC_USP7_MATH_1	222	226	PF00917	0.797
DOC_USP7_MATH_1	234	238	PF00917	0.654
DOC_USP7_MATH_1	26	30	PF00917	0.715
DOC_USP7_MATH_1	88	92	PF00917	0.647
DOC_USP7_MATH_1	95	99	PF00917	0.558
DOC_WW_Pin1_4	116	121	PF00397	0.530
DOC_WW_Pin1_4	150	155	PF00397	0.596
DOC_WW_Pin1_4	197	202	PF00397	0.803
DOC_WW_Pin1_4	206	211	PF00397	0.738
DOC_WW_Pin1_4	227	232	PF00397	0.685
LIG_14-3-3_CanoR_1	214	221	PF00244	0.570
LIG_FHA_1	183	189	PF00498	0.754
LIG_FHA_1	228	234	PF00498	0.609
LIG_FHA_1	238	244	PF00498	0.741
LIG_FHA_1	26	32	PF00498	0.556
LIG_FHA_1	59	65	PF00498	0.484
LIG_FHA_2	151	157	PF00498	0.586
LIG_FHA_2	245	251	PF00498	0.564
LIG_FHA_2	7	13	PF00498	0.562
LIG_FHA_2	88	94	PF00498	0.597
LIG_GBD_Chelix_1	235	243	PF00786	0.636
LIG_LIR_Gen_1	160	171	PF02991	0.551
LIG_LIR_Nem_3	160	166	PF02991	0.560
LIG_LIR_Nem_3	72	77	PF02991	0.652
LIG_NRP_CendR_1	278	280	PF00754	0.582
LIG_Pex14_2	159	163	PF04695	0.431
LIG_REV1ctd_RIR_1	71	79	PF16727	0.466
LIG_RPA_C_Plants	255	266	PF08784	0.494
LIG_SH2_NCK_1	264	268	PF00017	0.565
LIG_SH3_1	17	23	PF00018	0.542
LIG_SH3_3	17	23	PF00018	0.542
LIG_SH3_3	189	195	PF00018	0.604
LIG_SH3_3	228	234	PF00018	0.600
LIG_SH3_3	28	34	PF00018	0.450
LIG_SH3_3	40	46	PF00018	0.456
LIG_SH3_3	63	69	PF00018	0.490
LIG_SUMO_SIM_anti_2	271	277	PF11976	0.544
LIG_TRAF2_1	248	251	PF00917	0.646
MOD_CK1_1	100	106	PF00069	0.693
MOD_CK1_1	182	188	PF00069	0.716
MOD_CK1_1	225	231	PF00069	0.730
MOD_CK1_1	237	243	PF00069	0.556
MOD_CK1_1	25	31	PF00069	0.693
MOD_CK2_1	150	156	PF00069	0.571
MOD_CK2_1	244	250	PF00069	0.653
MOD_CK2_1	47	53	PF00069	0.491
MOD_CK2_1	6	12	PF00069	0.566
MOD_GlcNHglycan	102	105	PF01048	0.682
MOD_GlcNHglycan	111	114	PF01048	0.631
MOD_GlcNHglycan	136	139	PF01048	0.494
MOD_GlcNHglycan	181	184	PF01048	0.650
MOD_GlcNHglycan	222	225	PF01048	0.614
MOD_GlcNHglycan	24	27	PF01048	0.765
MOD_GlcNHglycan	270	273	PF01048	0.616
MOD_GlcNHglycan	90	93	PF01048	0.628
MOD_GlcNHglycan	97	100	PF01048	0.652
MOD_GSK3_1	105	112	PF00069	0.761
MOD_GSK3_1	116	123	PF00069	0.493
MOD_GSK3_1	18	25	PF00069	0.730
MOD_GSK3_1	182	189	PF00069	0.586
MOD_GSK3_1	197	204	PF00069	0.617
MOD_GSK3_1	216	223	PF00069	0.488
MOD_N-GLC_1	197	202	PF02516	0.690
MOD_NEK2_1	105	110	PF00069	0.769
MOD_NEK2_1	239	244	PF00069	0.724
MOD_NEK2_1	47	52	PF00069	0.662
MOD_NEK2_2	27	32	PF00069	0.503
MOD_PIKK_1	222	228	PF00454	0.662
MOD_PKA_2	213	219	PF00069	0.570
MOD_Plk_1	106	112	PF00069	0.665
MOD_Plk_2-3	6	12	PF00069	0.556
MOD_Plk_4	234	240	PF00069	0.564
MOD_Plk_4	47	53	PF00069	0.526
MOD_Plk_4	60	66	PF00069	0.461
MOD_Plk_4	97	103	PF00069	0.612
MOD_ProDKin_1	116	122	PF00069	0.531
MOD_ProDKin_1	150	156	PF00069	0.596
MOD_ProDKin_1	197	203	PF00069	0.805
MOD_ProDKin_1	206	212	PF00069	0.733
MOD_ProDKin_1	227	233	PF00069	0.684
TRG_DiLeu_BaEn_2	130	136	PF01217	0.554
TRG_DiLeu_BaLyEn_6	143	148	PF01217	0.447
TRG_ENDOCYTIC_2	264	267	PF00928	0.548
TRG_ER_diArg_1	252	255	PF00400	0.621
TRG_ER_diArg_1	34	36	PF00400	0.560

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6J0	Leptomonas seymouri	46%	100%
A0A1X0P427	Trypanosomatidae	34%	100%
A0A422N2W4	Trypanosoma rangeli	30%	100%
A4HFM2	Leishmania braziliensis	73%	100%
A4I2Q0	Leishmania infantum	99%	100%
D0A5V2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AD76	Leishmania major	90%	100%
E9AZ00	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%