Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X0L5_LEIDO

TriTrypDb:

LdBPK_270970.1 , LdCL_270016300 , LDHU3_27.1590

Length:

646

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X0L5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0L5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	223	227	PF00656	0.583
CLV_C14_Caspase3-7	391	395	PF00656	0.653
CLV_C14_Caspase3-7	46	50	PF00656	0.482
CLV_C14_Caspase3-7	479	483	PF00656	0.627
CLV_NRD_NRD_1	190	192	PF00675	0.497
CLV_NRD_NRD_1	267	269	PF00675	0.575
CLV_NRD_NRD_1	272	274	PF00675	0.570
CLV_NRD_NRD_1	328	330	PF00675	0.672
CLV_NRD_NRD_1	469	471	PF00675	0.574
CLV_NRD_NRD_1	565	567	PF00675	0.815
CLV_NRD_NRD_1	592	594	PF00675	0.840
CLV_NRD_NRD_1	611	613	PF00675	0.779
CLV_NRD_NRD_1	614	616	PF00675	0.775
CLV_NRD_NRD_1	620	622	PF00675	0.771
CLV_PCSK_KEX2_1	272	274	PF00082	0.551
CLV_PCSK_KEX2_1	313	315	PF00082	0.593
CLV_PCSK_KEX2_1	327	329	PF00082	0.636
CLV_PCSK_KEX2_1	468	470	PF00082	0.584
CLV_PCSK_KEX2_1	594	596	PF00082	0.845
CLV_PCSK_KEX2_1	611	613	PF00082	0.786
CLV_PCSK_KEX2_1	620	622	PF00082	0.778
CLV_PCSK_KEX2_1	66	68	PF00082	0.576
CLV_PCSK_PC1ET2_1	313	315	PF00082	0.581
CLV_PCSK_PC1ET2_1	594	596	PF00082	0.702
CLV_PCSK_PC1ET2_1	611	613	PF00082	0.786
CLV_PCSK_PC1ET2_1	620	622	PF00082	0.778
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.551
CLV_PCSK_PC7_1	268	274	PF00082	0.534
CLV_PCSK_SKI1_1	124	128	PF00082	0.464
CLV_PCSK_SKI1_1	2	6	PF00082	0.573
CLV_PCSK_SKI1_1	32	36	PF00082	0.566
CLV_PCSK_SKI1_1	393	397	PF00082	0.682
CLV_PCSK_SKI1_1	608	612	PF00082	0.789
DEG_APCC_DBOX_1	75	83	PF00400	0.541
DEG_Nend_UBRbox_1	1	4	PF02207	0.623
DEG_SPOP_SBC_1	162	166	PF00917	0.648
DEG_SPOP_SBC_1	171	175	PF00917	0.592
DEG_SPOP_SBC_1	416	420	PF00917	0.633
DOC_CKS1_1	16	21	PF01111	0.539
DOC_CKS1_1	27	32	PF01111	0.550
DOC_CKS1_1	39	44	PF01111	0.381
DOC_CYCLIN_RxL_1	66	77	PF00134	0.457
DOC_CYCLIN_yCln2_LP_2	39	45	PF00134	0.477
DOC_MAPK_gen_1	151	158	PF00069	0.503
DOC_MAPK_gen_1	66	75	PF00069	0.499
DOC_MAPK_JIP1_4	67	73	PF00069	0.502
DOC_MAPK_MEF2A_6	66	75	PF00069	0.499
DOC_PP1_RVXF_1	56	62	PF00149	0.460
DOC_PP2B_LxvP_1	195	198	PF13499	0.573
DOC_PP4_FxxP_1	126	129	PF00568	0.557
DOC_USP7_MATH_1	152	156	PF00917	0.550
DOC_USP7_MATH_1	170	174	PF00917	0.565
DOC_USP7_MATH_1	198	202	PF00917	0.586
DOC_USP7_MATH_1	289	293	PF00917	0.636
DOC_USP7_MATH_1	402	406	PF00917	0.687
DOC_USP7_MATH_1	408	412	PF00917	0.615
DOC_USP7_MATH_1	474	478	PF00917	0.663
DOC_USP7_MATH_1	495	499	PF00917	0.697
DOC_USP7_MATH_1	554	558	PF00917	0.685
DOC_USP7_MATH_1	568	572	PF00917	0.582
DOC_USP7_MATH_1	597	601	PF00917	0.644
DOC_USP7_MATH_1	623	627	PF00917	0.711
DOC_USP7_MATH_1	629	633	PF00917	0.654
DOC_USP7_UBL2_3	590	594	PF12436	0.707
DOC_USP7_UBL2_3	607	611	PF12436	0.543
DOC_USP7_UBL2_3	616	620	PF12436	0.586
DOC_WW_Pin1_4	15	20	PF00397	0.543
DOC_WW_Pin1_4	26	31	PF00397	0.407
DOC_WW_Pin1_4	38	43	PF00397	0.378
DOC_WW_Pin1_4	400	405	PF00397	0.800
DOC_WW_Pin1_4	6	11	PF00397	0.648
DOC_WW_Pin1_4	83	88	PF00397	0.550
LIG_14-3-3_CanoR_1	151	157	PF00244	0.507
LIG_14-3-3_CanoR_1	191	196	PF00244	0.513
LIG_14-3-3_CanoR_1	272	277	PF00244	0.671
LIG_14-3-3_CanoR_1	290	295	PF00244	0.704
LIG_14-3-3_CanoR_1	296	304	PF00244	0.653
LIG_14-3-3_CanoR_1	429	435	PF00244	0.588
LIG_14-3-3_CanoR_1	484	488	PF00244	0.646
LIG_14-3-3_CanoR_1	497	503	PF00244	0.462
LIG_Actin_WH2_2	227	244	PF00022	0.459
LIG_BIR_III_2	215	219	PF00653	0.573
LIG_BIR_III_4	394	398	PF00653	0.607
LIG_BRCT_BRCA1_1	257	261	PF00533	0.495
LIG_BRCT_BRCA1_1	413	417	PF00533	0.551
LIG_BRCT_BRCA1_1	8	12	PF00533	0.606
LIG_Clathr_ClatBox_1	260	264	PF01394	0.532
LIG_deltaCOP1_diTrp_1	350	354	PF00928	0.581
LIG_EH1_1	129	137	PF00400	0.445
LIG_eIF4E_1	130	136	PF01652	0.412
LIG_FHA_1	105	111	PF00498	0.660
LIG_FHA_1	234	240	PF00498	0.450
LIG_FHA_1	248	254	PF00498	0.335
LIG_FHA_1	417	423	PF00498	0.645
LIG_FHA_1	545	551	PF00498	0.782
LIG_FHA_1	626	632	PF00498	0.677
LIG_FHA_2	212	218	PF00498	0.632
LIG_FHA_2	249	255	PF00498	0.424
LIG_FHA_2	497	503	PF00498	0.524
LIG_FHA_2	512	518	PF00498	0.617
LIG_FHA_2	551	557	PF00498	0.662
LIG_FHA_2	88	94	PF00498	0.551
LIG_KLC1_Yacidic_2	226	231	PF13176	0.565
LIG_LIR_Gen_1	350	359	PF02991	0.578
LIG_LIR_Gen_1	372	382	PF02991	0.663
LIG_LIR_Gen_1	88	99	PF02991	0.516
LIG_LIR_Nem_3	119	125	PF02991	0.581
LIG_LIR_Nem_3	350	354	PF02991	0.581
LIG_LIR_Nem_3	372	378	PF02991	0.663
LIG_LIR_Nem_3	506	512	PF02991	0.778
LIG_LIR_Nem_3	88	94	PF02991	0.551
LIG_SH2_CRK	122	126	PF00017	0.553
LIG_SH2_NCK_1	130	134	PF00017	0.448
LIG_SH2_SRC	229	232	PF00017	0.560
LIG_SH2_SRC	375	378	PF00017	0.670
LIG_SH2_SRC	440	443	PF00017	0.641
LIG_SH2_STAP1	212	216	PF00017	0.546
LIG_SH2_STAP1	23	27	PF00017	0.571
LIG_SH2_STAT5	229	232	PF00017	0.560
LIG_SH2_STAT5	304	307	PF00017	0.752
LIG_SH2_STAT5	421	424	PF00017	0.640
LIG_SH3_3	146	152	PF00018	0.506
LIG_SH3_3	628	634	PF00018	0.662
LIG_SH3_3	72	78	PF00018	0.587
LIG_SH3_3	81	87	PF00018	0.611
LIG_SH3_4	590	597	PF00018	0.654
LIG_SUMO_SIM_anti_2	245	251	PF11976	0.441
LIG_SUMO_SIM_par_1	106	111	PF11976	0.620
LIG_SUMO_SIM_par_1	245	251	PF11976	0.480
LIG_SUMO_SIM_par_1	547	553	PF11976	0.651
MOD_CDK_SPK_2	15	20	PF00069	0.519
MOD_CDK_SPK_2	6	11	PF00069	0.604
MOD_CDK_SPxK_1	26	32	PF00069	0.573
MOD_CK1_1	154	160	PF00069	0.503
MOD_CK1_1	164	170	PF00069	0.705
MOD_CK1_1	255	261	PF00069	0.487
MOD_CK1_1	275	281	PF00069	0.645
MOD_CK1_1	284	290	PF00069	0.578
MOD_CK1_1	400	406	PF00069	0.674
MOD_CK1_1	411	417	PF00069	0.590
MOD_CK1_1	420	426	PF00069	0.487
MOD_CK1_1	47	53	PF00069	0.523
MOD_CK1_1	483	489	PF00069	0.670
MOD_CK1_1	513	519	PF00069	0.736
MOD_CK1_1	520	526	PF00069	0.676
MOD_CK1_1	544	550	PF00069	0.627
MOD_CK1_1	557	563	PF00069	0.660
MOD_CK2_1	162	168	PF00069	0.615
MOD_CK2_1	172	178	PF00069	0.540
MOD_CK2_1	248	254	PF00069	0.427
MOD_CK2_1	289	295	PF00069	0.695
MOD_CK2_1	349	355	PF00069	0.600
MOD_CK2_1	451	457	PF00069	0.680
MOD_CK2_1	496	502	PF00069	0.529
MOD_CK2_1	511	517	PF00069	0.621
MOD_CK2_1	550	556	PF00069	0.672
MOD_CK2_1	92	98	PF00069	0.632
MOD_Cter_Amidation	604	607	PF01082	0.701
MOD_GlcNHglycan	102	105	PF01048	0.603
MOD_GlcNHglycan	158	161	PF01048	0.585
MOD_GlcNHglycan	200	203	PF01048	0.616
MOD_GlcNHglycan	297	300	PF01048	0.693
MOD_GlcNHglycan	399	402	PF01048	0.829
MOD_GlcNHglycan	410	413	PF01048	0.658
MOD_GlcNHglycan	435	438	PF01048	0.643
MOD_GlcNHglycan	46	49	PF01048	0.498
MOD_GlcNHglycan	499	502	PF01048	0.627
MOD_GlcNHglycan	519	522	PF01048	0.714
MOD_GlcNHglycan	559	562	PF01048	0.711
MOD_GlcNHglycan	580	585	PF01048	0.743
MOD_GlcNHglycan	587	590	PF01048	0.660
MOD_GlcNHglycan	597	600	PF01048	0.569
MOD_GlcNHglycan	631	634	PF01048	0.657
MOD_GlcNHglycan	92	97	PF01048	0.597
MOD_GSK3_1	100	107	PF00069	0.558
MOD_GSK3_1	152	159	PF00069	0.505
MOD_GSK3_1	187	194	PF00069	0.621
MOD_GSK3_1	248	255	PF00069	0.428
MOD_GSK3_1	290	297	PF00069	0.705
MOD_GSK3_1	37	44	PF00069	0.456
MOD_GSK3_1	393	400	PF00069	0.717
MOD_GSK3_1	411	418	PF00069	0.512
MOD_GSK3_1	447	454	PF00069	0.629
MOD_GSK3_1	483	490	PF00069	0.752
MOD_GSK3_1	497	504	PF00069	0.488
MOD_GSK3_1	512	519	PF00069	0.639
MOD_GSK3_1	546	553	PF00069	0.718
MOD_GSK3_1	585	592	PF00069	0.716
MOD_GSK3_1	623	630	PF00069	0.678
MOD_GSK3_1	83	90	PF00069	0.671
MOD_N-GLC_1	171	176	PF02516	0.633
MOD_NEK2_1	156	161	PF00069	0.508
MOD_NEK2_1	248	253	PF00069	0.422
MOD_NEK2_1	294	299	PF00069	0.701
MOD_NEK2_1	417	422	PF00069	0.526
MOD_NEK2_1	496	501	PF00069	0.580
MOD_NEK2_1	5	10	PF00069	0.597
MOD_NEK2_1	640	645	PF00069	0.783
MOD_NEK2_2	349	354	PF00069	0.579
MOD_PIKK_1	275	281	PF00454	0.609
MOD_PIKK_1	403	409	PF00454	0.652
MOD_PIKK_1	554	560	PF00454	0.637
MOD_PK_1	447	453	PF00069	0.670
MOD_PKA_1	191	197	PF00069	0.527
MOD_PKA_1	272	278	PF00069	0.515
MOD_PKA_1	468	474	PF00069	0.580
MOD_PKA_1	611	617	PF00069	0.725
MOD_PKA_2	152	158	PF00069	0.546
MOD_PKA_2	187	193	PF00069	0.502
MOD_PKA_2	272	278	PF00069	0.553
MOD_PKA_2	281	287	PF00069	0.641
MOD_PKA_2	289	295	PF00069	0.754
MOD_PKA_2	468	474	PF00069	0.580
MOD_PKA_2	483	489	PF00069	0.492
MOD_PKA_2	496	502	PF00069	0.455
MOD_PKA_2	510	516	PF00069	0.624
MOD_PKA_2	611	617	PF00069	0.779
MOD_PKB_1	593	601	PF00069	0.713
MOD_Plk_1	171	177	PF00069	0.605
MOD_Plk_1	232	238	PF00069	0.451
MOD_Plk_1	349	355	PF00069	0.578
MOD_Plk_1	48	54	PF00069	0.550
MOD_Plk_1	550	556	PF00069	0.707
MOD_Plk_1	580	586	PF00069	0.593
MOD_Plk_1	87	93	PF00069	0.538
MOD_Plk_4	134	140	PF00069	0.443
MOD_Plk_4	252	258	PF00069	0.469
MOD_Plk_4	417	423	PF00069	0.645
MOD_ProDKin_1	15	21	PF00069	0.534
MOD_ProDKin_1	26	32	PF00069	0.410
MOD_ProDKin_1	38	44	PF00069	0.383
MOD_ProDKin_1	400	406	PF00069	0.798
MOD_ProDKin_1	6	12	PF00069	0.649
MOD_ProDKin_1	83	89	PF00069	0.551
MOD_SUMO_rev_2	386	395	PF00179	0.670
MOD_SUMO_rev_2	560	568	PF00179	0.700
MOD_SUMO_rev_2	575	584	PF00179	0.645
TRG_DiLeu_BaLyEn_6	55	60	PF01217	0.467
TRG_ENDOCYTIC_2	122	125	PF00928	0.547
TRG_ENDOCYTIC_2	375	378	PF00928	0.670
TRG_ENDOCYTIC_2	509	512	PF00928	0.641
TRG_ER_diArg_1	280	283	PF00400	0.564
TRG_ER_diArg_1	327	329	PF00400	0.660
TRG_ER_diArg_1	467	470	PF00400	0.573
TRG_NLS_Bipartite_1	593	615	PF00514	0.666
TRG_NLS_MonoCore_2	65	70	PF00514	0.524
TRG_NLS_MonoExtC_3	610	615	PF00514	0.707
TRG_NLS_MonoExtN_4	590	597	PF00514	0.709
TRG_NLS_MonoExtN_4	608	615	PF00514	0.538
TRG_NLS_MonoExtN_4	618	624	PF00514	0.574
TRG_Pf-PMV_PEXEL_1	58	62	PF00026	0.450

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HFN4	Leishmania braziliensis	69%	100%
A4I2R1	Leishmania infantum	100%	100%
E9AD88	Leishmania major	89%	100%
E9AZ12	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%