Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X0L4_LEIDO

TriTrypDb:

LdBPK_270890.1 , LdCL_270015500 , LDHU3_27.1480

Length:

896

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X0L4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0L4

PDB structure(s): 7am2_BK

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.705
CLV_C14_Caspase3-7	525	529	PF00656	0.584
CLV_C14_Caspase3-7	667	671	PF00656	0.411
CLV_NRD_NRD_1	209	211	PF00675	0.463
CLV_NRD_NRD_1	622	624	PF00675	0.505
CLV_NRD_NRD_1	663	665	PF00675	0.416
CLV_NRD_NRD_1	694	696	PF00675	0.521
CLV_NRD_NRD_1	833	835	PF00675	0.478
CLV_PCSK_FUR_1	502	506	PF00082	0.578
CLV_PCSK_KEX2_1	209	211	PF00082	0.518
CLV_PCSK_KEX2_1	504	506	PF00082	0.493
CLV_PCSK_KEX2_1	622	624	PF00082	0.466
CLV_PCSK_KEX2_1	663	665	PF00082	0.416
CLV_PCSK_KEX2_1	693	695	PF00082	0.536
CLV_PCSK_KEX2_1	833	835	PF00082	0.433
CLV_PCSK_PC1ET2_1	504	506	PF00082	0.547
CLV_PCSK_PC1ET2_1	693	695	PF00082	0.614
CLV_PCSK_PC7_1	829	835	PF00082	0.440
CLV_PCSK_SKI1_1	196	200	PF00082	0.503
CLV_PCSK_SKI1_1	239	243	PF00082	0.547
CLV_PCSK_SKI1_1	332	336	PF00082	0.510
CLV_PCSK_SKI1_1	669	673	PF00082	0.463
CLV_PCSK_SKI1_1	694	698	PF00082	0.480
CLV_PCSK_SKI1_1	713	717	PF00082	0.206
CLV_PCSK_SKI1_1	801	805	PF00082	0.455
CLV_PCSK_SKI1_1	836	840	PF00082	0.451
CLV_PCSK_SKI1_1	86	90	PF00082	0.670
DEG_APCC_DBOX_1	331	339	PF00400	0.540
DEG_APCC_DBOX_1	712	720	PF00400	0.451
DEG_Nend_UBRbox_1	1	4	PF02207	0.672
DEG_SCF_FBW7_2	875	882	PF00400	0.575
DEG_SPOP_SBC_1	24	28	PF00917	0.764
DEG_SPOP_SBC_1	463	467	PF00917	0.621
DEG_SPOP_SBC_1	777	781	PF00917	0.631
DOC_ANK_TNKS_1	846	853	PF00023	0.441
DOC_CKS1_1	867	872	PF01111	0.462
DOC_CKS1_1	876	881	PF01111	0.448
DOC_CYCLIN_RxL_1	327	339	PF00134	0.557
DOC_CYCLIN_yClb1_LxF_4	230	236	PF00134	0.496
DOC_MAPK_gen_1	193	203	PF00069	0.511
DOC_MAPK_gen_1	430	440	PF00069	0.448
DOC_MAPK_gen_1	666	674	PF00069	0.444
DOC_MAPK_MEF2A_6	166	173	PF00069	0.606
DOC_MAPK_MEF2A_6	433	440	PF00069	0.503
DOC_MAPK_MEF2A_6	476	484	PF00069	0.628
DOC_MAPK_MEF2A_6	747	754	PF00069	0.411
DOC_MAPK_NFAT4_5	433	441	PF00069	0.501
DOC_PP1_RVXF_1	415	421	PF00149	0.539
DOC_PP1_RVXF_1	861	868	PF00149	0.577
DOC_PP4_FxxP_1	58	61	PF00568	0.500
DOC_PP4_FxxP_1	867	870	PF00568	0.605
DOC_USP7_MATH_1	19	23	PF00917	0.798
DOC_USP7_MATH_1	24	28	PF00917	0.659
DOC_USP7_MATH_1	35	39	PF00917	0.694
DOC_USP7_MATH_1	464	468	PF00917	0.700
DOC_USP7_MATH_1	777	781	PF00917	0.629
DOC_USP7_MATH_1	857	861	PF00917	0.528
DOC_USP7_MATH_1	95	99	PF00917	0.807
DOC_USP7_MATH_2	48	54	PF00917	0.636
DOC_WW_Pin1_4	138	143	PF00397	0.696
DOC_WW_Pin1_4	276	281	PF00397	0.504
DOC_WW_Pin1_4	398	403	PF00397	0.538
DOC_WW_Pin1_4	476	481	PF00397	0.632
DOC_WW_Pin1_4	583	588	PF00397	0.451
DOC_WW_Pin1_4	773	778	PF00397	0.603
DOC_WW_Pin1_4	786	791	PF00397	0.573
DOC_WW_Pin1_4	866	871	PF00397	0.460
DOC_WW_Pin1_4	875	880	PF00397	0.441
LIG_14-3-3_CanoR_1	196	201	PF00244	0.511
LIG_14-3-3_CanoR_1	245	250	PF00244	0.491
LIG_14-3-3_CanoR_1	36	40	PF00244	0.635
LIG_14-3-3_CanoR_1	517	521	PF00244	0.470
LIG_14-3-3_CanoR_1	694	702	PF00244	0.539
LIG_14-3-3_CanoR_1	801	809	PF00244	0.495
LIG_Actin_WH2_2	229	244	PF00022	0.474
LIG_Actin_WH2_2	651	668	PF00022	0.505
LIG_Actin_WH2_2	788	803	PF00022	0.445
LIG_BRCT_BRCA1_1	222	226	PF00533	0.384
LIG_BRCT_BRCA1_1	51	55	PF00533	0.597
LIG_BRCT_BRCA1_1	65	69	PF00533	0.615
LIG_deltaCOP1_diTrp_1	227	235	PF00928	0.537
LIG_deltaCOP1_diTrp_1	410	415	PF00928	0.502
LIG_EH1_1	624	632	PF00400	0.543
LIG_eIF4E_1	220	226	PF01652	0.508
LIG_eIF4E_1	731	737	PF01652	0.385
LIG_FHA_1	132	138	PF00498	0.756
LIG_FHA_1	195	201	PF00498	0.468
LIG_FHA_1	214	220	PF00498	0.515
LIG_FHA_1	328	334	PF00498	0.537
LIG_FHA_1	464	470	PF00498	0.747
LIG_FHA_1	477	483	PF00498	0.593
LIG_FHA_1	538	544	PF00498	0.503
LIG_FHA_1	599	605	PF00498	0.542
LIG_FHA_1	718	724	PF00498	0.536
LIG_FHA_1	787	793	PF00498	0.539
LIG_FHA_2	197	203	PF00498	0.510
LIG_FHA_2	265	271	PF00498	0.440
LIG_FHA_2	728	734	PF00498	0.444
LIG_LIR_Apic_2	314	318	PF02991	0.522
LIG_LIR_Gen_1	115	124	PF02991	0.674
LIG_LIR_Gen_1	254	264	PF02991	0.410
LIG_LIR_Gen_1	432	443	PF02991	0.431
LIG_LIR_Gen_1	495	503	PF02991	0.482
LIG_LIR_Gen_1	559	569	PF02991	0.446
LIG_LIR_Nem_3	115	121	PF02991	0.672
LIG_LIR_Nem_3	156	162	PF02991	0.492
LIG_LIR_Nem_3	254	260	PF02991	0.411
LIG_LIR_Nem_3	38	42	PF02991	0.593
LIG_LIR_Nem_3	432	438	PF02991	0.425
LIG_LIR_Nem_3	495	500	PF02991	0.450
LIG_LIR_Nem_3	52	58	PF02991	0.476
LIG_LIR_Nem_3	585	591	PF02991	0.646
LIG_LIR_Nem_3	66	72	PF02991	0.485
LIG_NRBOX	403	409	PF00104	0.448
LIG_NRBOX	433	439	PF00104	0.448
LIG_NRBOX	448	454	PF00104	0.355
LIG_PCNA_yPIPBox_3	178	188	PF02747	0.559
LIG_PCNA_yPIPBox_3	209	219	PF02747	0.544
LIG_Pex14_2	374	378	PF04695	0.594
LIG_PROFILIN_1	8	14	PF00235	0.670
LIG_RPA_C_Fungi	519	531	PF08784	0.381
LIG_SH2_CRK	39	43	PF00017	0.540
LIG_SH2_CRK	405	409	PF00017	0.274
LIG_SH2_CRK	435	439	PF00017	0.494
LIG_SH2_CRK	877	881	PF00017	0.459
LIG_SH2_PTP2	615	618	PF00017	0.519
LIG_SH2_STAT5	247	250	PF00017	0.447
LIG_SH2_STAT5	302	305	PF00017	0.542
LIG_SH2_STAT5	315	318	PF00017	0.537
LIG_SH2_STAT5	615	618	PF00017	0.481
LIG_SH2_STAT5	724	727	PF00017	0.427
LIG_SH2_STAT5	731	734	PF00017	0.356
LIG_SH2_STAT5	744	747	PF00017	0.370
LIG_SH2_STAT5	868	871	PF00017	0.478
LIG_SH2_STAT5	877	880	PF00017	0.454
LIG_SH3_3	13	19	PF00018	0.766
LIG_SH3_3	139	145	PF00018	0.715
LIG_SH3_3	303	309	PF00018	0.557
LIG_SH3_3	361	367	PF00018	0.746
LIG_SH3_3	584	590	PF00018	0.677
LIG_SH3_3	6	12	PF00018	0.769
LIG_SH3_3	806	812	PF00018	0.615
LIG_SH3_3	867	873	PF00018	0.476
LIG_SH3_3	886	892	PF00018	0.482
LIG_Sin3_3	289	296	PF02671	0.469
LIG_SUMO_SIM_anti_2	379	388	PF11976	0.481
LIG_SUMO_SIM_par_1	169	175	PF11976	0.533
LIG_TRFH_1	302	306	PF08558	0.574
LIG_TYR_ITIM	37	42	PF00017	0.554
LIG_TYR_ITIM	403	408	PF00017	0.408
LIG_TYR_ITIM	875	880	PF00017	0.452
LIG_UBA3_1	542	549	PF00899	0.418
LIG_UBA3_1	791	798	PF00899	0.411
LIG_Vh1_VBS_1	644	662	PF01044	0.386
LIG_WW_3	93	97	PF00397	0.773
MOD_CK1_1	122	128	PF00069	0.753
MOD_CK1_1	133	139	PF00069	0.749
MOD_CK1_1	22	28	PF00069	0.821
MOD_CK1_1	251	257	PF00069	0.434
MOD_CK1_1	38	44	PF00069	0.593
MOD_CK1_1	465	471	PF00069	0.724
MOD_CK1_1	498	504	PF00069	0.529
MOD_CK1_1	545	551	PF00069	0.557
MOD_CK1_1	649	655	PF00069	0.418
MOD_CK1_1	759	765	PF00069	0.466
MOD_CK1_1	776	782	PF00069	0.494
MOD_CK1_1	794	800	PF00069	0.466
MOD_CK1_1	98	104	PF00069	0.774
MOD_CK2_1	208	214	PF00069	0.411
MOD_CK2_1	221	227	PF00069	0.382
MOD_CK2_1	264	270	PF00069	0.502
MOD_CK2_1	420	426	PF00069	0.528
MOD_CK2_1	535	541	PF00069	0.435
MOD_CMANNOS	412	415	PF00535	0.512
MOD_Cter_Amidation	620	623	PF01082	0.589
MOD_DYRK1A_RPxSP_1	583	587	PF00069	0.453
MOD_GlcNHglycan	114	117	PF01048	0.689
MOD_GlcNHglycan	120	124	PF01048	0.710
MOD_GlcNHglycan	31	34	PF01048	0.775
MOD_GlcNHglycan	324	327	PF01048	0.496
MOD_GlcNHglycan	343	346	PF01048	0.556
MOD_GlcNHglycan	390	393	PF01048	0.439
MOD_GlcNHglycan	422	425	PF01048	0.536
MOD_GlcNHglycan	497	500	PF01048	0.481
MOD_GlcNHglycan	537	540	PF01048	0.430
MOD_GlcNHglycan	549	552	PF01048	0.403
MOD_GlcNHglycan	593	596	PF01048	0.644
MOD_GlcNHglycan	648	651	PF01048	0.427
MOD_GlcNHglycan	666	669	PF01048	0.313
MOD_GlcNHglycan	780	783	PF01048	0.572
MOD_GlcNHglycan	97	100	PF01048	0.762
MOD_GSK3_1	119	126	PF00069	0.665
MOD_GSK3_1	131	138	PF00069	0.704
MOD_GSK3_1	19	26	PF00069	0.791
MOD_GSK3_1	243	250	PF00069	0.489
MOD_GSK3_1	322	329	PF00069	0.447
MOD_GSK3_1	368	375	PF00069	0.627
MOD_GSK3_1	38	45	PF00069	0.623
MOD_GSK3_1	459	466	PF00069	0.725
MOD_GSK3_1	476	483	PF00069	0.389
MOD_GSK3_1	484	491	PF00069	0.494
MOD_GSK3_1	547	554	PF00069	0.570
MOD_GSK3_1	645	652	PF00069	0.356
MOD_GSK3_1	753	760	PF00069	0.426
MOD_GSK3_1	773	780	PF00069	0.334
MOD_N-GLC_1	321	326	PF02516	0.493
MOD_N-GLC_1	346	351	PF02516	0.626
MOD_N-GLC_1	785	790	PF02516	0.613
MOD_NEK2_1	132	137	PF00069	0.774
MOD_NEK2_1	203	208	PF00069	0.393
MOD_NEK2_1	264	269	PF00069	0.475
MOD_NEK2_1	341	346	PF00069	0.533
MOD_NEK2_1	413	418	PF00069	0.522
MOD_NEK2_1	420	425	PF00069	0.467
MOD_NEK2_1	484	489	PF00069	0.586
MOD_NEK2_1	516	521	PF00069	0.504
MOD_NEK2_1	535	540	PF00069	0.224
MOD_NEK2_1	542	547	PF00069	0.408
MOD_NEK2_1	591	596	PF00069	0.620
MOD_NEK2_1	645	650	PF00069	0.358
MOD_NEK2_1	672	677	PF00069	0.351
MOD_NEK2_1	737	742	PF00069	0.382
MOD_NEK2_1	791	796	PF00069	0.458
MOD_NEK2_2	767	772	PF00069	0.530
MOD_PIKK_1	486	492	PF00454	0.613
MOD_PIKK_1	851	857	PF00454	0.556
MOD_PIKK_1	98	104	PF00454	0.807
MOD_PKA_1	694	700	PF00069	0.569
MOD_PKA_2	208	214	PF00069	0.563
MOD_PKA_2	322	328	PF00069	0.491
MOD_PKA_2	35	41	PF00069	0.664
MOD_PKA_2	372	378	PF00069	0.553
MOD_PKA_2	413	419	PF00069	0.567
MOD_PKA_2	516	522	PF00069	0.493
MOD_PKA_2	694	700	PF00069	0.495
MOD_PKA_2	95	101	PF00069	0.733
MOD_Plk_1	176	182	PF00069	0.432
MOD_Plk_1	213	219	PF00069	0.512
MOD_Plk_1	220	226	PF00069	0.508
MOD_Plk_1	63	69	PF00069	0.572
MOD_Plk_2-3	221	227	PF00069	0.529
MOD_Plk_2-3	376	382	PF00069	0.511
MOD_Plk_2-3	727	733	PF00069	0.433
MOD_Plk_4	196	202	PF00069	0.511
MOD_Plk_4	221	227	PF00069	0.442
MOD_Plk_4	264	270	PF00069	0.402
MOD_Plk_4	42	48	PF00069	0.610
MOD_Plk_4	468	474	PF00069	0.670
MOD_Plk_4	753	759	PF00069	0.433
MOD_Plk_4	816	822	PF00069	0.567
MOD_ProDKin_1	138	144	PF00069	0.693
MOD_ProDKin_1	276	282	PF00069	0.495
MOD_ProDKin_1	398	404	PF00069	0.533
MOD_ProDKin_1	476	482	PF00069	0.616
MOD_ProDKin_1	583	589	PF00069	0.451
MOD_ProDKin_1	773	779	PF00069	0.596
MOD_ProDKin_1	786	792	PF00069	0.566
MOD_ProDKin_1	866	872	PF00069	0.461
MOD_ProDKin_1	875	881	PF00069	0.448
MOD_SUMO_rev_2	391	400	PF00179	0.565
TRG_DiLeu_BaEn_1	278	283	PF01217	0.533
TRG_DiLeu_BaEn_1	641	646	PF01217	0.469
TRG_DiLeu_BaLyEn_6	166	171	PF01217	0.503
TRG_DiLeu_BaLyEn_6	511	516	PF01217	0.534
TRG_DiLeu_BaLyEn_6	787	792	PF01217	0.435
TRG_ENDOCYTIC_2	39	42	PF00928	0.544
TRG_ENDOCYTIC_2	405	408	PF00928	0.409
TRG_ENDOCYTIC_2	435	438	PF00928	0.465
TRG_ENDOCYTIC_2	615	618	PF00928	0.569
TRG_ENDOCYTIC_2	877	880	PF00928	0.449
TRG_ER_diArg_1	622	624	PF00400	0.496
TRG_ER_diArg_1	663	666	PF00400	0.430
TRG_ER_diArg_1	72	75	PF00400	0.540
TRG_ER_diArg_1	826	829	PF00400	0.453
TRG_ER_diArg_1	832	834	PF00400	0.442
TRG_ER_diArg_1	84	87	PF00400	0.525
TRG_NES_CRM1_1	285	297	PF08389	0.470
TRG_NES_CRM1_1	432	446	PF08389	0.522
TRG_Pf-PMV_PEXEL_1	217	221	PF00026	0.516
TRG_Pf-PMV_PEXEL_1	332	336	PF00026	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I525	Leptomonas seymouri	67%	95%
A0A0S4JJP4	Bodo saltans	27%	100%
A0A1X0P5I8	Trypanosomatidae	40%	100%
A0A422N2Z0	Trypanosoma rangeli	42%	100%
A4HFM6	Leishmania braziliensis	86%	100%
A4I2Q4	Leishmania infantum	100%	100%
D0A5V6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AD80	Leishmania major	96%	100%
E9AZ04	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5B8L6	Trypanosoma cruzi	42%	100%