XRN 5'-3' exonuclease N-terminus, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

XRN 5'-3' exonuclease N-terminus, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X0L0_LEIDO

TriTrypDb:

LdBPK_270800.1 , LdCL_270014600 , LDHU3_27.1330

Length:

570

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X0L0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0L0

Function

Biological processes
Term	Name	Level	Count
GO:0000956	nuclear-transcribed mRNA catabolic process	7	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006401	RNA catabolic process	5	1
GO:0006402	mRNA catabolic process	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010629	negative regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0048519	negative regulation of biological process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	15
GO:0003824	catalytic activity	1	15
GO:0004518	nuclease activity	4	15
GO:0004527	exonuclease activity	5	15
GO:0005488	binding	1	15
GO:0016787	hydrolase activity	2	15
GO:0016788	hydrolase activity, acting on ester bonds	3	15
GO:0097159	organic cyclic compound binding	2	15
GO:1901363	heterocyclic compound binding	2	15
GO:0003723	RNA binding	4	1
GO:0004532	RNA exonuclease activity	5	1
GO:0004534	5'-3' RNA exonuclease activity	7	1
GO:0004540	RNA nuclease activity	4	1
GO:0008409	5'-3' exonuclease activity	6	1
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	6	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.571
CLV_C14_Caspase3-7	435	439	PF00656	0.623
CLV_MEL_PAP_1	465	471	PF00089	0.513
CLV_NRD_NRD_1	166	168	PF00675	0.332
CLV_NRD_NRD_1	196	198	PF00675	0.335
CLV_NRD_NRD_1	301	303	PF00675	0.384
CLV_NRD_NRD_1	314	316	PF00675	0.384
CLV_NRD_NRD_1	351	353	PF00675	0.587
CLV_NRD_NRD_1	420	422	PF00675	0.527
CLV_NRD_NRD_1	518	520	PF00675	0.580
CLV_NRD_NRD_1	544	546	PF00675	0.648
CLV_NRD_NRD_1	98	100	PF00675	0.264
CLV_PCSK_FUR_1	349	353	PF00082	0.635
CLV_PCSK_KEX2_1	196	198	PF00082	0.336
CLV_PCSK_KEX2_1	301	303	PF00082	0.356
CLV_PCSK_KEX2_1	314	316	PF00082	0.404
CLV_PCSK_KEX2_1	351	353	PF00082	0.601
CLV_PCSK_KEX2_1	518	520	PF00082	0.584
CLV_PCSK_KEX2_1	556	558	PF00082	0.747
CLV_PCSK_KEX2_1	98	100	PF00082	0.263
CLV_PCSK_PC1ET2_1	351	353	PF00082	0.601
CLV_PCSK_PC1ET2_1	556	558	PF00082	0.686
CLV_PCSK_SKI1_1	108	112	PF00082	0.322
CLV_PCSK_SKI1_1	314	318	PF00082	0.492
CLV_PCSK_SKI1_1	331	335	PF00082	0.261
CLV_PCSK_SKI1_1	34	38	PF00082	0.361
CLV_PCSK_SKI1_1	356	360	PF00082	0.572
CLV_PCSK_SKI1_1	60	64	PF00082	0.239
DEG_APCC_DBOX_1	33	41	PF00400	0.571
DEG_APCC_DBOX_1	75	83	PF00400	0.555
DOC_CYCLIN_yCln2_LP_2	238	244	PF00134	0.498
DOC_MAPK_gen_1	301	308	PF00069	0.394
DOC_MAPK_gen_1	466	473	PF00069	0.462
DOC_MAPK_gen_1	72	81	PF00069	0.522
DOC_MAPK_gen_1	96	104	PF00069	0.500
DOC_MAPK_MEF2A_6	274	282	PF00069	0.334
DOC_PP1_RVXF_1	272	278	PF00149	0.339
DOC_PP2B_LxvP_1	345	348	PF13499	0.576
DOC_SPAK_OSR1_1	468	472	PF12202	0.308
DOC_USP7_MATH_1	112	116	PF00917	0.523
DOC_USP7_MATH_1	204	208	PF00917	0.550
DOC_WW_Pin1_4	124	129	PF00397	0.567
DOC_WW_Pin1_4	444	449	PF00397	0.547
LIG_14-3-3_CanoR_1	352	359	PF00244	0.587
LIG_14-3-3_CanoR_1	466	472	PF00244	0.388
LIG_14-3-3_CanoR_1	487	497	PF00244	0.553
LIG_14-3-3_CanoR_1	512	520	PF00244	0.465
LIG_14-3-3_CanoR_1	52	59	PF00244	0.551
LIG_14-3-3_CanoR_1	60	69	PF00244	0.479
LIG_14-3-3_CanoR_1	98	103	PF00244	0.497
LIG_AP2alpha_2	240	242	PF02296	0.509
LIG_APCC_ABBA_1	139	144	PF00400	0.541
LIG_APCC_ABBA_1	397	402	PF00400	0.601
LIG_BRCT_BRCA1_1	385	389	PF00533	0.489
LIG_eIF4E_1	171	177	PF01652	0.571
LIG_eIF4E_1	233	239	PF01652	0.483
LIG_eIF4E_1	312	318	PF01652	0.455
LIG_FHA_1	159	165	PF00498	0.550
LIG_FHA_1	340	346	PF00498	0.634
LIG_FHA_1	353	359	PF00498	0.333
LIG_FHA_1	372	378	PF00498	0.460
LIG_FHA_1	444	450	PF00498	0.606
LIG_FHA_1	496	502	PF00498	0.473
LIG_FHA_1	508	514	PF00498	0.476
LIG_FHA_1	76	82	PF00498	0.476
LIG_FHA_2	200	206	PF00498	0.544
LIG_FHA_2	235	241	PF00498	0.439
LIG_FHA_2	479	485	PF00498	0.560
LIG_FHA_2	504	510	PF00498	0.476
LIG_FHA_2	512	518	PF00498	0.420
LIG_FHA_2	92	98	PF00498	0.554
LIG_LIR_Apic_2	14	20	PF02991	0.488
LIG_LIR_Gen_1	172	178	PF02991	0.562
LIG_LIR_Gen_1	234	244	PF02991	0.384
LIG_LIR_Gen_1	276	283	PF02991	0.323
LIG_LIR_Nem_3	172	176	PF02991	0.542
LIG_LIR_Nem_3	234	239	PF02991	0.338
LIG_LIR_Nem_3	276	282	PF02991	0.323
LIG_LIR_Nem_3	286	292	PF02991	0.359
LIG_LIR_Nem_3	394	398	PF02991	0.489
LIG_Rb_LxCxE_1	151	172	PF01857	0.571
LIG_SH2_CRK	17	21	PF00017	0.561
LIG_SH2_CRK	83	87	PF00017	0.552
LIG_SH2_NCK_1	236	240	PF00017	0.494
LIG_SH2_SRC	9	12	PF00017	0.515
LIG_SH2_STAT3	163	166	PF00017	0.516
LIG_SH2_STAT5	130	133	PF00017	0.545
LIG_SH2_STAT5	159	162	PF00017	0.561
LIG_SH2_STAT5	163	166	PF00017	0.561
LIG_SH2_STAT5	236	239	PF00017	0.398
LIG_SH2_STAT5	312	315	PF00017	0.476
LIG_SH2_STAT5	387	390	PF00017	0.436
LIG_SH2_STAT5	9	12	PF00017	0.488
LIG_SH3_3	101	107	PF00018	0.535
LIG_SH3_3	226	232	PF00018	0.522
LIG_SH3_3	257	263	PF00018	0.574
LIG_SH3_3	442	448	PF00018	0.653
LIG_SH3_3	449	455	PF00018	0.405
LIG_SH3_3	47	53	PF00018	0.552
LIG_SUMO_SIM_anti_2	220	227	PF11976	0.493
LIG_SUMO_SIM_anti_2	77	84	PF11976	0.497
LIG_SUMO_SIM_par_1	77	84	PF11976	0.513
LIG_TRAF2_1	155	158	PF00917	0.560
LIG_TYR_ITAM	286	306	PF00017	0.515
LIG_TYR_ITIM	81	86	PF00017	0.571
LIG_WW_2	263	266	PF00397	0.574
LIG_WW_3	105	109	PF00397	0.571
MOD_CK1_1	116	122	PF00069	0.499
MOD_CK1_1	234	240	PF00069	0.465
MOD_CK1_1	245	251	PF00069	0.473
MOD_CK1_1	339	345	PF00069	0.585
MOD_CK1_1	383	389	PF00069	0.448
MOD_CK1_1	406	412	PF00069	0.523
MOD_CK1_1	507	513	PF00069	0.531
MOD_CK2_1	245	251	PF00069	0.439
MOD_CK2_1	5	11	PF00069	0.516
MOD_CK2_1	511	517	PF00069	0.434
MOD_CK2_1	91	97	PF00069	0.561
MOD_GlcNHglycan	118	121	PF01048	0.302
MOD_GlcNHglycan	178	181	PF01048	0.303
MOD_GlcNHglycan	191	194	PF01048	0.259
MOD_GlcNHglycan	283	286	PF01048	0.409
MOD_GlcNHglycan	318	321	PF01048	0.485
MOD_GlcNHglycan	336	339	PF01048	0.591
MOD_GlcNHglycan	524	527	PF01048	0.597
MOD_GSK3_1	108	115	PF00069	0.544
MOD_GSK3_1	116	123	PF00069	0.520
MOD_GSK3_1	124	131	PF00069	0.507
MOD_GSK3_1	467	474	PF00069	0.479
MOD_GSK3_1	48	55	PF00069	0.496
MOD_GSK3_1	486	493	PF00069	0.475
MOD_GSK3_1	503	510	PF00069	0.415
MOD_GSK3_1	518	525	PF00069	0.561
MOD_LATS_1	415	421	PF00433	0.576
MOD_N-GLC_1	120	125	PF02516	0.363
MOD_N-GLC_1	218	223	PF02516	0.269
MOD_N-GLC_1	558	563	PF02516	0.729
MOD_NEK2_1	176	181	PF00069	0.520
MOD_NEK2_1	242	247	PF00069	0.498
MOD_NEK2_1	334	339	PF00069	0.545
MOD_NEK2_1	488	493	PF00069	0.460
MOD_NEK2_2	120	125	PF00069	0.571
MOD_NEK2_2	380	385	PF00069	0.493
MOD_PIKK_1	206	212	PF00454	0.563
MOD_PIKK_1	254	260	PF00454	0.500
MOD_PIKK_1	339	345	PF00454	0.568
MOD_PIKK_1	371	377	PF00454	0.444
MOD_PIKK_1	478	484	PF00454	0.543
MOD_PIKK_1	91	97	PF00454	0.498
MOD_PKA_1	351	357	PF00069	0.596
MOD_PKA_1	518	524	PF00069	0.607
MOD_PKA_1	98	104	PF00069	0.489
MOD_PKA_2	351	357	PF00069	0.581
MOD_PKA_2	467	473	PF00069	0.397
MOD_PKA_2	477	483	PF00069	0.398
MOD_PKA_2	486	492	PF00069	0.456
MOD_PKA_2	51	57	PF00069	0.552
MOD_PKA_2	511	517	PF00069	0.548
MOD_PKA_2	518	524	PF00069	0.600
MOD_PKA_2	75	81	PF00069	0.523
MOD_PKA_2	98	104	PF00069	0.496
MOD_Plk_1	120	126	PF00069	0.516
MOD_Plk_1	242	248	PF00069	0.473
MOD_Plk_4	159	165	PF00069	0.564
MOD_Plk_4	212	218	PF00069	0.544
MOD_Plk_4	231	237	PF00069	0.236
MOD_Plk_4	245	251	PF00069	0.503
MOD_Plk_4	75	81	PF00069	0.494
MOD_ProDKin_1	124	130	PF00069	0.567
MOD_ProDKin_1	444	450	PF00069	0.530
MOD_SUMO_rev_2	183	192	PF00179	0.469
TRG_DiLeu_BaEn_1	372	377	PF01217	0.499
TRG_ENDOCYTIC_2	235	238	PF00928	0.367
TRG_ENDOCYTIC_2	289	292	PF00928	0.377
TRG_ENDOCYTIC_2	303	306	PF00928	0.319
TRG_ENDOCYTIC_2	395	398	PF00928	0.538
TRG_ENDOCYTIC_2	83	86	PF00928	0.553
TRG_ER_diArg_1	195	197	PF00400	0.561
TRG_ER_diArg_1	300	302	PF00400	0.374
TRG_ER_diArg_1	313	315	PF00400	0.391
TRG_ER_diArg_1	465	468	PF00400	0.424
TRG_ER_diArg_1	518	520	PF00400	0.585
TRG_ER_diArg_1	73	76	PF00400	0.566
TRG_NLS_MonoExtN_4	348	355	PF00514	0.608
TRG_Pf-PMV_PEXEL_1	196	201	PF00026	0.355
TRG_Pf-PMV_PEXEL_1	34	39	PF00026	0.361

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I835	Leptomonas seymouri	64%	97%
A0A0S4ILZ5	Bodo saltans	33%	97%
A0A0S4JAK8	Bodo saltans	28%	99%
A0A1X0P557	Trypanosomatidae	40%	100%
A0A3R7RG04	Trypanosoma rangeli	27%	69%
A0A422N1U3	Trypanosoma rangeli	42%	100%
A4HFL7	Leishmania braziliensis	80%	100%
A4I352	Leishmania infantum	99%	100%
D0A5U8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AD71	Leishmania major	92%	100%
E9AYZ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5AT41	Trypanosoma cruzi	38%	100%
V5BDQ7	Trypanosoma cruzi	30%	93%