LeishMANIAdb
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WD domain, G-beta repeat, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
WD domain, G-beta repeat, putative
Gene product:
WD domain, G-beta repeat, putative
Species:
Leishmania donovani
UniProt:
A0A3S7X0K8_LEIDO
TriTrypDb:
LdBPK_270690.1 * , LdCL_270013700 , LDHU3_27.1110
Length:
1035

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X0K8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0K8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 37 41 PF00656 0.657
CLV_C14_Caspase3-7 574 578 PF00656 0.546
CLV_C14_Caspase3-7 696 700 PF00656 0.517
CLV_C14_Caspase3-7 785 789 PF00656 0.579
CLV_C14_Caspase3-7 881 885 PF00656 0.476
CLV_NRD_NRD_1 284 286 PF00675 0.658
CLV_NRD_NRD_1 936 938 PF00675 0.653
CLV_NRD_NRD_1 986 988 PF00675 0.501
CLV_NRD_NRD_1 997 999 PF00675 0.434
CLV_PCSK_KEX2_1 284 286 PF00082 0.630
CLV_PCSK_KEX2_1 581 583 PF00082 0.542
CLV_PCSK_KEX2_1 848 850 PF00082 0.553
CLV_PCSK_KEX2_1 936 938 PF00082 0.656
CLV_PCSK_KEX2_1 986 988 PF00082 0.501
CLV_PCSK_KEX2_1 997 999 PF00082 0.499
CLV_PCSK_PC1ET2_1 284 286 PF00082 0.630
CLV_PCSK_PC1ET2_1 581 583 PF00082 0.542
CLV_PCSK_PC1ET2_1 848 850 PF00082 0.533
CLV_PCSK_SKI1_1 1027 1031 PF00082 0.506
CLV_PCSK_SKI1_1 182 186 PF00082 0.511
CLV_PCSK_SKI1_1 270 274 PF00082 0.389
CLV_PCSK_SKI1_1 706 710 PF00082 0.402
CLV_PCSK_SKI1_1 721 725 PF00082 0.436
CLV_PCSK_SKI1_1 848 852 PF00082 0.514
CLV_PCSK_SKI1_1 962 966 PF00082 0.422
CLV_PCSK_SKI1_1 987 991 PF00082 0.422
DEG_APCC_DBOX_1 177 185 PF00400 0.412
DEG_APCC_DBOX_1 269 277 PF00400 0.475
DEG_APCC_DBOX_1 705 713 PF00400 0.436
DEG_APCC_DBOX_1 871 879 PF00400 0.507
DEG_MDM2_SWIB_1 747 755 PF02201 0.568
DEG_Nend_UBRbox_3 1 3 PF02207 0.648
DEG_SPOP_SBC_1 430 434 PF00917 0.368
DOC_CKS1_1 53 58 PF01111 0.566
DOC_CKS1_1 796 801 PF01111 0.668
DOC_CYCLIN_RxL_1 1024 1034 PF00134 0.591
DOC_CYCLIN_yCln2_LP_2 11 17 PF00134 0.537
DOC_CYCLIN_yCln2_LP_2 22 25 PF00134 0.621
DOC_MAPK_gen_1 116 124 PF00069 0.595
DOC_MAPK_gen_1 633 643 PF00069 0.429
DOC_MAPK_MEF2A_6 636 643 PF00069 0.502
DOC_MAPK_MEF2A_6 834 843 PF00069 0.619
DOC_MAPK_NFAT4_5 636 644 PF00069 0.459
DOC_PP1_RVXF_1 119 126 PF00149 0.437
DOC_PP1_RVXF_1 464 471 PF00149 0.391
DOC_PP1_RVXF_1 960 966 PF00149 0.411
DOC_PP2B_LxvP_1 22 25 PF13499 0.621
DOC_PP2B_LxvP_1 850 853 PF13499 0.542
DOC_PP4_FxxP_1 1022 1025 PF00568 0.420
DOC_PP4_FxxP_1 566 569 PF00568 0.404
DOC_PP4_FxxP_1 85 88 PF00568 0.596
DOC_USP7_MATH_1 162 166 PF00917 0.628
DOC_USP7_MATH_1 209 213 PF00917 0.383
DOC_USP7_MATH_1 351 355 PF00917 0.730
DOC_USP7_MATH_1 395 399 PF00917 0.627
DOC_USP7_MATH_1 451 455 PF00917 0.475
DOC_USP7_MATH_1 527 531 PF00917 0.430
DOC_USP7_MATH_1 544 548 PF00917 0.644
DOC_USP7_MATH_1 674 678 PF00917 0.523
DOC_USP7_MATH_1 685 689 PF00917 0.491
DOC_USP7_MATH_1 698 702 PF00917 0.613
DOC_USP7_MATH_1 789 793 PF00917 0.591
DOC_USP7_MATH_1 805 809 PF00917 0.507
DOC_USP7_MATH_1 830 834 PF00917 0.564
DOC_USP7_MATH_1 917 921 PF00917 0.619
DOC_USP7_UBL2_3 656 660 PF12436 0.519
DOC_WW_Pin1_4 10 15 PF00397 0.665
DOC_WW_Pin1_4 105 110 PF00397 0.712
DOC_WW_Pin1_4 222 227 PF00397 0.606
DOC_WW_Pin1_4 331 336 PF00397 0.569
DOC_WW_Pin1_4 346 351 PF00397 0.605
DOC_WW_Pin1_4 511 516 PF00397 0.515
DOC_WW_Pin1_4 52 57 PF00397 0.566
DOC_WW_Pin1_4 759 764 PF00397 0.629
DOC_WW_Pin1_4 795 800 PF00397 0.669
DOC_WW_Pin1_4 818 823 PF00397 0.610
DOC_WW_Pin1_4 828 833 PF00397 0.603
DOC_WW_Pin1_4 924 929 PF00397 0.591
LIG_14-3-3_CanoR_1 178 182 PF00244 0.454
LIG_14-3-3_CanoR_1 193 201 PF00244 0.507
LIG_14-3-3_CanoR_1 352 359 PF00244 0.627
LIG_14-3-3_CanoR_1 500 509 PF00244 0.523
LIG_14-3-3_CanoR_1 62 66 PF00244 0.602
LIG_14-3-3_CanoR_1 702 709 PF00244 0.484
LIG_14-3-3_CanoR_1 783 787 PF00244 0.581
LIG_14-3-3_CanoR_1 81 86 PF00244 0.453
LIG_14-3-3_CanoR_1 834 841 PF00244 0.562
LIG_14-3-3_CanoR_1 857 865 PF00244 0.521
LIG_14-3-3_CanoR_1 901 909 PF00244 0.519
LIG_14-3-3_CanoR_1 936 943 PF00244 0.601
LIG_14-3-3_CanoR_1 986 995 PF00244 0.442
LIG_BIR_III_2 788 792 PF00653 0.597
LIG_BIR_III_4 577 581 PF00653 0.571
LIG_BIR_III_4 991 995 PF00653 0.522
LIG_BRCT_BRCA1_1 254 258 PF00533 0.477
LIG_BRCT_BRCA1_1 81 85 PF00533 0.615
LIG_BRCT_BRCA1_1 820 824 PF00533 0.712
LIG_Clathr_ClatBox_1 838 842 PF01394 0.613
LIG_FHA_1 106 112 PF00498 0.623
LIG_FHA_1 127 133 PF00498 0.604
LIG_FHA_1 139 145 PF00498 0.437
LIG_FHA_1 202 208 PF00498 0.496
LIG_FHA_1 214 220 PF00498 0.293
LIG_FHA_1 245 251 PF00498 0.515
LIG_FHA_1 313 319 PF00498 0.431
LIG_FHA_1 332 338 PF00498 0.574
LIG_FHA_1 362 368 PF00498 0.527
LIG_FHA_1 378 384 PF00498 0.461
LIG_FHA_1 447 453 PF00498 0.442
LIG_FHA_1 474 480 PF00498 0.363
LIG_FHA_1 512 518 PF00498 0.445
LIG_FHA_1 607 613 PF00498 0.505
LIG_FHA_1 636 642 PF00498 0.601
LIG_FHA_1 68 74 PF00498 0.568
LIG_FHA_1 796 802 PF00498 0.663
LIG_FHA_1 856 862 PF00498 0.616
LIG_FHA_1 868 874 PF00498 0.457
LIG_FHA_1 925 931 PF00498 0.677
LIG_FHA_1 976 982 PF00498 0.423
LIG_FHA_2 154 160 PF00498 0.591
LIG_FHA_2 35 41 PF00498 0.738
LIG_FHA_2 423 429 PF00498 0.382
LIG_FHA_2 943 949 PF00498 0.499
LIG_Integrin_RGD_1 633 635 PF01839 0.471
LIG_KLC1_Yacidic_2 401 406 PF13176 0.516
LIG_LIR_Apic_2 1021 1025 PF02991 0.496
LIG_LIR_Apic_2 82 88 PF02991 0.587
LIG_LIR_Gen_1 152 163 PF02991 0.438
LIG_LIR_Gen_1 315 323 PF02991 0.473
LIG_LIR_Gen_1 44 53 PF02991 0.605
LIG_LIR_Gen_1 481 489 PF02991 0.415
LIG_LIR_Gen_1 516 527 PF02991 0.557
LIG_LIR_Gen_1 687 697 PF02991 0.420
LIG_LIR_Nem_3 152 158 PF02991 0.399
LIG_LIR_Nem_3 315 320 PF02991 0.466
LIG_LIR_Nem_3 401 407 PF02991 0.590
LIG_LIR_Nem_3 44 50 PF02991 0.606
LIG_LIR_Nem_3 467 473 PF02991 0.480
LIG_LIR_Nem_3 481 485 PF02991 0.320
LIG_LIR_Nem_3 516 522 PF02991 0.453
LIG_LIR_Nem_3 687 692 PF02991 0.420
LIG_LIR_Nem_3 898 902 PF02991 0.503
LIG_MYND_1 459 463 PF01753 0.391
LIG_Pex14_2 138 142 PF04695 0.424
LIG_Pex14_2 747 751 PF04695 0.660
LIG_Pex14_2 984 988 PF04695 0.411
LIG_SH2_CRK 47 51 PF00017 0.690
LIG_SH2_NCK_1 155 159 PF00017 0.475
LIG_SH2_PTP2 404 407 PF00017 0.538
LIG_SH2_SRC 404 407 PF00017 0.538
LIG_SH2_SRC 968 971 PF00017 0.487
LIG_SH2_STAP1 47 51 PF00017 0.646
LIG_SH2_STAP1 482 486 PF00017 0.399
LIG_SH2_STAT5 153 156 PF00017 0.428
LIG_SH2_STAT5 174 177 PF00017 0.570
LIG_SH2_STAT5 366 369 PF00017 0.414
LIG_SH2_STAT5 404 407 PF00017 0.538
LIG_SH2_STAT5 926 929 PF00017 0.599
LIG_SH2_STAT5 982 985 PF00017 0.478
LIG_SH3_2 279 284 PF14604 0.621
LIG_SH3_3 20 26 PF00018 0.598
LIG_SH3_3 273 279 PF00018 0.483
LIG_SH3_3 389 395 PF00018 0.564
LIG_SH3_3 457 463 PF00018 0.386
LIG_SH3_3 826 832 PF00018 0.534
LIG_SH3_4 656 663 PF00018 0.502
LIG_SUMO_SIM_anti_2 1007 1013 PF11976 0.383
LIG_SUMO_SIM_anti_2 183 188 PF11976 0.395
LIG_SUMO_SIM_anti_2 800 805 PF11976 0.656
LIG_SUMO_SIM_par_1 329 334 PF11976 0.566
LIG_SUMO_SIM_par_1 378 384 PF11976 0.420
LIG_SUMO_SIM_par_1 474 481 PF11976 0.326
LIG_SUMO_SIM_par_1 600 605 PF11976 0.400
LIG_SUMO_SIM_par_1 677 684 PF11976 0.373
LIG_SUMO_SIM_par_1 690 696 PF11976 0.482
LIG_TRAF2_1 167 170 PF00917 0.513
LIG_TRFH_1 566 570 PF08558 0.373
LIG_UBA3_1 650 656 PF00899 0.364
LIG_WRC_WIRS_1 1019 1024 PF05994 0.481
LIG_WW_3 1024 1028 PF00397 0.463
MOD_CDC14_SPxK_1 349 352 PF00782 0.512
MOD_CDC14_SPxK_1 831 834 PF00782 0.506
MOD_CDK_SPK_2 759 764 PF00069 0.579
MOD_CDK_SPK_2 924 929 PF00069 0.671
MOD_CDK_SPxK_1 346 352 PF00069 0.509
MOD_CDK_SPxK_1 828 834 PF00069 0.516
MOD_CDK_SPxxK_3 511 518 PF00069 0.470
MOD_CDK_SPxxK_3 52 59 PF00069 0.562
MOD_CK1_1 177 183 PF00069 0.563
MOD_CK1_1 252 258 PF00069 0.451
MOD_CK1_1 290 296 PF00069 0.686
MOD_CK1_1 341 347 PF00069 0.600
MOD_CK1_1 36 42 PF00069 0.745
MOD_CK1_1 360 366 PF00069 0.466
MOD_CK1_1 446 452 PF00069 0.546
MOD_CK1_1 478 484 PF00069 0.389
MOD_CK1_1 540 546 PF00069 0.545
MOD_CK1_1 701 707 PF00069 0.461
MOD_CK1_1 774 780 PF00069 0.607
MOD_CK1_1 833 839 PF00069 0.712
MOD_CK1_1 86 92 PF00069 0.623
MOD_CK1_1 915 921 PF00069 0.738
MOD_CK2_1 112 118 PF00069 0.540
MOD_CK2_1 153 159 PF00069 0.474
MOD_CK2_1 162 168 PF00069 0.527
MOD_CK2_1 395 401 PF00069 0.577
MOD_CK2_1 484 490 PF00069 0.406
MOD_CK2_1 722 728 PF00069 0.569
MOD_CK2_1 738 744 PF00069 0.462
MOD_CK2_1 794 800 PF00069 0.536
MOD_CK2_1 942 948 PF00069 0.515
MOD_Cter_Amidation 579 582 PF01082 0.575
MOD_GlcNHglycan 1006 1009 PF01048 0.467
MOD_GlcNHglycan 105 108 PF01048 0.620
MOD_GlcNHglycan 159 163 PF01048 0.573
MOD_GlcNHglycan 190 193 PF01048 0.512
MOD_GlcNHglycan 326 329 PF01048 0.570
MOD_GlcNHglycan 353 356 PF01048 0.739
MOD_GlcNHglycan 372 375 PF01048 0.317
MOD_GlcNHglycan 387 390 PF01048 0.612
MOD_GlcNHglycan 398 401 PF01048 0.696
MOD_GlcNHglycan 416 419 PF01048 0.336
MOD_GlcNHglycan 445 448 PF01048 0.449
MOD_GlcNHglycan 486 489 PF01048 0.421
MOD_GlcNHglycan 539 542 PF01048 0.742
MOD_GlcNHglycan 67 70 PF01048 0.567
MOD_GlcNHglycan 709 712 PF01048 0.492
MOD_GlcNHglycan 756 759 PF01048 0.493
MOD_GlcNHglycan 766 769 PF01048 0.399
MOD_GlcNHglycan 807 810 PF01048 0.647
MOD_GlcNHglycan 81 84 PF01048 0.533
MOD_GlcNHglycan 824 827 PF01048 0.548
MOD_GlcNHglycan 85 88 PF01048 0.491
MOD_GlcNHglycan 913 917 PF01048 0.641
MOD_GlcNHglycan 938 941 PF01048 0.585
MOD_GSK3_1 149 156 PF00069 0.438
MOD_GSK3_1 158 165 PF00069 0.476
MOD_GSK3_1 176 183 PF00069 0.426
MOD_GSK3_1 188 195 PF00069 0.436
MOD_GSK3_1 203 210 PF00069 0.377
MOD_GSK3_1 340 347 PF00069 0.665
MOD_GSK3_1 357 364 PF00069 0.609
MOD_GSK3_1 366 373 PF00069 0.339
MOD_GSK3_1 442 449 PF00069 0.479
MOD_GSK3_1 469 476 PF00069 0.319
MOD_GSK3_1 540 547 PF00069 0.548
MOD_GSK3_1 57 64 PF00069 0.620
MOD_GSK3_1 590 597 PF00069 0.491
MOD_GSK3_1 722 729 PF00069 0.601
MOD_GSK3_1 743 750 PF00069 0.657
MOD_GSK3_1 77 84 PF00069 0.481
MOD_GSK3_1 818 825 PF00069 0.675
MOD_GSK3_1 851 858 PF00069 0.571
MOD_GSK3_1 908 915 PF00069 0.697
MOD_GSK3_1 931 938 PF00069 0.627
MOD_LATS_1 412 418 PF00433 0.377
MOD_N-GLC_1 323 328 PF02516 0.578
MOD_N-GLC_1 338 343 PF02516 0.499
MOD_N-GLC_1 674 679 PF02516 0.521
MOD_N-GLC_1 950 955 PF02516 0.452
MOD_NEK2_1 1 6 PF00069 0.572
MOD_NEK2_1 202 207 PF00069 0.577
MOD_NEK2_1 213 218 PF00069 0.378
MOD_NEK2_1 304 309 PF00069 0.448
MOD_NEK2_1 340 345 PF00069 0.614
MOD_NEK2_1 368 373 PF00069 0.433
MOD_NEK2_1 495 500 PF00069 0.505
MOD_NEK2_1 590 595 PF00069 0.668
MOD_NEK2_1 707 712 PF00069 0.500
MOD_NEK2_1 747 752 PF00069 0.558
MOD_NEK2_1 782 787 PF00069 0.579
MOD_NEK2_1 824 829 PF00069 0.754
MOD_NEK2_1 844 849 PF00069 0.701
MOD_NEK2_1 935 940 PF00069 0.626
MOD_NEK2_2 716 721 PF00069 0.463
MOD_PIKK_1 594 600 PF00454 0.487
MOD_PIKK_1 701 707 PF00454 0.567
MOD_PIKK_1 856 862 PF00454 0.610
MOD_PKA_1 936 942 PF00069 0.646
MOD_PKA_2 177 183 PF00069 0.438
MOD_PKA_2 192 198 PF00069 0.402
MOD_PKA_2 287 293 PF00069 0.692
MOD_PKA_2 324 330 PF00069 0.520
MOD_PKA_2 351 357 PF00069 0.630
MOD_PKA_2 437 443 PF00069 0.396
MOD_PKA_2 58 64 PF00069 0.625
MOD_PKA_2 701 707 PF00069 0.565
MOD_PKA_2 782 788 PF00069 0.585
MOD_PKA_2 833 839 PF00069 0.624
MOD_PKA_2 856 862 PF00069 0.530
MOD_PKA_2 900 906 PF00069 0.511
MOD_PKA_2 935 941 PF00069 0.670
MOD_Plk_1 202 208 PF00069 0.447
MOD_Plk_1 338 344 PF00069 0.582
MOD_Plk_1 360 366 PF00069 0.503
MOD_Plk_1 377 383 PF00069 0.307
MOD_Plk_1 743 749 PF00069 0.591
MOD_Plk_1 950 956 PF00069 0.501
MOD_Plk_4 1 7 PF00069 0.564
MOD_Plk_4 149 155 PF00069 0.600
MOD_Plk_4 182 188 PF00069 0.443
MOD_Plk_4 203 209 PF00069 0.493
MOD_Plk_4 260 266 PF00069 0.446
MOD_Plk_4 287 293 PF00069 0.670
MOD_Plk_4 313 319 PF00069 0.510
MOD_Plk_4 361 367 PF00069 0.478
MOD_Plk_4 431 437 PF00069 0.411
MOD_Plk_4 637 643 PF00069 0.473
MOD_Plk_4 674 680 PF00069 0.434
MOD_Plk_4 685 691 PF00069 0.439
MOD_Plk_4 719 725 PF00069 0.594
MOD_Plk_4 733 739 PF00069 0.450
MOD_Plk_4 747 753 PF00069 0.502
MOD_Plk_4 774 780 PF00069 0.607
MOD_Plk_4 87 93 PF00069 0.592
MOD_ProDKin_1 10 16 PF00069 0.668
MOD_ProDKin_1 105 111 PF00069 0.697
MOD_ProDKin_1 222 228 PF00069 0.622
MOD_ProDKin_1 331 337 PF00069 0.566
MOD_ProDKin_1 346 352 PF00069 0.608
MOD_ProDKin_1 511 517 PF00069 0.517
MOD_ProDKin_1 52 58 PF00069 0.562
MOD_ProDKin_1 759 765 PF00069 0.621
MOD_ProDKin_1 795 801 PF00069 0.670
MOD_ProDKin_1 818 824 PF00069 0.613
MOD_ProDKin_1 828 834 PF00069 0.604
MOD_ProDKin_1 924 930 PF00069 0.591
MOD_SUMO_for_1 550 553 PF00179 0.568
MOD_SUMO_rev_2 36 44 PF00179 0.618
MOD_SUMO_rev_2 574 583 PF00179 0.576
TRG_DiLeu_BaEn_1 118 123 PF01217 0.545
TRG_DiLeu_BaEn_1 203 208 PF01217 0.493
TRG_DiLeu_BaLyEn_6 554 559 PF01217 0.578
TRG_DiLeu_BaLyEn_6 846 851 PF01217 0.545
TRG_DiLeu_LyEn_5 118 123 PF01217 0.545
TRG_ENDOCYTIC_2 155 158 PF00928 0.384
TRG_ENDOCYTIC_2 404 407 PF00928 0.538
TRG_ENDOCYTIC_2 47 50 PF00928 0.607
TRG_ENDOCYTIC_2 482 485 PF00928 0.401
TRG_ER_diArg_1 872 875 PF00400 0.503
TRG_ER_diArg_1 935 937 PF00400 0.655
TRG_ER_diArg_1 986 988 PF00400 0.501
TRG_ER_diArg_1 997 999 PF00400 0.386
TRG_NLS_MonoExtC_3 283 288 PF00514 0.626
TRG_NLS_MonoExtN_4 282 289 PF00514 0.614
TRG_Pf-PMV_PEXEL_1 1027 1031 PF00026 0.506
TRG_Pf-PMV_PEXEL_1 306 310 PF00026 0.496
TRG_Pf-PMV_PEXEL_1 71 75 PF00026 0.513
TRG_Pf-PMV_PEXEL_1 997 1001 PF00026 0.456

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IJ23 Leptomonas seymouri 37% 96%
A4HFK8 Leishmania braziliensis 70% 100%
A4I2P0 Leishmania infantum 99% 100%
E9AD63 Leishmania major 92% 100%
E9AYY8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS