Leucine Rich repeat, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X0J8_LEIDO

TriTrypDb:

LdBPK_270660.1 , LdCL_270013100 , LDHU3_27.1040

Length:

352

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	8
GO:0042995	cell projection	2	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0110165	cellular anatomical entity	1	8
GO:0120025	plasma membrane bounded cell projection	3	8

Expansion

Sequence features

A0A3S7X0J8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0J8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	181	185	PF00656	0.428
CLV_NRD_NRD_1	202	204	PF00675	0.420
CLV_NRD_NRD_1	250	252	PF00675	0.496
CLV_NRD_NRD_1	278	280	PF00675	0.390
CLV_NRD_NRD_1	347	349	PF00675	0.488
CLV_NRD_NRD_1	50	52	PF00675	0.535
CLV_PCSK_KEX2_1	202	204	PF00082	0.420
CLV_PCSK_KEX2_1	250	252	PF00082	0.496
CLV_PCSK_KEX2_1	278	280	PF00082	0.390
CLV_PCSK_KEX2_1	347	349	PF00082	0.488
CLV_PCSK_KEX2_1	52	54	PF00082	0.541
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.518
CLV_PCSK_SKI1_1	138	142	PF00082	0.553
CLV_PCSK_SKI1_1	171	175	PF00082	0.397
CLV_PCSK_SKI1_1	202	206	PF00082	0.441
CLV_PCSK_SKI1_1	6	10	PF00082	0.415
DEG_Nend_UBRbox_1	1	4	PF02207	0.339
DOC_CYCLIN_RxL_1	197	208	PF00134	0.415
DOC_CYCLIN_RxL_1	264	275	PF00134	0.356
DOC_MAPK_gen_1	322	331	PF00069	0.359
DOC_USP7_MATH_1	103	107	PF00917	0.678
DOC_USP7_MATH_1	140	144	PF00917	0.506
DOC_USP7_MATH_1	75	79	PF00917	0.554
DOC_WW_Pin1_4	149	154	PF00397	0.424
DOC_WW_Pin1_4	163	168	PF00397	0.556
DOC_WW_Pin1_4	58	63	PF00397	0.727
LIG_14-3-3_CanoR_1	138	146	PF00244	0.501
LIG_14-3-3_CanoR_1	155	165	PF00244	0.378
LIG_14-3-3_CanoR_1	171	176	PF00244	0.437
LIG_14-3-3_CanoR_1	250	254	PF00244	0.525
LIG_14-3-3_CanoR_1	272	278	PF00244	0.424
LIG_14-3-3_CterR_2	347	352	PF00244	0.445
LIG_Actin_WH2_2	262	280	PF00022	0.418
LIG_AP2alpha_1	262	266	PF02296	0.345
LIG_APCC_ABBA_1	231	236	PF00400	0.364
LIG_Clathr_ClatBox_1	172	176	PF01394	0.368
LIG_Clathr_ClatBox_1	217	221	PF01394	0.369
LIG_FHA_1	139	145	PF00498	0.506
LIG_FHA_1	172	178	PF00498	0.401
LIG_FHA_1	235	241	PF00498	0.531
LIG_FHA_1	266	272	PF00498	0.371
LIG_FHA_1	287	293	PF00498	0.404
LIG_FHA_1	75	81	PF00498	0.439
LIG_GBD_Chelix_1	269	277	PF00786	0.378
LIG_LIR_Gen_1	166	177	PF02991	0.513
LIG_LIR_Gen_1	74	84	PF02991	0.443
LIG_LIR_Nem_3	166	172	PF02991	0.575
LIG_LIR_Nem_3	264	269	PF02991	0.430
LIG_LIR_Nem_3	74	79	PF02991	0.463
LIG_NRBOX	200	206	PF00104	0.398
LIG_PCNA_yPIPBox_3	203	217	PF02747	0.269
LIG_Pex14_2	262	266	PF04695	0.345
LIG_Rb_LxCxE_1	174	192	PF01857	0.417
LIG_SH2_PTP2	169	172	PF00017	0.440
LIG_SH2_STAT5	169	172	PF00017	0.545
LIG_SH2_STAT5	316	319	PF00017	0.380
LIG_SH3_3	25	31	PF00018	0.470
LIG_SUMO_SIM_anti_2	110	117	PF11976	0.408
LIG_SUMO_SIM_par_1	171	176	PF11976	0.374
LIG_WRC_WIRS_1	342	347	PF05994	0.435
MOD_CDC14_SPxK_1	152	155	PF00782	0.438
MOD_CDK_SPxK_1	149	155	PF00069	0.419
MOD_CK1_1	110	116	PF00069	0.541
MOD_CK1_1	222	228	PF00069	0.496
MOD_CK1_1	255	261	PF00069	0.357
MOD_CK1_1	286	292	PF00069	0.349
MOD_CK1_1	66	72	PF00069	0.679
MOD_CK2_1	222	228	PF00069	0.551
MOD_CK2_1	285	291	PF00069	0.430
MOD_CK2_1	331	337	PF00069	0.513
MOD_CK2_1	68	74	PF00069	0.672
MOD_CK2_1	99	105	PF00069	0.480
MOD_GlcNHglycan	101	104	PF01048	0.598
MOD_GlcNHglycan	105	108	PF01048	0.629
MOD_GlcNHglycan	109	112	PF01048	0.517
MOD_GlcNHglycan	158	161	PF01048	0.473
MOD_GlcNHglycan	191	194	PF01048	0.442
MOD_GlcNHglycan	221	224	PF01048	0.519
MOD_GlcNHglycan	306	309	PF01048	0.454
MOD_GSK3_1	110	117	PF00069	0.391
MOD_GSK3_1	138	145	PF00069	0.489
MOD_GSK3_1	156	163	PF00069	0.392
MOD_GSK3_1	205	212	PF00069	0.390
MOD_GSK3_1	234	241	PF00069	0.505
MOD_GSK3_1	286	293	PF00069	0.440
MOD_GSK3_1	99	106	PF00069	0.640
MOD_N-GLC_1	209	214	PF02516	0.409
MOD_N-GLC_1	99	104	PF02516	0.481
MOD_NEK2_1	156	161	PF00069	0.568
MOD_NEK2_1	189	194	PF00069	0.445
MOD_NEK2_1	205	210	PF00069	0.251
MOD_NEK2_1	219	224	PF00069	0.477
MOD_NEK2_1	271	276	PF00069	0.390
MOD_NEK2_1	331	336	PF00069	0.554
MOD_NEK2_1	42	47	PF00069	0.482
MOD_NEK2_1	9	14	PF00069	0.433
MOD_NEK2_2	249	254	PF00069	0.528
MOD_PIKK_1	252	258	PF00454	0.451
MOD_PKA_2	249	255	PF00069	0.466
MOD_PKA_2	271	277	PF00069	0.389
MOD_Plk_1	209	215	PF00069	0.269
MOD_Plk_1	290	296	PF00069	0.354
MOD_Plk_1	66	72	PF00069	0.745
MOD_Plk_2-3	142	148	PF00069	0.451
MOD_Plk_4	110	116	PF00069	0.411
MOD_Plk_4	291	297	PF00069	0.398
MOD_Plk_4	341	347	PF00069	0.469
MOD_Plk_4	75	81	PF00069	0.395
MOD_Plk_4	83	89	PF00069	0.360
MOD_ProDKin_1	149	155	PF00069	0.419
MOD_ProDKin_1	163	169	PF00069	0.551
MOD_ProDKin_1	58	64	PF00069	0.731
TRG_DiLeu_BaEn_1	327	332	PF01217	0.451
TRG_DiLeu_BaLyEn_6	185	190	PF01217	0.520
TRG_DiLeu_BaLyEn_6	200	205	PF01217	0.294
TRG_DiLeu_LyEn_5	327	332	PF01217	0.451
TRG_ENDOCYTIC_2	169	172	PF00928	0.571
TRG_ER_diArg_1	201	203	PF00400	0.422
TRG_ER_diArg_1	277	279	PF00400	0.368
TRG_ER_diArg_1	346	348	PF00400	0.417

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0A7	Leptomonas seymouri	39%	99%
A0A1X0NS64	Trypanosomatidae	28%	100%
A4HFK3	Leishmania braziliensis	68%	100%
E9AD57	Leishmania major	89%	100%
E9AHF2	Leishmania infantum	100%	100%
E9AYY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%