Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X0J7_LEIDO

TriTrypDb:

LdBPK_270700.1 , LdCL_270013600 , LDHU3_27.1100

Length:

571

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X0J7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0J7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.780
CLV_C14_Caspase3-7	28	32	PF00656	0.686
CLV_NRD_NRD_1	151	153	PF00675	0.774
CLV_NRD_NRD_1	213	215	PF00675	0.632
CLV_NRD_NRD_1	301	303	PF00675	0.576
CLV_NRD_NRD_1	316	318	PF00675	0.677
CLV_NRD_NRD_1	323	325	PF00675	0.637
CLV_NRD_NRD_1	360	362	PF00675	0.708
CLV_NRD_NRD_1	45	47	PF00675	0.765
CLV_NRD_NRD_1	527	529	PF00675	0.803
CLV_NRD_NRD_1	561	563	PF00675	0.815
CLV_NRD_NRD_1	64	66	PF00675	0.442
CLV_PCSK_FUR_1	358	362	PF00082	0.715
CLV_PCSK_FUR_1	564	568	PF00082	0.672
CLV_PCSK_KEX2_1	151	153	PF00082	0.774
CLV_PCSK_KEX2_1	213	215	PF00082	0.653
CLV_PCSK_KEX2_1	301	303	PF00082	0.576
CLV_PCSK_KEX2_1	315	317	PF00082	0.661
CLV_PCSK_KEX2_1	322	324	PF00082	0.644
CLV_PCSK_KEX2_1	360	362	PF00082	0.708
CLV_PCSK_KEX2_1	45	47	PF00082	0.756
CLV_PCSK_KEX2_1	527	529	PF00082	0.803
CLV_PCSK_KEX2_1	563	565	PF00082	0.813
CLV_PCSK_KEX2_1	566	568	PF00082	0.753
CLV_PCSK_KEX2_1	63	65	PF00082	0.455
CLV_PCSK_PC1ET2_1	563	565	PF00082	0.813
CLV_PCSK_PC1ET2_1	566	568	PF00082	0.753
CLV_PCSK_PC7_1	319	325	PF00082	0.585
CLV_PCSK_PC7_1	562	568	PF00082	0.674
CLV_PCSK_SKI1_1	366	370	PF00082	0.668
CLV_PCSK_SKI1_1	443	447	PF00082	0.668
CLV_PCSK_SKI1_1	45	49	PF00082	0.753
CLV_PCSK_SKI1_1	483	487	PF00082	0.687
CLV_PCSK_SKI1_1	556	560	PF00082	0.759
CLV_PCSK_SKI1_1	563	567	PF00082	0.770
DEG_SCF_FBW7_1	187	194	PF00400	0.746
DEG_SPOP_SBC_1	506	510	PF00917	0.749
DOC_CKS1_1	192	197	PF01111	0.740
DOC_CYCLIN_RxL_1	360	373	PF00134	0.641
DOC_CYCLIN_yCln2_LP_2	230	236	PF00134	0.572
DOC_MAPK_gen_1	155	164	PF00069	0.640
DOC_MAPK_gen_1	319	329	PF00069	0.698
DOC_MAPK_MEF2A_6	322	331	PF00069	0.685
DOC_MAPK_MEF2A_6	349	356	PF00069	0.711
DOC_MAPK_MEF2A_6	483	492	PF00069	0.706
DOC_PP2B_LxvP_1	138	141	PF13499	0.580
DOC_PP2B_LxvP_1	230	233	PF13499	0.699
DOC_PP4_FxxP_1	120	123	PF00568	0.757
DOC_USP7_MATH_1	109	113	PF00917	0.739
DOC_USP7_MATH_1	123	127	PF00917	0.576
DOC_USP7_MATH_1	173	177	PF00917	0.645
DOC_USP7_MATH_1	19	23	PF00917	0.595
DOC_USP7_MATH_1	288	292	PF00917	0.708
DOC_USP7_MATH_1	303	307	PF00917	0.598
DOC_USP7_MATH_1	413	417	PF00917	0.761
DOC_USP7_MATH_1	445	449	PF00917	0.630
DOC_USP7_MATH_1	461	465	PF00917	0.692
DOC_USP7_MATH_1	505	509	PF00917	0.692
DOC_USP7_MATH_1	511	515	PF00917	0.734
DOC_USP7_MATH_1	523	527	PF00917	0.791
DOC_WW_Pin1_4	119	124	PF00397	0.827
DOC_WW_Pin1_4	187	192	PF00397	0.610
DOC_WW_Pin1_4	45	50	PF00397	0.674
DOC_WW_Pin1_4	521	526	PF00397	0.797
DOC_WW_Pin1_4	543	548	PF00397	0.720
LIG_14-3-3_CanoR_1	172	178	PF00244	0.613
LIG_14-3-3_CanoR_1	301	311	PF00244	0.654
LIG_14-3-3_CanoR_1	385	391	PF00244	0.672
LIG_14-3-3_CanoR_1	402	408	PF00244	0.533
LIG_14-3-3_CanoR_1	483	489	PF00244	0.581
LIG_14-3-3_CanoR_1	527	534	PF00244	0.769
LIG_14-3-3_CanoR_1	556	565	PF00244	0.708
LIG_BRCT_BRCA1_1	545	549	PF00533	0.620
LIG_FAT_LD_1	50	58	PF03623	0.609
LIG_FHA_1	188	194	PF00498	0.646
LIG_FHA_1	292	298	PF00498	0.603
LIG_FHA_1	425	431	PF00498	0.716
LIG_FHA_1	485	491	PF00498	0.703
LIG_FHA_2	433	439	PF00498	0.637
LIG_FHA_2	46	52	PF00498	0.638
LIG_LIR_Apic_2	117	123	PF02991	0.753
LIG_LIR_Apic_2	219	225	PF02991	0.660
LIG_LIR_Apic_2	403	408	PF02991	0.647
LIG_LIR_Gen_1	196	207	PF02991	0.616
LIG_LIR_Nem_3	133	138	PF02991	0.599
LIG_LIR_Nem_3	196	202	PF02991	0.616
LIG_LIR_Nem_3	219	224	PF02991	0.604
LIG_LIR_Nem_3	341	347	PF02991	0.602
LIG_LIR_Nem_3	406	412	PF02991	0.628
LIG_Pex14_1	353	357	PF04695	0.561
LIG_SH2_CRK	199	203	PF00017	0.589
LIG_SH2_CRK	405	409	PF00017	0.661
LIG_SH2_GRB2like	203	206	PF00017	0.707
LIG_SH2_NCK_1	199	203	PF00017	0.589
LIG_SH2_NCK_1	234	238	PF00017	0.578
LIG_SH2_NCK_1	405	409	PF00017	0.661
LIG_SH2_SRC	203	206	PF00017	0.707
LIG_SH2_STAP1	199	203	PF00017	0.589
LIG_SH2_STAP1	234	238	PF00017	0.578
LIG_SH2_STAP1	293	297	PF00017	0.574
LIG_SH2_STAP1	75	79	PF00017	0.663
LIG_SH2_STAT3	339	342	PF00017	0.687
LIG_SH2_STAT3	419	422	PF00017	0.738
LIG_SH2_STAT5	137	140	PF00017	0.588
LIG_SH2_STAT5	203	206	PF00017	0.606
LIG_SH2_STAT5	293	296	PF00017	0.590
LIG_SH2_STAT5	405	408	PF00017	0.613
LIG_SH3_1	405	411	PF00018	0.775
LIG_SH3_2	522	527	PF14604	0.751
LIG_SH3_3	361	367	PF00018	0.672
LIG_SH3_3	405	411	PF00018	0.769
LIG_SH3_3	427	433	PF00018	0.684
LIG_SH3_3	519	525	PF00018	0.749
LIG_SUMO_SIM_anti_2	35	40	PF11976	0.781
LIG_SUMO_SIM_anti_2	487	492	PF11976	0.779
LIG_SUMO_SIM_par_1	484	489	PF11976	0.696
LIG_TRAF2_1	477	480	PF00917	0.714
LIG_WW_3	152	156	PF00397	0.670
MOD_CDC14_SPxK_1	524	527	PF00782	0.754
MOD_CDK_SPxK_1	521	527	PF00069	0.751
MOD_CDK_SPxxK_3	521	528	PF00069	0.752
MOD_CK1_1	111	117	PF00069	0.710
MOD_CK1_1	22	28	PF00069	0.608
MOD_CK1_1	255	261	PF00069	0.711
MOD_CK1_1	291	297	PF00069	0.606
MOD_CK1_1	526	532	PF00069	0.840
MOD_CK1_1	537	543	PF00069	0.661
MOD_CK1_1	545	551	PF00069	0.537
MOD_CK1_1	552	558	PF00069	0.630
MOD_CK1_1	93	99	PF00069	0.653
MOD_CK2_1	332	338	PF00069	0.638
MOD_CK2_1	432	438	PF00069	0.735
MOD_CK2_1	445	451	PF00069	0.752
MOD_CK2_1	45	51	PF00069	0.640
MOD_Cter_Amidation	43	46	PF01082	0.787
MOD_GlcNHglycan	114	117	PF01048	0.695
MOD_GlcNHglycan	16	19	PF01048	0.610
MOD_GlcNHglycan	167	170	PF01048	0.618
MOD_GlcNHglycan	234	237	PF01048	0.696
MOD_GlcNHglycan	257	260	PF01048	0.766
MOD_GlcNHglycan	373	376	PF01048	0.683
MOD_GlcNHglycan	388	391	PF01048	0.484
MOD_GlcNHglycan	447	450	PF01048	0.721
MOD_GlcNHglycan	539	542	PF01048	0.743
MOD_GlcNHglycan	98	101	PF01048	0.688
MOD_GSK3_1	108	115	PF00069	0.767
MOD_GSK3_1	119	126	PF00069	0.666
MOD_GSK3_1	183	190	PF00069	0.583
MOD_GSK3_1	193	200	PF00069	0.539
MOD_GSK3_1	248	255	PF00069	0.717
MOD_GSK3_1	456	463	PF00069	0.704
MOD_GSK3_1	494	501	PF00069	0.705
MOD_GSK3_1	507	514	PF00069	0.720
MOD_GSK3_1	517	524	PF00069	0.734
MOD_GSK3_1	532	539	PF00069	0.613
MOD_GSK3_1	541	548	PF00069	0.635
MOD_GSK3_1	550	557	PF00069	0.576
MOD_N-GLC_1	255	260	PF02516	0.721
MOD_N-GLC_1	512	517	PF02516	0.655
MOD_NEK2_1	14	19	PF00069	0.573
MOD_NEK2_1	144	149	PF00069	0.637
MOD_NEK2_1	164	169	PF00069	0.376
MOD_NEK2_1	467	472	PF00069	0.731
MOD_NEK2_1	492	497	PF00069	0.771
MOD_NEK2_1	512	517	PF00069	0.537
MOD_NEK2_1	534	539	PF00069	0.752
MOD_NEK2_1	549	554	PF00069	0.565
MOD_NEK2_1	558	563	PF00069	0.556
MOD_NEK2_2	270	275	PF00069	0.540
MOD_NEK2_2	400	405	PF00069	0.642
MOD_PIKK_1	123	129	PF00454	0.640
MOD_PIKK_1	248	254	PF00454	0.659
MOD_PIKK_1	403	409	PF00454	0.756
MOD_PIKK_1	492	498	PF00454	0.682
MOD_PK_1	527	533	PF00069	0.762
MOD_PKA_1	322	328	PF00069	0.532
MOD_PKA_1	527	533	PF00069	0.762
MOD_PKA_2	144	150	PF00069	0.638
MOD_PKA_2	171	177	PF00069	0.622
MOD_PKA_2	303	309	PF00069	0.696
MOD_PKA_2	322	328	PF00069	0.532
MOD_PKA_2	384	390	PF00069	0.672
MOD_PKA_2	526	532	PF00069	0.740
MOD_PKA_2	535	541	PF00069	0.759
MOD_Plk_1	183	189	PF00069	0.640
MOD_Plk_1	340	346	PF00069	0.602
MOD_Plk_1	512	518	PF00069	0.750
MOD_Plk_2-3	332	338	PF00069	0.638
MOD_Plk_2-3	475	481	PF00069	0.716
MOD_Plk_2-3	90	96	PF00069	0.658
MOD_Plk_4	173	179	PF00069	0.633
MOD_Plk_4	206	212	PF00069	0.590
MOD_Plk_4	288	294	PF00069	0.578
MOD_Plk_4	340	346	PF00069	0.597
MOD_Plk_4	432	438	PF00069	0.648
MOD_Plk_4	512	518	PF00069	0.828
MOD_ProDKin_1	119	125	PF00069	0.827
MOD_ProDKin_1	187	193	PF00069	0.608
MOD_ProDKin_1	45	51	PF00069	0.671
MOD_ProDKin_1	521	527	PF00069	0.799
MOD_ProDKin_1	543	549	PF00069	0.721
TRG_DiLeu_BaLyEn_6	188	193	PF01217	0.583
TRG_DiLeu_BaLyEn_6	364	369	PF01217	0.728
TRG_ENDOCYTIC_2	135	138	PF00928	0.613
TRG_ENDOCYTIC_2	199	202	PF00928	0.590
TRG_ENDOCYTIC_2	409	412	PF00928	0.647
TRG_ER_diArg_1	10	13	PF00400	0.636
TRG_ER_diArg_1	151	153	PF00400	0.774
TRG_ER_diArg_1	213	215	PF00400	0.653
TRG_ER_diArg_1	300	302	PF00400	0.584
TRG_ER_diArg_1	315	317	PF00400	0.648
TRG_ER_diArg_1	322	324	PF00400	0.728
TRG_ER_diArg_1	357	360	PF00400	0.642
TRG_ER_diArg_1	562	565	PF00400	0.738
TRG_ER_diArg_1	62	65	PF00400	0.617
TRG_NES_CRM1_1	479	493	PF08389	0.781
TRG_NLS_MonoExtC_3	561	566	PF00514	0.813
TRG_NLS_MonoExtN_4	562	567	PF00514	0.813
TRG_Pf-PMV_PEXEL_1	157	161	PF00026	0.611
TRG_Pf-PMV_PEXEL_1	64	69	PF00026	0.644

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Z3	Leptomonas seymouri	55%	100%
A4HFK7	Leishmania braziliensis	74%	100%
A4I2N9	Leishmania infantum	100%	100%
E9AD62	Leishmania major	92%	100%
E9AYY7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%