Mitochondrial RNA binding complex 1 subunit

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X0J4_LEIDO

TriTrypDb:

LdBPK_270710.1 , LdCL_270013500 , LDHU3_27.1090

Length:

868

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X0J4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X0J4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	824	828	PF00656	0.595
CLV_NRD_NRD_1	107	109	PF00675	0.348
CLV_NRD_NRD_1	222	224	PF00675	0.563
CLV_NRD_NRD_1	411	413	PF00675	0.496
CLV_NRD_NRD_1	6	8	PF00675	0.632
CLV_NRD_NRD_1	61	63	PF00675	0.524
CLV_NRD_NRD_1	799	801	PF00675	0.526
CLV_PCSK_KEX2_1	107	109	PF00082	0.348
CLV_PCSK_KEX2_1	192	194	PF00082	0.671
CLV_PCSK_KEX2_1	222	224	PF00082	0.551
CLV_PCSK_KEX2_1	411	413	PF00082	0.494
CLV_PCSK_KEX2_1	43	45	PF00082	0.590
CLV_PCSK_KEX2_1	6	8	PF00082	0.633
CLV_PCSK_KEX2_1	61	63	PF00082	0.377
CLV_PCSK_KEX2_1	799	801	PF00082	0.526
CLV_PCSK_KEX2_1	825	827	PF00082	0.531
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.605
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.581
CLV_PCSK_PC1ET2_1	825	827	PF00082	0.531
CLV_PCSK_SKI1_1	155	159	PF00082	0.399
CLV_PCSK_SKI1_1	181	185	PF00082	0.467
CLV_PCSK_SKI1_1	246	250	PF00082	0.464
CLV_PCSK_SKI1_1	265	269	PF00082	0.251
CLV_PCSK_SKI1_1	292	296	PF00082	0.595
CLV_PCSK_SKI1_1	43	47	PF00082	0.498
CLV_PCSK_SKI1_1	516	520	PF00082	0.511
CLV_PCSK_SKI1_1	559	563	PF00082	0.397
CLV_PCSK_SKI1_1	615	619	PF00082	0.475
CLV_PCSK_SKI1_1	69	73	PF00082	0.532
CLV_PCSK_SKI1_1	799	803	PF00082	0.525
DEG_APCC_DBOX_1	396	404	PF00400	0.426
DEG_APCC_DBOX_1	5	13	PF00400	0.609
DEG_APCC_DBOX_1	68	76	PF00400	0.515
DEG_Nend_Nbox_1	1	3	PF02207	0.582
DOC_CDC14_PxL_1	552	560	PF14671	0.413
DOC_CYCLIN_RxL_1	360	369	PF00134	0.538
DOC_CYCLIN_RxL_1	556	566	PF00134	0.336
DOC_CYCLIN_yClb1_LxF_4	242	248	PF00134	0.510
DOC_MAPK_DCC_7	336	344	PF00069	0.528
DOC_MAPK_gen_1	289	297	PF00069	0.599
DOC_MAPK_gen_1	3	11	PF00069	0.600
DOC_MAPK_gen_1	43	53	PF00069	0.583
DOC_MAPK_gen_1	462	472	PF00069	0.507
DOC_MAPK_gen_1	541	549	PF00069	0.374
DOC_MAPK_gen_1	825	831	PF00069	0.526
DOC_MAPK_MEF2A_6	336	344	PF00069	0.528
DOC_MAPK_MEF2A_6	383	390	PF00069	0.553
DOC_MAPK_MEF2A_6	615	622	PF00069	0.439
DOC_MAPK_NFAT4_5	383	391	PF00069	0.544
DOC_MAPK_NFAT4_5	615	623	PF00069	0.471
DOC_PP1_RVXF_1	142	148	PF00149	0.428
DOC_PP1_RVXF_1	153	159	PF00149	0.396
DOC_PP1_SILK_1	512	517	PF00149	0.523
DOC_PP2B_LxvP_1	782	785	PF13499	0.428
DOC_PP4_FxxP_1	658	661	PF00568	0.505
DOC_PP4_FxxP_1	802	805	PF00568	0.529
DOC_USP7_MATH_1	113	117	PF00917	0.521
DOC_USP7_MATH_1	196	200	PF00917	0.476
DOC_USP7_MATH_1	233	237	PF00917	0.439
DOC_USP7_MATH_1	510	514	PF00917	0.521
DOC_USP7_MATH_1	631	635	PF00917	0.630
DOC_USP7_MATH_1	756	760	PF00917	0.695
DOC_USP7_MATH_1	815	819	PF00917	0.590
DOC_USP7_MATH_1	90	94	PF00917	0.532
DOC_USP7_UBL2_3	188	192	PF12436	0.598
DOC_USP7_UBL2_3	43	47	PF12436	0.556
DOC_WW_Pin1_4	114	119	PF00397	0.545
DOC_WW_Pin1_4	343	348	PF00397	0.626
DOC_WW_Pin1_4	714	719	PF00397	0.633
DOC_WW_Pin1_4	790	795	PF00397	0.483
LIG_14-3-3_CanoR_1	433	443	PF00244	0.547
LIG_14-3-3_CanoR_1	44	54	PF00244	0.523
LIG_14-3-3_CanoR_1	503	507	PF00244	0.511
LIG_14-3-3_CanoR_1	598	602	PF00244	0.546
LIG_14-3-3_CanoR_1	6	10	PF00244	0.594
LIG_14-3-3_CanoR_1	61	71	PF00244	0.433
LIG_14-3-3_CanoR_1	636	646	PF00244	0.529
LIG_14-3-3_CanoR_1	649	653	PF00244	0.381
LIG_14-3-3_CanoR_1	687	697	PF00244	0.450
LIG_14-3-3_CanoR_1	747	753	PF00244	0.723
LIG_Actin_WH2_1	241	258	PF00022	0.497
LIG_Actin_WH2_2	233	248	PF00022	0.477
LIG_Actin_WH2_2	396	413	PF00022	0.443
LIG_Actin_WH2_2	447	464	PF00022	0.434
LIG_Actin_WH2_2	486	502	PF00022	0.530
LIG_Actin_WH2_2	511	529	PF00022	0.512
LIG_Actin_WH2_2	554	572	PF00022	0.448
LIG_Actin_WH2_2	579	597	PF00022	0.438
LIG_Actin_WH2_2	671	689	PF00022	0.523
LIG_APCC_ABBA_1	655	660	PF00400	0.503
LIG_APCC_ABBA_1	676	681	PF00400	0.471
LIG_BIR_III_2	533	537	PF00653	0.523
LIG_BRCT_BRCA1_1	348	352	PF00533	0.585
LIG_Clathr_ClatBox_1	731	735	PF01394	0.356
LIG_DCNL_PONY_1	1	4	PF03556	0.690
LIG_deltaCOP1_diTrp_1	180	186	PF00928	0.478
LIG_FHA_1	119	125	PF00498	0.289
LIG_FHA_1	32	38	PF00498	0.539
LIG_FHA_1	418	424	PF00498	0.541
LIG_FHA_1	817	823	PF00498	0.508
LIG_FHA_1	830	836	PF00498	0.384
LIG_FHA_2	131	137	PF00498	0.534
LIG_FHA_2	147	153	PF00498	0.277
LIG_FHA_2	462	468	PF00498	0.506
LIG_FHA_2	473	479	PF00498	0.476
LIG_FHA_2	55	61	PF00498	0.508
LIG_FHA_2	598	604	PF00498	0.605
LIG_GBD_Chelix_1	582	590	PF00786	0.480
LIG_LIR_Apic_2	550	554	PF02991	0.487
LIG_LIR_Gen_1	162	173	PF02991	0.496
LIG_LIR_Gen_1	199	209	PF02991	0.433
LIG_LIR_Gen_1	273	281	PF02991	0.536
LIG_LIR_Gen_1	467	473	PF02991	0.480
LIG_LIR_Gen_1	677	686	PF02991	0.453
LIG_LIR_Gen_1	735	741	PF02991	0.449
LIG_LIR_Gen_1	776	786	PF02991	0.391
LIG_LIR_Gen_1	78	88	PF02991	0.406
LIG_LIR_Nem_3	135	141	PF02991	0.414
LIG_LIR_Nem_3	162	168	PF02991	0.507
LIG_LIR_Nem_3	199	204	PF02991	0.433
LIG_LIR_Nem_3	273	277	PF02991	0.486
LIG_LIR_Nem_3	283	287	PF02991	0.506
LIG_LIR_Nem_3	355	361	PF02991	0.515
LIG_LIR_Nem_3	447	451	PF02991	0.436
LIG_LIR_Nem_3	467	472	PF02991	0.387
LIG_LIR_Nem_3	533	538	PF02991	0.484
LIG_LIR_Nem_3	677	682	PF02991	0.504
LIG_LIR_Nem_3	735	739	PF02991	0.414
LIG_LIR_Nem_3	776	781	PF02991	0.389
LIG_LIR_Nem_3	78	84	PF02991	0.391
LIG_LYPXL_S_1	137	141	PF13949	0.509
LIG_LYPXL_yS_3	138	141	PF13949	0.515
LIG_LYPXL_yS_3	284	287	PF13949	0.578
LIG_NRBOX	23	29	PF00104	0.512
LIG_NRBOX	557	563	PF00104	0.472
LIG_NRBOX	727	733	PF00104	0.397
LIG_Pex14_1	182	186	PF04695	0.453
LIG_Pex14_2	270	274	PF04695	0.453
LIG_REV1ctd_RIR_1	849	859	PF16727	0.542
LIG_SH2_PTP2	551	554	PF00017	0.510
LIG_SH2_SRC	551	554	PF00017	0.510
LIG_SH2_STAT3	332	335	PF00017	0.592
LIG_SH2_STAT3	522	525	PF00017	0.537
LIG_SH2_STAT5	126	129	PF00017	0.504
LIG_SH2_STAT5	217	220	PF00017	0.537
LIG_SH2_STAT5	551	554	PF00017	0.469
LIG_SH2_STAT5	736	739	PF00017	0.431
LIG_SH2_STAT5	778	781	PF00017	0.461
LIG_SH3_3	169	175	PF00018	0.483
LIG_SH3_3	341	347	PF00018	0.714
LIG_SH3_3	550	556	PF00018	0.412
LIG_SH3_3	613	619	PF00018	0.531
LIG_SH3_3	839	845	PF00018	0.540
LIG_Sin3_3	384	391	PF02671	0.468
LIG_Sin3_3	81	88	PF02671	0.418
LIG_SUMO_SIM_anti_2	8	13	PF11976	0.517
LIG_SUMO_SIM_anti_2	818	824	PF11976	0.573
LIG_SUMO_SIM_par_1	138	143	PF11976	0.501
LIG_SUMO_SIM_par_1	674	681	PF11976	0.466
LIG_SUMO_SIM_par_1	818	824	PF11976	0.497
LIG_TRAF2_1	438	441	PF00917	0.598
LIG_TYR_ITIM	356	361	PF00017	0.511
LIG_UBA3_1	123	129	PF00899	0.416
LIG_UBA3_1	27	31	PF00899	0.474
LIG_WRC_WIRS_1	469	474	PF05994	0.480
MOD_CK1_1	346	352	PF00069	0.640
MOD_CK1_1	416	422	PF00069	0.479
MOD_CK1_1	447	453	PF00069	0.468
MOD_CK1_1	482	488	PF00069	0.537
MOD_CK1_1	639	645	PF00069	0.566
MOD_CK1_1	647	653	PF00069	0.435
MOD_CK1_1	714	720	PF00069	0.619
MOD_CK1_1	751	757	PF00069	0.619
MOD_CK2_1	130	136	PF00069	0.538
MOD_CK2_1	146	152	PF00069	0.415
MOD_CK2_1	434	440	PF00069	0.641
MOD_CK2_1	597	603	PF00069	0.601
MOD_CK2_1	647	653	PF00069	0.385
MOD_CK2_1	677	683	PF00069	0.550
MOD_Cter_Amidation	4	7	PF01082	0.685
MOD_GlcNHglycan	162	165	PF01048	0.538
MOD_GlcNHglycan	177	180	PF01048	0.296
MOD_GlcNHglycan	198	201	PF01048	0.443
MOD_GlcNHglycan	292	295	PF01048	0.572
MOD_GlcNHglycan	336	339	PF01048	0.610
MOD_GlcNHglycan	348	351	PF01048	0.641
MOD_GlcNHglycan	375	378	PF01048	0.584
MOD_GlcNHglycan	415	418	PF01048	0.449
MOD_GlcNHglycan	437	440	PF01048	0.615
MOD_GlcNHglycan	454	457	PF01048	0.222
MOD_GlcNHglycan	563	566	PF01048	0.496
MOD_GlcNHglycan	728	731	PF01048	0.464
MOD_GlcNHglycan	806	809	PF01048	0.567
MOD_GlcNHglycan	812	815	PF01048	0.597
MOD_GSK3_1	114	121	PF00069	0.405
MOD_GSK3_1	15	22	PF00069	0.459
MOD_GSK3_1	227	234	PF00069	0.540
MOD_GSK3_1	295	302	PF00069	0.671
MOD_GSK3_1	413	420	PF00069	0.487
MOD_GSK3_1	468	475	PF00069	0.469
MOD_GSK3_1	557	564	PF00069	0.459
MOD_GSK3_1	584	591	PF00069	0.499
MOD_GSK3_1	631	638	PF00069	0.621
MOD_GSK3_1	644	651	PF00069	0.385
MOD_GSK3_1	663	670	PF00069	0.460
MOD_GSK3_1	747	754	PF00069	0.576
MOD_GSK3_1	786	793	PF00069	0.501
MOD_N-GLC_1	250	255	PF02516	0.444
MOD_N-GLC_1	31	36	PF02516	0.564
MOD_N-GLC_1	63	68	PF02516	0.610
MOD_N-GLC_1	663	668	PF02516	0.518
MOD_N-GLC_1	756	761	PF02516	0.466
MOD_NEK2_1	160	165	PF00069	0.540
MOD_NEK2_1	186	191	PF00069	0.525
MOD_NEK2_1	210	215	PF00069	0.445
MOD_NEK2_1	354	359	PF00069	0.512
MOD_NEK2_1	434	439	PF00069	0.622
MOD_NEK2_1	461	466	PF00069	0.481
MOD_NEK2_1	472	477	PF00069	0.482
MOD_NEK2_1	499	504	PF00069	0.588
MOD_NEK2_1	584	589	PF00069	0.408
MOD_NEK2_1	748	753	PF00069	0.504
MOD_NEK2_1	837	842	PF00069	0.588
MOD_NEK2_2	444	449	PF00069	0.426
MOD_NEK2_2	756	761	PF00069	0.544
MOD_PIKK_1	740	746	PF00454	0.503
MOD_PIKK_1	751	757	PF00454	0.689
MOD_PK_1	855	861	PF00069	0.564
MOD_PKA_2	432	438	PF00069	0.444
MOD_PKA_2	461	467	PF00069	0.500
MOD_PKA_2	5	11	PF00069	0.567
MOD_PKA_2	502	508	PF00069	0.535
MOD_PKA_2	569	575	PF00069	0.587
MOD_PKA_2	597	603	PF00069	0.601
MOD_PKA_2	635	641	PF00069	0.553
MOD_PKA_2	648	654	PF00069	0.370
MOD_PKA_2	667	673	PF00069	0.477
MOD_Plk_1	250	256	PF00069	0.462
MOD_Plk_1	299	305	PF00069	0.624
MOD_Plk_1	354	360	PF00069	0.518
MOD_Plk_1	625	631	PF00069	0.574
MOD_Plk_1	756	762	PF00069	0.492
MOD_Plk_1	90	96	PF00069	0.461
MOD_Plk_2-3	677	683	PF00069	0.457
MOD_Plk_4	250	256	PF00069	0.478
MOD_Plk_4	468	474	PF00069	0.471
MOD_Plk_4	488	494	PF00069	0.180
MOD_Plk_4	510	516	PF00069	0.486
MOD_Plk_4	557	563	PF00069	0.408
MOD_Plk_4	667	673	PF00069	0.481
MOD_Plk_4	837	843	PF00069	0.567
MOD_Plk_4	855	861	PF00069	0.484
MOD_Plk_4	90	96	PF00069	0.448
MOD_ProDKin_1	114	120	PF00069	0.537
MOD_ProDKin_1	343	349	PF00069	0.619
MOD_ProDKin_1	714	720	PF00069	0.628
MOD_ProDKin_1	790	796	PF00069	0.486
MOD_SUMO_for_1	46	49	PF00179	0.567
TRG_AP2beta_CARGO_1	467	476	PF09066	0.464
TRG_DiLeu_BaEn_1	235	240	PF01217	0.543
TRG_DiLeu_BaEn_1	681	686	PF01217	0.526
TRG_DiLeu_BaEn_2	275	281	PF01217	0.496
TRG_DiLeu_BaEn_2	40	46	PF01217	0.558
TRG_DiLeu_BaLyEn_6	363	368	PF01217	0.533
TRG_DiLeu_BaLyEn_6	527	532	PF01217	0.460
TRG_DiLeu_BaLyEn_6	671	676	PF01217	0.477
TRG_DiLeu_BaLyEn_6	744	749	PF01217	0.414
TRG_ENDOCYTIC_2	138	141	PF00928	0.414
TRG_ENDOCYTIC_2	284	287	PF00928	0.506
TRG_ENDOCYTIC_2	358	361	PF00928	0.503
TRG_ENDOCYTIC_2	736	739	PF00928	0.425
TRG_ENDOCYTIC_2	778	781	PF00928	0.416
TRG_ER_diArg_1	107	110	PF00400	0.518
TRG_ER_diArg_1	397	400	PF00400	0.498
TRG_ER_diArg_1	410	412	PF00400	0.433
TRG_ER_diArg_1	798	800	PF00400	0.525
TRG_NES_CRM1_1	389	402	PF08389	0.374
TRG_NES_CRM1_1	453	467	PF08389	0.435
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	44	49	PF00026	0.568
TRG_Pf-PMV_PEXEL_1	606	610	PF00026	0.434
TRG_Pf-PMV_PEXEL_1	799	803	PF00026	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC39	Leptomonas seymouri	50%	98%
A0A1X0P545	Trypanosomatidae	32%	99%
A0A3R7KBK6	Trypanosoma rangeli	32%	100%
A4HFK6	Leishmania braziliensis	80%	100%
A4I2N8	Leishmania infantum	100%	100%
D0A5T2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AD61	Leishmania major	93%	100%
E9AYY6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BE63	Trypanosoma cruzi	34%	100%